Background: While optimal cardiovascular health (CVH) has been linked to a lower risk of dementia, few studies considered individuals' genetic background. We aimed to examine the interaction between CVH and genetic predisposition on dementia risk among individuals with atherosclerotic cardiovascular disease (ASCVD). Methods: We included 30,818 ASCVD patients from the UK Biobank. CVH was assessed using Life's Essential 8, and genetic predisposition determined by a genetic risk score (GRS) incorporating 85 genetic variants. Cox proportional hazard models were used to estimate hazard ratios (HRs) for all-cause dementia, Alzheimer's disease (AD), and vascular dementia (VaD). Results: Over a median follow-up of 13.5 years, 1,360 cases of all-cause dementia were identified, including 489 AD and 440 VaD cases. Higher CVH levels were associated with a reduced risk of all-cause dementia (HR for high vs. low CVH: 0.60; 95 % CI: 0.47-0.77) and VaD (HR for high vs. low CVH: 0.32; 95 % CI: 0.19-0.54), with a stronger association in individuals with lower GRS. Although the overall CVH score was not associated with the risk of dementia in individuals with high GRS, higher levels of sleep and glucose control were associated with a lower risk of VaD. CVH levels showed no association with the risk of AD. Conclusion: Higher CVH levels were associated with a lower risk of VaD, not AD, with a stronger association in individuals with low GRS. Improvements in specific LE8 components, particularly sleep health and blood glucose management, were associated with reduced VaD risk across various genetic risk strata.

Background Cuproptosis is increasingly recognized as an essential factor in the pathological process of Alzheimer’s disease (AD). However, the specific role of cuproptosis-related genes in AD remains poorly understood. Methods Our first step was to obtain gene expression data from the GEO database and identify differentially expressed cuproptosis-associated genes (DECAGs) in AD. GO, KEGG, and GSEA analyses were then conducted on these genes. Subsequently, we attempted to classify AD patients by unsupervised clustering. Then, four machine-learning models were used to screen hub-genes from the DECAGs. We also explored the immune features of these genes and predicted target drugs. Molecular docking analysis was then performed on the predicted drugs and their corresponding hub-gene related proteins. Candidate markers were then validated by single-cell analysis and intracellular communication was investigated in a GEO scRNA-seq dataset. Lastly, we examined the expression levels of the hub-genes in peripheral blood cells using real-time quantitative PCR. Results 19 DECAGs were found in AD and the key biological processes and molecular functions associated with AD were further determined. Two subtypes of peripheral blood cells showed significant alternations in AD: Cluster1 and Cluster2. Five hub-genes including FDX1 , GLS , PDK1 , MAP2K1 , and SOD1 were then screened out from the machine-learning study. All of the five hub-genes were significantly correlated with various immunocytes. We discovered compounds targeting hub-gene related proteins and forecasted multiple strong hydrogen bonding interactions between the picked predicted drugs and the target proteins by molecular docking analysis. Subsequently, in the single-cell analysis of AD peripheral blood, all hub-genes except SOD1 were found to be up-regulated in B cells, NK cells, and CD4+ T cells, possibly acting on the MIF pathway. Finally, we discovered that the levels of PDK1 expression in AD patients were remarkably upregulated, while FDX1 and GLS were significantly decreased using qPCR. Conclusion This study examined changes in intercellular communication between immune cells in the peripheral blood and identified five novel feature genes associated with cuproptosis in AD patients. These results facilitated a deeper understanding of the molecular mechanisms of AD and suggested novel therapeutic targets.

BackgroundMigraine is a common primary headache that has a significant impact on patients’ quality of life. The co-occurrence of migraine and depression is frequent, resulting in more complex symptoms and a poorer prognosis. The evidence suggests that depression and migraine comorbidity share a polygenic genetic background.ObjectiveThe aim of this study is to identify related genetic variants that contribute to genetic susceptibility to migraine with and without depression in a Chinese cohort.MethodsIn this case-control study, 263 individuals with migraines and 223 race-matched controls were included. Eight genetic polymorphism loci selected from the GWAS were genotyped using Sequenom’s MALDI-TOF iPLEX platform.ResultsIn univariate analysis, ANKDD1B rs904743 showed significant differences in genotype and allele distribution between migraineurs and controls. Furthermore, a machine learning approach was used to perform multivariate analysis. The results of the Random Forest algorithm indicated that ANKDD1B rs904743 was a significant risk factor for migraine susceptibility in China. Additionally, subgroup analysis by the Boruta algorithm showed a significant association between this SNP and migraine comorbid depression. Migraineurs with depression have been observed to have worse scores on the Beck Anxiety Inventory (BAI) and the Migraine Disability Assessment Scale (MIDAS).ConclusionThe study indicates that there is an association between ANKDD1B rs904743 and susceptibility to migraine with and without depression in Chinese patients.

In this hospital-based cross-sectional analytic study, we retrospectively reviewed clinical data of patients with acute ischemic stroke (AIS) between January 2017 and April 2023. Atrial cardiopathy was defined as any presence of the following: left atrial diameter >= 52 mm (males) or >= 47 mm (females), elevated P-wave terminal force in V1 > 5000 mu V ms, or serum N terminal pro B type natriuretic peptide > 250 pg/ml. Initial stroke severity was defined by the National Institutes of Health Stroke Scale (NIHSS; moderate-to-severe, >= 5; and severe, >= 15). Univariate and multivariate binary logistic regression analyses were performed to assess the association between atrial cardiopathy and stroke severity. Among 662 AIS patients (mean age 70 years [interquartile range 61-78], 31.3% women), 303 (45.8%) had atrial cardiopathy. Multivariable logistic regression analysis showed that the presence of atrial cardiopathy was significantly associated with a higher odd of moderate-to-severe stroke (adjusted odds ratio [OR] 2.16, 95% confidence interval [CI] 1.46-3.20, p < 0.001) and severe stroke (adjusted OR 4.89, 95%CI 2.45-9.76, p < 0.001). This association remained significant in a sensitivity analysis excluding those with atrial fibrillation or coronary artery disease. Findings of the current study revealed that the association of atrial cardiopathy was with initial stroke severity independent of atrial fibrillation and was even confirmed in patients without atrial fibrillation; future studies to explore improved stroke prevention strategies for patients with atrial cardiopathy are needed.

Whether physical activity is associated with functional outcomes from ischemic stroke remains poorly understood. We aimed to explore the association of pre-stroke physical activity and functional outcomes in patients with acute ischemic stroke according to sex. Pre-stroke physical activity was assessed using a four-level questionnaire named Saltin-Grimby Physical Activity Level Scale (SGPALS). Our primary outcome was functional independence, defined as a modified Rankin Scale score of 0-2 three months after stroke onset. A prospective cohort study design was used to estimate the multivariable-adjusted odds of functional independence with pre-stroke physical activity. We analyzed 257 men and 142 women participants, including 230 physically inactive and 169 active ones in the final analysis. Physical active participants were at a higher odds of achieving functional independence at 3 months (adjusted OR 4.14, 95%CI 2.35 - 7.31). When stratified by sex adjusted point estimates from logistic regression models indicated that pre-stroke physical activity was significantly associated with 3-month functional independence in both men (OR 4.59, 95%CI 2.19-9.63) and women (OR 3.64, 95%CI 1.44-9.18). This study showed an association between physical activity and functional independence 3 months after ischemic stroke. Moreover, no indication of sex difference in this association were observed.

Purpose To report a case of branch retinal artery occlusion (BRAO) of the left eye combined with left congenital common carotid artery occlusion (CCAO) and internal carotid artery occlusion (ICAO). Methods Case report. Results A 36-year-old man presented with sudden vision loss of only the left eye without any signs or symptoms of brain diseases. Fluorescein fundus angiography (FFA) showed left BRAO, and computed tomography angiography (CTA) of the head and neck showed entire left CCAO and ICAO. The patient's left vertebral artery was anastomosed with the left occipital artery via the muscular branch, supplying blood retrogradely to the left external carotid artery. The right internal carotid artery compensated for blood supply to the left anterior cerebral artery and middle cerebral artery via anterior communication, and the left posterior communication artery compensated for blood supply to the left middle cerebral artery. Conclusions To our knowledge, this study was the first to report a case of BRAO combined with congenital CCAO and ICAO with vision loss as the first symptom and proposed the importance of head and neck examination in retinal artery occlusion at the first visit to a doctor.

OBJECTIVES To investigate the clinical efficacy of mild therapeutic hypothermia (MTH) with different rewarming time on neonatal hypoxic-ischemic encephalopathy (HIE). METHODS A prospective study was performed on 101 neonates with HIE who were born and received MTH in Zhongshan Hospital, Xiamen University, from January 2018 to January 2022. These neonates were randomly divided into two groups: MTH1 group (n=50; rewarming for 10 hours at a rate of 0.25°C/h) and MTH2 group (n=51; rewarming for 25 hours at a rate of 0.10°C/h). The clinical features and the clinical efficacy were compared between the two groups. A binary logistic regression analysis was used to identify the factors influencing the occurrence of normal sleep-wake cycle (SWC) on amplitude-integrated electroencephalogram (aEEG) at 25 hours of rewarming. RESULTS There were no significant differences between the MTH1 and MTH2 groups in gestational age, 5-minute Apgar score, and proportion of neonates with moderate/severe HIE (P>0.05). Compared with the MTH2 group, the MTH1 group tended to have a normal arterial blood pH value at the end of rewarming, a significantly shorter duration of oxygen dependence, a significantly higher proportion of neonates with normal SWC on aEEG at 10 and 25 hours of rewarming, and a significantly higher Neonatal Behavioral Neurological Assessment score on days 5, 12, and 28 after birth (P<0.05), while there was no significant difference in the incidence rate of rewarming-related seizures between the two groups (P>0.05). There were no significant differences between the two groups in the incidence rate of neurological disability at 6 months of age and the score of Bayley Scale of Infant Development at 3 and 6 months of age (P>0.05). The binary logistic regression analysis showed that prolonged rewarming time (25 hours) was not conducive to the occurrence of normal SWC (OR=3.423, 95%CI: 1.237-9.469, P=0.018). CONCLUSIONS Rewarming for 10 hours has a better short-term clinical efficacy than rewarming for 25 hours. Prolonging rewarming time has limited clinical benefits on neonates with moderate/severe HIE and is not conducive to the occurrence of normal SWC, and therefore, it is not recommended as a routine treatment method.

目的 比较巴曲酶不同应用时机对急性脑梗死(ACI)患者神经功能的影响.方法 选择2019年9月至2020年8月我院收治的136例ACI患者,随机分为两组各68例.对照组入院12 h后给予巴曲酶,观察组入院后即刻给予巴曲酶,之后隔日用药1次,连续治疗14 d.对比两组的临床疗效、神经功能缺损状况、凝血功能、不良反应.结果 观察组治疗总有效率高于对照组(P<0.05).治疗前,两组的NIHSS评分、FIB水平比较无统计学差异(P>0.05);治疗后,观察组的NIHSS评分、FIB水平低于对照组(P<0.05).两组患者治疗前后的PT比较无统计学差异(P<0.05).两组的不良反应发生率比较无统计学差异(P>0.05).结论 ACI患者入院后即刻采用巴曲酶治疗效果更佳,可明显减轻神经功能缺损状况,改善凝血功能,利于症状快速缓解,应用价值较高.

How to prevent stroke in daily life and grasp the possibility of illness as early as possible have become important problems. In this paper, we predict the possibility of the disease through the physiological indicators of the at-risk population. In this process, we first dealt with the common problems of missing data and imbalance between classes in medical data sets, and then we combined multiple simple neural networks and XGBoost tree model through ensemble learning methods. After training this strong classifier with the processed data set, we used this model to predict the incidence of stroke and compared it with the results of other classifiers. After several experiments, we got an average accuracy rate of 75.77 % and an average specificity of 78.8%, which means that our model can better identify high-risk individuals while ensuring a certain overall accuracy rate. On the whole, our work can quickly derive disease risk through easily accessible physiological indicators, and provide references for early diagnosis and treatment of stroke.

目的 探究普罗布考联合瑞舒伐他汀对脑梗死患者炎症介质及相关实验室检查指标的影响.方法 选择2019年12月至2021年2月厦门大学附属第一医院收治的脑梗死患者106例,按随机数字表法分为对照组(53例)和观察组(53例).对照组采用瑞舒伐他汀治疗,观察组在对照组基础上加用普罗布考治疗.比较两组炎症介质、血清神经元特异性烯醇化酶(NSE)、中枢神经系统特异性蛋白(S100β)、人甲壳质酶蛋白40(YKL-40)及血脂水平.结果 观察组治疗后肿瘤坏死因子-α(TNF-α)、降钙素原(PCT)、超敏C反应蛋白(hs-CRP)、白介素-6(IL-6)及基质金属蛋白酶9(MMP-9)水平均低于对照组,NSE、S100β、YKL-40水平均低于对照组,三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白(LDL-C)水平均低于对照组,高密度脂蛋白(HDL-C)高于对照组,差异有统计学意义(P＜0.05);两组不良反应比较,差异无统计学意义(P＞0.05).结论 在脑梗死患者中采用普罗布考联合瑞舒伐他汀治疗可有效降低炎症反应,减轻神经损伤,调节血脂水平,促进神经功能改善,安全可靠.

目的:探讨阿替普酶联合阿加曲班在急性脑梗死(ACI)患者中的应用价值.方法:选择2019年3月至2020年10月厦门大学附属第一医院就诊的92例ACI患者,依据随机数字表法分成两组,各46例.对照组予以阿替普酶,观察组加用阿加曲班,连续用药14 d.对比两组临床疗效、神经功能损伤因子、血流动力学指标、不良反应.结果:观察组治疗总有效率为93.48％,高于对照组的78.26％,差异有统计学意义(P<0.05);治疗前,两组神经元特异性烯醇化酶(NSE)、S100β蛋白水平和全血低切黏度(LSV)、全血高切黏度(HSV)比较,差异无统计学意义(P>0.05);治疗后,观察组NSE、S100β蛋白和LSV、HSV水平低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05).结论:阿替普酶联合阿加曲班能够降低ACI患者神经功能损伤因子水平,改善其血流动力学,效果显著.

Introduction: Matrix metalloproteinase-9 (MMP9) plays a key role in blood–spinal cord barrier dysfunction. MMP9 blockade leads to improved injured locomotor recovery. However, it is still unknown whether MMP9 deficiency affects gene expression or signal transduction pathways in the spinal neuron. Material and Methods: In this study, we first screen the MMP9 knockdown mice with high superoxide dismutase (SOD) expression and low MMP9 expression by polymerase chain reaction analysis. Then, the gene microarrays were used to screen differentially expressed genes in the spinal neuron from MMP-9 knockout and wild-type mice. There were six groups in this experiment, including three negative control groups: SOD_1, SOD_2, and SOD_3, and three experiment groups: SOD_ MMP9_1, SOD_ MMP9_2, and SOD_ MMP9_3. The gene ontology terms were used to predict the potential functions of these differentially expressed genes, and the Kyoto Encyclopedia of Genes and Genomes was used to analyze the potential functions of these target genes in the pathways. Results: We found that the gene expression in the spinal neuron from MMP9 knockout mice was significantly altered compared to wild-type mice. FoxO signaling, axon guidance, ubiquitin-mediated proteolysis, regulation of actin cytoskeleton, and proteoglycans were changed. Discussion and Conclusion: In summary, MMP9 plays a role in spinal neuron signaling and the underlying mechanism may through affecting several signaling pathways.

Bone marrow mesenchymal stem cells (BMSCs) are used as a great promising choice for the treatment of cerebral ischemia. Herein, we discuss the neuroprotective effects of the combination of BMSCs transplantation and mild hypothermia (MH) in an ischemia-reperfusion rat model. First, BMSCs were isolated using density gradient centrifugation and the adherent screening method, followed by culture, identification and labeling with DAPI. Second, adult male SD rats were divided into 5 groups: sham group (surgery without blockage of middle cerebral artery), model group (middle cerebral artery occlusion (MCAO) was established 2h prior to reperfusion), BMSCs group (injection of BMSCs via the lateral ventricle 24h after MCAO), MH group (mild hypothermia for 3h immediately after MCAO) and combination therapy group (combination of BMSCs and MH). Finally, the modified neurological severity score (mNSS) test was performed to assess behavioral function at different time points (before MCAO, before transplantation, at day 1, day 5 and day 10 after transplantation). After that, the brain was subjected to TTC staining, and the homing and angiogenesis were evaluated by immumofluorescence and immunohistochemistry. Immunofluorescence staining and Western Blot analysis were performed to calculate the percentage of the infarct area and explore glial fibrillary acidic protein (GFAP) and vascular endothelial growth factor (VEGF). Our results showed that the combination therapy significantly decreased mNSS scores (P<0.01) and reduced the percentage of the infarct area (P<0.01) than a single treatment. Moreover, the expression of GFAP and VEGF increased significantly in the combination therapy group (at day 5, day 10 after transplantation; at all time points after transplantation, respectively) compared to the single treatment groups. Taken together, it was suggested that the combination of BMSCs transplantation and MH can significantly reduce the percentage of the infarct area and improve functional recovery by promoting homing and angiogenesis, which may be a beneficial treatment for cerebral ischemia.

Neurogenesis in the cerebral infarction after an ischemic event is important to the rehabilitation of patients. However, the mechanism of angiogenesis around cerebral ischemia is not clear. Our study designed to test whether the nerve growth factor (NGF)-P-focal adhesion kinase (FAK) signaling pathway for associations with angiogenesis plays a key role in post-acute cerebral ischemia of rats. Firstly, we implanted the Matrigel, a carrier of basement membrane matrix, into the abdominal skin of rats to identify the relevant components of the NGF-P-FAK signaling pathway related to angiogenesis. Secondly, we used a model established by ligation of the middle cerebral artery (MCA) to observe the effect of the same signal pathway on angiogenesis in the subventricular and subgranular zones of the dentate gyrus(SVG and SGZ). The results showed that the tissue scores was significantly increased by NGF. However, the tissue scores was signifcaintly decreased by FAK inhibitor TAE226. Furthermore, CD31 and α-SMA were significantly increased by NGF and were decreased by anti-NGF and TAE226 in Matrigel. The P-FAK protein expression in Matrigel was markedly increased by NGF and decreased by TAE226. In the SVZ and SVG of cerebral ischemia, the numbers of BrdU-positive cells were significantly increased by NGF and decreased by TAE226, respectively. Our findings suggest that the therapy targeting the NGF-P-FAK signaling pathway may be an option for patients suffering from cerebral ischemia.

Objective To explore the Efficacy and safety of intravenous thrombolysis with different doses of rt-PA in the treatment of acute anterior circulation cerebral infarction with atrial fibrillation.Methods Retrospective analysis of 61 cases of patients with anterior circulation of cerebral infarction with atrial fibrillation from October 2009 to October 2014 in the First Affiliated Hospital of Xiamen University, the incidence within 4.5 hours of intravenous thrombolysis,and divided into two groups by rt-PA usage,19 cases in adequate group,received 0.9 mg/kg rt-PA intravenous thrombolytic therapy,42 cases in low dose group, received 0.6 mg/kg rt-PA intravenous thrombolysis.Before and after thrombolysis 1,7 and 30 days,NIHSS score was measured, the indexes of coagulation were observed at before thrombolysis and 1,7 days after thrombolysis,,CT scans were performed at 1, 7, and 14 days after thrombolysis,and Rankin (MRS) scores were compared at 90 days after thrombolysis.Results NIHSS 1,7,30 days scores of 2 groups were significantly decreased after thrombolysis(P<0.05),there was no statistically significant at at each time point after thrombolysis.Plasma prothrombin time increased significantly at 1 day and 7 days after thrombolysis,fibrinogen was significantly lower,compared with the low dose group, the difference was significant (P<0.05).There was no significant difference between the two groups in clinical outcome and mortality.The rate of mucosal bleeding in low dose group was lower than that in adequate group (P<0.05).Conclusion Low-dose rt-PA group intravenous thrombolysis with anterior circulation of atrial fibrillation is more safe,can reduce the risk of bleeding, reduce neurological deficits and improve the quality of life of patients.

Objective:To study the clinical features,risk factors and prognosis of AOP infarction,then control study with unilateral paramedian thalamic infarction.Methed:From March 2010 to June 2015,20 cases of AOP infarction in our hospital were selected as the group A,another 24 cases of unilateral paramedian thalamic infarction were selected as the group B,clear diagnosis through clinical data and magnetic resonance,the clinical features,the degree of neurological deficits and the prognosis after 90 d of two groups were compared.Result:The characteristic of AOP infarction was bilateral paramedian thalamic infarction with or without the midbrain infarction. The main clinical manifestations were altered mental status,amnesia and ophthalmoplegia.The incidence of atrial fibrillation in group A was higher than group A,two groups of 24 h,3 d National Institutes of Health Stroke Scale (NIHSS) score and treatment 90 d modified RANKIN scale(mRS) scores had statistically significant differences (P>0.05).Conclusion:The AOP infarction is a special type of thalamic infarction.The AOP term is more serious in clinical manifestations and prognosis compared with unilateral paramedian thalamic infarction.

目的：评价东菱迪芙联合拜阿司匹林0.1 g＋波立维75 mg双抗治疗基底动脉血栓形成临床效果及其安全性。方法将96例患者随机分为两组，治疗组48例常规治疗上加用东菱迪芙日＋双抗-拜阿司匹林0.1g＋波利维75mg治疗，对照组48例为常规治疗（拜阿司匹林0.1g），疗程为2周。分别于治疗前和治疗第7天、14天行Fib（纤维蛋白原）测定，分别于治疗前和治疗7天、14天、30天进行神经功能缺损程度评分（ NIHSS评分），治疗第7天行颅脑CT检查，治疗后90天行MRS评估。结果治疗后Fib下降程度在治疗组治疗第7天及第14天较治疗前均有显著性差异（P＜0.05），治疗第7天较对照组有显著性差异（P＜0.05），治疗第14天较对照组无显著性差异（P＞0.05）。治疗后NIHSS评分下降程度在治疗组治疗第7天、第14天、第30天均较治疗前有显著性差异（P＜0.05）、均较对照组有显著性差异（P＜0.05）。临床疗效总有效率治疗组为79.17％，对照组为60.42％，两组总有效率比较有统计学意义（ P＜0.01）。治疗组治疗中未出现颅内出血等不良反应。结论东菱迪芙联合双抗治疗基底动脉血栓形成，取得较好的临床疗效。

目的 评价东菱迪芙治疗内囊纹状体梗死临床效果及其安全性. 方法 将86例患者随机分为两组,治疗组43 例为常规治疗上加用东菱迪芙治疗,对照组43例为常规治疗(拜阿司匹林0.1g,1日1次、立普妥20mg,每晚1次),疗程为2周. 治疗前均行颅脑MRA+DWI检查,分别于治疗前和治疗后第七天、第十四天行纤维蛋白原、C反应蛋白、白介素6测定,分别于治疗前和治疗后第七天、第十四天进行 NIHSS评分,治疗后第七天行颅脑CT检查,治疗后90d行MRS评估. 结果 治疗后Fib、CRP下降程度在治疗组治疗第七天及治疗第十四天较治疗前均有显著性差异(P<0.05)、较对照组有显著性差异(P<0.05). 治疗后白介素6 下降程度在治疗组治疗第七天、第十四天较治疗前均有显著性差异( P<0.05 )、较对照组有显著性差异( P<0.05 ). 治疗后NIHSS评分下降程度在治疗组治疗第七天、治疗第十四天均较治疗前有显著性差异( P<0.05),治疗组在治疗第七天较对照组无差异,在治疗第十四天较对照组有显著性差异(P<0.05). 90d MRS评估治疗组疗效较对照组有统计学意义. 不良反应:治疗期间治疗组有3例皮肤黏膜出血,1例血尿,对照组无1例出血现象,随访90 d 两组均未出现颅内出血及系统性严重出血等不良反应. 结论 东菱迪芙治疗内囊纹状体梗死安全有效.

目的 研究低分子肝素钠治疗急性期非大面积心源性脑栓塞的临床效果并考察患者的病后功能状态.方法 本研究是为期15个月的多中心、随机、对照、单盲试验.入组患者94例被随机分配到低分子肝素钠治疗组(研究组)和阿司匹林治疗组(对照组).在入组各时间点行美国国立卫生研究所脑卒中评分(U.S.National Institutes of Health Stroke Score,NIHSS);出院后3个月,应用Barthel指数(BI)及修正的Rankin量表(mRS)指数了解2组患者病后的功能状态.结果 在急性期,治疗组的神经功能恢复评分优于对照组.出院3月后,应用修正的Rankin量表评定的神经功能恢复效果显示低分子肝素钠组效果好于阿司匹林组(P＜0.05).结论 对于非大面积心源性脑栓塞患者,急性期应用低分子肝素钠可使得其在急性期神经功能恢复及3个月的功能状态优于阿司匹林,且不增加出血转化机率.

Objective To determine the safety and efficacy of intra-arterial recombinant tissue plasminogen activator（r-tPA）for the treatment of acute cerebral infarction（ACI）in patients under the guidance of computed