BACKGROUND:The impact of COVID-19 on the epidemiology, clinical characteristics, and infection spectrum of viral and bacterial respiratory infections in Western China is unknown.METHODS:We conducted an interrupted time series analysis based on surveillance of acute respiratory infections (ARI) in Western China to supplement the available data.RESULTS:The positive rates of influenza virus, Streptococcus pneumoniae, and viral and bacterial coinfections decreased, but parainfluenza virus, respiratory syncytial virus, human adenovirus, human rhinovirus, human bocavirus, non-typeable Haemophilus influenzae, Mycoplasma pneumoniae, and Chlamydia pneumoniae infections increased after the onset of the COVID-19 epidemic. The positive rate for viral infection in outpatients and children aged <5 years increased, but the positive rates of bacterial infection and viral and bacterial coinfections decreased, and the proportion patients with clinical symptoms of ARI decreased after the onset of the COVID-19 epidemic. Non-pharmacological interventions reduced the positive rates of viral and bacterial infections in the short term but did not have a long-term limiting effect. Moreover, the proportion of ARI patients with severe clinical symptoms (dyspnea and pleural effusion) increased in the short term after COVID-19, but in the long-term, it decreased.CONCLUSIONS:The epidemiology, clinical characteristics, and infection spectrum of viral and bacterial infections in Western China have changed, and children will be a high-risk group for ARI after the COVID-19 epidemic. In addition, the reluctance of ARI patients with mild clinical symptoms to seek medical care after COVID-19 should be considered. In the post-COVID-19 era, we need to strengthen the surveillance of respiratory pathogens.

Japanese encephalitis (JE), a mosquito-borne zoonotic disease, has emerged as a major public health concern around the world. Previous research has shown that JE has serious sequelae, and the recent shift in the population from children to adults presents a significant challenge for JE treatment and prevention. Therefore, we examined the differences in clinical manifestations (clinical symptoms, clinical signs, complications, and clinical typing) of JE between children and adults over the 15 years in Gansu Province to provide a theoretical basis for better response to JE treatment. Clinical typing was found to be statistically significant in the child versus adult groups and the groups with or without vaccination. Only the dysfunction of consciousness differed statistically between children with and without vaccination, whereas neurological symptoms such as vomiting (jet vomiting), irritability, drowsiness, convulsions, and hyperspasmia differed statistically between children and adults, and the rest of the symptoms did not differ statistically. Only pupil size changes were statistically different in clinical signs between the children with and without vaccination, while blood pressure changes, change in pupil size, positive meningeal stimulation signs, and positive pathological reflexes (increased muscle tone and Babinski's sign) were statistically different between adults and children. Bronchopneumonia was the most common complication, especially in adults. Therefore, the authors believe that children and adults differ in some clinical manifestations and propose that efforts should be directed toward developing individualized treatment plans for different age groups and employing more effective supportive treatment for various populations. In addition, we suggest expanding the coverage of the JE vaccine and increasing overall vaccination rates and adopting multiple measures in conjunction with JE prevention and control.

In 2008, Mainland China included the Japanese encephalitis (JE) vaccine in the Expanded Program on Immunization (EPI) to control the JE epidemic. However, Northwest China experienced the largest JE outbreak since 1994 in 2018, and the effects of the EPI in different regions are unclear. Therefore, we used an interrupted time series design to evaluate the effects of the EPI in different regions. In this study, β1 and β1+β3 represented the slope or trend of the JE incidence before and after the EPI, respectively; β2 was the level change of the JE incidence immediately after the EPI; β3 represented the slope change of the JE incidence before and after the EPI. We found that the JE incidence in all regions showed a decreasing trend before the EPI (β1<0.000, P<0.05). The JE incidence in Mainland China (β2=-7.669, P<0.05), East China (β2=-9.791, P<0.05), Central China (β2=-10.695, P<0.05), South China (β2=-6.551, P<0.05) and Southwest China (β2=-2.216, P<0.05) decreased by 7.669/100,000, 9.791/100,000, 10.695/100,000, 6.551/100,000 and 2.216/100,000 immediately after the EPI, and the EPI had short-term effects on the JE incidence in these regions. The slope of the JE incidence in Mainland China (β3=0.272, P<0.05), East China (β3=0.337, P<0.05), Central China (β3=0.381, P<0.05), South China (β3=0.254, P<0.05) and Southwest China (β3=0.081, P<0.05) increased by 0.272, 0.337, 0.381, 0.254 and 0.081 after the EPI, and the EPI had long-term effects on the JE incidence in these regions. The JE incidence in many regions (excluding North China) showed a decreasing trend after the EPI (β1+β3 <0.000). Northwest China (GDP from 2008 to 2020 ranked last in Mainland China) and Southwest China (GDP from 2008 to 2020 ranked fifth in Mainland China), with underdeveloped economy, used to be low-epidemic regions of JE, but they have become high-epidemic regions in recent years. Economic development may contribute to the geographic variations in the effects of the EPI. Therefore, it is significant for JE control in Mainland China to increase support for underdeveloped regions and adjust the vaccine strategy according to the new epidemic situation of JE.

ObjectiveTo examine characteristics of pathogens identified among patients with fever and rash syndrome (RFIs) in Gansu province from 2009 to 2019, and to provide a reference for implementing targeted prevention measures and conducting pathogen surveillance. Methods Sentinel surveillance data on 5 822 RFIs cases reported in Gansu province from 2009 through 2019 were extracted from the Information Management System for Prevention and Treatment of AIDS and Viral Hepatitis and other Major Infectious Diseases. Multiple correspondence analysis was adopted to analyze characteristics of pathogens isolated from the RFIs patients. Results Enterovirus infection was confirmed in 1 653 (28.39%) of the all RFIs patients reported during the period and the number (proportion) of the patients confirmed with other pathogen infections were 548 (9.41%) for measles virus, 201 (3.45%) for rubella virus, and 495 (8.50%) for varicella-zoster virus, respectively. No pathogen infection was confirmed in 2 925 (50.24%) RFIs patients. The results of multiple correspondence analysis showed that enteroviruses infection was more frequently diagnosed in hospitalized cases in western and central Gansu province, during summer/autumn season, among scattered children aged ≤ 5 years and kindergarten children, among patients hospitalized in provincial and county-level hospitals; measles virus infection was more frequently confirmed among the patients in eastern and southern areas of Gansu province, during winter/spring season, in the adults (≥ 18 years) with some specific occupations, and among patients seeking medication at municipal hospitals; and more varicella-zoster virus and rubella virus infections were detected among the students aged 6 to 17 years. No pathogen infection was identified among the majority of the RFIs patients visiting doctors in outpatient/emergency departments. Conclusion The main pathogens inducing RFIs incidents in Gansu province from 2009 to 2019 include enterovirus, measles virus, varicella-zoster virus and rubella virus, and there were disparities in the detection rate of the pathogens among various populations, in different seasons and in various geographical areas.

目的 应用自回归移动平均(autoregressive integrated moving average,ARIMA)乘积季节模型建立适合预测兰州市丙肝月报告发病人数的最优模型,为丙肝防控工作提供参考依据.方法 收集2010年1月至2019年12月兰州市丙肝月报告发病人数,基于2010年1月至2018年12月丙肝月报告发病人数建立ARIMA乘积季节模型,比较2019年1-12月预测值和实际值以进行预测模型性能检验,并对2020年进行预测.结果 兰州市丙肝月报告发病人数总体呈现下降趋势,并于每年2月份达到最低值,于3月份迅速上升至峰值,有季节性和周期性.根据2010年1月至2018年12月丙肝月报告发病数据拟合出最佳预测模型ARIMA(2,1,0)(0,1,1)12,该模型拟合2019年1-12月的预测值与实际值的相对误差范围是0.00％ ～57.28％,平均相对误差为16.96％,2020年预测结果显示兰州市丙肝报告发病人数略有下降.结论 基于本研究数据,ARIMA(2,1,0)(0,1,1)12模型能较好地拟合兰州市丙肝的月报告发病人数,可用于短期的预测.

Objective:To evaluate the impact of the Japanese encephalitis vaccine included in an expanded immunization program on the reported incidence rate of Japanese encephalitis in Gansu province.Methods:Information on the reported incidence rate of Japanese encephalitis in Gansu province from 1987 to 2019 was collected through the National Population Health Science Data Center and the China Disease Prevention and Control Information System. In addition, the trend of Japanese encephalitis reported incidence rate in Gansu province before and after the inclusion of the Japanese encephalitis vaccine in the expanded immunization program was analyzed using an interrupted time-series design.Results:The annual reported incidence rate of Japanese encephalitis in Gansu province from 1987 to 2019 was 0.448/per 100 000. However, after the inclusion of the Japanese encephalitis vaccine in the expanded immunization program in Gansu province in 2008, the amount of change in the level of Japanese encephalitis reported incidence rate was -2.223/per 100 000 ( t=-2.90, P=0.007), the amount of change in the slope of Japanese encephalitis reported incidence rate was 0.082 ( t=2.87, P=0.008) with the slope of Japanese encephalitis reported incidence rate as 0.071 ( β1+ β3=0.071). Conclusions:The Japanese encephalitis vaccine has achieved good prevention and control effects in Gansu province in the short term after its inclusion in the expanded immunization program, but outbreaks of Japanese encephalitis have still occurred. Therefore, in the future, Gansu province should promptly adjust the immunization strategy of the Japanese encephalitis vaccine, and strengthen the vaccination of the adult population, especially the rural adult population in the southeastern region of Gansu province, based on the continued focus on the works on Japanese encephalitis vaccination for children and adolescents.

Background: We aimed to quantify the impact of each vaccine strategy (including the P3-inactivated vaccine strategy [1968-1987], the SA 14-14-2 live-attenuated vaccine strategy [1988-2007], and the Expanded Program on Immunization [EPI, 2008-2020]) on the incidence of Japanese encephalitis (JE) in regions with different economic development levels. Methods: The JE incidence in mainland China from 1961 to 2020 was summarized by year, then modeled and analyzed using an interrupted time series analysis. Results: After the P3-inactivated vaccine was used, the JE incidence in Eastern China, Central China, Western China and Northeast China in 1968 decreased by 39.80 % (IRR = 0.602, P < 0.001), 7.80 % (IRR = 0.922, P < 0.001), 10.80 % (IRR = 0.892, P < 0.001) and 31.90 % (IRR = 0.681, P < 0.001); the slope/trend of the JE incidence from 1968 to 1987 decreased by 30.80 % (IRR = 0.692, P < 0.001), 29.30 % (IRR = 0.707, P < 0.001), 33.00 % (IRR = 0.670, P < 0.001) and 41.20 % (IRR = 0.588, P < 0.001). After the SA 14-14-2 live-attenuated vaccine was used, the JE incidence in Eastern China and Northeast China in 1988 decreased by 2.60 % (IRR = 0.974, P = 0.009) and 14.70 % (IRR = 0.853, P < 0.001); the slope/trend of the JE incidence in Eastern China and Central China from 1988 to 2007 decreased by 4.60 % (IRR = 0.954, P < 0.001) and 4.70 % (IRR = 0.953, P < 0.001). After the EPI was implemented, the JE incidence in Eastern China, Central China and Western China in 2008 decreased by 10.50 % (IRR = 0.895, P = 0.013), 18.00 % (IRR = 0.820, P < 0.001) and 24.20 % (IRR = 0.758, P < 0.001), the slope/ trend of the JE incidence in Eastern China from 2008 to 2020 decreased by 17.80 % (IRR = 0.822, P < 0.001). Conclusions: Each vaccine strategy has different effects on the JE incidence in regions with different economic development. Additionally, some economically underdeveloped regions have gradually become the main areas of the JE outbreak. Therefore, mainland China should provide economic assistance to areas with low economic development and improve JE vaccination plans in the future to control the epidemic of JE.

The Jinchang Cohort was an ongoing 20-year ambispective cohort with unique metal exposures to an occupational population. From January 2014 to December 2019, the Jinchang Cohort has completed three phases of follow-up. The baseline cohort was completed from June 2011 to December 2013, and a total of 48 001 people were included. Three phases of follow-ups included 46 713, 41 888, and 40 530 participants, respectively. The death data were collected from 2001 to 2020. The epidemiological, physical examination, physiological, and biochemical data of the cohort were collected at baseline and during follow-up. Biological specimens were collected on the baseline to establish a biological specimen bank. The concentrations of metals in urine and serum were detected by inductively coupled plasma mass spectrometry (ICP-MS). The new areas of research aim to study the all-cases mortality, the burden of diseases, heavy metals and diseases, and the course of the chain from disease to high-risk outcomes using a combination of macro and micro means, which provided a scientific basis to explore the pathogenesis of multi-etiology and multi-disease and to evaluate the effects of the intervention measures in the population.

目的 通过对近年"一带一路"沿线国家出入我国国境的人员传染病监测结果的分析,探讨降低传染病跨国传播潜在风险的策略.方法 收集2012-2016年原国家质量监督检验检疫总局发布的传染病监测数据,从世界银行、世界卫生组织和中国"一带一路"官方网站检索各国的社会经济、人口及地理相关资料,进行流行病学描述与关联性分析.结果 2012-2016年,来自"一带一路"沿线国家出入我国国境人员传染病病例检出种类逐年增加,检出量占全部出入境检出传染病例数的比例由2012年的9.9％增加至2016年的33.6％.检出传染病病例数以流感为首位,多来自东亚和东南亚国家;检出的传染病以呼吸道传染病为主;传染病病例来源国地理特征与检出病种数分级的构成有统计学意义(P＜0.05);社会人口特征对检出病种数的分级的构成无统计学意义(P＞0.05).结论 随着"一带一路"倡议的深入推进,应进一步加强对出入境人员的传染病监测,对不同来源国家及不同地理带的出入境人员采取针对性的检疫策略.

Background: Whether the asymptomatic hyperuricemia (AH) raises the risk of cardiovascular disease with or without hyperuricemia-related comorbidities still remains contentious. Our study was aimed to quantitatively access the incidence risk of coronary heart disease (CHD) and stroke associated with AH. Methods: Multivariate-adjusted Cox regression models were applied to evaluate the risk of cardiovascular disease (CVD). Serum uric acid beyond normouricemia was quarterly stratified based on the distribution of healthy population without CVD onset. Results: 1,062 CVD first attack cases were collected among the 48,001 cohort participants (age range: 18-92, mean age: 47.2±13.9 years-old) with a mean follow-up duration of 5.78±0.83 years. 14,464 baseline population with comorbidities were excluded to further study the association between AH and CVD incidence. The AH showed overall non-association with CVD incident. However, significantly increased adjusted hazard ratio (HR) of CVD with 95% confidence interval (CI) were observed when the fourth quartile compared with normouricemia stratum in the total cohort population (CHD: 1.70, 1.34-2.16; stroke: 1.55, 1.13-2.13), male (CHD: 1.94, 1.47-2.56), female (CHD: 1.71, 1.03-2.35; stroke: 2.02, 1.14-3.58) and aged over 50 years-old population. Meanwhile, the age-standardized incidence rate of CVD in the fourth quartile was 2 to 3 time higher than the normouricemia population. Consistent results were also observed in the AH population in absence of comorbidities (CHD: 2.40, 1.39-4.14; stroke: 1.85, 1.12-3.59). Conclusion: Asymptomatic hyperuricemia patients exposed to higher level of uric acid (male>487 mmol/L, female>422 mmol/L) could significantly increase the incidence risk of CHD and stroke, with or without hyperuricemia-related comorbidities.

Objective To understand the compositions of pathogens and seasonal distribution characteristics of rash and fever syndrome (RFS) in Gansu Province from 2009 to 2019, so as to provide references for further disease surveillance and scientific prevention and control. Methods Descriptive epidemiological methods were used to analyze the composition of pathogens of RFS in Gansu Province from 2009 to 2019 and the seasonal variation characteristics of the main pathogens. Results The compositions of pathogens of RFS in Gansu Province were dominated by viruses, mainly enterovirus (56.04%), measles virus (19.14%), varicella-zoster virus (16.85%) and rubella virus (7.33%). The differences of positive rate of the main pathogens in different age groups and different seasons were statistically significant (all P Conclusions From 2009 to 2019, the compositions of pathogens of RFS in Gansu Province were mainly viruses and the main pathogens have obvious seasonal characteristics. Seasonal and targeted proventive methods should be adopted for high-risk populations.

目的 探讨甘肃省2017-2018年流行性乙型脑炎(简称乙脑)的流行病学特征和疾病负担.方法 利用甘肃省2017年1月1日—2018年12月31日乙脑病例数据和随访数据,计算乙脑的发病率、死亡率、病死率以及潜在减寿年数,比较不同分组的乙脑病例病情转归情况,采用二项Logistic回归分析模型分析甘肃省乙脑患者病情转归的主要影响因素.结果 乙脑发病率、死亡率以及病死率随着年龄增长而增加.不同年龄(H=61.797,P＜0.001)、不同临床分型(H=53.953,P＜0.001)、有无意识障碍(H=64.367,P＜0.001)以及有无脑膜刺激征(H=5.251,P=0.022)的乙脑病例病情转归比较均有统计学差异.二项Logistic逐步回归分析模型结果显示,年龄(OR=3.217,P＜0.001)、临床分型(OR=1.621,P＜0.001)及有无意识障碍(OR=1.969,P=0.002)对甘肃省乙脑病例病情转归的影响均有统计学意义.甘肃省2017年和2018年乙脑病例的潜在寿命损失分别为945.84人年和1 056.92人年,0～＜15岁损失最小,女性损失高于男性.结论 成人乙脑发病率、死亡率及病死率均高于儿童,乙脑造成的潜在寿命损失也主要以成人为主,影响乙脑病例转归的主要因素为年龄、临床分型以及有无意识障碍.

目的 了解孕妇人群丙型肝炎病毒(hepatitis C virus,HCV)感染的影响因素,为科学制定预防控制策略提供理论依据.方法 采用1:2配比的病例对照的研究方法,对甘肃省妇幼保健院2008-2018年兰州地区227例抗-HCV阳性的孕妇进行研究.采用条件logistic回归模型进行孕妇HCV感染影响因素的单因素及多因素分析.结果 2008-2018年甘肃省妇幼保健院产科孕妇抗-HCV阳性率为0.33％(227/69 620).单因素条件logistic回归分析模型结果表明,产次[COR(95％CI)= 1.539(1.088～2.177)]、输血史[COR(95％CI)= 104.536(14.458～755.83)]和侵入性器械诊疗[COR(95％CI)=2.222(0.903～5.469)]是孕妇HCV感染的影响因素.多因素条件logistic回归模型分析结果显示,输血史[OR(95％CI)= 98.296(13.578～711.597)]为孕妇感染HCV独有的危险因素.结论 孕妇HCV感染的危险因素主要为输血史,应及时采取有效措施做好育龄妇女HCV感染预防控制工作.

目的 运用向量自回归(vector autoregressive,VAR)模型分析甘肃省流行性乙型脑炎(简称乙脑)发病与气象因素的动态响应关系,为不同气象条件下乙脑的防控提供科学依据.方法 用2014年1月-2018年12月乙脑发病率和同期气象数据建立VAR模型,通过脉冲响应和方差分解定量分析气象因素对乙脑发病的影响.结果 VAR(2)模型的拟合优度为0.95,调整后拟合优度为0.95,希尔不等系数(Theil inequality coefficient,TIC)为0.06.平均气温、日照时数和降雨量对乙脑发病率变化的贡献到第6期分别为9.52％、2.13％和38.62％.结论 VAR(2)模型可用于分析乙脑发病与气象因素的动态关系,乙脑的防控及预测预警可考虑结合当地气象因素.

目的 探索Group LASSO(least absolute shrinkage and selection operator)Logistic回归分析模型在研究流行性乙型脑炎(简称乙脑)早期临床症状与预后之间的关系中的应用.方法 收集整理2017-2018年甘肃省乙脑报告发病数据,建立乙脑预后影响因素的Group LASSO Logistic回归分析模型,通过交叉验证法选择惩罚参数,筛选出影响乙脑预后的早期临床症状.结果 纳入的866名乙脑患者中,有预后结局的共764名,其中死亡者占22.5％、有后遗症者占12.6％、好转者占17.8％、痊愈者占47.1％.筛选出的变量有意识障碍、呼吸衰竭、呼吸节律改变、肌张力增强及乙脑疫苗接种史.结论 通过构建Group LASSO Logistic回归分析模型可以筛选出对预后有影响的早期临床症状.

目的 系统评价2008～2018年中国大陆孕产妇人群丙型肝炎病毒(hepatitisC virus,HCV)抗体阳性率,为孕产妇人群HCV的防治策略提供科学依据.方法 计算机检索PubMed、Web of Science、SinoMed、CNKI、VIP和WanFang Data数据库,搜集2008年1月至2018年12月中国大陆孕产妇人群HCV抗体阳性率的横断面研究,检索时限均为建库至2020年8月30日.由2名评价员独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用Stata 15.0软件进行Meta分析.结果 共纳入108个研究,总样本量为657 765例.Meta分析结果显示,中国大陆孕产妇人群HCV抗体合并阳性率为0.235％[95％CI (0.189％,0.286％)].西部地区孕产妇人群HCV抗体阳性率最高为0.291％[95％CI (0.221％,0.378％)],其次为东北地区0.240％[95％CI (0.099％,0.442％)]和中部地区0.235％[95％CI (0.016％,0.319％)];东部地区最低为0.193％[95％CI (0.119％,0.281％)].医院病例报告来源的孕产妇HCV抗体阳性率0.291％[95％CI (0.221％,0.372％)]高于艾滋病哨点监测人群0.164％[95％CI(0.122％,0.207％)].结论 中国大陆孕产妇人群HCV抗体阳性率维持在相对较低水平.

目的 了解2012-2015年甘肃省儿童急性下呼吸道感染(acute lower respiratory tract infection,ALRTI)病原流行病学特征.方法 收集2012-2015年甘肃省10家哨点医院458例感染ALRTI患儿的病例监测数据,通过描述性流行病学方法分析各病毒和细菌感染状况与流行病学特征.结果 458例儿童ALRTI患者中男女比例为1.81∶1,病毒的阳性检出率为33.62％(95％CI:29.28％～37.97％),其中呼吸道合胞病毒的阳性检出率居于首位(12.23％);细菌的阳性检出率为24.84％ (95％ CI:20.04％ ～ 29.65％),其中分离出肺炎链球菌阳性的患者检出率最高(18.47％);不同性别儿童病毒阳性检出率与细菌阳性检出率均没有差别(均有P＞ 0.05);不同年龄儿童病毒阳性检出率无差别(x2 =5.980,P=0.050),而细菌阳性检出率不同(x2=12.078,P=0.002),不同季节病毒感染阳性检出率和细菌感染阳性检出率均有差异(均有P＜0.05),经Lo-gistics回归分析得,季节、年龄和哨点医院是儿童ALRTI病毒的影响因素(均有P＜0.05),而哨点医院和年份是影响细菌感染的因素(均有P ＜0.05).结论 甘肃省0-14岁儿童ALRTI以呼吸道合胞病毒、流感病毒和副流感病毒为主,细菌感染以肺炎链球菌和流感嗜血杆菌为主,其中病毒感染人数较细菌感染人数多,病毒和细菌感染存在相同的发病高峰.

Objective To understand the etiological surveillance of febrile respiratory syndrome (FRS) in Gansu Province, and evaluate the monitoring results, so as to provide reference basis for improving its monitoring ability. Methods The cases of FRS surveillance in 17 sentinel hospitals were collected in Gansu Province from 2009 to 2019. The method of observational epidemiological study was used to analyze the status of pathogen surveillance and evaluate the surveillance results. Results The total testing rate of FRS pathogens was 89.00% in Gansu Province during 2009-2019, and the total detection rate was 31.43%. The detection ability of all pathogens (virus / bacteria) was higher than that of any pathogen (virus/bacteria) (P Conclusions The level of FRS pathogen testing is relatively high in Gansu Province. It is recommended that the detection capability of pathogens should be improved by reasonably adjusting the species of pathogen testing, collecting matched specimen types, and repeatedly testing negative cases to improve the monitoring platform and the monitoring system.

目的 了解甘肃省腹泻症候群病原谱分布与流行特征.方法 采集甘肃省2009-2018年哨点医院腹泻症候群监测病例的粪便标本,以实时荧光链式反应检测病毒核酸,以分离培养法检测细菌.结果 4 406例标本中检出1 547例阳性病例,病原阳性率35.11％.其中1 281例检出病毒,病毒阳性率47.20％;287例检出细菌,细菌阳性率8.57％.病原谱前五位是轮状病毒(46.04％)、星状病毒(13.37％)、诺如病毒(13.15％)、志贺菌(9.90％)和腺病毒(7.81％).轮状病毒、诺如病毒、星状病毒、志贺菌与非伤寒沙门菌在各年龄段感染情况的差异具有统计学意义(均有P＜0.05).11月到次年3月病毒阳性率较高,6-8月细菌阳性率较高.各病原流行季节不同,四季都以轮状病毒感染为主.结论 甘肃省腹泻症候群病例病原谱较广泛,病毒性腹泻更常见,发病具有明显的季节高峰.加强持续性监测可掌握病原特征与流行趋势,有助于对重点人群采取针对性与季节性防控措施.