目的:分析益气化瘀通痹方治疗气阴两虚夹瘀型糖尿病周围神经病变疗效及对患者血流动力学的影响.方法:将106例气阴两虚夹瘀型糖尿病患者,随机分为对照组和观察组,每组各53例,对照组在糖尿病基础治疗基础上给予西药治疗,观察组给予益气化瘀通痹方治疗.比较治疗前后血清炎症因子水平、神经传导速度及血流动力学指标,观察治疗前后中医症候积分及NSS、NDS评分.结果:治疗后观察组IL-6、TNF-α、hs-CRP水平均低于对照组(P<0.05),观察组感觉神经及运动神经等各项神经传导速度均高于对照组(P<0.05),观察组血浆比黏度、全血黏度及纤维蛋白原指数均高于对照组(P<0.05).结论:益气化瘀通痹方可减轻气阴两虚夹瘀型糖尿病患者周围神经病变的神经症状及神经缺陷,降低炎性因子,增加神经传导速度,有效改善血液流变性,改善临床症状.

目的 探究黄连温胆汤加味联合耳穴压豆治疗痰热内扰型失眠的临床效果.方法 选取痰热内扰型失眠患者82例,随机分为观察组和对照组,各41例.观察组采用黄连温胆汤配合耳穴压豆治疗,对照组予口服艾司唑仑片治疗,比较两组治疗前后疗效、中医症候积分、睡眠质量及不良反应.结果 观察组总有效率(90.24％)显著高于对照组(70.73％,P<0.05);治疗后,观察组中医证候积分、睡眠质量积分均较对照组降低(P<0.05);观察组不良反应发生少于对照组(P<0.05).结论 黄连温胆汤加味联合耳穴压豆能有效治疗痰热内扰型失眠,改善中医证候及睡眠质量,减少不良反应发生.

Objective To investigate the associativity between TCM syndrome differentiation and pattern types for diabetic foot and expression of advanced glycosylation endoproducts(AGEs) in arteries of amputation. Methods One hundred cases with diabetic foot were divided into stagnant deficiency of both Qi and blood type, stagnant deficiency of both Qi and Yin type and heat toxin in collaterals type according to syndrome differentiation in TCM. The studying of the expression of AGEs in artery was with immunohistochemistry method. Results The expression of AGEs was highest in stagnant deficiency of both Qi and blood type and lowest in heat toxin in collaterals type. There were significant differences for expression of AGEs among the three types(P<0.01). Conclusion There is high associativity between TCM syndrome differentiation and pattern types for diabetic foot and expression of AGEs.