Objective :To investigate and compare the effects of different testing instruments and reagent combinations on PT and APTT coagulation detection ,reflect the differences in different detection systems ,to provide reference basis for data comparison for laboratories .Methods :Based on the different detection systems in varied manufacturers ,instru‐ments and reagents or different types sub‐group in the same manufacturers and instruments ,non‐parametric test and ANOVA rank method for statistical analysis ,by organized the data of PT and APTT in CGL sample from different la‐boratories issued by CAP in 2013 .To investigate and compare the effects of different testing instruments and reagent combinations .Results:There are different results of PT and APTT in varied detection systems .No significant difference exists in varied instrument manufacturers or reagents ,but there are significant difference in the results of the same manufacturer with different type reagents .On the contrary ,the results showed no significant difference in the same manufacturer with different type instrument .Conclusion:Manufacturer with the same instruments and reagents corre‐sponding detection results have good comparison .Construction of the data system available for reference in blood coag‐ulation detection is very important .

Objective To investigate the diurnal variations of hematological and biochemical parameters in cynomolgus monkeys.Methods The blood samples were collected in 12 cynomolgus monkeys(6 of each sex) at 9:30(am) ～ 10:30(am),12:30(pm) ～ 13:30(pm),15:30(pm) ～ 16:30(pm) and 19:30(pm) ～ 20:30(pm).The hematological and biochemical parameters were determined with automated hematological and biochemical analyzers respectively.The plasma cortisol levels were determined by high-performance liquid chromatography(HPLC).Results White blood count(WBC) and blood urea nitrogen(BUN) increased significantly in the afternoon in male and female monkeys.Hemoglobin(HGB) and hematocrit(HCT) markedly reduced in the afternoon in female monkeys.The activities of asparate aminotransferase(AST) and alanine aminotransferase(ALT) significantly increase in the afternnon in female monkeys.The serum glucose and plasma cortisol reduced significantly in the afternoon in male monkeys.Conclusions Parts of the hematological and biochemical parameters show obvious diurnal variation in male and female cynomolgus monkeys.