High-fat diet (HFD)-induced obesity is a crucial risk factor for metabolic syndrome, mainly due to adipose tissue dysfunctions associated with it. However, the underlying mechanism remains unclear. This study has used genetic screening to identify an obesity-associated human lncRNA LINK-A as a critical molecule bridging the metabolic microenvironment and energy expenditure in vivo by establishing the HFD-induced obesity knock-in (KI) mouse model. Mechanistically, HFD LINK-A KI mice induce the infiltration of inflammatory factors, including IL-1β and CXCL16, through the LINK-A/HB-EGF/HIF1α feedback loop axis in a self-amplified manner, thereby promoting the adipose tissue microenvironment remodeling and adaptive thermogenesis disorder, ultimately leading to obesity and insulin resistance. Notably, LINK-A expression is positively correlated with inflammatory factor expression in individuals who are overweight. Of note, targeting LINK-A via nucleic acid drug antisense oligonucleotides (ASO) attenuate HFD-induced obesity and metabolic syndrome, pointing out LINK-A as a valuable and effective therapeutic target for treating HFD-induced obesity. Briefly, the results reveale the roles of lncRNAs (such as LINK-A) in remodeling tissue inflammatory microenvironments to promote HFD-induced obesity.

玉环鼓词是温州鼓词在流传过程中异地繁殖衍生的具有玉环海岛民俗文化特色的民间曲艺.随着社会的发展,传统古村落在城市化进程中逐渐消失,艺人和受众群体逐渐减少,鼓词演出市场逐渐萎缩,玉环鼓词出现了传承断层现象.面对这一现状,当地文化部门、学校、社会,要形成合力,传承保护好本土非物质文化遗产,为子孙后代留下地域文化的根脉,为未来新文化的创造保留更多的基因和种源.

浙江沿海传统婚俗中,存在着婚礼仪式唱婚礼歌和吟"洞房经"的现象.它是古老的吴越歌谣在民间传统婚俗中的活态遗存,带有浓厚的宗教仪式感和民俗文化色彩,是婚俗仪式的诗意表达和艺术呈现.浙江沿海传统婚礼仪式歌在长期的发展过程中,形成了各自的特色和相对固定的模式.台州"洞房经"、舟山"贺新郎"、嘉兴"浪柳园",不仅为婚礼歌贴上了地域的标签,也是不同区域文化传播、交流、融合以及生活变迁、民俗与民歌同步延续的生动写照.

中国地方领导干部队伍建设从时空规定性出发,立足党的使命、组织路线以及积极领导责任来统领地方领导干部队伍建设.党管干部与集中统一,分级分类的干部管理体制以及中国特色干部制度为中国特色地方领导干部队伍建设提供了有效的领导、组织保障与制度基础.以抓住地方领导干部队伍建设的关键环节、抓住地方领导干部队伍的关键少数以及推进地方领导干部日常培养制度化为基本路径遵循,推动具有中国特色领导品格与行为特质的地方领导干部队伍建设.

维护国家意识形态安全是档案工作的重要政治责任.在传承档案工作维护意识形态安全责任传统基础上,有效维护中国特色意识形态安全成为新时代档案工作肩负的重要责任.通过服务历史研究、服务立德树人实践、强化档案信息网络传播、服务党和国家中心工作开展来维护历史真实性、维护校园意识形态安全、维护网络意识形态安全是档案工作履行维护国家意识形态安全责任的基本路径.

浙东锣鼓是中国传统吹打乐的代表性乐种之一,它依附于民间礼俗仪式场域,是仪式行为的音声表达.在浙东一带,凡岁时节庆、庙会社火、婚丧仪礼、祭祖祈神、开渔谢洋等民间礼俗活动皆离不开锣鼓.浙东锣鼓之所以生生不息流传至今,是因为它具有礼俗文化基质和礼俗仪式功能,并在传承中不断发展.民众在礼俗仪式音乐中,获得了传统文化的认同感和本土文化身份的归属感.

Event Detection (ED) aims to identify event trigger words from a given text and classify it into an event type. Most of current methods to ED rely heavily on training instances, and almost ignore the correlation of event types. Hence, they tend to suffer from data scarcity and fail to handle new unseen event types. To address these problems, we formulate ED as a process of event ontology population: linking event instances to pre-defined event types in event ontology, and propose a novel ED framework entitled OntoED with ontology embedding. We enrich event ontology with linkages among event types, and further induce more event-event correlations. Based on the event ontology, OntoED can leverage and propagate correlation knowledge, particularly from datarich to data-poor event types. Furthermore, OntoED can be applied to new unseen event types, by establishing linkages to existing ones. Experiments indicate that OntoED is more predominant and robust than previous approaches to ED, especially in data-scarce scenarios.

Organelles use specialized molecules to regulate their essential cellular processes. However, systematically elucidating the subcellular distribution and function of molecules such as long non-coding RNAs (lncRNAs) in cellular homeostasis and diseases has not been fully achieved. Here, we reveal the diverse and abundant subcellular distribution of organelle-associated lncRNAs from mitochondria, lysosomes and endoplasmic reticulum. Among them, we identify the mitochondrially localized lncRNA growth-arrest-specific 5 (GAS5) as a tumour suppressor in maintaining cellular energy homeostasis. Mechanistically, energy-stress-induced GAS5 modulates mitochondrial tricarboxylic acid flux by disrupting metabolic enzyme tandem association of fumarate hydratase, malate dehydrogenase and citrate synthase, the canonical members of the tricarboxylic acid cycle. GAS5 negatively correlates with levels of its associated mitochondrial metabolic enzymes in tumours and benefits overall survival in individuals with breast cancer. Together, our detailed annotation of subcellular lncRNA distribution identifies a functional role for lncRNAs in regulating cellular metabolic homeostasis, highlighting organelle-associated lncRNAs as potential clinical targets to manipulate cellular metabolism and diseases.

保障公务员考录的实质价值与工具价值均衡实现是公务员考录制度建设的基本出发点与目标追求.建立在管理思维基础上的现行公务员考录制度,在保障公务员考录价值均衡实现方面尚存在明显的体制、机制缺陷,对考试手段的科学运用尚存在明显的局限.有鉴于此,应立足治理思维对公务员考录制度进行改革,重构公务员考录主体的权利、权力及其实现机制,探索实行两轮制公务员考录机制;重构公务员考录流程、重新界定公务员考录笔试与面试功能;改革公务员考录考试手段运用机制,对考试命题机制与面试机制进行改革,实现命题管理统一性与命题组织分类化的统一以及面试效度、信度、公平性的统一.如此,有助于最大限度地提升公务员考录价值的均衡实现程度,最大限度地提升公务员考录的科学性与有效性.

文章从马克思主义劳动理论出发,在劳动建构道德的命题探讨中理解并揭示"以劳树德"的理论内涵,构建研究的理论基础;在新时代公民道德建设的场域下,观照道德的主体性、成长性与目的 性等问题,赋予劳动积极的道德价值,厘清"以劳树德"的现实关照;从"注重德育社会主体价值与个人主体价值的统一,注重德育主体性、系统性和生成性的统一,注重德育内在规定性和价值性的统一"三个方面,明确"以劳树德"的行动路向.

Organelles entail specialized molecules to regulate their essential cellular processes. However, systematically elucidating the subcellular distribution of functional molecules such as long non-coding RNAs (lncRNAs) in tissue homeostasis and diseases has not been fully achieved. Here, we characterized the organelle-associated lncRNAs from mitochondria, lysosome, and endoplasmic reticulum (ER), respectively, and revealed the diverse and abundant distribution of lncRNAs. Among them, we identified mitochondrial lncRNA Growth-Arrest-Specific 5 (GAS5) as a tumor suppressor in maintaining cellular energy homeostasis. Mechanistically, energy stress-induced GAS5 modulated mitochondria TCA flux by declining metabolic tandem association of FH-MDH2-CS, the canonical members of the TCA cycle. Remarkably, the expression of GAS5 negatively related with levels of its associated mitochondrial metabolic enzymes and breast cancer development. Together with the detailed functional annotations, this subcellular lncRNA identification revealed the human cell’s inquisitively complex architecture, aiding in the development of new strategies for the clinical application of organelle-associated lncRNAs.

Genetic factors are considered to play a critical role in patients with early-onset Parkinson's disease (EOPD). The genetic spectrum of EOPD patients has been extensively investigated in Caucasian populations but rarely in the Chinese population. In this study, a total of 21 unrelated Chinese EOPD patients were enrolled. Multiplex ligation-dependent probe amplification assay and whole-exome sequencing were performed, followed by Sanger sequencing. Detailed clinical features were presented. Two novel likely pathogenic variants (p.Q648X in ATP13A2 and p.N521fs in PINK1) and 10 previously reported Parkin pathogenic variations (exon 2 deletion, exon 3-4 deletion, exon 4 deletion, exon 6-7 deletion, exon 7 deletion; p.G284R, p.G329 V, p.R366W, p.N428fs, p.M458 L) were identified in 9 out of 21 (42.86%) patients. The frequency (33.33%) of Parkin variations is much higher in our cohort than that in the East Asian population. The patient carrying the ATP13A2 variant showed no response to levodopa treatment. Our findings broaden the genetic spectrum and clinical features of EOPD patients.

There is some doubt that all nodules <8mm are really mainly benign and that simple follow-up is adequate in all cases. The purpose of this study is to create a predictive model for the diagnosis of benign and malignant small pulmonary nodules. This was a retrospective case-control study of patients who had undergone pulmonary nodule resection at the Zhejiang University Jinhua Hospital. Patients with pulmonary nodules of <= 10mm in size on chest high-resolution computed tomography were included. Patients' demographic characteristics, clinical features, and high-resolution computed tomography findings were collected. Logistic regression and receiver-operating characteristic analysis were used to create a predictive model for malignancy. A total of 216 patients were included: 160 with malignant and 56 with benign nodules. Nodule density (odds ratio [OR]=0.996, 95% confidence interval [CI]: 0.993-0.998, P=.001), vascular penetration sign (OR=3.49, 95% CI: 1.39-8.76, P=.008), nodule type (OR=4.27, 95% CI: 1.48-12.29, P=.007), and incisure surrounding nodules (OR=0.18, 95% CI: 0.04-0.84, P=.03) were independently associated with malignant nodules. These factors were used to create a mathematical model that had an area under the receiver-operating characteristic curve of 0.744. Using a cut-off of 0.762 resulted in 63.1% sensitivity and 75.0% specificity. This study proposes a pulmonary nodule prediction model that can estimate benign/malignant lung nodules with good sensitivity and specificity. Mixed ground-glass nodules, vascular penetration sign, density of lung nodules, and the absence of incisure signs are independently associated with malignant lung nodules.

浙东渔歌的衬词衬腔基于吴语方言的发音特点,以富有生活气息的语气词、感叹词、象声词加强语气,衬托歌腔,活跃气氛,加深思想感情的表达.浙东渔歌衬词衬腔十分丰富,几乎达到首首皆有衬词、曲曲皆有衬腔的程度,形成了一定的地域特色.衬词衬腔的运用,加强了歌曲的语感和韵味,深化了歌曲的腔词关系,赋予歌曲浓厚的生活气息,增强了歌曲的表现力.

新中国成立70年来,我国干部队伍建设立足建设党的干部队伍这一根本目标,秉持党的干部队伍建设优良传统,与时俱进地丰富和发展干部德才兼备标准的内涵.在此基础上,立足制度建设这一干部管理建设的根本,通过干部管理模式与干部管理体制改革,以及干部选拔任用、考核、激励与监督机制改革,逐步建立起体现国情规定性、适应社会主义市场经济社会干部管理需要的干部管理体制机制,持续深化干部队伍政治建设、能力建设、道德建设、纪律与作风建设,推动党的干部队伍建设不断深化.

老子的"大音希声"音乐美学思想对东西方音乐文化乃至现代艺术流派产生了深远的影响,许多现代艺术流派与以老子为代表的道家思想形成了跨越时空的呼应,那些后现代主义、超现实主义的音乐家们从各种角度实现了对老子"道"的体验.老子把形而上的"道"看得比形而下的"音声""物象"更为根本、更为重要,这就促使我们去探讨音乐现象之外的音乐之道,追溯"大音希声"的本质意义和音乐美的最高境界.

在现代管理中重提德性伦理建设具有重要的意义,它既能为现代管理培养德才兼备的管理主体,又能为现代管理实践提供重要的人文精神支撑.中国自古以来极为重视德性管理伦理建设,传统德性管理伦理在伦理精神塑造、组织考核选拔、民间舆论控制等德性养成机制方面都具有独特优势,但由于传统德性管理伦理产生于封建社会,其重私德而轻公德、强调服从而忽略平等的价值观,与现代管理伦理的公共精神背道而驰.随着我国社会主义市场经济的发展,社会结构调整使德性伦理在现代管理中的作用逐渐消解,遭遇了价值认同危机及养成机制不足等困境,现代社会管理仍需借鉴传统德性伦理来促进管理之“善”的实现.在新的时代背景下,需要对德性管理伦理的德性内容及养成机制加以重建,在社会主义核心价值观的引领下,通过构建个人私德、职业道德和社会公德体系,重建德性自修、家教训导、组织约束、道德楷模等德性养成机制,加强对组织管理者的道德约束和道德激励,才能使德性伦理在现代管理中的积极作用得到有效发挥.

本文采用波浪订正的Ekman模型,研究分析了三种Stokes漂流近似公式(单波公式、e指数公式、Phillips谱近似公式)对海洋表层流场估算的影响.海表总流场由海表面高度(SSH)数据计算的地转流和海浪模式WAVEWATCH Ⅲ输出结果计算的非地转流组成,并采用拉格朗日浮标观测数据对计算结果进行了验证.研究表明,随着Stokes漂流近似公式精度的提高,其计算的拉格朗日流速更接近于谱积分公式的计算结果,更贴近拉格朗日浮标观测数据.与谱积分公式计算的海表拉格朗日流速相比,单波公式的平均相对偏差为0.0834,e指数公式的平均相对偏差为0.0392,Phillips谱近似公式的平均相对偏差为0.0101,说明Phillips谱近似公式在不同风速下均能对谱积分公式有良好的近似效果.在低风速条件下,由Stokes漂流近似公式精度引起的海洋表层流场估算误差可以忽略不计,但随着风速增加,由近似公式精度引起的偏差逐渐变大,此时应该选择Phillips谱近似公式计算Stokes漂流,来减小误差.

浙东儿歌童谣是流传于浙东沿海地区,具有鲜明的海洋民俗文化色彩和吴越方言特色,反映儿童生活,富有童真趣味的本土原生性民间歌谣.自古以来,在浙东民间,关于海洋环境、气象、节令、渔汛、海产、航行、捕捞、贸易、娱乐、游戏、神话、传说、信仰、习俗,具有启蒙教育意义的歌谣,源源不断地涌现出来,从精神层面滋养着浙东沿海渔民的后代.海洋文化基质是浙东儿歌童谣生成的根源性因素.

Text representations is a key task for many natural language processing applications such as document classification, ranking, sentimental analysis and so on. The goal of it is to numerically represent the unstructured text documents so that they can be computed mathematically. Most of the existing methods leverage the power of deep learning to produce a representation of text. However, these models do not consider about the problem that text itself is usually semantically ambiguous and reflects limited information. Due to this reason, it is necessary to seek help from external knowledge base to better understand text. In this paper, we propose a novel framework named Text Concept Vector which leverages both the neural network and the knowledge base to produce a high quality representation of text. Formally, a raw text is primarily conceptualized and represented by a set of concepts through a large taxonomy knowledge base. After that, a neural network is used to transform the conceptualized text into a vector form which encodes both the semantic information and the concept information of the original text. We test our framework on both the sentence level task and the document level task. The experimental results illustrate the effectiveness of our work. (C) 2017 Elsevier Ltd. All rights reserved.