Emerging evidence suggests vitamin D deficiency might be linked to increased headache risk, though consistent conclusions are lacking due to population and methodological heterogeneity. In addition, childhood and adolescent obesity may influence headache development through metabolic and inflammatory pathways, but the specific role of body mass index (BMI) in the relationship between vitamin D and headache is currently unclear. Therefore, this study used National Health and Nutrition Examination Survey (NHANES) large-scale population-based data to investigate the association between vitamin D levels and headache risk in children and adolescents aged 6 to 19 years and to analyze the possible mediating effect of BMI on this relationship. The aim of this study was to explore the complex association between vitamin D levels and headache. We analyzed 2 cycles of the NHANES dataset, which included a total of 7066 children and adolescents aged 6 to 19 years. Multivariate linear regression models, subgroup analyses and smoothed curve fitting were used to investigate the associations between vitamin D levels and headache, and the potential mediating role of BMI was explored. The results of the present study revealed a evident negative correlation between vitamin D levels and headache risk in children and adolescents, a finding that was further supported by smoothed curve fitting. Notably, this negative correlation was stronger in the female and adolescent groups. The results of the mediation analysis revealed that BMI had a evident mediating effect, with a mediation ratio of 20.94%. This study found that lower vitamin D levels were associated with a higher likelihood of headache in children and adolescents, and that BMI may play a partial mediating role. This finding provides new strategies for the prevention and treatment of headache in children and adolescents. More prospective studies are necessary to further validate this association and its underlying mechanisms.

Background The Dietary Index for Gut Microbiota (DI-GM) is a novel metric developed in 2024 to assess diet-related gut microbiota health. While gut microbiota is implicated in metabolic and immune function, its link with hypertension through dietary patterns remains understudied.Methods In a cross-sectional analysis encompassing 25,270 adults from six NHANES cycles, we assessed the DI-GM-hypertension association using multivariable linear regression, subgroup analyses, and smoothing curve fitting. The potential mediation by the Systemic Immune-Inflammation Index (SII) was also evaluated.Results An evident inverse association was found between DI-GM and hypertension. Smoothed curves further supported this negative relationship. Mediation analyses demonstrated a partial mediating effect of SII, with a mediation ratio of 3.5%.Conclusion This study fills the gap in the current research field. It provides new ideas and evidence support for future dietary interventions and individualized management by integrating the relationship between gut microbiota, inflammatory markers, and hypertension. However, as a cross-sectional study, these findings, while demonstrating an association between DI-GM and hypertension, do not establish causality.

Abstract Mindfulness-Based Stress Reduction (MBSR) improves well-being in acute myocardial infarction (AMI) patients, but its molecular cardioprotective mechanisms are unclear. In this prospective pilot study, 51 post-PCI AMI patients (17 MBSR plus standard therapy, 34 controls) were assessed for inflammatory markers (CRP, IL-6, PCT), echocardiography, and functional capacity at baseline and 6 months. Genome-wide DNA methylation profiling in a subgroup (n = 5/group) assessed changes from baseline to 6 months within MBSR and compared groups at the 6-month follow-up. At follow-up, the MBSR group showed greater reductions in CRP, IL-6, and PCT (adjusted P = 0.001, < 0.001, 0.003), alongside improved left ventricular ejection fraction, global longitudinal strain, wall motion score index, and 6-minute walk distance; all remained significant after false discovery rate correction (all q < 0.05). MBSR induced widespread DNA methylation changes (7,665 intra-group and 7,791 inter-group differentially methylated sites), which were nominally enriched in pathways related to immune response, inflammation, oxidative stress, and neuroendocrine (HPA axis) regulation. Exploratory uncorrected analysis linked BRD4 hypermethylation with lower CRP (ρ=-0.601) and improved GLS (ρ = 0.802), and PTTG1IP hypomethylation with improved LVEF (ρ = 0.717). These findings suggest MBSR modulates the DNA methylome within a novel “epigenetic-inflammatory-cardiac functional axis”, providing a mechanistic framework for its cardioprotective effects.

Background and aimsAlthough exercise performance is an essential tool for managing heart failure, there is still no consensus on whether exercise prescriptions can be universally applied to all types of heart failure patients. This study aimed to describe and evaluate the evidence on exercise interventions for patients with heart failure by creating an evidence map.MethodsWe searched PubMed, Web of Science, EMBASE, the Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang Database, VIP Database to identify systematic reviews and meta-analysis. We used A Measurement Tool to Assess Systematic Reviews (AMSTAR-2) to evaluate the quality of included systematic reviews and meta-analysis. Bubble charts were employed to visualize key characteristics like intervention effectiveness, literature quality, literature quantity, and heart failure types. Matrix bubble charts were used to show the distribution of outcome indicators, exercise methods, literature quantity, and heart failure types.ResultsA total of 113 systematic reviews/meta-analyses were included and over 80% of studies conclude that exercise is beneficial for heart failure patients. Three heart failure types involved varied due to different classification criteria used in the included literature. Eleven types of exercise interventions have been applied in patients with heart failure and mixed modality exercise is the exercise type with the highest attention. Existing researches focus more on the improvement of exercise capacity and cardiorespiratory function in heart failure patients. Most researchers tend to focus on conducting exercise intervention studies in HFrEF.ConclusionsThe evidence map provides a visual overview of the research volume and findings on exercise interventions for heart failure patients. Exercise interventions have significant advantages for heart failure patients, but there is room for improvement in study quality, heart failure classification, and outcome indicators. Future research should focus on designing more high-quality studies to provide more high-level evidence for this field.

Few studies exist on the impact of social support on cardiac events following implantation of implantable cardioverter-defibrillators (ICD) or cardiac resynchronization therapy devices with defibrillators (CRT-D). This study aims to investigate the longitudinal association between social support and adverse cardiac events among ICD/CRT-D recipients during a 1-year follow-up. This hospital-based longitudinal study included 101 patients undergoing first ICD/CRT-D implantation. Demographic and clinical data were collected as confounders. Social support, anxiety, and depression scores were assessed at baseline and during follow-ups (1, 3, 6, 12 months). Cardiac events (primary endpoint: all-cause mortality or appropriate ICD shocks; secondary endpoint: primary endpoint events, heart failure hospitalization, or acute coronary syndrome) were documented. Kaplan-Meier analyses and Cox proportional hazards models (adjusted for age, sex, NYHA class, and ICD indication) evaluated associations, while time-dependent Cox models analyzed temporal effects. Patients with higher baseline social support exhibited a reduced risk of the primary composite endpoint (log-rank χ² = 5.53, p = 0.019) and secondary composite endpoint (log-rank χ² = 14.64, p < 0.001). After multivariable adjustment (age, sex, NYHA class, ICD indication, anxiety/depression scores), high social support was independently linked to 65.6

Influenced by the fast pace and unhealthy living habits of modern society, the diagnosis rate of non-alcoholic fatty liver disease (NAFLD) has been increasing year by year, and the age structure of the patients is showing a younger age structure, which poses a serious challenge to public health safety. Currently, the specific pathogenesis of NAFLD is unclear, and there are differences in the understanding and treatment of NAFLD between TCM and Western medicine. The purpose of this paper is to analyze and compare the Chinese and Western medicine nursing strategies for NAFLD and the combination of Chinese and Western medicine in the treatment of NAFLD, as well as to explore innovative paths of nursing research, and then to develop a review, with the aim of providing a reference for the future Chinese and Western medicine clinical treatment.

BACKGROUNDS:11,12-Diacetyl-carnosol (DACA), a derivative of carnosol, exhibits significant anti-inflammatory and antioxidant properties. However, its antidepressant effects and underlying mechanisms remain unclear. High mobility group box 1 protein (HMGB1)-mediated inflammatory responses and associated neurofunctional impairments play a crucial role in the pathogenesis of depression. This study aimed to investigate whether DACA exerts anti-inflammatory and antidepressant effects and whether its mechanisms involve the HMGB1/NF-κB/NLRP3 signaling pathway. METHODS:(1) A depression model was established in mice through 6 weeks of chronic unpredictable mild stress (CUMS). From the 4th week of stimulation, the treatment group received DACA for 3 weeks. (2) BV2 cells were stimulated with LPS+ATP, and the treatment group was cultured in DACA medium for 24 h. (3) Supernatants from BV2 cells were used to culture primary neurons. To confirm the critical role of HMGB1 in DACA's antidepressant effects, CUMS-stressed mice were treated with glycyrrhizin (GZA) or the DACA+GZA combination. Depressive-like behaviors were evaluated using the sucrose preference test (SPT), open field test (OFT), tail suspension test (TST), forced swim test (FST), and Morris water maze (MWM). Hippocampal microglial cell and primary neuron morphology were assessed by immunofluorescence, and dendritic spine density in hippocampal neurons was examined using Golgi staining. IL-6 and TNF-α concentrations in mouse serum and BV2 supernatant were measured by ELISA. Western blotting was used to detect protein expressions of HMGB1, NF-κB p65, p-NF-κB p65, NLRP3, and IL-1β in the hippocampus and BV2 cells. RESULTS:CUMS-exposed mice showed decreased sucrose preference, increased immobility in TST and FST, prolonged escape latency in MWM, and reduced crossings. Microglial activation and upregulation of HMGB1, NF-κB p65, p-NF-κB p65, NLRP3, and IL-1β were observed in both CUMS-stressed mice and LPS+ATP-induced BV2 cells, with reduced dendritic spine density in the hippocampus. DACA significantly reversed these phenomena. The effects of DACA were comparable to those of GZA treatment, and no changes were observed with the DACA+GZA combination. CONCLUSION:The HMGB1/NF-κB/NLRP3 signaling pathway is involved in DACA's therapeutic effects on depression.

ObjectiveThe study aims to evaluate and compare the efficacy and safety between ticagrelor and clopidogrel in acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention (PCI).MethodsWe searched MEDLINE (via PubMed), Cochrane, Embase, and the Cochrane library databases for eligible citations (the last search was up to December 2021). Subgroup analyses were performed based on region, study design, dose, and single-center/multicenter. Meta regressions were conducted to explore the source of heterogeneity. A sensitivity analysis was conducted to assess the robustness of the results. Funnel plots and Egger's test were preformed to test publication bias of the meta-analysis.ResultsA total of 29 studies were included, totaling 165,981 patients. Ticagrelor reduced the overall incidence rate of major adverse cardiovascular events (MACEs) (HR 0.74; 95% CI, 0.62, 0.89; P = 0.001; I2 = 88.3%, P < 0.001) and all-cause mortality (HR 0.85; 95% CI, 0.75, 0.97; P = 0.019; I2 = 39.7%, P = 0.052) compared with clopidogrel. However, there was a higher risk of major bleeding (HR 1.21; 95% CI, 1.02,1.44; P = 0.026, I2 = 59.3%, P = 0.012) and all bleeding (HR 1.42; 95% CI, 1.24, 1.62; P < 0.001, I2 = 76.4%, P < 0.001) with ticagrelor compared to clopidogrel. The stability of the results was demonstrated by sensitivity analysis. Furthermore, subgroup analyses and meta-regression revealed that the heterogeneity in the study may stem from factors such as whether it was conducted in a single-center or multicenter setting, as well as the geographical region.ConclusionTicagrelor has demonstrated superior efficacy compared to clopidogrel in ACS patients undergoing PCI, particularly in Asia and Europe. Nevertheless, it is crucial to acknowledge that the utilization of ticagrelor is linked to a heightened risk of bleeding. To provide guidance for clinical decision-making regarding the use of ticagrelor, future multicenter randomized trials that are relevant and encompass longer follow-up periods are necessary.The category of the manuscript: a meta-analysisPROSPERO registration number CRD42021274198.

BackgroundWork stress is considered as a risk factor for coronary heart disease, but its link with heart rate variability (HRV) among heart attack survivors is unknown yet. The aim of this study was to investigate associations between baseline work stress and the changes of HRV over one-year after onset of acute coronary syndrome (ACS).MethodsHundred and twenty-two patients with regular paid work before their first ACS episode were recruited into this hospital-based longitudinal cohort study. During hospitalization (baseline), all patients underwent assessments of work stress by job strain (JS) and effort-reward imbalance (ERI) models, and were assigned into low or high groups; simultaneously, sociodemographic and clinical data, as well depression, anxiety, and job burnout, were collected. Patients were followed up 1, 6, and 12 months after discharge, with HRV measurements at baseline and each follow-up point. Generalized estimating equations were used to analyze the effects of baseline work stress on HRV over the following 1 year.ResultsAfter adjusting for baseline characteristics and clinical data, anxiety, depression, and burnout scores, high JS was not associated with any HRV measures during follow-up (all p > 0.10), whereas high ERI was significantly related to slower recovery of 5 frequency domain HRV measures (TP, HF, LF, VLF, and ULF) (all p < 0.001), and marginally associated with one time domain measure (SDNN) (p = 0.069). When mutually adjusting for both work stress models, results of ERI remained nearly unchanged.ConclusionWork stress in terms of ERI predicted lower HRV during the one-year period after ACS, especially frequency domain measures.

Acute coronary syndrome (ACS) poses a significant threat to health and well-being, although percutaneous coronary intervention (PCI) is an effective treatment method. However, many patients undergoing PCI for coronary heart disease often experience negative emotions such as depression and anxiety, as well as sleep disturbances, poor adherence to medications, and somatic symptoms. These adverse psychological effects can contribute to an increased risk of cardiovascular events. Mindfulness-based stress reduction (MBSR), a highly effective mind-body therapy, has been increasingly utilized in the recovery process of patients with coronary heart disease. Several scholars have conducted mindfulness interventions for post-PCI patients with coronary heart disease and achieved promising outcomes. This article primarily focuses on applying mindfulness-based stress reduction in PCI patients with coronary heart disease and its future prospects.

Aims Through evolving a precise RNA nuclease, hpCas13d, we have successfully inhibited hypertrophic cardiomyopathy in a compound heterozygous model. However, further investigation is needed to assess the long-term therapeutic effects and safety profiles of hpCas13d treatment. Materials and methods AAV-hpCas13d[RQ] was subcutaneously injected into neonatal Myh6RH/RQ mice. Sequential echocardiography analyses were conducted at 4 months and 12 months to evaluate the sustained therapeutic effects of hpCas13d. Electrocardiography was employed to assess cardiac arrhythmias, and mice were euthanized at 12 months. Quantification of Myh6RQ degradation induced by hpCas13d[RQ] was performed using digital droplet PCR and cDNA sequencing. Histological analysis, RNA sequencing, and proteomic analyses were utilized to examine the inhibitory effects on pathological phenotypes and downstream signaling pathways. Biodistribution, tissue damage, and host immune response to AAV-hpCas13d[RQ] were assessed to evaluate long-term safety profiles. Key findings The allele-specific RNA degradation persisted for 12 months in AAV-hpCas13d[RQ]-treated Myh6RH/RQ mice. Partial degradation of pathogenic Myh6RQ transcripts proved adequate for the long-term inhibition of cardiac hypertrophy, arrhythmias, fibrosis, and cellular apoptosis in Myh6RH/RQ mice. RNA sequencing and proteomic analyses revealed that hpCas13d[RQ] treatment impeded hypertrophy and fibrosis, mitochondrial dysfunction, and abnormalities in ion channels downstream of mutant Myh6. Prolonged treatment with AAV-hpCas13d from the neonatal stage did not induce significant tissue damage, liver toxicity, humoral responses, or cellular immune reactions against the AAV9 capsid and bacterial hpCas13d. Significance These results underscore the promising translational potential of AAV-hpCas13d in treating cardiovascular diseases and advancing in vivo gene therapy.

The diagnosis and treatment capability levels of healthcare professionals directly affect the overall quality of medical services. Enhancing these capability levels requires strengthening the professional skill training of healthcare workers, especially those in primary care settings in economically underdeveloped areas. To understand the actual needs for professional skill training among primary healthcare workers, thereby providing data support for targeted training initiatives. An online survey was conducted using convenience sampling and subsequently, snowball sampling from May 10, 2023 to January 31, 2024. The survey included 3811 healthcare workers across China, and 3617 valid questionnaires were recovered. Descriptive analysis was used to compare the professional backgrounds and training needs of healthcare workers at different medical facility levels. Univariate and multivariate logistic regression analyses were employed to explore factors influencing the training of primary healthcare workers. The survey revealed that 70.1% of respondents were female, and 94.2% were from medical facilities below the provincial level, with 43.2% from township-level or lower medical facilities. Significant differences were found in age distribution, work experience, professional titles, educational levels, and training needs among provincial/national, prefectural/county, and township levels (P < 0.05). Busy clinical work schedules were the primary barrier to training participation. Most healthcare workers (78.7%) expected more than four training sessions per year, with the optimal frequency being quarterly. The most anticipated training topics among primary care workers were latest medical guidelines, new technologies/skills, and advanced management concepts, with over 80% interest. Compared with prefectural/county-level facilities, primary care workers at grassroots facilities are more significantly impacted by lower professional titles, lower education levels, weaker medical/technical skills, and insufficient specialized funding (odds ratio > 1, P < 0.001). Training should be tailored to the needs of healthcare workers at different medical facility levels. Particularly for primary care settings, providing special funding support and training in the latest medical guidelines, new technologies/skills, and advanced management concepts are important to improve the composition of titles, education, and professional technicians.

There is a lack of bibliometric analysis in research regarding primary therapy for end-stage renal disease (ESRD). This study aims to analyze the literature on ESRD therapy published over the past decade to understand current conditions and study trends for future research. Data were collected from the Web of Science Core Collection (WOSCC) database. Tools like CiteSpace 6.2.R4, 6.1.R6, VOSviewer 1.6.18, and Bibliometrix R4.1.1 were used to reveal research trends and hotspots. In addition, KEGG/GO analysis examined the probable functionalities of genes implicated in ESRD therapy to guide future research. The bibliometric analysis presented in this paper indicates that the number of publications has remained relatively stable since 2013. The level of international collaboration is notably high, with the United States serving as the dominant research hub in this field. The University of California system is the most prolific institution, and Transplantation Proceedings is the most frequently published journal in this area. Kalantar-Zadeh, Kamyar is recognized as the most published and cited author. Keywords such as “secondary hyperparathyroidism,” “uremic toxins,” “cyclosporine,” “mycophenolate mofetil,” and “biomarkers” have seen a surge in interest recently, reflecting emerging research trends. Furthermore, inflammation and stem cell research have been identified as promising new therapeutic avenues for ESRD. This study identifies major areas, frontiers, and trends in research on primary treatments for ESRD, providing significant implications for future research.

心脏起搏器各参数中起搏阈值是最重要的功能参数,起搏阈值升高是起搏器植入术后重要的并发症之一.正常植入后起搏阈值存在一定的波动,近年来随着激素电极的应用,起搏阈值变化的幅度明显减小.现代观点认为起搏阈值受生理、药物、心肌病变及纤维化、电极导线、化疗、电解质等多种因素的影响.

目的 探究银杏叶提取物通过自由基清除作用保护脑缺血大鼠钠、钾-三磷酸腺苷酶(Na,K-ATPase)活性.方法 选取40只成年大鼠,均进行大脑中动脉闭塞手术,建立脑缺血模型,排除死亡个体4例,使用随机数字表法分为4组(对照组,低剂量组,中剂量组,高剂量组)分别给予安慰剂及不同剂量银杏叶提取物,干预48h后处死大鼠,取脑皮质,观察各组脑皮质病理变化并比较各组Na,K-ATPase活性.检测各组大鼠MDA、SOD、CAT及炎症因子水平并观察其TLR4、NF-κB蛋白表达.结果 对照组大鼠脑皮质结构受损严重,表现为细胞皱缩、空泡变性、细胞着色不均、排列紊乱,神经细胞凋亡,研究组大鼠脑皮质病理变化明显减轻,且随银杏叶提取物剂量增加进一步缓解;对照组Na,K-ATPase活性显著低于低剂量组、中剂量组、高剂量组,且随剂量上升,其活性均呈现升高趋势;对照组MDA水平显著高于低剂量组、中剂量组、高剂量组,且随剂量上升,MDA呈现降低趋势(P＜0.05);对照组SOD、CAT水平显著低于低剂量组、中剂量组、高剂量组,且随剂量上升,呈现升高趋势(P＜0.05);对照组IL-1β、IL-6、TNF-α水平显著高于低剂量组、中剂量组、高剂量组,且随剂量上升,其水平均呈现降低趋势(P＜0.05);对照组TLR4、NF-κB蛋白及mRNA相对表达量显著高于低剂量组、中剂量组、高剂量组,且随剂量上升,其水平均呈现降低趋势(P＜0.05).结论 银杏叶提取物可通过调控脑缺血大鼠TLR4/NF-κB通路及自由基清除作用保护脑缺血大鼠Na,K-ATPase活性,从而抑制其大脑炎性因子释放及神经元细胞凋亡,保护脑缺血大鼠脑组织.

Objective: This study investigated the association between job burnout and quality of life (QoL) after acute coronary syndrome (ACS) in a Chinese sample. Methods: This was a one-year longitudinal study. Participants included patients with a first episode of ACS who were still employed. The Copenhagen Burnout Inventory (CBI) assessed job burnout before discharge, and QoL was assessed using the Medical Outcome Study 8-Items Short Form Health Survey (SF-8) and the Seattle Angina Questionnaire (SAQ) before discharge (baseline), at one month, six months and 12 months after discharge. Generalized estimating equations determined the association between job burnout and longitudinal changes of QoL. Results: All participants were assigned to either a "low job burnout" group (n = 70) or a "high job burnout" group (n = 50), based on the upper quartile of job burnout scores. Longitudinally over 1-year follow-up period, the scores of the SF-8 and SAQ among patients with a high level of burnout were lower than those in the low job burnout group. Job burnout was significantly associated with lower physical and mental health (SF-8), as well as greater physical limitation and lower treatment satisfaction (SAQ) over time. Conclusion: Job burnout at baseline predicted slow improvement of QoL after ACS in a Chinese working sample.

BACKGROUND:Due to the lack of evidence and inconsistency of sex differences in Heart failure (HF) in the Chinese population, this study aimed to compare sex differences in functional capacity and quality of life (QoL) between women and men after standard HF medications therapies, and analyze whether sex differences were associated with the composite endpoints of all-cause mortality or HF-related hospitalization and cardiac event-free survival rate in Chinese patients with HF.METHODS:This was a 1-year longitudinal study. Participants included patients with HF from March 2017 to December 2018. At baseline and followed up at 1, 6, and 12 months later, functional capacity was assessed by 6-minute walk testing (6MWT), QoL was measured with the Kansas City Cardiomyopathy Questionnaire (KCCQ) and EuroQoL five dimensions (EQ-5D). The Cox proportional hazards model and Kaplan-Meier curves were used to determine sex differences in subsequent outcomes. The Cox proportional hazards model was used to identify the risk factors for composite endpoints. Kaplan-Meier curves were used to compare survival.RESULTS:All patients were assigned to either men group (n = 94) or women group (n = 60). Longitudinal follow-ups showed a continuously increasing in 6MWT, Kansas City Cardiomyopathy Questionnaire overall score, EQ-5D visual analogue scale, and EQ-5D Index score in both groups (all P < 0.001); however, women reported a lower level of all parameters at the 1, 6, and 12 months follow-ups (all P < 0.05). In addition, women had a higher risk of all-cause mortality or HF-related hospitalization and a lower cardiac event-free survival rate than men (log-rank test, P = 0.027).CONCLUSION:Women reported worse functional capacity, QoL, and prognosis than men in a sample of Chinese patients with HF. Our findings highlight the importance of paying attention to sex differences in HF.

(1) Background: Targeting a sample of Chinese employees in this study, the correlation of work stress with changes in quality of life (QoL) was explored subsequent to acute coronary syndrome (ACS). (2) Methods: Patients suffering from the first ACS episode, with regular paid work before ACS, were eligible for this one-year longitudinal study. Effort–reward imbalance (ERI), together with job strain (JS) models, were employed to evaluate work stress before discharge, and QoL prior to discharge (baseline), as well as at 1, 6, and 12 months following discharge, were measured using the 8-Items Short Form (SF-8), in addition to the Seattle Angina Questionnaire (SAQ). Moreover, generalized estimating equations were used to determine the relationship of work stress to longitudinal QoL variations. (3) Results: After adjusting for covariates, high work stress at the baseline measured by JS was associated with the slow recovery of both mental health (p < 0.01) and physical health (p < 0.05) in SF-8, while ERI-measured work stress was related to slower improvement in SF-8 physical health (p < 0.001), SAQ-angina stability (AS) (p < 0.05), SF-8 mental health (p < 0.001), and SAQ-angina frequency (AF) (p < 0.05). After mutual adjustment for JS and ERI, high work stress as assessed by JS displayed no correlation with any QoL alteration (all p > 0.05), whereas ERI-determined work stress at a high level still presented a relationship to slow improvement in SF-8 physical health, SAQ-AS, SF-8 mental health, and SAQ-AF (all p < 0.05). (4) Conclusion: Work stress was associated with slow recovery of QoL in patients with ACS across one year. For ACS patients, ERI was a stronger predictor of QoL variations than JS.