目的 分析血清红细胞分布宽度(RDW)、尿β2微球蛋白(β2-MG)对妊娠期高血压疾病患者早期肾损伤的诊断价值.方法 选取2016年3月-2019年3月台州市第一人民医院收治的妊娠期高血压疾病患者90例为妊娠期高血压疾病组(其中轻度子痫前期28例、中度子痫前期30例、重度子痫前期32例),同时选择同期本院就诊正常妊娠妇女96例作为对照组,检测β2-MG、RDW水平,比较妊娠期高血压疾病组与对照组β2-MG、RDW水平变化.比较妊娠期高血压疾病组不同程度子痫前期患者β2-MG、RDW水平变化,比较妊娠期高血压疾病组中不同程度子痫前期患者β2-MG、RDW阳性率.计算ROC曲线下面积(AUC),绘制ROC曲线分析β2-MG、RDW单个与两个联合检测的诊断价值.结果 妊娠期高血压疾病组β2-MG、RDW水平高于对照组,差异有统计学意义(P＜0.05).妊娠期高血压疾病组中重度子痫前期患者β2-MG、RDW水平显著高于中度子痫前期、轻度子痫前期患者,中度子痫前期患者β2-MG、RDW水平高于轻度子痫前期患者,差异均有统计学意义(P＜0.05).妊娠期高血压疾病组中重度子痫前期患者β2-MG、RDW阳性率显著高于轻度、中度子痫前期患者,中度子痫前期患者β2-MG、RDW阳性率显著高于轻度子痫前期患者,差异有统计学意义(P＜0.05).不同两个指标联合检测明显优于单个指标检测的诊断效率,两个指标联合检测的敏感度为98.2％、特异度为98.3％.结论 妊娠期高血压疾病患者RDW、β2-MG随病情加重而升高,联合检测RDW、β2-MG指标可及早确定早期肾损伤.

目的:分析血液透析(HD)患者并发感染性心内膜炎(IE)的临床表现及结局.方法:收集2013年1月至2017年12月在温州医科大学附属第一医院诊断为终末期肾脏病,并维持HD患者460例的临床资料.结果:9例患者并发IE,男5例,女4例,年龄(58.2±13.8)岁.透析通路均为隧道型中心静脉导管(CVC),中位透析时间20.0(1.8,36.0)个月.发热9例(占100％)为主要临床表现,6例并发脑梗死、心力衰竭和脑出血.所有患者均行血培养,7例阳性,主要细菌是葡萄球菌(占71.4％).经胸超声心动图(TTE)检查7例,食道超声(TEE)1例,同时行TTE和TEE检查1例,均发现赘生物.累及部位以二尖瓣最常见(5/9),其次为三尖瓣(2/9).保守治疗8例,外科手术1例;好转出院4例,自动出院5例.结论:用CVC HD患者出现发热症状,要考虑到IE的可能,可以借助TTE或TEE和血培养明确诊断.

目的:探讨N-乙酰半胱氨酸(Nac)对终末糖基化产物(AGEs)诱导的人肾小管上皮细胞(HK-2细胞)IL-1β(白介素-1β)、IL-6(白介素-6)的抑制作用.方法:将体外培养的HK-2细胞分成正常对照组(NG组)、AGEs组、药物干预组1(N1组)、药物干预组2(N2组),培养72 h,应用反转录实时定量聚合酶链式反应(RT-qPCR)方法检测IL-1β和IL-6 mRNA表达,酶联免疫吸附法(ELISA)测定培养上清中细胞因子的蛋白浓度.蛋白质印迹法(Western blot)检测NF-κB/p65的含量.结果:NG组、AGEs组、N1组和N2组细胞内IL-1β和IL-6 mRNA和蛋白表达,以及NF-κB/p65含量差异均有统计学意义;与NG组比较,AGEs组细胞内IL-1β和IL-6mRNA和蛋白表达明显增加.N1、N2组较AGEs组表达水平下降,AGEs组NF-κB/p65含量高于其他组,差异均具有统计学意义(均P<0.05).结论:AGEs可诱导HK-2细胞表达IL-1β和IL-6,NF-κB信号通路可能参与了此过程.

化脓性脊柱炎是一种严重影响患者神经功能和生活质量疾病,以往关于血液透析(hemodialysis,HD)患者化脓性脊柱炎的病程和治疗的报道很少[1].本文对4例用微创技术治疗的患者及4例接受保守治疗患者在诊断、治疗和预后作了简要介绍,观察经皮脊柱内镜进行病灶清除的微创手术方法的临床疗效及诊断价值,现报道如下.

Objective To compare the effects of warfarin and bayaspirin to keep long-term catheter unblocked and security for hemodialysis. Methods Prospective observation were made on 72 cases of the patients with long-term catheter who were taking aspirin anticoagulation in 18 hemodialysis units in Wenzhou from February 2013 to April,they were randomly assigned to warfarin group and aspirin group after catheter dysfunction,then observe the conduit dysfunction and bleeding events between two groups.Results The conduit dysfunction events were 0.63 times /year and 2.70 times/year(P<0.01)in warfarin group and aspirin group. Malfunction-free catheter survival in a year was 50% and 23.5% in two groups. There are three major bleeding and seven minor bleeding events in warfarin group and 2 cases with gastrointestinal bleeding and epistaxis in the aspirin group(P<0.01).Conclusions Warfarin(INR1.5~2.5)is better to keep long-term hemodialysis catheter unblocked compared with aspirin(100mg/day),but greatly increase bleeding risk.

目的:评价骨化三醇不同给药方案对血液透析患者矿物质及骨代谢紊乱(CKD-MBD)及FGF23的影响.方法:选取血甲状旁腺素(PTH)水平在300～ 621 pg/ml(正常的4～9倍)之间的血液透析患者,随机分成骨化三醇常规治疗组(常规组,22例)和间歇给药组(间歇组,26例),疗程16周,检测治疗前后血清FGF-23水平、钙磷代谢等指标变化.结果:(1)两组患者治疗终点与治疗前比较,血PTH均明显下降、血维生素D及FGF23均明显升高(P＜0.05).间歇组在治疗终点,血钙明显升高、碱性磷酸酶明显下降(P＜0.05),而持续组,治疗前后血钙、碱性磷酸酶无明显变化.(2)在不同治疗时间点,持续组PTH明显下降(P＜0.05);间歇组PTH、碱性磷酸酶明显下降,血钙明显升高(P＜0.05).治疗第4周、第8周,间歇组PTH下降较持续组明显(P＜0.05).(3)治疗期间,持续组有6例患者血磷升高,间歇组无血磷升高患者.治疗期间无高钙血症发生.结论:骨化三醇不同给药方案能不同程度下降患者血PTH、升高FGF23,间歇组较持续组明显;间歇给药组血钙明显升高、碱性磷酸酶明显下降.两组治疗方案均能改善继发性甲状旁腺功能亢进,间歇给药组降PTH效果更佳.骨化三醇治疗轻中度继发性甲状旁腺功能亢进安全有效.

Objective: To investigate the effect of magnesium on calciifcation of vascular smooth muscle cells (VSMCs) induced by elevated calcium (Ca++) and phosphate (P) culture.Methods: The fetus’s umbilical artery VSMCs were extracted under aseptic conditions and cultured in vitro. Cells were divided into three groups: normal control group (normal concentration of Ca++ and P, group A), positive control group (high calcium and phosphate, group B), treatment groups (high calcium and phosphate + magnesium sulfate, group C). The cells were cultured for 3 days, then Part (B1, C1) were continued to develop in high calcium and phosphate culture medium, Part (B2, C2) were changed to develop in ordinary solution. Respectively the calcium content of cell layer were determinated in calcium content test in the 4, 7, 10 days. Meanwhile, the protein expression of Cbfa1 and Prps2 were observed by Western bloting.Results: The primary cells were identiifed, purity of cultures was assessed by positive immunostaining for α-SMA. Compared with negative control group, the sedimentary on the cells layer of experimental group (B) was observed. The calcium content in calcium content test showed that the high calcium and high phosphorus group (B, B1 and B2) increased signiifcantly (P<0.05), compared with the B, B1 and B2 group, magnesium sulfate group (C, C1 and C2) showed a lower intracellular calcium levels. Western blot test results conifrmed that: compared with control group (A), the expression of Cbfa1 increased in B group in 24 hours, 72 hours; compared with B group, the expression of Cbfa1 declined in C group in 12 hours, 24 hours, 72 hours. compared with B1, B2 group, the expression of Prps2 increased in C1, C2 group in 4 days, 7 days, 10 days, was statistically signiifcant (P<0.05).Conclusion: High calcium and high phosphorus promote the VSMCs’ calciifcation. While magnesium has a signiifcant effect to inhibit the VSMCs calciifcation, activate the Prps2 pro-tein expression, promote the calciifcation fade.

Objective: To report the technical success and long-term clinical outcomes of arteriovenous ifstula (AVF) stenosis after percutaneous transluminal balloon angioplasty (PTA).Methods: A total of 30 patients with stenosis of AVF were enrolled. There were 16 men and 14 women, and the median age was 64.8±13.2 years. Mean time between ifstula creation and intervention was 16.5±13.8 months. The mean duration of hemodialysis time was 31.5±30.2 months. They were examined by digital subtraction angiography (DSA) when they under-went PTA. After the treatment of PTA, all of the patients were examined by 64-multislice spiral computed tomog-raphy angiography every 3 months.Results: The technical success rate was 90.0% in the hemodialysis patients (17 native AVFs and 10 arteriovenous grafts). Primary patency at ifrst, second, third, fourth and iffth three months was 100%, 91.3%, 79.5%, 72.6% and 62.2% respectively. Univariate analysis indicated that there was no signiif-cant correlation between the clinical factors (including age, diabetes mellitus, location, length, grade, and number of stenosis) and primary patency (P>0.05).Conclusion: PTA is an effective treatment method for arteriovenous stenosis, which has high rates of technical success and less complication.

目的：：分析温州地区维持性血液透析( MHD)患者矿物质代谢水平达标率,通过加强医务人员相关知识及指南推广学习和患者宣教,了解患者矿物质代谢水平对比情况。方法：收集温州地区MHD患者血钙、血磷、全段甲状旁腺激素( iPTH)的资料,其中2013年上半年患者(第一次调查组)共2227例,根据美国肾脏病( KDOQI)指南及中华医学会肾脏病学分会( CSN)制订的《慢性肾脏病矿物质和骨异常诊治指导》对患者的血钙、血磷、iPTH的达标率及三项均达标的比例进行分析,根据分析结果对医务人员进行培训学习和对患者进行宣教,与2013年下半年患者(第二次调查组共2455例)进行对比,了解两组患者矿物质代谢水平对比情况。结果：按照KDOQI指南推荐的钙磷代谢治疗目标,第一次调查组患者血钙、血磷、iPTH的达标率及三项均达标的比例分别为44.90%,46.30%,27.64%,6.29%,而第二次调查组患者分别为50.55%,50.59%,27.88%,9.12%,较第一次调查组增加5.65%、4.29%、-0.06%、2.83%；按《慢性肾脏病矿物质和骨异常诊治指导》建议的治疗目标,血钙、血磷、iPTH的达标率及三项均达标的比例,第一次调查组患者分别为57.66%,46.30%,61.14%,16.97%,第二次调查组患者分别为63.10%,50.59%,63.24%,20.67%,第二次调查结果较第一次调查结果分别增加5.44%、4.29%、2.10%、3.70%。三级医院两次调查结果没有差异,二级医院第二次调查血钙、血磷的达标率及三项均达标的比例均较第一次调查提高。结论：通过加强医务人员相关知识及指南推广学习和患者宣教,第二次调查组患者血钙、血磷水平及三项均达标的比例较第一次调查组患者明显升高,其中二级医院进步明显,iPTH的达标情况较上半年无明显变化。

Objective To study the effectiveness of niacinamide in treating maintenance hemodialysis patients with hyperphosphatemia.Methods It was a prospective and randomized controlled trial.Patients with hyperphosphatemia (serum phosphate ＞ 1.45 mmol/L) were randomly assigned into two groups:control group (continue their original phosphate binder and rocaltrol treatment) and niacinamide therapy group (additionally received niacinamide,titrated from 600 mg/d to 1200 mg/d).The treatment lasted for 8 weeks.Serum phosphate and calcium were tested every 2 weeks and normalized protein catabolic rate and other relevant indexes were tested monthly.Results 100 patients were recruited and 93 of them completed the trial,including 44 from the therapy group and 49 from the control group.By the repeated measures analysis of variance,changes of serum phosphate in two groups displayed a statistical significant difference,but the levels of serum calcium in both remained steady.At the end of trial,compared to control group,therapy group appeared decreased serum phosphate levels [(1.59±0.36) mmol/L vs (1.94±0.25) mmol/L,P ＜ 0.001] and increased serum HDL levels [(1.32±0.54) mmol/L vs (1.09±0.41) mmol/L,P=0.02].Meanwhile,two groups showed no significant difference in intact parathyoid hormone and alkaline phosphatase.Adverse reactions including thrombocytopenia and gastrointestinal dysfunction were observed in niacinamide therapy group.Conclusions Niacinamide is effective on controlling hyperphosphatemia along with phosphate binder in maintenance hemodialysis patients.It also increases the serum HDL levels.Nonetheless,it is important to monitor the number of platelet.

目的 了解温州地区维持性血液透析患者矿物质代谢紊乱情况及相关影响因素. 方法 收集2013年在温州地区长期维持性血液透析患者血钙、血磷、全段甲状旁腺激素(iPTH)的资料,并根据美国肾脏病协会指南(KDOQI)及中华医学会肾脏病学分会(CSN)制订的《慢性肾脏病矿物质和骨异常诊治指导》计算患者的血钙、血磷、iPTH的达标率,并对相关影响因素进行分析.结果 共收集2 227例2013年在温州地区各家透析中心维持性血液透析患者的资料.按KDOQI指南标准,患者血钙、血磷、iPTH的达标率分别为44.90％、46.30％、27.64％,3项均达标者占6.29％;按《慢性肾脏病矿物质和骨异常诊治指导》建议,患者血钙、血磷、iPTH的达标率分别为57.66％、46.30％、61.14％,3项均达标者占16.97％.此外,三级医院维持性血液透析患者的平均血磷水平为(1.67±0.51)mmol/L,血磷达标率49.10％,二级医院患者的平均血磷水平为(1.79±0.53)mmol/L,达标率为43.22％,三级医院维持性血液透析患者的血磷达标率情况优于二级医院.血白蛋白、含钙磷结合剂的使用及透析频率是影响血钙达标的独立相关因素.患者的性别、年龄、活性维生素D的使用、透析龄及透析频率是影响血磷达标的独立相关因素.患者活性维生素D的使用是影响iPTH达标的独立相关因素.结论 温州地区维持性血液透析患者矿物质代谢紊乱纠正情况与有关指南的要求仍然存在较大差距;患者性别、营养状态、透析频率、含钙磷结合剂的服用、活性维生素D的使用等是影响维持性血液透析患者矿物质代谢紊乱纠正的主要相关因素.

OBJECTIVE To investigate the clinical diagnosis and treatment for nosocomial infections in uremic patients with sustained of hemodialysis ,so as to improve the clinical cure rate .METHODS A total of 89 cases of uremia continuous hemodialysis patients from Jan .2012 to Apr .2013 were selected as study objects .Then the pathogen distribution ,risk factors and treatment and other aspects of 31 cases of patients with nosocomial infec-tion were analyzed .SPSS 13 .0 software was used for statistical analysis .RESULTS Among 89 cases ,there were 31 cases of patients with nosocomial infections ,accounting for 34 .83% .The main infection site was respiratory tract ,accounting for 64 .52% .K lebsiella pneumoniae were the top bacteria ,accounting for 29 .55% ,and Pseud-omonas aeruginosa were 20 .46% .The age (≥60 years) ,diabetic nephropathy ,hospital stay (≥60 d) ,body mass index (≥ 24 kg/m2 ) ,albumin (<30 g/L) were the risk factors ,and the difference was significant (P<0 .05) .CONCLUSION Uremia continuous hemodialysis causing nosocomial infections and the disease itself has closely relation .The standard operation and strengthening the application of antimicrobial agents can reduce the incidence of infection .

目的 研究白藜芦醇(resveratrol,Res)对血管钙化的抑制作用,观察不同浓度的Res对高钙高磷诱导的人脐动脉血管平滑肌细胞(hVSMC)成骨样转化的影响.方法 体外培养hVSMC细胞,通过形态学和α-SMA标记进行鉴定.用高钙高磷(钙2.5 mmol/L、磷3.0 mmol/L)培养基诱导hVSMC成骨样转化,通过茜红素染色法鉴定成骨样转化.以普通培养hVSMC作为对照组,加高钙高磷为阳性对照组,实验组为阳性对照加不同浓度的Res(5、10、20 μmol/L)干预,培养12d后,检测各组细胞含钙量,实时荧光定量PCR检测hVSMC成骨样转化相关基因骨特异性碱性磷酸酶(BAP)、骨形态蛋白(BMP-2)、骨桥蛋白(OPN)的表达水平;Western blotting和免疫荧光标记方法检测BAP、BMP-2、OPN蛋白的表达.结果 与对照组比较,阳性对照组细胞内含钙量明显升高约5倍,α-SMA蛋白表达下降,而成骨样细胞特异性标记BAP、BMP-2、OPN mRNA和蛋白质表达均显著升高(P＜0.01).不同浓度Res干预后后,细胞内含钙量下降,BAP、BMP-2、OPN mRNA水平降低(P＜0.05、0.01);BMP-2及OPN的蛋白表达显著降低(P＜0.01),并与Res浓度呈负相关.结论 hVSMC在高钙高磷条件下发生成骨样转化,而Res抑制此过程的进展并与其浓度呈正相关.

Objective To determine the condition of conjunctival and corneal calcificationin in maintenance haemodialysis patients,and explore the relationship between conjunctival and corneal calcificationin (CCC) and abdominal aortic calcification (AAC).Methods CCC was evaluated by slit -lamp eye photographs,and was graded and scored according to Porter' s classification system in the literature.Abdomen lateral X-ray examination were used as a criteria to determine the abdominal aortic calcification.The abdominal aortic calcification (AAC) score was calculated.Spearman correlation coefficient was used to analyze the relationship between CCC and AAC.Logistic regression analysis was used to determine the risk factor of CCC in MHD patients.Results Ninety-eight MHD patients were recruited.Their average age and dialysis vintage were (61.89±12.54) years and 51.67 (3.00～ 192.00)months,ninety-seven patients had conjunctival and corneal calcificationin,and seventy-two patients had abdominal aortic calcification,The median CCC was 8 (0,17),the median AAC was 6 (0,20),and the CCC was positively correlated with AAC (r=0.376,P ＜ 0.001).Compared with the patients of CCC score≤5,the patients of CCC score ＞ 10 had a higher level of phosphate,calcium-phosphate product,iPTH,hs-CRP,and longer dialysis vintage,as well as a higher score of AAC (all P ＜ 0.05).Multivariate logistic regression analysis showed that the higher score of AAC and the longer dialysis vintage were independent risk factors for severe corneal calcificationin calcification.Conclusions Conjunctival and corneal calcificationin is common in MHD patients,and CCC is positively associated with AAC,the risk of CCC rises as a result of a severer AAC and a longer dialysis vintage.

The purpose of this study was to investigate the correlation of conjunctival and corneal calcification (CCC) with cardiovascular calcification in patients undergoing maintenance hemodialysis (MHD). A total of 122 patients undergoing MHD in our hospital were included in this study. Conjunctival and corneal calcification was examined by slit lamp and graded. Abdominal aortic calcification (AAC), aortic valve calcification (AVC), and mitral valve calcification (MVC) were determined by X-ray or ultrasound. The correlation of CCC with AAC, AVC, and MVC was analyzed. Biochemical, hematological, and cardiovascular data were compared between patients with different severity of CCC or AAC. Mitral valve calcification was significantly associated with AAC in our patients. Conjunctival and corneal calcification positively correlated with AAC. We also found that patients with severe CCC exhibited significantly higher levels of serum calcium, phosphate, product of calcium and phosphate, serum copper, cystatin, intact parathyroid hormone, and vitamin D than patients with mild CCC. In addition to significantly increased levels of serum calcium, product of calcium and phosphate, serum copper, and cystatin, patients with severe AAC also had higher high-sensitivity C-reactive protein level and greater left ventricular posterior wall thickness and left ventricular end-diastolic interventricular septum thickness than patients with mild AAC. Our results suggest that patients undergoing MHD with severe CCC or AAC have high degree of mineral metabolism disorder, inflammation, and cardiovascular function disorder. The strong correlation between CCC and AAC indicates that CCC score might be used as an indirect indicator to predict cardiovascular risks in patients undergoing MHD.

目的:分析2010年1月至2012年12月温州市18家医院维持性血液透析患者的特点和死亡原因.方法:回顾性分析维持性血液透析大于3个月死亡患者269例的临床资料,按年龄分3组:20 ～ 44岁(青年组),45 ～ 64岁(中年组)和≥65岁(老年组),分析3组间透析龄、原发病、死亡原因、首次透析时及死亡前1年内实验室检查的差别.结果:透析龄在青年组最长,平均(49.4±60.3)月,老年组透析龄最短,平均(34.1±26.8)月;死亡患者中原发病以糖尿病最多,占39.4％.脑血管疾病为首要死亡原因,3组患者间差异无统计学意义;心血管疾病为第二位死亡原因,在中年组多见;全身衰竭死亡在老年组患者中最多,占23.7％,3组间差异有统计学意义(P=0.01).进入透析时及死亡前1年内血肌酐、尿素氮和血白蛋白在3组间差异有统计学意义(P＜ 0.01或P＜ 0.05),老年组患者低于青年组和中年组患者.结论:温州地区维持性血液透析死亡患者绝大多数为老年患者,原发病以糖尿病最多见,主要死因为脑血管疾病,其次为心血管疾病,全身衰竭死亡在老年组中较多见,且营养状况相对较差.

国外学者认为结膜和角膜钙化是尿毒症患者常见的一种转移性钙化.严重的球结膜和角膜钙化预示着患者会在1年内死亡[1].血液透析相关红眼症状是结膜和角膜钙化的重要表现[2],对于早期发现和早期干预有重要意义.现将2012年1月至2013年6月本科血液透析相关红眼症状10例报告如下.

Objective To summarize the main points of nursing care for red eye syndrome associated with hemodialysis, alleviate the sufferings of patients,improve the quality of life and long-term survival rate of patients. Methods Ten cases of red eye syndrome associated with hemodialysis received the inquiry and eye exam,including slit-lamp examination, blood biochemical examination. The corresponding nursing and prevention measures: strictly controlling the level of blood phosphorus; adequate dialysis; good diet,medication,psychological care; paying attentions to eye health; maintaining defecate unobstructed. Results After 4 weeks of treatment and nursing,the blood phosphorus decreased significantly,red eye symptoms improved in 5 patients obviously,4 cases were with mild conjunctival hyperemia in both eyes,1 case with moderate conjunctival hyperemia in both eyes. After 8 weeks of standard treatment,the level of blood phosphorus recovered to the basic level,there was no conjunctival hyperemia,red eye symptoms disappeared completely,but the conjunctival and corneal calcification score had not been improved. Conclusion In the nursing intervention of red eye syndrome associated with hemodialysis,regular monitoring the levels of blood calcium,blood phosphorus and PTH,strict controlling of calcium phosphorus diet and adequate dialysis are the crucial measures.

Objective: To study the effect of high-flux hemodialysis on the soluble intercellular adhesion molecule-1 and inflammatory factors in maintenance hemohemodialysis patients.Methods: Forty MHD patients were selected and divided into two groups,conventional hemodialysis group(HD group) and high flux hemodialysis group(HFHD group),the observation time was twelve weeks.The concentrations of sICAM-1,TNF-α,CRP,β 2 MG were measured at the beginning,pre-dialysis and post-dialysis of the end of experiment.The value of KT/ V at the beginning and the end of experiment was calculated.Results: In HFHD group,the concentrations of CRP,TNF-α,β 2 MG,sICAM-1 decreased at the end of experiment,it had significant difference at post-hemodialysis compared to pre-hemodialysis(P0.05).The concentrations of TNF-α,β 2 MG,sICAM-1 at pre-hemodialysis of the end of experiment had statistically difference compared to the beginning of the experiment(P0.05),and at the end of experiment,the concentrations of β 2 MG,sICAM-1 had significant difference compared to the HD group(P0.05).In HD group,the concentrations of CRP,TNF-α,β 2 MG,sICAM-1 all increased at the end of experiment.Conclusion: Compared to the conventional hemodialysis,high-flux hemodialysis can decrease the concentration of sICAM-1 and TNF-α.

维持性血液透析(血透)已成为许多终末期肾病患者长期替代的治疗方法.近10年来,全国各地成立了多家血液透析中心,但相关的流行病学调查资料少见报道.随着行业管理越来越趋向规范化,卫生行政部门和学术团体组织开始重视和开展透析登记工作.我们将温州市23家血液透析单位2002年至2011年的透析登记资料进行总结并报告如下.