2,3,5-triacetoxymethyl-6-methylpyrazine and 2,3,5,6-tetracetoxymethylpyrazine were synthesized from tetramethylpyrazine by bromination and esterification,then were hydrolyzed into 2,3,5-trihydroxymethyl-6-methylpyrazine and 2,3,5,6-tetrahydroxymethylpyrazine.The structures were confirmed by UV,1H NMR,13C NMR,IR and MS.

麦麸在我国应用历史悠久。麦麸除作为动物饲料外,还可作为中药炮制的铺料。近年来国内外的深入研究表明,麦麸所含活性成分有突出药用价值,同时麦麸还可通过影响体内物质而产生药效。麦麸在预防和治疗心脑血管疾病及部分癌症方面有突出疗效,对便秘和肥胖症也有明显作用。麦麸在麸炒中作用显著,可明显改变药物成分及其含量。

Referring to relative documents,the recent advances in pharmacological effects on cardiovascular system and other aspects and corresponding mechanisms of ligustrazine were summarized.The prediction for its research direction was raised.

将水飞蓟宾进行衍生化,制备水溶性衍生物。水飞蓟宾与丁二酸酐在碱性条件下反应,生成水飞蓟宾-3,23-二琥珀酸单酯和水飞蓟宾-3-琥珀酸单酯,其结构经UV、IR、1H-NMR和MS波谱确证。在本反应条件下,可以选择性地对水飞蓟宾分子中的醇羟基进行酯化,制得水溶性好的衍生物。对产物进行抗急性干损伤的研究,产物可降低ALT活性,对CCl4致小鼠急性肝损伤具有保护作用。