[目的]了解重庆市2004-2020年传染病领域公共卫生服务公平程度,分析公共卫生服务公平性与传染病发病率之间的相关性,探索基于文献分析法定量评价服务公平性的可行性.[方法]系统收集2004-2020年重庆市涉及传染病预防控制公共卫生服务公平性研究的相关文献,采用"五分度评分法"计算公共卫生服务不公平性的严重程度.运用Spearman相关分析和线性回归分析卫生服务不公平程度与传染病发病率的关系进行分析.[结果]重庆市传染病领域公共卫生服务公平程度呈波动性上升趋势,从2004年(23.3％)提升至2020年的40.0％,上升程度为16.7％;传染病发病率与公共卫生服务公平程度呈负相关关系(r=-0.593,P<0.05).[结论]传染病领域公共卫生服务公平程度至2004年起逐年提升,但重庆市公共卫生服务公平性整体仍处于较低水平,卫生服务不公平问题亟需解决,公平程度有待进一步提升.

目的 分析重庆市2002-2019年卫生人力资源的发展变化趋势,运用ARIMA模型对重庆市未来五年的卫生人力资源进行预测,为相关部门制定或调整相应的卫生政策、优化医疗卫生人力资源配置提供参考.方法 采用EXCEL建立卫生人力资源数据库,运用SPSS 21.0拟合ARIMA时间序列模型对重庆市2020-2024年卫生技术人员数、执业(助理)医师数以及执业护士数进行预测分析.结果 重庆市卫生技术人员、执业(助理)医师、注册护士年均增长率分别为6.28％、4.75％、9.90％;ARIMA预测结果显示到2024年重庆市卫生技术人员、执业(助理)医师、注册护士的数量将分别达到325783人、118943人和159667人;ARIMA预测模型的相对误差均小于10％,拟合度较高,预测效果较好.结论 重庆市卫生人力资源逐年增长,新医改之后增长速度明显提高,但与国家平均水平仍有一定差距;医护比逐渐合理,但有待进一步优化;在新冠肺炎疫情背景下,政府还应重点考虑公共卫生人才的培养和管理,扩大多元化卫生人才队伍,不断优化卫生人力资源配置.

(Z)-2,3-dihydroind-en-1-one ON-prop-2-ynyloxyme was synthesized from 1-indanone and hydroxylamine hydrochloride by condensation, alklation with bromopropyne, The substituted reaction temperature,reaction time and catalyst was investigated.The method is simple, lower cost and a higher yield of the target product,suitable for industrial production.

Objective:To design and synthesize 1,2,3,4-tetrahydroisoquinolines and to determine its inhibition effect on monoamine oxidase(MAO).Methods:1-aminomethyl-1,2,3,4-tetrahydroisoquinoline was synthesized from phenylethylamine via acylation,amination with phthalimide potassium,bisehler-napieralski cyclization,hydrazinolysis and reduction reaction.Then the title compounds were synthesized.Results:Four compounds with tetrahydroisoquinoline moiety were synthesized and their structures were confirmed by infrared spectroscopy,nuclear magnetic resonance spectroscopy and mass spectrometry.Pharmacological test in vitro showed that all the five compounds had certain MAO inhibitory activity,and compound(5~7) displayed preferable selective inhibition on MAO-A.Conclusion:The obtained compounds(5~7) need further study.

Objective:To investigate the inhibition of rasagiline on monoamine oxidase(MAO) in mouse liver and brain tissues.Methods:After being extracted by differential centrifugation,activities of MAO-A and MAO-B in mouse liver and brain tissues were determined by UV spectrophotometry respectively.Results:Inhibition effect of rasagiline was stronger on MAO-B than on MAO-A and inhibition effect of rasagiline was stronger in the brain than in the liver.Conclusion:Rasagiline exerts selective inhibition effects on MAO-B in mouse liver and brain tissues.

Hydrogen-association classified molecular electronegafivity-distance vector,based on the two-dimensional topological structure,and consists of 10 parameters which express the interaction between four types of atoms.Structure-activity relationship for novel antitumour drug tetraznbigen and its derivatives was studied based on H-MEDV in this paper. Quatitative structure-activity relationship(QSAR) model was constructed by multiple linear regression(MLR) and stepwise multiple regression(SMR).The correlation coefficient(R) is 0.862.Crossvalidation was performed by leave-one-out procedure(LOO) and the correlation coefficient is 0. 713. It showed good performance in predictability and reliability.

目的:利用正交实验法优选药物重要中间体1-氨甲基-1,2,3,4-四氢异喹啉盐酸盐(1)的合成工艺条件.方法:采用正交实验方法,考察合成(1)中的酰化、邻苯二甲酰亚胺N-烃化、Bischler-Napieralski反应、肼解与还原等主要反应的关键条件对收率的影响,筛选出主要反应的优选实验条件.结果:合成(1)的总收率达到了62.4％,约为原来总收率的2.5倍.结论:该合成工艺路线具有原料廉价易得、反应操作简便、兼顾环保以及产品收率高且品质好等优点；具有较好的工业化生产前景.

建立了新化合物N-氯乙酰基-4-乙酰基-β-苯乙胺、4-[[(羟基)亚胺基]乙基]-N-氯乙酰基-β-苯乙胺和N-氯乙酰基-4-羟乙基-β-苯乙胺的合成方法,并且着重考察了N-氯乙酰基-4-乙酰基-β-苯乙胺的合成条件.结果表明,其合成的最适条件为:原料与三氯化铝的摩尔比为1∶3,原料与乙酰氯的摩尔比为1∶2,在20℃条件下滴加原料的二氯甲烷溶液,滴加完毕后反应体系控制在30℃,在此条件下反应,产物收率可达85％.产品结构通过IR、1H NMR、MS确证.