OBJECTIVE:To explore the effect of long-term oral dose of Captopril on free radicals and related enzymes of mice cerebral tissue in order to give experimental basis for clinical use of captopril.METHODS:30 normal adult mice were divided into control group(water)and captopril group(captopril 11.08～14.92 mg·kg -1 ·d -1 ).Both groups were given medicine for 14 weeks. Free radicals and the activity of related enzymes(MDA,SOD,GSH-Px,Na+-K+-ATP enzyme,Ca2+-Mg2+-ATP enzyme)in cerebral tissue were detected.RESULTS:Compared with control group,in captopril group the content of MDA decreased(P0.05),the activity of SOD,GSH-Px hadn't changed obviously.The activity of Ca2+-Mg2+-ATP enzyme and Na+-K+-ATP enzyme declined,but there was no statistical significance.CONCLUSION:Oral does of captopril for a long time can reduce free radicals and strengthen the antioxidant function of cerebral tissue,but it may damage the neuron membrane function of cerebral tissue.

Objective To explore the effect of captopril orally administered for long term on learning and memory function of normal mice in order to provide experiment base for clinical application of captopril.Methods Normal adult mice were divided control group and captopril group.The mice were administered with captopril (11.08—14.92 mg·kg-1·d-1) for 12 weeks. The effect of captopri on learning and memory was detected with Morris water maze,Avoiding dark,Step-down and cholinergic system (Ach content,AchE activity).Results Compared with control group.the latency,distance,average speed and starting angle of mice treated with captopril did not change significantly from the first day to the fourth day;the time in platform,time in platform quadrant,times passing platform ,distance in platform/total distance×100%,starting angle,and average speed also did not change significantly in the fifth day in Morris water maze (P0.05);the error times and the latency of mice treated with captopril did not decrease in the second day in Avoiding dark(P0.05),the error times of mice treated with captopril did not decrease in the first day and in the second day,the latency did not prolong in the second day in Step-down(P0.05).The biochemical results showed that the content of Ach in the brain was significantly increased (P0.01),the AchE content was also increased(P0.05) in mice treated with captopril compared with control group.Conclusion Taking captopril for a long time may promote the function of learning and memory in normal adult mice.

<span id="ChDivSummary" name="ChDivSummary" class="abstract-text">iv西洋参茎叶皂甙25mg.kg（-1）、50mg.kg^-1能明显降低麻醉正常犬动脉血压、左室压及左室压最大上升速率,而对左室舒张期末压无明显影响,从而使心脏做功和耗氧减少,有利于抗心肌缺血作用。能明显减轻实验性心肌梗塞犬左室舒张期末压的增加及心脏指数的减少,也使左室压最大下降速率的降低明显减轻,表明西洋参茎叶皂甙能够改善心肌梗塞犬的循环功能.且对心肌舒张功能具有保护作用。</span>