目的观察感通颗粒对鼠非特异性炎症及免疫性炎症和解热止痛作用影响。方法采用小鼠耳壳炎症模型、大鼠足肿胀和棉球肉芽组织增生模型观察抗炎作用,另外观察小鼠非特异性免疫功能及解热镇痛作用。结果感通颗粒能抑制小鼠二甲苯所致小鼠耳壳炎症和角叉菜胶所致的大鼠足肿胀,减轻大鼠棉球肉芽组织的重量,提高小鼠对碳末廓清指数和吞噬指数,并具有解热止痛、增强机体免疫力的功能。结论感通颗粒具有明显的消炎和抗感冒作用。

Objective To observe the protective effect mechanisms of Inonotus obliquus on Vascular dementia (VD) rats. Methods Wistar rats were selected, used repeatedly occlusion of bilateral common carotid arteries and reperfusion, combined with intraperitoneal injection of sodium nitroprusside depressor preparation of VD animal model, randomly divided into control group, model group, IO group (0.5, 1.0, 2.0 g/kg), and intragastric administration for 8 weeks. The changes of free radical and related enzymes and cholinergic system in the brain tissue of rats were detected. Results Free radical and enzyme assay showed that compared with the model group, SOD and CAT activity of brain tissue in rats of Inonotus obliquus groups increased and MDA content decreased (P < 0.05), Na+-K+-ATP and the activity of the enzyme GSH-PX activity had no obvious change, inonotusobliquus large dose group (2.0 g/kg) Ca2+-Mg2+-ATP enzyme activity in rat' s brain increased significantly (P < 0.05). The detection of cholinergic system and related enzymes showed that there were no significant changes in the content of acetylcholine and cholinesterase in the brain tissue of the rats in each dose group compared to the model group. Conclusion The protective mechanism of obliquus obliquus against VD rats may be related to enhancing the activity of anti free radical related enzymes, increasing the antioxidant capacity of the body, and alleviating the damage of free radical in brain tissue; its mechanism maybe irrelevant to choline system.

目的 研究血栓心脉宁对缺血再灌注致血管性痴呆(VD)大鼠脑组织乙酰胆碱(Ach)、胆碱酯酶(AchE)、自由基及相关酶的影响,探讨血栓心脉宁对大鼠VD治疗作用机制.

目的:探讨桦褐孔菌对血管性痴呆(VD)大鼠行为学及组织病理形态的影响,阐明桦褐孔菌对VD大鼠的保护作用.方法:选用Wistar大鼠100只,采用反复夹闭大鼠双侧颈总动脉再灌注联合腹腔注射硝普钠降压法制备VD模型,大鼠分为正常对照组,模型组,阳性药组(吡拉西坦,0.5g,kg-1),低、中、高剂量(0.5、1.0和2.0 g·kg-1)桦褐孔菌组,连续灌胃给药8周后,观察大鼠行为学和组织病理学变化.结果:Morris水迷宫实验,与模型组比较,中和高剂量桦褐孔菌组大鼠在实验第2～6天,到达平台的潜伏期和游程明显缩短(P＜0.05或P＜0.01),实验第7天穿越平台次数、穿越有效区次数、有效区停留时间、有效区停留距离、有效区停留时间/总时间和有效区停留距离/总路程均明显增加(P＜0.05),高剂量桦褐孔菌组大鼠平台停留时间和平台停留时间/总时间明显增加(P＜0.05).组织病理形态观察,与模型组比较,高剂量桦褐孔菌组大鼠脑组织皮质区和海马区的病理性损伤明显减轻.结论:桦褐孔菌对VD大鼠具有保护作用,能改善VD大鼠的学习记忆能力,减轻VD大鼠脑组织的病理损伤.

Objective:To explore the influence of total alkaloids of Corydalis Ochotensis(TAOCO) on the behavior and pathomorphology of brain tissue of the rats with Alzheimer's disease(AD) induced by β-amyloid protein 25-35(Aβ25-35),and to clarify its therapeutic effects on the AD rats.Methods:The Wistar rats were divided into mormal control group(treated with 0.5 mL·100 g-1 distilled water) (n=9),model group(treated with 0.5 mL·100 g-1 distilled water)(n=9),positive drug group(treated with 1.75 mg·kg-1 donepezil hydrochloride)(n=9),and low,middle and high doses (treated with 2.0,4.0 and 8.0 mg·kg-1) of TAOCO groups(n=8,n=9,n=9).The rat AD models were made by injecting Aβ25-35 into hippocampus.On the 14th day after operation,the rats were administered for 7 d.Morris water maze test was used to detect the spatial learning and memory ability of the rats;dark avoidance task was used to observe the passive avoidance ability of the rats;the pathomorphology of the cerebral cortex and hippocampus of the rats were detected.Results:The Morris water maze test results showed that compared with model group,the latency to platform of the rats in low dose of TAOCO group was decreased on the 4th and 5th days(P<0.05);the latency and swimming distance to reach the platform of the rats in middle dose of TAOCO group were decreased on the 5th day(P<0.05),and the starting angle of the rats was reduced on the 3th day(P<0.05);the latencies to reach the platform of the rats in high dose of TAOCO group were decreased on the 2nd and 5th days(P<0.05),and the starting angle of the rats was decreased on the 6th day(P<0.01).Compared with model group,on the 7th day,the time of staying on platform,distance of staying on platform,time of staying on platform/total time,distance of staying on platform/total distance of the rats in different doses of TAOCO groups were all increased significantly(P<0.05) within 1.5 min.Compared with model group,the times of crossing platform and time of staying in effective area of the rats in low and high doses of TAOCO groups were significantly increased(P<0.05).The dark avoidance task results showed that compared with model group,the error latencies and the error times of the rats in different doses of TAOCO groups had no significant differences on the 2nd day(P>0.05).Compared with model group,there was no obvious improvement of the cerebral cortex and hippocampus injury of the rats in low and middle doses of TAOCO groups.In high dose of TAOCO group,the cerebral cortex and hippocampus injury of the rats were significantly improved.Conclusion:TAOCO can improve the learning and memory function of the AD rats and reduce the pathological injury of brain tissue of AD rats.

目的 观察5年生种植人参原粉、水提物和醇提物长期应用对小鼠学习记忆的影响,为人参的食用提供实验依据.方法 正常成年昆明小鼠140只,雌雄各半,体重18～22g,随机分为10组,即:对照组,5年生种植人参原粉小、中、大剂量(0.25、0.5、1.0g生药/kg)组,5年生种植人参水提物小、中、大剂量(0.25、0.5、1.0g生药/kg)组,5年生种植人参醇提物小、中、大剂量(0.25、0.5、1.0g生药/kg)组,每组14只,连续灌胃给药3个月后进行东莨菪碱致学习记忆获得障碍实验.结果 与模型组比较,人参醇提物大剂量小鼠第1天的到达平台潜伏期、游程有缩短的趋势,但无统计学意义,第4天的游程明显缩短(P＜0.05),其他指标无明显变化.人参原粉小、中、大剂量组,人参水提物小、中、大剂量组,人参醇提物小、中剂量组第1天至第5天到达平台的潜伏期、游程、朝向角、游泳速度无明显变化,第6天小鼠在1.5min内穿越平台的次数、穿越有效区的次数、平台停留距离、平台区的逗留时间、有效区停留距离、有效区停留时间、平台停留距离/总路程比、在平台区的逗留时间/总时间、有效区停留距离/总路程、有效区停留时间/总时间均无明显变化.结论 长期食用5年生种植人参原粉、水提物及醇提物对小鼠东莨菪碱致学习记忆获得障碍无明显的改善作用.

Objective To observe the influence of XueShuanXinMaiNing(XSXMN)in the behavior and structures of cerebral cortex and hippocampus of the rats withβamyloid protein(Aβ)-induced Alzheimer’s disease(AD),and to explore its therapeutic effects on the rat AD.Methods 100 male Wistar rats were selected.According to weight, the rats were randomly divided into sham operation group, model group, positive drug group (donepezil hydrochloride,1.75 mg· kg-1 ),XSXMN 1.1 g· kg-1 group and XSXMN 2.2 g· kg-1 group. The rat AD models were made by injecting Aβinto hippocampus.After oral administration for 15 d,Morris water maze test, dark avoidance task and pathology test were performed.Results In Morris water maze test,compared with model group,the latency and swimming distance to platform of the rats in XSXMN 1.1 g·kg-1 group were decreased on the 2nd,4th and 5th day(P<0.05 or P<0.01);in XSXMN 2.2 g·kg-1 group,the latency to platform of the rats were decreased from the 3nd to 6th day(P<0.05 or P<0.01),the swimming distances to platform of the rats were decreased from the 3rd to 5th day(P<0.05 or P<0.01).On the 7th day,in XSXMN groups,the times of passing platform,time of staying on platform,distance of staying on platform,time of staying in effective area, distance of staying in effective area, time of staying on platform/total time, distance of staying on platform/total distance,time of staying on platform/total time were all increased significantly(P<0.05 or P<0.01)within 90 s. In dark avoidance task,compared with model group,the error latency and the error times of the rats in XSXMN groups had no obvious change on the 2nd day.The pathological results showed that there were degeneration nerve cells and necrosis nerve cells in the rat cerebral cortex in XSXMN groups,while in the rat hippocampus there were less number of nerve cells with obscure cell layer and many degeneration and necrosis cells were found;compared with model group,there was no obvious improvement.Conclusion XSXMN can improve the learning and memory function of the AD rats.

目的 观察5年生种植人参食用对正常成年小鼠睡眠的影响,为人参的食用提供实验依据.方法 正常成年昆明小鼠140只,雌雄各半,体重18-22g,随机分为10组,即:对照组,5年生种植人参原粉小、中、大剂量(0.25、0.5、1.0g生药／kg)组,5年生种植人参水提物小、中、大剂量(0.25、0.5、1.0g生药/kg)组,5年生种植人参醇提物小、中、大剂量(0.25、0.5、1.0g生药/kg)组,每组14只.各组小鼠连续灌胃给药3个月后进行戊巴比妥钠催眠、戊巴比妥钠阈下催眠及水合氯醛阈下催眠实验.结果 戊巴比妥钠催眠实验中,与对照组比较,人参原粉小、中、大剂量组,人参水提物小、中、大剂量组及人参醇提物小、中、大剂量组睡眠的潜伏期及睡眠持续时间无明显变化(P＞0.05);戊巴比妥钠阈下催眠,水合氯醛阈下催眠实验中,与对照组比较,人参原粉小、中、大剂量组,人参水提物小、中、大剂量组及人参醇提物小、中、大剂量组30min内睡眠发生率无明显变化(P＞0.05).结论 5年生种植人参食用对正常成年小鼠睡眠无明显影响.

目的 观察5年生种植人参食用对正常幼年小鼠睡眠的影响,为人参的食用提供实验依据.方法 正常成年昆明小鼠140只,3-4W,雌雄各半,随机分为10组,即:对照组,5年生种植人参原粉小、中、大剂量(0.25、0.5、1.0g生药/kg)组,5年生种植人参水提物小、中、大剂量(0.25、0.5、1.0g生药/kg)组,5年生种植人参醇提物小、中、大剂量(0.25、0.5、1.0g生药/kg)组,每组14只.各组小鼠连续灌胃给药3个月后进行戊巴比妥钠催眠、戊巴比妥钠阈下催眠及水合氯醛阈下催眠实验.结果 戊巴比妥钠催眠实验中,与对照组比较,人参原粉小、中、大剂量组,人参水提物小、中、大剂量组及人参醇提物小、中、大剂量组小鼠的睡眠的潜伏期及睡眠持续时间无明显变化(P＞0.05);戊巴比妥钠阈下催眠,水合氯醛阈下催眠实验中,与对照组比较,人参原粉小、中、大剂量组,人参水提物小、中、大剂量组及人参醇提物小、中、大剂量组小鼠30min内睡眠发生率无明显变化(P＞0.05)及.结论 5年生种植人参食用对正常幼年小鼠睡眠无明显影响.

目的：探讨血栓心脉宁对大鼠血管性痴呆（VD）的治疗作用。方法选用Wistar大鼠，采用永久性结扎双侧颈总动脉法制作VD动物模型，动物分为假手术组、模型组及血栓心脉宁组（1.1 g/kg、2.2 g/kg）。连续灌胃给药8 w。通过Morris水迷宫、病理学，观察血栓心脉宁对VD大鼠是否有治疗作用。结果水迷宫实验中，血栓心脉宁组与模型组相比，小剂量组在第2天、第5天的潜伏期缩短（P＜0.01，P＜0.05），大剂量组在第2～6天潜伏期缩短（P＜0.05），第3天到达平台的朝向角变小（P＜0.05）。与模型组相比，血栓心脉宁小剂量组在第2天、第5天的游程缩短（P＜0.05），血栓心脉宁大剂量组在第1～6天的游程缩短（P＜0.05）。病理结果显示，血栓心脉宁可改善VD的大脑皮层及海马病理学变化。结论长期应用血栓心脉宁可改善 VD大鼠的学习记忆功能。

目的 探讨氨氯地平对血管性痴呆(VD)大鼠学习记忆的影响,为其临床应用提供实验依据.方法 选用Wistar大鼠,采用永久性结扎双侧颈总动脉法制作VD动物模型,动物分为假手术组、模型组及氨氯地平组,氨氯地平0.3～0.6 mg·kg-1·d-1连续给药8 w.通过Morris水迷宫、避暗行为学及病理学实验,观察氨氯地平对VD大鼠学习记忆的影响.结果 水迷宫实验中,氨氯地平组大鼠与模型组相比,第1天的游程明显缩短(P＜0.05),第5天的朝向角明显变小(P＜0.01),潜伏期、平均速度及第7天在2 min内穿越平台的次数、在平台区的逗留时间、在平台象限内的逗留时间、平台区象限内的游程占总游程的百分比、朝向角及平均速度均无显著差异,第3天及第5天寻找平台的策略由周边型、随机型转为趋向型、直线型增快(P＜0.05及P＜0.01);避暗试验中,氨氯地平组大鼠第2天的错误次数及错误潜伏期与模型组比无显著差异.病理结果显示,氨氯地平组皮层神经细胞数无明显减少,核固缩、深染的坏死神经细胞及嗜神经细胞现象较模型组减少,海马神经细胞数无明显减少,排列整齐,结构清晰,坏死细胞比模型组少,氨氯地平可减轻阻断双侧颈总动脉所致VD的病理变化.结论 长期应用氨氯地平可改善VD大鼠的学习记忆功能.

OBJECTIVE:To explore the effect of long-term oral dose of Captopril on free radicals and related enzymes of mice cerebral tissue in order to give experimental basis for clinical use of captopril.METHODS:30 normal adult mice were divided into control group(water)and captopril group(captopril 11.08～14.92 mg·kg -1 ·d -1 ).Both groups were given medicine for 14 weeks. Free radicals and the activity of related enzymes(MDA,SOD,GSH-Px,Na+-K+-ATP enzyme,Ca2+-Mg2+-ATP enzyme)in cerebral tissue were detected.RESULTS:Compared with control group,in captopril group the content of MDA decreased(P0.05),the activity of SOD,GSH-Px hadn't changed obviously.The activity of Ca2+-Mg2+-ATP enzyme and Na+-K+-ATP enzyme declined,but there was no statistical significance.CONCLUSION:Oral does of captopril for a long time can reduce free radicals and strengthen the antioxidant function of cerebral tissue,but it may damage the neuron membrane function of cerebral tissue.

Objective To explore the effect of captopril orally administered for long term on learning and memory function of normal mice in order to provide experiment base for clinical application of captopril.Methods Normal adult mice were divided control group and captopril group.The mice were administered with captopril (11.08—14.92 mg·kg-1·d-1) for 12 weeks. The effect of captopri on learning and memory was detected with Morris water maze,Avoiding dark,Step-down and cholinergic system (Ach content,AchE activity).Results Compared with control group.the latency,distance,average speed and starting angle of mice treated with captopril did not change significantly from the first day to the fourth day;the time in platform,time in platform quadrant,times passing platform ,distance in platform/total distance×100%,starting angle,and average speed also did not change significantly in the fifth day in Morris water maze (P0.05);the error times and the latency of mice treated with captopril did not decrease in the second day in Avoiding dark(P0.05),the error times of mice treated with captopril did not decrease in the first day and in the second day,the latency did not prolong in the second day in Step-down(P0.05).The biochemical results showed that the content of Ach in the brain was significantly increased (P0.01),the AchE content was also increased(P0.05) in mice treated with captopril compared with control group.Conclusion Taking captopril for a long time may promote the function of learning and memory in normal adult mice.

目的 探讨卡托普利对血管性痴呆(VD)大鼠学习记忆的影响.方法 选用Wistar大鼠,采用永久性结扎双侧颈总动脉(2-VO)法制作VD动物模型,动物分为正常对照组、模型组及卡托普利组,卡托普利7.52～10.48 mg·kg-1·d-1连续给药8 w,通过Morris水迷宫、避暗行为学及病理学实验,观察卡托普利对VD大鼠学习记忆的影响.结果 与模型组比较,卡托普利组大鼠第1～6天到达平台的潜伏期及游程、朝向角、游泳速度无明显改变,第7天大鼠在2 min内穿越平台的次数、在平台区的逗留时间、在平台区象限的逗留时间及平台区象限内的游程占总游程的百分比、平均速度、朝向角无明显变化(P>0.05);与模型组比较,卡托普利组鼠第2天避暗的错误次数及错误潜伏期也无明显变化(P>0.05);卡托普利组大鼠大脑皮层、海马细胞无明显变化.结论 卡托普利对血管性痴呆大鼠学习记忆无明显影响.

目的 探讨刺五加注射液对血管性痴呆(VD)大鼠是否有治疗作用.方法 结扎双侧颈总动脉16 w,制作大鼠VD模型,通过Morris水迷宫实验、跳台实验及皮层和海马病理,观察刺五加注射液对VD的影响.结果 与模型组比,刺五加注射液组大鼠水迷宫第3～6天达到平台的潜伏期明显缩短(P<0.05或P<0.01),第3天到达平台的游程明显缩短(P<0.05),第7天大鼠在2 min内穿越平台的次数明显增加(P<0.05),寻找平台的策略由边缘型、随机型转为趋向型、直线型明显增快(P<0.05或P<0.01),第1天、第2天跳台的错误次数明显减少(P<0.05),刺五加注射液明显减轻VD大鼠皮层及海马的病理变化.结论 刺五加注射液对VD大鼠有治疗作用.

Objective To explore the effect of donepezil hydrochloride on learning and memory function of normal under age rats,and provide experimental basis for clinical application of donepezil hydrochloride.Methods Fourty Wistar rats just away from galactic were divided into control group(n=20) and donepezil hydrochlorid group(n=20),donepezil hydrochloride was given to the rats in donepezil hydrochloride group(0.45 mg·kg-1,8 weeks),the effects of donepezil hydrochloride on space discrimination ability and passive avoidance ability of normal under age rats were detected with Morris water maze and Step-down behavior test.Results Compared with control group,the latency,distance,average speed and starting angle of rats treated by donepezil hydrochloride did not change significantly from the first day to the sixth day,the time in platform,time in platform quadrant,times passing platform,distance in platform / total distance×100% and average speed also did not change significantly in the seventh day in the Morris water maze(P>0.05);the error times of rats treated by donepezil hydrochloride did not decrease in the first day and in the second day,the latency did not prolong in the second day in Step-down behavior test(P>0.05).Conclusion Donepezil hydrochloride do not improve the learning and memory function of normal under age rats.

目的:初步探讨西洋参二醇皂苷(PQS)对大鼠糖尿病肾病(DN)的治疗作用及其作用机制。方法:将Wistar大鼠腹腔注射链脲佐菌素(STZ)建立DN模型,按空腹血糖值及体重将大鼠随机分为模型组、西洋参二醇皂苷小、大剂量(西洋参二醇组皂苷100、200mg/kg)组、阳性药组(卡托普利10mg/kg),连续灌胃给药,每10d测定一次血糖,35d后酶免法测定尿β2-MG、免疫组化法检测肾脏GLUT-1。结果:西洋参二醇皂苷小、大剂量组大鼠β2-MG、肾脏GLUT-1明显低于模型组(P<0.05,P<0.01),西洋参二醇皂苷大剂量组血糖值明显低于模型组(P<0.05)。结论:西洋参二醇皂苷对DN大鼠有治疗作用,其机制可能与其降低血糖及肾脏GLUT-1功能有关。

BACKGROUND: Ginsenoside extracted from the stem and leaf of ginseng (GSL) and choline have both been shown to improve learning and memory functions; however, further Studies are needed to understand the synergistic effects of a combination of both.OBJECTIVE: To verify the combined improved synergistic effects of GSL and choline on learning and memory disorders in rats.DESIGN: Control observation.SETTING: Taishan Medical College.MATERIALS: A total of 150 male Kunming mice weighing (20 +/- 2) g and 40 healthy male Wistar rats weighing (220 20) g were provided by the Experimental Animal Department of Jilin University. Animal experimentation received confirmed consent from the local ethic committee. GSL was provided by the Department of Chemistry, Norman Bethune Medical University, and choline was provided by the Third Experiment Factory, Shanghai.METHODS: This study was performed at the Life Science Institute, Taishan Medical College from October 2006 to February 2007. (1) Scopolamine-induced learning and memory disorders in rats: Forty rats were randomly divided into control group, model group, combination group (400 mg/kg GSL + 200 mg/kg choline), GSL (400 mg/kg) group, and choline (200 mg/kg) group, 8 rats/group. Rats were perfused and administrated in the morning, once a day for 14 successive days. Rats in the control group and model group were perfused with 20 mL/kg distilled water and underwent Morris water maze spatial resolution test I hour after perfusion on the 10(th), 11(th), and 12(th) days after administration. Rats also underwent passive step-down avoidance test I hour after reperfusion on the 13(th) and 14(th) days after administration. Thirty minutes prior to experimentation, rats in the remaining three groups were intraperitoneally (i.p) injected with 2 mg/kg scopolamine, and rats in the control group were i.p. injected with 2 rnL/kg saline. 02 Scopolamine-induced learning disorder and memory acquired disorder in mice: Fifty mice were randomly divided into control group, model group, combination group (400 mg/kg GSL +200 mg/kg choline), GSL (400 mg/kg) group, and choline (200 mg/kg) group, with 10 mice/group. Mice were perfused and administrated in the morning, once a day for 9 successive days. Mice in the control group and model group were perfused with 20 mL/kg distilled water and underwent passive step down avoidance test I hour after reperfusion on the 8(th) and 9(th) day after administration. Twenty minutes prior to training, mice in the remaining three groups were i.p. injected with 2 mg/kg scopolamine, and mice in the control group were i.p. injected with 10 mL/kg saline. 3) Sodium nitrite-induced memory consolidation disorder in mice: Grouping, administration, and testing were the same as mentioned above. After training, mice in the remaining three groups were immediately subcutaneously injected with 120 mg/kg sodium nitrite, and mice in the control group were subcutaneously injected with 20 mL/kg saline. 4 Ethanol-induced memory reconsolidation disorder in mice: Grouping, administration. and testing were the same as mentioned above. At 24 hours after training and 20 minutes before retraining, mice in the remaining four groups were perfused with 10 mL/kg ethanol (0.3 volume fraction, and mice in the control group were perfused with 10mL/kg saline. MAIN OUTCOME MEASURES: Synergistic effects of GSL and choline on learning and memory deficits induced by scopolamine, sodium nitrite, and ethanol in experiment animals.RESULTS: All 40 rats and 150 mice were included in the final analysis. 1 Synergistic effects of GSL and choline on learning and memory disorders induced by scopolamine in rats. During passive step-down avoidance and Morris water maze spatial resolution tests, the number of error responses and length of maze training in the model group were significantly greater than in the control group (P < 0.01): while the number of error responses and length of maze training in the combination group were significantly less than in the model group, GSL group, and choline group (P < 0.05 0.01). The Q value was > 1 after combining administration which suggests that the combination of GSL and choline had synergistic effects. 2 Synergistic effects of GSL and choline on learning disorder and memory-acquired disorder induced by scopolamine in mice: During passive step- down avoidance test, the number of error responses in the model group were significantly greater than in the control group (P < 0.01); while the number of error responses in the model group, GSL group, and choline group (P < 0.05-0.01). The Q value was > 1 after combining administration, which suggests GSL and choline had synergistic effects. 3 Synergistic effects of GSL and choline on memory sodium nitrate-induced consolidation disorder in mice. During passive step down avoidance test, the number of error responses in the combination group were significantly less than in the model group. GSL group, and choline group (P < 0.06 0.01). The Q value was > 1 after combined administration which suggests GSL and choline had synergistic effects.CONCLUSION: GSL and choline have synergistic effects on learning and memory functions.

目的：初步探讨西洋参二醇皂苷（PQS）对大鼠糖尿病肾病（DN）的治疗作用及其作用机制。方法：将Wistar大鼠腹腔注射链脲佐菌素（STZ）建立DN模型，按空腹血糖值及体重将大鼠随机分为模型组、西洋参二醇皂苷小、大剂量（西洋参二醇组皂苷100、200mg／kg）组、阳性药组（卡托普利10mg／kg），连续灌胃给药，每10d测定一次血糖，35d后酶免法测定尿β2-MG、免疫组化法检测肾脏GLUT-1。结果：西洋参二醇皂苷小、大剂量组大鼠β2-MG、肾脏GLUT-1明显低于模型组（P〈0．05，P〈0．01），西洋参二醇皂苷大剂量组血糖值明显低于模型组（P〈0．05）。结论：西洋参二醇皂苷对DN大鼠有治疗作用，其机制可能与其降低血糖及肾脏GLUT-1功能有关。