目的 分析广州市在校医学生复发性阿弗他溃疡的影响因素,为制定干预措施,控制和降低复发性阿弗他溃疡的发病率提供理论依据.方法 利用自编的<复发性阿弗他溃疡调查表>,对广州医学院631名在校学生进行流行病学问卷调查.结果 数据收集后经Logistic回归分析显示,喜食辛辣食品、油炸上火食品、便秘、胃病、熬夜失眠及情绪紧张6种因素为复发性阿弗他溃疡最具可能性危险因素,其OR值均大于1.而喜食水果、蔬菜为复发性阿弗他溃疡可能性保护因素,其OR值小于1.结论 喜食辛辣食品、喜食油炸上火食品、便秘、胃病、熬夜失眠及情绪紧张6种因素,可能是诱发广州市医学生复发性阿弗他溃疡的致病相关危险因素;而喜食水果、蔬菜可能是其保护因素.

Objective To observe the effect of low dose naloxone on analgesia of butorphanol. Methods 80 Kunming Jimpy mice were divided into 2 groups. 40 accepted hot-plate method and another 40 accepted stretching method. Each group was randomly divided into 4 groups furtherly: Group BS (butorphanol combined with sodium chloride) and group BN1, group BN2, group BN3 (butorphanol combined with naloxone 100 ng/kg, 10 ng/kg and 1 ng/kg respectively). Pain threshold in hot-plate test ( HPPT) and the number of stretching times were observed. Results Compared with group BS, HPPT of Jimpy mice in group BN2 increased significantly at 20 and 30 min(P 0.05)and the number of stretching times of Jimpy mice in group BN2 reduced significantly (P 0.05). Conclusion Low dose naloxone can enhance the analgesic effect of butorphanol, and the dose of 10 ng/kg has the best effect.

In order to investigating and analysis the incidence and associated factors of aphthous ulcer(RAU)in the school medical students of Guangzhou,and to provide reference to control and reduce the incidence of RAU,self-compiled the recurrent aphthous ulcers questionnaire surveywas applied to the 631 students for a investigating questionnaire.The results showed that 375 students suffering from aphthous ulcers in them,the incidence is 59.43%,and 8.56% students are the frequently seizures,the occasionally seizures are 50.87%,the suffering students with gastrointestinal symptoms are 47.46%,and almost suffering students consider that the attacks of RAU are related to diet.It concluded the attacks of RAU in Guangzhou medical students may be closely related with dietary factors,the base of interrupting demand in diet are larger.

Objective To observe the surface anesthetic effect of verapamil hydrochloride combined with lidocaine hydrochloride on rabbits.Methods 12 rabbits were used in the blink reflex experiment to observe the surface anesthetic effect of physiological saline combined with lidocaine hydrochloride(left eye),and verapamil hydrochloriden combined with lidocaine hydrochloride(right eye) on rabbits respectively.Results Blink times of the right eye are fewer than those of the left eye(P<0.01).Conclusion Verapamil hydrochloride can enhance the surface anesthetic effect of lidocaine hydrochloride.

Objective To observe the influence of low dose naloxone(naloxone) on the analgesic effect of fentanyl(fentanyl).Methods Analgesic dose given to the mice were divided into FS Group(fentanyl combined with NS Group), FN1 group, FN2 group and FN3 Group(fentanyl and small dose of naloxone 100、10、1 ng/kg combination group) four groups.With hot plate and writhing on the FN was observed in mice hot plate analgesic pain threshold(pain threshold in hot-plate test, HPPT) and writhing number of implications.Results Compared with the FS, FN2 group, HPPT of group FN2 and FN3 HPPT in 5 min increased(P <0.05), writhing number reduction(P <0.05).Conclusion Low dose naloxone can enhance the analgesic effect of fentanyl.