目的 探讨阿奇霉素联合炎琥宁治疗小儿支原体肺炎的临床效果.方法 将本院收治的85例支原体肺炎患儿随机分为观察组(43例)和对照组(42例),对照组给予阿奇霉素注射和口服,观察组在对照组基础上给予炎琥宁冻干粉静脉滴注,治疗2个疗程后比较两组患儿的临床疗效.结果 对照组总有效率为78.57％,观察组总有效率为95.35％,两组比较差异有统计学意义(P＜0.05)；观察组的退热时间、咳嗽消失时间、啰音消失时间、X线体征恢复时间等临床指标改善情况优于对照组,差异有统计学意义(P＜0.05).结论 阿奇霉素联合炎琥宁治疗小儿支原体肺炎,可显著提高临床总有效率,缩短临床治疗时间,具有临床推广应用意义.

Objective To investigate the role of selecting different mode of pulling out the indwelling urine catheter after cesarean section in preventing urinary retention. Methods Three hundreds patients who received cesarean section through abdominal transverse incision to lower uterine segment and analgesic pump from April 2011 to October 2012, were collected and randomly assigned to two groups, 150 cases in each group. Both groups were guided by doctor's instruction and kept indwelling catheter opening for 8 hours before extubation. The urine catheters of control group patients were pulled out at the time of opening for 8 hours, so do those of trial group patients but were guided to clip the catheter after infusion of last bottle fluid (about 500 mL) and pull out catheters immediately after feeling bladder filling. Results By applying different mode of pulling out catheters, the urinary output in 3.5 hours after extubation of trial group was significantly more than that of control group (P < 0.01), the proportion of lying-in women who need resettlement of catheter was significantly less than that of control group (P < 0.05). Conclusion This trial proves at a certain extent that extubation of clipping catheter and pulling out after having micturition desire is more effective than that of pulling out after long-term opening for 8 hours in preventing urinary retention and worthy of promoting.

Objective To investigate the clinical effect of montelukast sodium combined with ketotifen treating cough variant asthma in children.Methods 120 children with cough variant asthma were randomly divided into the observation group(n=60) and the control group(n=60).Oral montelukast sodium combined with ketotifen were given in the observation group while oral ketotifen combined with procaterol hydrochloride were given in the control group.The treatment lasted for two weeks,repeated the author can follow-up treatment.Results The total effective rate(98.3%) of the observation group was significantly higher than that(78.3%) of the control group;the total recurrence rate(5.0%) of the observation group was significantly lower than that(16.7%) of the control group(P<0.05).Conclusion The effect of montelukast sodium combined with ketotifen treating cough variant asthma in children is better with lower recurrence rate.It is worthy of clinical promotion and application.

药检所正确执行药品质量标准是正确实施药品检验、发出准确无误检验报告的关键环节。目前有的中成药质量标准多,检验项目、限度、规格、有效期规定不尽相同,不仅使药检部门监督检验容易造成偏差,还不能有效控制药品内在质量。

目的提高主动脉夹层的正确诊断率,减少误诊的发生。方法对2010年1月至2011年7月我院急诊及消化科就诊的3例主动脉夹层患者的临床特点、误诊情况进行回顾性分析。结果误诊脑血管意外1例,急腹症2例。结论对于发病突然,且无法用一元论解释的症状,或发病症状无法用常规疾病解释时我们应该想到主动脉夹层的可能,并给以详细的体格检查,避免误诊、误治。

目的 探讨三种急诊非静脉曲张上消化道出血镜下止血治疗方法及疗效.方法 对30例非静脉曲张上消化道出血行急诊胃镜检查后,立即行胃镜下止血治疗,按出血情况予药物注射止血、金属钛夹止血以及这两种方法联合止血.结果 所有患者即时止血率及急诊镜下止血率均100%.结论 急诊胃镜是检查上消化道出血病因及止血治疗的重要方法,具有出血灶检出率高、止血治疗快速安全有效的特点,值得临床推广应用.

Objective: To prepare enteric-coated pellets of Rabeprazole sodium. Methods: Rabeprazole sodium enteric-coated peliets were prepared by the centrifugal granulation equipment and Rabeprazole sodium peliets discussed on quality through particle size distribution, fragility, determination, related substance, release and dissloution. Results: The pellets was between 16-24 meshes, quality uniformity, the disso1ution was 95% and the release was 90%. Conclusion: Rabeprazole sodium enteric-coated pellets can be prepared by the centrifugal granulation equipment.

Objective:To prepare compound Guishao Fukang Capsules and establish its quality control method. Methods:TLC was used to identify Angelica sinensis and Herba leonuri,HPLC was used to determine the content of paeoniflorin in compound Guishao Fukang Capsules. Results:The linear ranges of paeoniflorin was 0.303～1.515 μg(r=0.999 8), the average recovery was 99.66 %,RSD was 0.27 %(n=6).Conclusion:The preparation was stability, the content determination method was accurate reliable and reproducible and can be used in the quality control of compound Guishao Fukang Capsules.

目的浅析我国儿童用药状况。方法介绍和分析了国内和国外儿童用药体系的建立情况,对国内的儿童用药情况做出分析。结果与结论应进一步完善儿童用药保障体系。

目的:观察急诊内镜下止血治疗联合静脉注射常规剂量奥美拉唑(OME)与单用大剂量奥美拉唑对上消化道出血的疗效。方法:将60例上消化道急性性出血的患者随机分为两组,甲组单用静脉注射大剂量OME;乙组采用急诊内镜下止血治疗联合静脉注射常规剂量OME,观察两组止血时间、再出血情况及出血病因诊断等以评价疗效。结果:甲组止血总有效率为100%,乙组止血总有效率为100%,两组差异无统计学意义。所有患者内镜检查无明显不良反应。甲组7例(23.3%)患者上消化道出血原因不详。结论:内镜急诊止血联合静脉注射常规奥美拉唑与单用大剂量静脉应用奥美拉唑对上消化道活动性出血疗效均较好,但内镜急诊止血经济、诊断率高,并发症少等优点。

对中药复方制剂制备思路和方法进行探索,提倡复方制剂制备工艺研究须在中医药理论指导下对组方进行分析,选择适宜的剂型,优选合理的制备工艺流程。

目的探讨治疗胸腰椎骨折脱位的最佳手术方案.方法22例胸腰椎骨折脱位伴不同程度的神经损伤患者均行AF内固定复位手术治疗,AF复位内固定后,经手术切口行脊髓造影,排除血性脑脊液后注入造影剂,应用C型臂X光机动态观察了解椎管通畅和减压复位情况.结果21例患者行造影检查,18例显示椎管通畅,骨折脱位得到解剖复位,未行椎管减压,占81.81%,3例显示椎管不畅,行椎弓根入路侧前方减压或椎板切除减压及取出突出的椎间盘组织.未造影的1例系硬膜囊破裂,给予修补.结论应用AF内固定技术与术中脊髓造影治疗胸腰椎骨折脱位,手术创伤小,出血少,可得到解剖复位,且术后神经功能恢复好,术中脊髓造影对是否需进一步手术起指导作用.

急性出血性坏死性胰腺炎是一种发病急、进展快、并发症多、预后差的急腹症,其发病率占全部胰腺疾病的6%一197%,病因目前不清楚.现将本院自1994年6月～1997年4月间,经治的27例急性出血性坏死性胰腺炎患者的诊治及转归结果分析总结如下.