AIM:This study aims to examine the effects of lateral positions during the second stage of labour on maternal and neonatal outcomes. DESIGN:A prospective observational study was conducted in three Chinese hospitals from June to November 2020. METHODS:Eligible women were divided into groups based on their use of lithotomy or lateral positions during the second stage of labour. Propensity score matching (PSM) was employed to assess the effects of lateral positions on maternal outcomes (perineal tears, episiotomy use, postpartum blood loss, duration of the second stage of labour, and mode of birth) and neonatal outcomes (Apgar scores at one and 5 min postpartum). RESULTS:After PSM matching, lateral positions were associated with a 21% reduced risk of episiotomy use among primiparous women. Primiparous women adopting lateral positions also had significantly reduced risks of moderate perineal tears. There were no significant differences in the duration of the second stage of labour, mode of birth or rates of blood loss over 500 mL at 2 h postpartum. However, lateral positions increased the duration of the second stage of labour by 10 min among primiparous women who adopted lateral positions in this study, and both primiparous and parous women using lateral positions had greater postpartum blood loss. Cases of Apgar scores less than seven and severe perineal tears were rare. CONCLUSION:This prospective observational study indicates that lateral positions during the second stage of labour may offer protective benefits for the perineum among primiparous women. However, their use requires careful clinical judgement, as they may not be suitable for primiparous women experiencing slower labour progress, and additional attention should be given for monitoring postpartum blood loss, regardless of parity.

This study aimed to translate the Sexual and Reproductive Empowerment (SRE) Scale for adolescents and young adults (AYAs) into Chinese and adapt it to the Chinese cultural context. The objective was to provide a reliable assessment tool for evaluating sexual and reproductive health empowerment among Chinese AYAs, thereby supporting efforts to promote and improve their sexual and reproductive health. A validation study of the scale was conducted. Translation and back-translation followed the Brislin translation model, and the Chinese version of SRES for AYAs (C-SRES) was finalized after cultural adaptation through expert consultation. A cross-sectional survey was then administered using the C-SRES. A total of 581 nursing college students from Henan province, China, were recruited through convenience sampling. Psychometric properties were assessed in line with the COnsensus-based Standards for the selection of Health Measurement Instruments (COSMIN) checklist. Reliability was evaluated using Cronbach’s α, split-half reliability. Stability using the test-retest method (Intraclass Correlation Coefficients, ICCs). Validity was assessed through content validity, exploratory factor analysis (EFA), confirmatory factor analysis (CFA), as well as convergent and discriminant validity. Confirmatory factor analysis indicated that the C-SRES, comprising 6 dimensions and 21 items, demonstrated strong reliability and validity (Cronbach’s α = 0.89, scale content validity index = 0.96, test-retest reliability = 0.89). Model fit indices were acceptable: incremental fit index (IFI) = 0.91, goodness-of-fit index (GFI) = 0.90, comparative fit index (CFI) = 0.91, root mean square error of approximation (RMSEA) = 0.07, and root mean square residual (RMR) = 0.07. The C-SRES demonstrated satisfactory reliability and validity, supporting its use as an effective tool for evaluating SRE among Chinese AYAs. In addition to providing a reliable assessment instrument, the scale can assist researchers, educators, and clinicians in identifying factors often overlooked in health studies. It thus offers a valuable basis for developing targeted interventions and further strengthening the sexual and reproductive empowerment of AYAs in China.

Purpose: Delayed onset of lactogenesis is a significant barrier to achieving the WHO-recommended 50% exclusive breastfeeding rate in the first six months. This study maps the main factors influencing this condition, addressing gaps in the current research landscape. Methods: Following Arksey and O'Malley's scoping review framework, databases such as PubMed, Web of Science (WOS), Service Platform (VIP), Wanfang Data Knowledge Service Platform, and China Biomedical Literature Database (CBM) were searched on February 1, 2023. Studies in Chinese and English involving pregnant and postpartum women, focusing on delayed onset of lactogenesis, were included without restrictions on publication date or geography. Results: Forty-six studies published between 2002 and 2022 met the inclusion criteria, revealing variable incidences of delayed lactogenesis among different groups. Thirty-four influencing factors were identified and organized into five themes: maternal-infant characteristics, perinatal mental state, physical activity participation during pregnancy, breastfeeding behaviors, and medical staff interventions. Within eighteen major factors highlighted, factors such as age, pre-pregnancy BMI, gestational weight gain, average LATCH score within 24 hours postpartum, labor analgesia, sleep, frequency of postpartum breastfeeding, and timing of initial breast suckling/pumping showed inconsistent or conflicting conclusions. Conclusion: High and variable incidences of delayed lactogenesis underline its multifactorial nature. Effective interventions require strong advocacy from healthcare professionals and adherence by pregnant women. Further research using standardized methods is essential to clarify inconsistent or conflicting findings on the influencing factors.

Non-pharmaceutical midwifery techniques, including perineal warm compresses, to improve maternal outcomes remain controversial. The aims of this study are to assess the effects of perineal warm compresses on reducing perineal trauma and postpartum perineal pain relief. This systematic review included randomized controlled trials (RCTs). We searched seven bibliographic databases, three RCT register websites, and two dissertation databases for publications from inception to 15 March 2023. Chinese and English publications were included. Two independent reviewers conducted the risk of bias assessment, data extraction, and the evaluation of the certainty of the evidence utilizing the Cochrane risk of bias 2.0 assessment criteria, the Review Manager 5.4, and the online GRADEpro tool, respectively. Seven RCTs involving 1362 primiparous women were included. The combined results demonstrated a statistically significant reduction in the second-, third- and/or fourth- degree perineal lacerations, the incidence of episiotomy, and the relief of the short-term perineal pain postpartum (within two days). There was a potential favorable effect on improving the integrity of the perineum. However, the results did not show a statistically significant supportive effect on reducing first-degree perineal lacerations and the rate of perineal lacerations requiring sutures. In summary, perineal warm compresses effectively reduced the second-, third-/or fourth-degree perineal trauma and decreased the short-term perineal pain after birth.

目的:探讨智慧教育背景下慕课课程建设过程以及学习者的学习行为特点,为护理慕课资源的合理建设和有效利用提供参考.方法:对2021年2月—2021年7月在中国大学MOOC平台注册学习《孕产期妇女保健与护理》课程学员的视频观看、作业提交、单元测试、期末考试及论坛互动情况等学习行为进行分析.结果:《孕产期妇女保健与护理》在中国大学MOOC平台上两期课程的在线注册人数共7949人.视频观看人数比例随着课程的进行而呈递减趋势,观看视频的人数高于完成作业、测验和考试的人数,在成绩及格的学习者中,积极参与课堂交流论坛互动发言的比例明显高于不及格组(P<0.001).结论:慕课学习者群体呈多元化,课程持续参与度较弱,完成率偏低,互动行为是影响学习效果的重要因素.高校应根据慕课学习者行为特点加强在线互动行为,建设课程应用与教学服务相融通的优质慕课.

目的:探讨某综合大学护理学院本科护生的社会智能情况及影响因素,旨在为临床护理人文关怀教育提供相应的现实依据和有益参考.方法:采用社会智能量表(TSIS)对某综合大学中护理学院的798名本科护生进行问卷调查,了解其社会智能水平及影响因素.结果:本科护生社会智能整体水平处于中等水平(95.95±12.226),性格、性别、生源地、家中排行、是否独生子女、是否班干部以及接受的家庭教育类型,各组之间比较差异有统计学意义(P<0.05).结论:护理教育者需要根据护生个体的不同家庭及社会情况,制定针对性的培养方案,同时将学校教育和家庭教育进行有效衔接,建立密切的家校关系和师生关系,为培养具有较高社会智能的临床护士奠定基础.

Objective: Upright positions in the second stage of labour are recommended by many international organizations. However, they have not been widely used worldwide, especially in China. One of the important factors is the absence of a practice programme based on the best available evidence. We thus developed a Practice Programme for Upright Positions in the Second Stage of Labour following the UK Medical Research Council framework. Under the guidance of the programme, whether the use of upright positions can improve the maternal birth experience is a question of great concern. This study aimed to explore the birth experience of Chinese women who adopted upright positions in the second stage of labour. Design: This qualitative descriptive study was conducted as part of an implementation study that developed an evidence-based intervention and used strategies to integrate the evidence-based intervention into routine obstetric clinical practice. Setting: The maternity department of a tertiary comprehensive hospital in Hebei Province, China. Participants: Semi-structured interviews with twelve eligible women who adopted upright positions in the second stage of labour were conducted between March and April 2022. Qualitative data were analyzed by using conventional content analysis. Findings: The average age of included women was 26.5 & PLUSMN; 3.5 years, and ten of them were primiparous women. Eight women adopted epidural analgesia during labour to relieve labour pain. All women gave birth in at least one type of upright position in the passive second stage of labour and adopted the semi-recumbent position in the active second stage of labour. Through conventional content analysis, we found that the use of upright positions in the second stage of labour could possibly promote an overall positive birth experience. Women giving birth in upright positions generally perceived they were more involved in their birthing process, and had greater physical and mental capacity to cope with childbirth. Key conclusions: Women have a positive birth experience when using upright positions in the second stage of labour. Implications for practice: This study suggests upright positions could improve women's birth experience and have the potential to be widely applied in clinical practice.

BACKGROUND:Upright positions, as a non-pharmacological, have been well documented in multiple studies to promote normal labor, facilitate favourable birth outcomes and positive childbirth experience. Yet, the application status of upright positions in China, and even globally, is unfavourable. Thus, we have developed the Program for Upright Positions in the Second Stage of Labor (UPSSL program) for the widespread application of upright positions. While there is limited research evidence on the areas of improvement and corresponding strategies for embedding the evidence into midwifery practice.OBJECTIVES:To explore perspectives of health care providers on improvement areas of upright positions in the second stage of labor, and to identify corresponding strategies in order to develop a management framework for successful implementation of upright positions.METHODS:A qualitative descriptive design with semi-structured interviews was conducted in the study. The participants involving 13 midwives, six obstetricians and six department managers were selected from three hospitals in Beijing, China. ATLAS.TI 8 software was utilized to manage, identify the transcript data, and the thematic analysis method guided the data analysis.RESULTS:A management framework of upright positions in the second stage of labor was developed based on our study, which included five improvement areas : (1) promoting the renewal of midwifery notions and the professional training;(2) strengthening maternal health education based on the "trinity" approach; (3) promoting multidisciplinary cooperation and refining the labor procedures in upright positions; (4) optimizing midwifery human resource allocation and formulating incentive policies; (5) encouraging partner involvement and improving the birth environment.CONCLUSIONS:The study findings could provide a comprehensive view to promote UPSSL Program to be utilized in practice. Our study also provided a way for midwives, obstetricians, and other healthcare providers to work together to facilitate high quality maternal care.IMPLICATIONS FOR PRACTICE:Our findings will be useful for nursing managers to carry out the UPSSL program through several strategies, such as strengthening the professional training for assisting labor in the upright positions, reallocating midwifery human resources, and developing the childbirth education on the upright positions.

Existing research concerning the effects of the sitting birth position during the second stage of labour on maternal and neonatal outcomes remains controversial, and there is a lack of studies to explore its effect on the childbirth experience. The objective of this study is to explore whether the sitting birth position would influence maternal and neonatal outcomes, as well as the childbirth experience. The prospective cohort design was conducted in the study from February to June 2023, a total of 222 women (including primiparous women and multiparous women) were enrolled in our study, and they were divided into the sitting position cohort (n = 106) or the lithotomy position cohort (n = 116). The pre-designed questionnaire and Childbirth Experience Questionnaire (CEQ) were used for data collection during hospitalisation. Chi-square, Fisher’s exact test, t-tests, or the Mann–Whitney U test were utilised to assess differences between groups. Multivariate linear regression and logistic regression were employed to control possible confounders. The study found that primiparous women in the sitting position cohort had a shorter duration of the second stage of labour, higher spontaneous vaginal birth rates, lower episiotomy rates, and a better childbirth experience (p < 0.01). After adjusting for confounding factors through multiple linear and logistic regression analyses, the results remained consistent with those reported above. No neonate in each cohort had Apgar scores at 1 min and 5 min postpartum less than 7 or a Cord artery pH less than 7.00, regardless of parity. Based on the findings, we recommend that women could take the sitting birth position into account when giving birth for a positive childbirth experience, especially for primiparous women. The study could also serve as a reference for healthcare providers in the management of childbirth positions and the development of high-quality maternal care.

Objective:To systematically evaluate the effect of different non-surgical interventions on postpartum pelvic floor dysfunction.Methods:Randomized controlled trials on the effect of different non-surgical interventions to improve postpartum pelvic floor dysfunction were searched in databases including CNKI,VIP,Wanfang,Sino Med, Pub Med,Web of Science,EMbase and the Cochrane Library from inception to December 26,2021. Two researchers independently performed literature screening,data extraction and quality evaluation.Stata 16. 0 was used to conduct a network meta-analysis. Results:A total of 49 RCTs including 5 278 patients were included,involving 15 interventions. The results of the network meta-analysis showed that acupuncture combined with biofeedback and electric stimulation had the best effect on pelvic floor muscle strength scores, compared with Kegel exercise,the difference was statistically significant（P＜0. 05）. For effective rate of urinary incontinence treatment, acupuncture combined with electric stimulation had the best effect,compared with Kegel exercise,Kegel exercise combined with biofeedback and electric stimulation and vaginal dumbbell,routine care,or Kegel exercise combined with vaginal dumbbell,the differences were all statistically significant（P＜0. 05）. Kegel exercise combined with electric stimulation had the best effect on the incidence of pelvic organ prolapse,compared with Kegel exercise or routine care,the differences were statistically significant（P＜0. 05）. Conclusion:Current evidence shows that acupuncture combined with electric stimulation can improve urinary incontinence symptoms effectively,while combined with biofeedback can effectively enhance pelvic floor muscle strength,and Kegel exercise combined with electric stimulation has the good effect on reducing the incidence of pelvic organ prolapse. At the same time,it should be suggested to choose the appropriate intervention according to the characteristics of the patient’s condition.

Background: Perineal trauma during childbirth and postpartum perineal pain significantly affected the new mother’s physical, psychological, and social experiences toward spontaneous vaginal birth. The effects of perineal warm compresses remain inconclusive. Objectives: To assess the effects of perineal warm compresses during the second stage of labor on reducing perineal trauma and postpartum perineal pain relief. Search Strategy: We searched seven bibliographic databases, three register websites of randomized controlled trials (RCTs), and two dissertation databases for publications from inception to March 15, 2023. Selection Criteria: RCTs published in Chinese and English. Data Collection and Analyses: Two independent reviewers conducted the risk of bias assessing, data extraction, and the certainty of the evidence evaluation utilizing the Cochrane risk of bias 2.0 assessment criteria, the Review Manager 5.4, and the online GRADEpro tool respectively. Main Results: Seven RCTs involving 1362 primiparous women were included. The combined results demonstrated a statistical reduction on the second-(RR=0.40, 95 %CI: [0.27,0.59]), third- and/or fourth- degree perineal lacerations(RR=0.34, 95 %CI: [0.20,0.57]), the incidence of episiotomy (RR=0.69, 95 %CI: [0.58,0.83]) and relief on the short-term perineal pain postpartum (within two days) (MD=-0.94, 95 %CI: [-1.10,-0.77]); a potential favorable effect on improving the integrity of perineum (RR=3.36, 95 %CI: [1.22,9.27]); did not show a statistically significant supportive effect on reducing the first-degree perineal lacerations ((RR=1.43, 95 %CI: [1.05,1.95])) and the rate of perineal lacerations requiring suture (RR=0.68, 95 %CI: [0.45,1.02]). Conclusions: Perineal warm compresses effectively reduced the second-, third-/or fourth-degree perineal trauma and decreased the short-term perineal pain after birth.

ObjectiveTo systematically evaluate the effect of different non-surgical interventions on postpartum pelvic floor dysfunction.MethodsRandomized controlled trials on the effect of different non-surgical interventions to improve postpartum pelvic floor dysfunction were searched in databases including CNKI，VIP，Wanfang，SinoMed， PubMed，Web of Science，EMbase and the Cochrane Library from inception to December 26，2021.Two researchers independently performed literature screening，data extraction and quality evaluation.Stata 16.0 was used to conduct a network meta⁃analysis.ResultsA total of 49 RCTs including 5 278 patients were included，involving 15 interventions. The results of the network meta⁃analysis showed that acupuncture combined with biofeedback and electric stimulation had the best effect on pelvic floor muscle strength scores， compared with Kegel exercise，the difference was statistically significant（P<0.05）.For effective rate of urinary incontinence treatment， acupuncture combined with electric stimulation had the best effect，compared with Kegel exercise，Kegel exercise combined with biofeedback and electric stimulation and vaginal dumbbell，routine care，or Kegel exercise combined with vaginal dumbbell，the differences were all statistically significant （P<0.05）.Kegel exercise combined with electric stimulation had the best effect on the incidence of pelvic organ prolapse，compared with Kegel exercise or routine care，the differences were statistically significant （P<0.05）.ConclusionCurrent evidence shows that acupuncture combined with electric stimulation can improve urinary incontinence symptoms effectively，while combined with biofeedback can effectively enhance pelvic floor muscle strength，and Kegel exercise combined with electric stimulation has the good effect on reducing the incidence of pelvic organ prolapse.At the same time，it should be suggested to choose the appropriate intervention according to the characteristics of the patient's condition.

Objective:To investigate and analyze the gap between the current clinical practice and guidelines of infant safe sleep protection strategies in China, and to provide a basis for further construction of evidence-based practice programs and evidence-based transformation of infant safe sleep protection strategies that conform to the actual situation in China.Methods:From March to May 2021, a total of 50 medical staff and 100 caregivers from the Obstetrics Ward, Neonatal Ward and Child Health Clinic in Peking University First Hospital were selected by the convenient sampling method. The survey was carried out at the organizational, the medical staff level and the caregiver. At the organizational level, the Maternity Ward, Neonatal Ward and Child Health Care Clinic of the hospital were investigated, and relevant support systems and supporting documents were reviewed. On-site observation was adopted at the medical staff level. At the caregiver level, the self-designed Infant Safe Sleep Protection Strategy Behavior Questionnaire was used to conduct the survey and the results were statistically analyzed.Results:There were 15 items with an execution rate of 0, 6 items with an execution rate of 1% to 50%, 6 items with an execution rate of 51% to 99% and 4 items with an execution rate of 100%. Multiple linear regression analysis shows that the influencing factor of caregivers' practice of infant safe sleep protection strategy was their educational level ( P<0.05) , and there was a positive correlation between them ( r=0.238, P<0.05) . Conclusions:There is still a big gap between clinical practice and guidelines of infant safe sleep protection strategies, and relevant training should be strengthened to narrow the gap between clinical practice and guidelines.

了解护理学专业本科生职业使命感现状,探索应对策略,为护理教育者实施相应的干预手段提供理论依据.

基于泛雅平台，搭建护理学导论课程站点。通过超星泛雅、学银在线遴选现行一流护理学导论课程视频，作为辅助 教学资源；利用各种技术录制护理学导论课程速课、微课及教学直播视频完善充实线上教学资源；进一步优化教学 大纲，进行整合教学内容、融入德育的实践，并补充增加线上课程思政资源。创新教学手段，通过学习通群聊答 疑、直播互动、主题讨论、选人、问卷、投票等形式，进行护理学导论线上教学中案例教学法、情境教学法、微课 翻转课堂等教学方法的实践。优化课程评价，课程成绩注重过程性考核。

目的 探讨慢加急性肝衰竭(ACLF)继发细菌感染病原菌及预后评估.方法 选取2016年1月-2020年10月郑州大学第一附属医院感染性疾病科收治的ACLF继发细菌感染患者100例,根据患者继发细菌感染后30 d内临床结局分为死亡组39例和生存组61例.统计并记录患者感染发生部位及病原菌类型,多因素分析不良预后的影响因素,受试者工作特征曲线(ROC)分析临床指标对ACLF继发细菌感染患者的预测价值.结果 100例ACLF继发细菌感染患者中,腹腔感染51例,呼吸道感染34例;共分离鉴定出病原菌172株,其中革兰阴性菌129株占比75.00％;多因素分析结果,肝功能Child-Pugh分级为C级、抗菌药物应用时机>12 h为影响ACLF继发细菌感染患者不良预后的危险因素;ROC曲线分析显示,总胆红素(Tbil)、国际标准化比值(INR)、甲胎蛋白(AFP)、降钙素原(PCT)、C-反应蛋白(CRP)、白细胞介素-6(IL-6)、中性粒细胞计数(NEU)、中性粒细胞/淋巴细胞比值(NLR)、红细胞分布宽度(RDW)联合预测的曲线下面积为0.976高于各单项指标(P<0.05).结论 联合AFP水平、INR、PCT、CRP水平、IL-6、NLR、RDW可有效诊断ACLF继发细菌感染患者的预后,肝功能Child-Pugh分级为C级、抗菌药物应用时机>12 h为影响ACLF继发细菌感染患者不良预后的危险因素.

AIMS:This study aimed to develop a Practice Programme for Upright Positions in the Second Stage of Labour to provide a reference for midwifery professionals in the standardized implementation of upright positions in clinical practice.BACKGROUND:The adoption of upright positions in the second stage of labour is recommended by many international organizations, but upright positions have not been widely used and their implementation varies greatly across studies.METHODS:The Practice Programme for Upright Positions in the Second Stage of Labour was developed under the guidance of the Medical Research Council framework for developing and evaluating complex interventions and the World Health Organization handbook for guideline development. Four stages were conducted: (1) establishing the intervention development group, (2) identifying a theoretical basis and forming a content framework, (3) evidence retrieval and synthesis and (4) refining and modelling the practice programme.RESULTS:The content framework of the Practice Programme for Upright Positions in the Second Stage of Labour was formed based on the literature review, semi-structured interviews and expert consultation, including indications and contraindications, implementation methods, observations, potential risks and precautions. According to each item, we conducted a series of systematic reviews, and summarized the available best evidence from clinical guidelines, systematic reviews and original studies. Eventually, the Practice Programme for Upright Positions in the Second Stage of Labour was developed, integrating the findings of the iterative evidence reviews and revised by stakeholders.CONCLUSIONS:This study first reported the development process of the Practice Programme for Upright Positions in the Second Stage of Labour, characterized by evidence-based, iteratively processed and highly rigorous. The implications may guide researchers to embed the intervention normatively into clinical practice for improving maternal and infant outcomes.IMPLICATIONS FOR NURSING MANAGEMENT:The Practice Programme for Upright Positions in the Second Stage of Labour could facilitatesystematic management of labour positions and guide midwives in the successful implementation of upright positions.

日的:探讨康惠尔透明贴(水胶体敷料)对PICC固定处皮肤的保护作用.方法:选取140例神经外科PICC置管的患者作为研究对象,随机分为康惠尔透明贴组和3M透明敷贴组各70例,比较两组PICC置管后病人皮肤过敏发生时间、愈合时间、局部皮肤情况(瘙痒、红斑、湿疹样小水泡).结果:康惠尔透明贴组局部皮肤不良反应发生率显著低于3M透明敷贴组(P<0.01),不良反应发生时间、愈合时间显著低于3M透明敷贴组(P<0.01).结论:PICC置管术后穿刺局部皮肤用康惠尔透明贴固定优于3M透明敷贴.

目的 基于泛雅网络教学平台,阐述构建基础护理学课程考评体系的过程及实施效果,为高校基础护理学考核方案的制定提供参考依据.方法 以2016级170名涉外护理专业本科生为试验组,依托泛雅网络教学平台构建基础护理学"多维度、四结合"为一体的考评体系,编制问卷对考核效果进行调查.以2015级153名涉外护理专业本科生为对照组,比较两组课程总评成绩.结果 试验组85.7％的学生认为该考评体系优于传统考核方式,90.5％的学生对总评成绩满意,超过90％的学生表示考核公平、难度适中,有利于发挥真实水平,但51.1％的学生表示增加了学业负担.试验组与对照组课程总评成绩比较差异有统计学意义(t=5.12,P<0.01).结论 该考评体系既能客观、公正地评价学生课程学习效果又有较强的可操作性,对高校基础护理学课程教学具有一定的指导意义和推广价值.

目的 观察盆腔器官脱垂(pelvic organ prolapse,POP)患者子宫主韧带组织中炎性因子、氧化损伤标志物水平变化,并分析其与病情程度的关系.方法 选取2018年6月至2019年在河南新郑郑州西亚斯医院接受治疗的50例POP患者和50例非POP以及无尿失禁患者作为研究对象,分别作为POP组和对照组.检测2,3-二羟基苯甲酸(2,3-Dihydorxybenzoate,2,3-DHB)、丙二醛(Malondialdehyde,MDA)、白细胞介素-1(Interleukin-1,IL-1)、白细胞介素-6(Interleukin-6,IL-6)、肿瘤坏死因子-α(Tumor necrosis factor,TNF-α)、脂质过氧化物(Lipid peroxidation,LPO)、总抗氧化能力(Total-Anti Oxidative Capacity,T-AOC)、一氧化氮(Nitric Oxide,NO)水平,并对盆腔器官脱垂程度与炎性因子及氧化损伤标志物相关性进行分析.结果 POP组患者子宫主韧带中的IL-6、IL-1、TNF-α水平显著高于正常组(P＜0.05);POP组患者子宫主韧带组织中的2,3-DHB、LPO、MDA水平显著高于正常组,T-AOC、NO表达水平明显低于正常组(P＜0.05);盆腔器官脱垂程度越严重,患者子宫主韧带组织中的2,3-DHB、LPO、MDA表达水平越高,T-AOC、NO表达水平越低(P＜0.05).结论 POP患者子宫主韧带组织中炎性因子、氧化损伤标志物水平发生显著改变,POP发生机制可能与炎性损伤及氧化应激相关.