Objective: To study the protective effects of resveratrol (RSV) on cardiac function in rats with high altitude hypobaric hypoxia and its mechanisms. Methods: Thirty-six rats were randomly divided into control group, hypobaric hypoxia group (HH) and hypobaric hypoxia + RSV group (HH+RSV) according to the random number, 12 rats in each group. Rats in the HH and HH+RSV groups were subjected to chronic long-term high altitude hypobaric hypoxia intervention for 8 weeks in a hypobaric chamber at a simulated altitude of 6 000 m for 20 h / d. The rats of HH + RSV were fed with RSV at a dose of 400 mg/(kg·d). The rats were tested once a week for body weight and twice a week for food intake. Before execution, the rats were tested by blood cell analyzer for routine blood parameters and echocardiogram for cardiac function parameters in each group. The routine blood indexes of each group were measured by blood cell analyzer, the cardiac function indexes of each group were measured by echocardiography, myocardial hypertrophy was evaluated by HE staining, myocardial tissue reactive oxygen levels were evaluated by dihydroethidium (DHE) staining. Oxidative stress was evaluated by serum and myocardial tissue total antioxidant capacity (T-AOC), superoxide dismutase activity (SOD) and malondialdehyde (MDA) content. Results: Compared with the C group, the body mass and food intake of rats were decreased significantly (P＜0.05) in HH group, while compared with the C group, RSV had no significant effects on the body mass and food intake of rats in the HH+RSV group (P＞0.05). Compared with the C group, the levels of erythrocytes and hemoglobin of rats in the HH group were increased significantly (P＜0.05), while the platelet concentration was decreased significantly(P＜0.05); compared with the HH group, the erythrocyte and hemoglobin levels were decreased significantly (P＜0.05) and platelet concentration was increased significantly(P＜0.05) in rats of the HH+RSV group. Compared with the C group, the cardiac coefficient, myocardial fiber diameter and thickness were significantly increased in the HH group (P＜0.05); compared with the HH group, the cardiac coefficient and myocardial fiber thickness were significantly decreased in the HH+RSV group (P＜0.05). Echocardiographic analysis showed a significant increase in ventricular wall thickness (P＜0.05) and a significant decrease in ejection fraction and cardiac output (P＜0.05) in the HH group compared with the C group, and a significant decrease in ventricular wall thickness and a significant improvement in cardiac function (P＜0.05) in the HH+RSV group compared with the HH group. The results of DHE staining showed that myocardial tissue reactive oxygen levels were increased significantly in the HH group compared with the C group (P＜0.05); myocardial tissue reactive oxygen levels were significantly restored in the HH+RSV group compared with the HH group (P＜0.05). The oxidative/antioxidant results showed that the serum and myocardial T-AOC and SOD activities were decreased significantly (P＜0.05) and the MDA level was increased significantly (P＜0.05) in the HH group compared with the C group; the serum and myocardial T-AOC and SOD activities were increased significantly (P＜0.05) and the MDA level was decreased significantly(P＜0.05) in the HH+RSV group compared with the HH group. Conclusion: Long-term plateau hypobaric hypoxia exposure leads to myocardial hypertrophy and reduced cardiac function in rats. Resveratrol intervention significantly improves myocardial hypertrophy and cardiac function in rats caused by altitude hypobaric hypoxia exposure, which is closely related to reducing of reactive oxygen species and improving myocardial oxidative stress levels.

目的 探索木犀草素的抗缺氧作用,为抗缺氧新药物的研制提供思路.方法 将40只昆明(KM)雄性小鼠分为4组,每组10只,连续灌胃(0.5％羧甲基纤维素钠溶液、25、50和100 mg/kg木犀草素溶液)15d,进行常压密闭缺氧实验,记录小鼠存活时间(survival time,ST)、检测小鼠血清以及心、肝等组织的谷胱甘肽过氧化物酶(glutathione peroxidase,GSH-Px)和总超氧化物歧化酶(total-superoxide dismutase,T-SOD)活力,总抗氧化能力(total antioxidant capacity,T-AOC),丙二醛(malondialdehyde,MDA)含量,观察木犀草素对常压缺氧小鼠的保护作用.结果 与对照组相比,木犀草素中、高剂量灌胃给预组小鼠在常压密闭缺氧条件下的常压缺氧密闭时间(the survival time,ST)、标准耐缺氧时间(standard hypoxia tolerance time,STT)和校准后的标准耐缺氧时间(adjusted standard hypoxia tolerance time,ASTT)均显著延长(P＜0.05),木犀草素高剂量组小鼠血清中GSH-PX和T-SOD活力显著提高(P＜0.05)、肝组织中MDA含量显著下降(P＜0.05)、心脏组织T-SOD活力显著提高(P＜0.05).结论 中、高剂量的木犀草素可以显著延长小鼠的缺氧存活时间,具有抗缺氧作用.

该文梳理了美军2021年度军事作业医学领域的研究进展,涵盖美军作业效能维护的最新条令、指南和部队健康报告,极端自然环境和特殊作业环境损伤的发病机制研究进展及防护装备研发成果,以及女性军人健康维护和效能提升专职咨询机构70年发展历程回顾与最新政策制度等内容,旨在为我军同领域研究提供有益的借鉴和参考.

目的 为实现应急救援下脑水肿监测仪的快速连接以判断脑水肿的目的,自行设计了无创脑水肿快速固定装置,并应用于临床.方法 选取2019年3月—2020年2月中国人民解放军总医院第五医学中心神经内科的104例脑水肿患者,应用随机数字表法将患者随机分为观察组(52人)和对照组(52人),观察组实施自行设计的快速电极固定装置进行监测,对照组实施常规电极固定方法监测,分析两组监测的效果.结果 观察组操作时间明显短于对照组,电极移位脱落情况、患者满意度及舒适度明显优于对照组,差异均有统计学意义(P<0.05).结论 应急救援下无创脑水肿监测仪电极快速固定装置大大缩短操作时间且确保电极固定牢固,不易脱落,患者满意度及舒适度明显提高,为应急救援下快速监测赢得了宝贵时间.

调查我校与邻校两个中学校1000名中学生膳食营养状况,从调查结果中分析现在中学生的膳食营养摄入情况和不良健康情况,结果显示中学生膳食营养存在较大问题,部分营养素摄入量存在严重不足,影响了学生营养状况与健康状况,需给予针对性干预,改善学生营养健康情况.

目的：探讨红细胞体积分布宽度（RDW）、前清蛋白（PA）及C反应蛋白（CRP）与重症监护病房（ICU）危重患者预后的关系。方法回顾性分析2013年12月至2014年12月该院 ICU 收治的危重症患者95例，按照预后分为存活组和病死组，比较2组 RDW 、CRP 、PA 、急性生理学及慢性健康状况Ⅱ（APACHE Ⅱ）评分，并将 RDW和 CRP 分别与 APACHE Ⅱ评分进行相关性分析，同时作受试者工作特征（ROC）曲线分析。结果病死组 RDW较存活组明显升高[15（14，17），14（13，15），P＜0．05）]；CRP 也显著高于存活组[102（24，280），32（12．35，86．95），（P＜0．01）]；病死组 APACHE Ⅱ评分与存活组比较，差异有统计学意义[28（21，37），17（13，23），P＜0．001]，而 PA与存活组比较，差异无统计学意义[（163．75±80．97）mg／L ，（121．96±81．87）mg／L ，P＞0．05]。 RDW 和 APACHEⅡ评分呈正相关（r＝0．322，P＝0．023），CRP 和 APACHE Ⅱ评分呈正相关（r ＝0．462，P ＜0．001），CRP 和 RDW 也呈正相关（r ＝0．328，P＜0．05）。 RDW 的 AUC 为0．674，当 RDW 的 cut off 值为14．0时，判断患者预后为病死的敏感度为85．2％，特异度为54．3％。 CRP 曲线下面积（AUC）为0．705，当 CRP 的 cut off 值为101．2时，敏感度为52．2％，特异度为86．1％。与 APACHE Ⅱ评分比较，把 APACHE Ⅱ评分和 RDW 、CRP 结合时患者病死率 AUC 从0．772增加至0．797。结论 APACHE Ⅱ评分结合 RDW 、CRP 能为监测 ICU 患者预后提供新的、更有价值的临床意义。

目的:探讨医院静脉药物配置中心的管理方法,为开展医院临床药学工作、减少药品浪费、降低医疗成本、提高医疗质量提供依据。方法:建立静脉药物配置中心,对静脉药物配置中心的工作流程、工作环境、清洁消毒措施等多方面进行管理。结果:静脉药物配置中心对药品集中配置后,改良了配药环境及条件,药物稳定性得到了保障。节约了护理人力资源,提高了护理工作质量,降低了患者药品费用负担,提升了医院临床医疗服务水平。结论:静脉药物配置中心有序高效的管理,是液体质量的有效保障。

目的：观察40例健康受试者在溶栓药物试验应用中的采血方法对凝血检查结果的影响，探讨溶栓药物试验多次采血方法的最佳组合方案。方法将参加该试验的40例受试者凝血化验结果当日汇总、及时查找与药物无关的影响因素、及时改变标本采集方法。结果采血方法改变后标本合格率100%。结论凝血功能检查要采用规范的采血配套材料和规范的护理操作。

<正>2009年6～12月,我们对24例健康受试者静脉滴注白细胞减少症药物盐酸千金藤碱,经精心护理,效果满意。现报告如下。1资料与方法1.1临床资料本组健康受试者24名,男12名,女12名;年龄29～39岁。实验单次及多次给药,受试者体重≥50 kg、身高≥150 cm、血压90～140/60～90 mm Hg(1 mm Hg=0.133kPa),通过全身体检、女性妊娠试验阴性、无药物过敏史及晕

自1996年以来,我院收治经淋巴结活检病理证实的坏死增生性淋巴结病9例.现报道如下. 1 临床资料 1.1一般资料:本组9例,男7例,女2例,年龄11～45岁,平均29岁.冬春季节发病6例,夏季2例,秋季1例.