目的 探讨非布司他对高尿酸血症痛风患者血清炎症因子及血管内皮细胞的影响及疗效观察.方法 选取2017年1月～2019年1月我院内科门诊治疗高尿酸血症痛风患者90例,随机分为观察组(n=45)和对照组(n=45).对照组予口服别嘌呤醇片300 mg/次,3次/d.观察组予口服非布司他片40 mg/次,1次/d.两组均连用12周.观察两组治疗前后血清炎症因子[超敏C反应蛋白(hs-CRP)、肿瘤坏死因子(TNF-α)和白介素(IL-6)]及血管内皮功能指标[内皮素-1(ET-1)和一氧化氮(NO)]的变化,并比较其临床效果及不良反应.结果 治疗12周后,两组血清hs-CRP、TNF-α和IL-6水平均显著下降(P<0.01或P<0.05),且观察组下降值与对照组相比更显著(P<0.05);同时两组血清ET-1水平显著下降,NO水平显著上升(P<0.01或P<0.05),且观察组变化值与对照组相比更显著(P<0.05);观察组临床总有效率较对照组更高(x2=4.05,P<0.05).观察组和对照组不良反应发生率分别为4.44％(2/45)和8.89％(4/45),症状均较轻,两组相比差异无统计学意义(P>0.05).结论 非布司他治疗高尿酸血症痛风患者的疗效较别嘌呤醇更确切,安全性较好,不仅可降低血清hs-CRP、TNF-α和IL-6水平,控制炎症反应;而且可降低血清ET-1水平,升高NO水平,纠正血管内皮功能紊乱.

目的:探讨在新医改背景下,药剂科能否够尽快完成职能转变,药剂科部门组长能否切实履行好自己的工作职责,对于医院药品“零差价”政策的实施、医院战略发展目标的实现等会产生的影响.方法:文章结合药剂科工作职能的转变,探讨了台州恩泽医疗中心(集团)浙江省台州医院药剂科部门组长绩效考核的建立与评价问题,在旧的部门组长绩效考核存在的不足基础上,构建、设计适合当前药剂科部门组长绩效考核所需求的绩效考评体系.结论:医院药剂科部门组长绩效考核的实施,对促进药剂科服务功能作用的发挥、激发部门组长的工作积极性、提升整个科室的工作绩效起到了显著的促进作用.

Objective:To investigate the effect of anastrozole on sex hormone levels and michigan cancer foundation-7 ( MCF-7 ) cell inhibition in postmenopausal women with breast cancer. Methods: Totally 80 women with breast cancer were selected. Among them, 40 cases of patients received the routine management and tamoxifen treatment were included into the control group, and another 40 cases of patients received the routine management and anastrozole treatment were included into the observation group. The changes of sex hormone levels, effects and adverse drug reactions of two groups were compared between basetine and three months after treat-ment, meanwhile, the incidence of MCF-7 cell inhibition between two groups. Results:After treatment, the levels of estradiol( ER) , progesterone(PR) and luteotropic hormone(LH) were lower than baselime, however, the level of testosterone was contrary(P <0. 05). Meanwhile, the level of ER, PR and LH in control group were lower than baselime however, the level of testosterone was cont-ray (P<0. 05). The incidence of MCF-7 cell inhibillion between two grugs at time 72 h were higher than the 48 h, the incedence of MCF-7 cell inhibition in observation group were significantly higher than control groups at time 48 h and 72 h (P<0. 05). The rate of total effective in control group(45. 0%) was lower than the observation group(70. 0%)(P>0. 05). There was no significant differente in the micidence of adverse reactions. Conclusion:Anastrozole used for postmenopausal women with breast cancer has significant effi-cacy, high safety and promising inhibitory effect on MCF-7 cell. It can effectively adjust sex hormone level, reduce occurrence and transfer risks of breast cancer.

Tripterygium wilfordii is widely used in treatment of autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus.The curative effect of Tripterygium wilfordii has been proved exactly and being far greater than other Chinese herbs.But lots of adverse effects of Tripterygium wilfordii can not be avoided due to its narrow therapeutic window in clinical tests during the past half century.Efficacy enhancement and attenuation of side effects of Tripterygium wilfordii are hotspots of current researches.This paper reviewed material basis of toxicity of Tripterygium wilfordii,clinical manifestations of toxicosis and rational methods of attenuation.

药源性肝损害已成为国内外常见且较严重的药源性疾病,一些药物引起的常见的药源性肝损害屡有报道,我们也都熟知,但我们往往忽视药物引起的罕见的药源性肝损害,本文就临床用药过程中引起罕见药源性肝损害的五大类药物进行综述,望广大临床医师和药师警惕,并积极预防和治疗。

目的 考察奥硝唑注射液在盐酸莫西沙星氯化钠注射液中配伍的稳定性.方法 用紫外分光光度法考察真硝哇和莫西沙星在配伍6h内的含量变化,并观察其外观、pH值和紫外吸收光谱.结果 在室温避光条件下,0～6h内配伍液外观、pH值和紫外吸收光谱无明显变化;两者相对百分含量在配伍前后无明显变化.结论 在室温避光条件下,奥硝唑注射液和盐酸莫西沙星氯化钠注射液混合后6h内性质稳定,临床上可配伍使用.