Background Globally, depression is a serious public health problem and it has a high incidence and recurrence rate. The underlying mechanism between the activities of daily living (ADL) disability and depression was not well understood. Our study aimed to explore the mediating role of frailty on the longitudinal association between ADL disability and depressive symptoms. Methods This study analyzed data from the China Health and Retirement Longitudinal Study (CHARLS) from 2011 to 2018. A total of 2,245 participants aged ≥45 years old were included. Linear regression, cox regression, and mediation analysis were used to explore the association of ADL disability with development of depressive symptoms and the potential mediating role of frailty. Results The results showed that both scores on ADL and frailty were positively associated with the risk of depressive symptoms (P<0.05). No interaction between ADL and covariates on depressive symptoms was found for all subgroups. The association between ADL disability and depressive symptom scores was partially mediated by frailty (mediated proportion = 16.05%) in the Chinese middle-aged and elderly population. Conclusion There were positive associations between both scores on ADL and frailty and new-onset depressive symptoms. Individuals with high scores on ADL disability had a higher risk of depressive symptoms, and frailty partially mediated this association.

Lung adenocarcinoma is recognized as one of the most recurrent tumours in adults. Long non-coding RNAs (lncRNAs) are non-protein-coding transcripts and have been demonstrated to regulate biological functions during tumorigenesis. Our study aims to investigate the underlying molecular mechanisms of LINC00461/microRNA-195 (miR-195)/HOXA10 responsible for its involvement in lung adenocarcinoma. We firstly selected differentially expressed lncRNAs and genes by the Cancer Genome Atlas (TCGA) database and Gene Expression Omnibus (GEO). The functional role of LINC00461 in lung adenocarcinoma was then determined using ectopic expression, knockdown and reporter assay experiments. Besides, we detected the expression profiles of LINC00461, miR-195, HOXA10 and apoptosis- and invasion-related genes. Cell proliferation, migration and invasion were evaluated. In vivo tumour formation ability was analysed. Overexpressed LINC00461 and HOXA10 but down-regulated miR-195 were observed in primary and metastatic lung adenocarcinoma. LINC00461 negatively regulated miR-195, while miR-195 negatively regulated HOXA10. Forced LINC00461 expression decreased expression of miR-195 and Bax, increased expression of HOXA10, MMP-2, MMP-9 and Bcl-2, promoted cell proliferation, migration and invasion as well as tumour formation, and enhanced radiosensitivity of lung adenocarcinoma cells. However, these effects were reversed by lentivirus-mediated miR-195-forced expression, thereby suggesting that miR-195 could antagonize the harmful effect of LINC00461 on lung adenocarcinoma cells. Collectively, the present study provides evidence supporting the inhibitory effect of LINC00461 silencing on lung adenocarcinoma, which suppresses lung adenocarcinoma cell migration, invasion and radiosensitivity via HOXA10 by binding to miR-195, which provides a promising basis for the targeted intervention treatment for human lung adenocarcinoma.

Objective To explore the working mode of clinical pharmacists in the grading pharmaceutical care for patients with chronic obstructive pulmonary disease (COPD) . Methods The standard of grading pharmaceutical care was established according to the guidelines for the clinical diagnosis and treatment of COPD, and the content of grading pharmaceutical care was determined. The patients were randomly divided into pharmaceutical care group (intervention group) and control group. Pharmacists gave different grades of pharmaceutical care for patients of intervention group and established the archives for patients. The effectiveness (including FEV1/FVC, FEV1％ expected value and length of hospital stay, and the safety and compliance of the two groups were compared. Results The lung function of the two groups was improved significantly at the time of hospital discharge (P < 0. 05) . The average length of hospitalization in intervention group was shorter than that in control group [ (9. 5 ± 2. 99) d vs. (11. 4 ± 2. 57) d, P < 0. 05];the rate of compliance in intervention group was higher than that in control group (94. 11％ vs. 85. 33％, P < 0. 05) ;the incidence rate of adverse reaction in intervention group was lower than that in control group (9. 5％ vs. 15. 06％, P< 0. 05) . Conclusion We can find key subjects of pharmaceutical care through grading pharmaceutical care for COPD patients, which can improve the quality and level of pharmaceutical care and quantify the work of clinical pharmacists.

1例66岁女性患者,因活动性呼吸困难1个月余入院,诊断为特发性肺间质纤维化,给予头孢唑肟注射剂、注射用甲泼尼龙琥珀酸钠、兰索拉唑注射液、L-谷氨酰胺呱仑酸钠颗粒进行治疗,使用甲泼尼龙琥珀酸钠(40 mg,bid)缓慢静推过程中患者出现剧烈喷射状呕吐,连续5次,考虑该患者喷射性呕吐可能是由注射用甲泼尼龙琥珀酸钠所致,故将静脉用甲泼尼龙琥珀酸钠替换为口服泼尼松片(200 mg,qd),患者呕吐症状缓解后停止.

1临床资料患者女性,53岁,无明显诱因出现活动后呼吸困难4个月,加重5天,于2015-1-30就诊于当地医院,行心脏彩超:三尖瓣返流速度4.2m/s,肺动脉压79mmHg,给予扩冠、利尿等治疗后症状略有好转。为明确病因转至另一家医院,复查心脏彩超:三尖瓣返流速度3.75m/s,肺动脉压73mmHg,进一步检查:肺功能:FEV1/FVC 87.8%,FEV1/pre73.3%。D-二聚体（0-500）2484μg/L,双下肢血管彩超:右侧

One 32 year-old female patient was admitted mainly because 17 days after cesarean section and fever for 7 days. The patient was diagnosed as puerperal infection and was treated with moxifloxacin and meropenem successively. Jaw skin numbness appeared during the treatment of meropenem (1 g, q 8 h). And the patient further developed limb numbness, weak patellar tendon reflex, hypoalgesia, limitation of activity 2 days later. Nervous system disease and thrombotic disease were excluded after consultation of neurology department and cardiovascular surgery. ADR induced by meropenem was considered and meropenem was stopped immediately. The next day, the above system was improved without any treatment.

慢性阻塞性肺疾病（COPD）是以不完全可逆气流受限为特征的慢性气道疾病。NIPPV对急性期COPD患者的疗效得到肯定［1］，为探讨NIPPV对我国COPD稳定期患者的疗效，本研究采用 Meta 分析方法，系统评价我国COPD稳定期患者应用NIP-PV的RCT，为临床提供依据。

目的 通过检测肺功能来评价重组抗 IgE 人源化单克隆抗体治疗支气管哮喘急性发作期的疗效. 方法 采用酶联免疫吸附法(ELISA)检测患者血清中IgE水平,每2 w或4 w给予IgE抗体皮下注射,检测患者肺功能(FVC、FEV1、FEV1/FVC%、MMEF75/25),评价重组抗 IgE人源化单克隆抗体治疗支气管哮喘急性发作期的疗效. 结果 治疗后FVC、FEV1、FEV1/FVC%,MMEF75/25 较治疗前比较差异显著(P<0.05),三组间无差异(P>0.05). 结论 重组抗IgE人源化单克隆抗体治疗轻中重支气管哮喘急性发作期均有效,但轻、中、重度急性治疗效果三组间无明显差异.

正>肺毛霉病是一种发病率低但死亡率极高的肺真菌病,临床上以急性化脓性感染为主,慢性感染罕见。我科于2014年8月诊断肺毛霉菌病1例,但其病程长,进展慢,为慢性原发性肺毛霉菌病,现报告如下。1临床资料患者男,56岁,因咳嗽、咳痰50天,发热3天入院。入院前50天出现咳嗽、咳黄痰,量中等,不易咳出,无发热及咯血,肺CT示双肺多发斑片状高密度影,初诊为"社区获得性肺炎",给予抗感染治疗(左

孤立性肺结节（ SPN）无肺不张、肺门增大或胸腔积液的表现〔1〕；SPN在胸部X线片中的检出率只有0．09％～0．20％，多数是在不经意间发现〔2〕，随着高分辨率CT（HRCT）的广泛应用，越来越多地被发现并得到重视。同时根据直径， SPN分为直径≤8 mm的亚厘米结节、8 mm＜结节≤3 cm的典型SPN，再根据CT上是否存在磨玻璃样变结节（ GGN），将SPN分为纯磨玻璃样变结节（ PGGN）、纯实质样结节或混杂磨玻璃样变结节（ MGGN）。常见的SPN病因主要有肿瘤样病变（包括良性病变、恶性病变）、感染性病变、非感染性病变（结节病等）、先天性疾病（支气管闭锁、肺囊肿）等。由于良恶性病变治疗手段及预后差异显著，因此其良恶性的鉴别对于临床诊断和治疗具有重要意义。本文就根据HRCT表现鉴别SPN良恶性的研究进展进行简单总结。

肺血栓栓塞症（ PTE ）指来自右心或静脉系统的血栓阻塞肺动脉或其分支，以肺循环和呼吸功能障碍为表现的疾病，通常所说的肺栓塞即指PTE。急性PTE已成为临床常见的致死性疾病之一，但其临床表现缺乏特异性，漏诊、误诊率高。

骨化性气管支气管病（TO）是指气管、支气管黏膜下有多发性骨质或软骨组织结节状增生并突向管腔的良性病变〔1〕。到目前为止，TO 的国外报道较多，但国内报道仅70余例。经查阅PubMed 数据库〔2〕，自1964年以来文献报道TO 合并肿瘤的共5例，其中合并肺癌2例，结合本例共3例，且均为肺腺癌，合并肺黏液表皮样癌、肺霍奇金淋巴瘤和胸腺瘤各1例，查阅CNKI 数据库及万方数据库国内此前尚无报道。2013年12月吉林大学第二医院呼吸内科诊断1例骨化性气管支气管病合并肺腺癌患者，现将其临床特点报告如下。

<正>目的探讨检测血清总IgE及肺功能在诊断咳嗽变异性哮喘(CVA)诊断中的意义。为CVA诊断提供新方法,提高临床疗效。方法选择CVA发作期、支气管哮喘急性发作期患者各40例,其中CVA发作期符合《内科学》

<正>慢性阻塞性肺疾病(COPD)是一种不完全可逆的气流受限为特征的疾病,是世界上第二大非传染性疾病,每年引起270多万人死亡,其病因与肺部对有害气体或有害颗粒的异常炎症反应有关〔1〕。药物仍是目前治疗COPD的主要手段(主要应用支气管扩张药物改善气流受限、缓解气促等对症治疗)。笔者

<正>目的通过脉冲振荡法(IOS)测定支气管哮喘患者的呼吸阻抗,探讨IOS对支气管哮喘的诊断意义。为支气管哮喘的诊断提供新方法。方法随机招募2012年06月至2012年12月于吉林大学第二医院呼吸内科门诊确诊的支气管哮喘急性发作期的患者81例,其中男44例,女37例,哮喘病史5年及5年以上,上述患者全部符

<正>目的探讨慢性阻塞性肺疾病急性加重期(AECOPD)患者血清中肺泡表面活性物质蛋白D(SP-D)及C-反应蛋白(CRP)的水平变化与肺功能的关系,尝试描述AECOPD患者疾病严重程度、病情进展及预后。方法随机招募2010年3月至2011年3月吉林大学第二医院呼吸内科住院及门诊COPD患者共

<正>目的肺功能评价重组抗IgE人源化单克隆抗体治疗支气管哮喘急性发作期的疗效。方法收集吉林大学第二医院门诊及住院支气管哮喘急性发作期的患者共29例,年龄为18～75岁,平均为44±11.2岁,分为轻度支气管哮喘急性发作期组8例、中度支气管哮喘急性发作期组11例及重度支气管哮喘急性发作期组10例,采用酶联免疫法检测患者血清中总IgE水平,根据患

<正>目的通过监测中重度慢性阻塞性肺疾病(COPD)患者的肺功能,来描述噻托溴铵对中重度COPD患者肺功能的远期影响,进一步指导COPD患者治疗。方法招募2012年01月01日-2012年06月01日于吉林大学第二医院呼吸内科门诊就诊及住院患者明确诊断为中重度COPD患者65例。将患者随机分成两组:观察组(噻托溴铵治疗组)32例,

<正>目的探讨肺弥散功能检查在支气管哮喘与慢性阻塞性肺疾病(COPD)鉴别中的意义,提供除了支气管舒张试验以外的可能的鉴别方法。方法随机招募2012年01月至2012年11月于吉林大学第二医院呼吸内科门诊就诊初诊肺功能明确诊断为COPD的患者共79例,诊断标准符合中华医学会呼吸病学分会COPD学组COPD诊治

目的：县市级医院年度致病菌及临床用药统计分析。方法：对我院2013年全年12个月的致病菌、痰培养及分泌物培养结果加以统计和分析。分析常见菌致病菌和特殊致病菌的敏感药物、耐药药物。结论：常见菌致病菌和特殊致病菌对头胞哌酮舒巴坦均敏感，对阿奇霉素、克林霉素普遍耐药。