BACKGROUND:Kangquan formula (KQF), a traditional Chinese medicine compound, is clinically effective and safe against benign prostatic hyperplasia (BPH). However, the mechanism of action of KQF is not clear. PURPOSE:To explore the potential mechanism of action of KQF on BPH by integrating urine microecology and metabolomics. METHODS:The BPH rat model was induced using testosterone propionate. Histopathology, immunofluorescence, and immunohistochemistry staining were used to evaluate the curative effect of KQF on BPH. In addition, 16S rRNA sequencing, nontargeted metabolomics, and western blot analysis were performed to analyze the effects of KQF on the urinary microecological diversity, metabolic profile, and epithelial barrier in rats with BPH. Finally, association analysis was used to demonstrate the correlation among urinary microorganisms, metabolites, and phenotypes. RESULTS:KQF decreased the wet weight, volume, and prostate index in rats with BPH, promoted the expression of caspase-3, a marker of apoptosis in prostate tissue, and inhibited the expression of proliferation cell nuclear antigen (PCNA), a marker of proliferation. Low-dose KQF intervention increased the urine flora richness, reduced the abundance of harmful bacteria such as Morganella, and increased the abundance of probiotics such as Staphylococcus, Romboutsia, Turicibacter, and Bacillus. In addition, low-dose KQF intervention increased the content of 103 metabolites, including citramalic acid and uracil, while also upregulating the content of 120 metabolites, including pralidoxime and d-glucuronic acid, in the urine of rats with BPH. Glycerophospholipid, glycine, serine, threonine, nucleotide, amino sugar, and nucleotide sugar may be the key metabolic pathways involved in the therapeutic effects of KQF. Moreover, low-dose KQF intervention upregulated the protein expression of uroepithelial barrier markers ZO-1, occludin, and UP II in the prostatic area of rats with BPH. The association analysis revealed overall consistency and differential correlation among urine microbes, metabolites, and phenotypes. CONCLUSIONS:This study was the first to analyze the mechanism of action of KQF on BPH from the perspective of urine microenvironment. KQF alleviated the pathological changes of prostate tissue in rats with BPH and regulated the imbalance of cell proliferation/apoptosis in BPH tissues. It also exerted its effect probably by improving the diversity of urine microecology, restoring urinary metabolic profile homeostasis, and remodeling the integrity of the urinary epithelial barrier in rats with BPH.

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive memory decline and cognitive dysfunction, primarily affecting the elderly. Approximately 50 million people worldwide are currently affected, with projections suggesting an increase to 152 million by 2050, especially among individuals over 65, where the incidence rate can be as high as 30%. This phenomenon significantly reduces the quality of life for patients and imposes substantial psychological and economic burdens on families and society. Therefore, finding effective treatment options is crucial. In recent years, Traditional Chinese Medicine (TCM) has gradually shown its potential in the treatment of AD. TCM views AD as a form of “dementia” or “amnesia,” attributing its root causes to dysfunctions of organs such as the kidneys and spleen, as well as deficiencies in qi (vital energy) and blood. Through methods like regulating qi and blood and strengthening kidney function, TCM aims to improve symptoms via a holistic approach. Many herbal formulas, such as Tianma Guoteng Decoction and Angong Niuhuang Pill, have been widely studied, demonstrating promising neuroprotective effects. Furthermore, both domestic and international studies indicate that TCM has made positive strides in the clinical application of AD, particularly in multicenter clinical trials, showing improvements in cognitive abilities and delays in disease progression. Herbal components such as astragalus polysaccharides, ginsenosides, curcumin, and Ginkgo biloba extract (GBE) exhibit significant neuroprotective effects through mechanisms like antioxidation, anti-inflammation, and the clearance of beta-amyloid (Aβ) protein. However, standardization and clinical validation remain major challenges to its widespread application. Looking ahead, integrating modern medical research methods, such as molecular biology and genetics, will provide new perspectives for TCM in the treatment of AD, facilitating the extraction and application of its effective components, thereby improving patients’ quality of life. Overall, TCM has achieved significant success in the treatment of AD, but further in-depth research is needed to fully realize its potential.

Diabetic kidney disease (DKD) is a severe complication of diabetes, characterized by chronic inflammation and fibrosis. Tang Shen Ping Decoction (TSPD), a traditional Chinese medicine formulation, has shown therapeutic efficacy in DKD, yet its molecular mechanisms remain to be fully elucidated. To explore the multitarget mechanisms of TSPD, this study integrated network pharmacology, transcriptomic analysis, molecular docking, and molecular dynamics simulations, followed by in vivo and in vitro validation. A total of 248 active compounds and 649 potential targets of TSPD were identified, among which network pharmacology and transcriptomic integration highlighted 21 key genes involved in DKD pathogenesis. Protein-protein interaction network analysis further identified ALB, CCL2, EGF, FN1, and PTGS2 as central targets. Molecular docking confirmed strong binding affinities between core TSPD compounds, including quercetin and kaempferol, and these targets, particularly CCL2. Molecular dynamics simulations validated the stability of these interactions, identifying CCL2 as a crucial therapeutic target. In vivo experiments demonstrated that TSPD significantly improved renal function, attenuated fibrosis, and down-regulated CCL2, NF-κB, and TGF-β1 expression in DKD rats. In vitro, TSPD effectively suppressed CCL2/NF-κB activation and reduced the secretion of inflammatory cytokines (TNF-α, IL-6, and IL-1β) in high-glucose-treated HK-2 cells. Functional analysis confirmed that CCL2 overexpression exacerbated inflammation, while its silencing enhanced the anti-inflammatory effects of TSPD. These findings reveal that TSPD exerts renoprotective effects by targeting the CCL2/NF-κB axis, offering mechanistic insights into its anti-inflammatory and antifibrotic actions and providing a theoretical foundation for its clinical application in DKD treatment.

BackgroundBenign prostatic hyperplasia (BPH) affects 30% of men worldwide, folate is essential for life. However, few studies have investigated the relationship between folate levels and BPH. The present study aims to explore the relationship between red blood cell (RBC) folate, a better indicator of long-term folate intake, and BPH in United States (US) men.MethodsWe used statistics from four cycles of the "National Health and Nutrition Examination Survey" (NHANES2001-2008), RBC folate data come from laboratory data and BPH date come from questionnaire data. A multivariate conditional logistic regression model and subgroup analysis were using to assess the association between RBC folate and BPH.Results647 males from four survey cycles in the NHANES2001-2008, of which, 574 men (88.7%) had BPH. After adjusting for potential confounders, a considerable correlation was observed between RBC folate and BPH; With the first quintiles of RBC folate as the reference, multivariable-adjusted odds ratios (ORs) and confidence intervals (95% CIs) of the second, third, fourth, and the highest quintiles were 1.19 (0.58 similar to 2.44), 1.39 (0.65 similar to 2.97), 2.27 (0.96 similar to 5.39), 2.26 (1.35 similar to 3.76) and 5.37 (1.85 similar to 15.59), respectively.ConclusionsIndividuals with high levels of RBC folate were associated with an increased risk of self-reported benign prostatic hyperplasia of US men.

Background: Benign prostatic hyperplasia (BPH) is a common disease in older men worldwide. However, there is currently no effective treatment for BPH. Bushen Tongluo Formula (Kidney-supplementing and collaterals-unblocking formula [KCF]) is a traditional Chinese medicine formula commonly used to ameliorate the symptoms of BPH, although the specific molecular mechanisms remain unclear. Purpose: We aimed to discover the effects and potential mechanisms of KCF against BPH. Methods: Sixty male SD rats were randomly assigned to one of six group (n = 10): control, low-dosage KCF, medium-dosage KCF, high-dosage KCF, BPH model, and finasteride. A rat model of BPH was established by surgical castration followed by subcutaneous injection of testosterone propionate (TP) for 4 weeks. After treatment, the prostate index, histopathological staining, serum levels of estradiol (E2) and dihydrotestosterone (DHT), protein/mRNA levels of E-cadherin, TGF-beta 1, caspase-3, Ki67, and vimentin, abundances of serum metabolites, and the proliferation, cell cycle, and apoptosis of BPH-1 cells were documented. Results: KCF treatment for 4 weeks reduced the prostate volume and prostate index, alleviated histopathological changes to the prostate of rats with TP-induced BPH, decreased serum levels of E2 and DHT, reduced protein/mRNA levels of TGF-beta 1 and vimentin, and increased E-cadherin levels. Moreover, KCF-spiked serum inhibited proliferation of BPH-1 cells, blocked the cell cycle, and promoted apoptosis. KCF was also found to regulate the contents of three metabolites (D-maltose, citric acid, and fumaric acid). Conclusion: The present study was the first to report that KCF exhibited therapeutic effects against BPH by regulating energy metabolism and inhibiting epithelial-mesenchymal transition in prostate tissues. Hence, KCF presents a viable treatment option for BPH.

象思维在中医理论体系的建构中起关键作用.文中运用观物取象、取象比类思维模式,溯源中医学对前列腺的认识,引入"精室""男子胞"的概念,对于发展中医藏象学说具有重要意义;运用象模型,参考现代医家对良性前列腺增生的认识,将其病机概括为"肾气不足,正虚为本""因虚致实,痰瘀互结""久病入络,瘀阻成癥";结合药物法象理论和现代研究结果,阐述课题组经长期实践总结的有效复方"康泉方",全方紧扣病机、药精力专,可作为临床治疗良性前列腺增生的核心组方.

历代医家对于血脉与经络的关系,众说纷纭,缺乏清晰明朗的阐释,造成后人认识及应用上的诸多混淆.通过对血脉、经络理论进行深入剖析,区分血脉和经络,进一步对其进行源流推演,明确古代医家通过解剖审视血脉,运用意象思维管窥经络.同时在哲学体用观的指导下,确立血脉理论的方法论规则为"由体而得用",即血脉以血、脉为体,以血为用;经络理论的方法论规则为"由用而得体",即经络以血气为体,以气为用.

Background: Nonalcoholic fatty liver disease (NAFLD) is a common liver disease highly associated with metabolic diseases and gut dysbiosis. Several clinical trials have confirmed that fructooligosaccharides (FOSs) are a viable alternative treatment for NAFLD. However, the mechanisms underlying the activities of FOSs remain unclear.Methods: In this study, the effects of FOSs were investigated with the use of two C57BL/6 J mouse models of NAFLD induced by a high-fat, high-cholesterol (HFHC) diet and a methionine-and choline-deficient (MCD) diet, respectively. The measured metabolic parameters included body, fat, and liver weights; and blood glucose, glucose tolerance, and serum levels of glutamate transaminase, aspartate transaminase, and triglycerides. Liver tissues were collected for histological analysis. In addition, 16 S rRNA sequencing was conducted to investigate the effects of FOSs on the composition of the gut microbiota of mice in the HFHC and MCD groups and treated with FOSs.Results: FOS treatment attenuated severe metabolic changes and hepatic steatosis caused by the HFHC and MCD diets. In addition, FOSs remodeled the structure of gut microbiota in mice fed the HFHC and MCD diets, as demonstrated by increased abundances of Bacteroidetes (phylum level), Klebsiella variicola, Lactobacillus gasseri, and Clostridium perfringens (species level); and decreased abundances of Verrucomicrobia (phylum level) and the Fissicatena group (genus level). Moreover, the expression levels of genes associated with lipid metabolism and inflammation (i.e., ACC1, PPAR gamma, CD36, MTTP, APOC3, IL-6, and IL-1 beta) were down-regulated after FOS treatment.Conclusion: FOSs alleviated the pathological phenotype of NAFLD via remodeling of the gut microbiota composition and decreasing hepatic lipid metabolism, suggesting that FOSs as functional dietary supplements can potentially reduce the risk of NAFLD.

阿尔兹海默症（Alzheimer's disease，AD）具有很高的致死率和致残率，现已成为美国人口十大死亡原因之一。经联合国预测，AD的患病率将来很可能主要在中国和印度等发展中国家增加。而AD尚无有效防治方法，AD的发病机理也复杂多样，其中，氧化应激学说和胆碱能缺失学说与AD的发生发展密切相关。天然抗AD药物，被这两种学说引导的，陆生微生物和植物是其集中来源。笔者现从微生物菌群对AD的影响进行综述，说明延缓衰老，健康饮食，炎症的控制对AD的重大意义。

目的 观察益肾生精颗粒对肾阳虚型少弱精子症患者的疗效.方法 将110例少弱精子症患者随机分成治疗组和对照组各55例,治疗组服用益肾生精颗粒,对照组服用左卡尼汀口服液,疗程均为3个月,观察2组治疗前后的精液指标以及性激素水平的变化.结果 治疗组治疗后精子浓度、存活率、总活力及前向运动精子明显优于治疗前(P<0.01);对照组治疗后存活率、总活力及前向运动精子优于治疗前(P<0.05);治疗组治疗后精子浓度提升明显优于对照组(P<0.01),治疗组治疗后精子存活率、总活力及前向运动精子改善也比对照组治疗后好(P<0.05);治疗组治疗后睾酮值明显高于治疗前(P<0.01),雌激素值治疗后低于治疗前(P<0.05),黄体生成素、卵泡刺激素及泌乳素值治疗前后比较变化不明显(P>0.05);对照组睾酮、雌激素、黄体生成素、卵泡刺激素及泌乳素值治疗前后比较变化不明显(P>0.05).结论 自拟方益肾生精颗粒治疗肾阳虚型少弱精子症有较好的临床疗效,能明显提高患者的精子总活力、存活率、前向运动精子及浓度,效果明显比左卡尼汀口服液好.运用益肾生精颗粒治疗肾阳虚型少弱精子症,疗效确切,没有明显不良反应,值得临床上进一步推广和使用.

目的 探析闽西南地区早泄患者的中医体质特征,了解其体质分布的特点,探索中医治疗早泄的新思路.方法 收集早泄患者486例,并以备孕育龄正常男性200例为对照组,对两组进行中医体质辨识,分析两组的中医体质构成特点.结果 两组体质构成有显著性差异(P<0.001);早泄组平和质和偏颇体质与对照组比较有显著性差异(P<0.001);早泄组单一偏颇和混合偏颇质与对照组比较无明显差异(P>0.05);早泄组偏颇体质与平和质比较有显著性差异(P<0.001);早泄组混合偏颇体质与单一偏颇体质比较有显著性差异(P<0.001).阳虚质、湿热质、气虚质3种体质类型占单一偏颇体质的67.92％;湿热痰湿质、湿热阳虚质、湿热阴虚质、气虚阳虚质、湿热气虚质5种体质类型占混合偏颇体质的58.26％.结论 闽西南地区早泄患者以偏颇体质为主;偏颇体质中以混合偏颇体质为主;单一偏颇体质以阳虚质、湿热质、气虚质为主;混合偏颇体质以湿热痰湿质、湿热阳虚质、湿热阴虚质、气虚阳虚质、湿热气虚质为主.湿热复合类体质为主要的混合偏颇体质类型.临床上诊治早泄宜辨体、辨病、辨证三者相结合,以适应复杂的临床要求.

BACKGROUND:Kangquan Recipe (KQR) is a traditional Chinese medicine compound made by our research group for the treatment of benign prostatic hyperplasia (BPH). Whether KQR can treat BPH as a single drug or play a role in the treatment of BPH in combination therapy needs further study. AIM OF THE STUDY:To investigate the effect of KQR on the expression of TGF-β/Smad signaling pathway-related factors in rats with BPH. In-depth analysis revealed the relevant signal transduction mechanism by which KQR acts to treat BPH. MATERIALS AND METHODS:Forty-eight male Sprague-Dawley rats were randomly divided into six groups of 8 rats each. In addition to the control group, 40 rats were castrated and then injected with testosterone propionate to form a prostatic hyperplasia model. After 30 days, three groups received different concentrations of KQR (14 g/kg, 7 g/kg, and 3.5 g/kg), and the finasteride group received 0.5 mg/kg finasteride. The BPH group and the control group received the same volume of saline. All groups were treated for a total of 30 days. Rat body weight, prostate volume, wet weight, index, histology, and the mRNA and protein levels of TGF-β, TGF-βR1, TGF-βR2, p-Smad2, p-Smad3, BAMBI, E-cadherin, and N-cadherin in the prostate tissue were measured after the end of treatment. RESULTS:Compared with the control group, the BPH group had increased prostate wet weight, volume, and index, and the histology showed significant BPH. Compared with the BPH group, the three KQR groups and the finasteride group all had varying levels of reduction in the prostate wet weight, volume, and index of the prostate and varying degrees of improvement in the histological manifestations of BPH. KQR downregulates the mRNA and/or protein expression of TGF-β, TGF-βR1, TGF-βR2, p-Smad2, p-Smad3, and N-cadherin protein in prostate tissue and increases the mRNA and protein expression of BAMBI and E-cadherin protein. CONCLUSIONS:In the model of BPH induced by testosterone propionate after castration, KQR can inhibit the conduction of the TGF-β/Smad signaling pathway by upregulating the expression of BAMBI protein and reversing EMT in rat prostate tissue.

Introduction: Kawasaki disease (KD) is an acute febrile and eruptive disease with systemic vasculitis of unknown etiology presenting predominantly in early childhood, most commonly in those under 5 years old. Although KD has been reported in almost all populations, it is especially common in North East Asia such as Japan, Korea and Taiwan which has the highest incidence worldwide that in contrast to the US, Europe and Australia. It is reported that more than 1 in 100 Japanese have had KD by 12 years of age. KD is a potentially life-threatening condition because it can cause serious pediatric-acquired heart disease such as asymptomatic coronary artery ectasia or an aneurysm. Intravenous immunoglobulin (IVIG) is a routine and effective treatment for KD and significantly reduces risk of coronary artery abnormalities during the acute phase of illness from approximately 15%-25% to 5%-8%. In spite of its effectiveness, some patient do not respond to this therapy and still develop coronary aneurysms. Chinese herbal medicine (CHM) as a therapy alone for KD was rare. The success of this patient with KD treated by CHM provided a new way of thinking for harmonizing Eastern-Western drug for KD and the potential utilization of CHM as a source of new drugs could be an alternative. Clinical features and outcome: A 17 month-old boy suffered from persistent fever, poor appetite, vomiting diarrhea, slight cough, running nose and throat congestion for 2 days and was diagnosed with an upper respiratory infection. He had taken cefprozil suspension plus ankahuangmin 2 days for his symptoms before his final diagnosis of KD, but it was unsuccessful. He continued to have a fever, in addition, he presented with bilateral bulbar conjunctival congestion without exudate, labial and lingual erythema and was diagnosed with KD before his first CHM visit, his parents refused to continue receiving Western medicine. Therefore, his parents sought CHM for further intervention. His symptoms subsided, and the blood tests, electrocardiogram (ECG) and echocardiographies show completely normal after regular therapy with Xiao Chai Hu Tang combined with Bu Yang Huan Wu Tang , Huang Lian Jie Du Tang , and Wu Ling San for approximately 21 days. Neither complications nor side-effects were noted during the CHM treatment. Conclusions: In this case, CHM may be an effective alternative therapy for the treatment of KD, and furthermore, may also be applied as an option to salvage failed intravenous immunoglobulin procedures. Further controlled trials are warranted to determine whether this is an effective treatment option for other cases of KD.

Alzheimer’s disease (AD) is the most common neurodegenerative disorder associated with aging. There are currently no effective treatments for AD. Bazhu decoction (BZD), a traditional Chinese medicine (TCM) formula, has been employed clinically to alleviate AD. However, the underlying molecular mechanisms are still unclear. Here we found that middle- and high-doses of BZD ameliorated the behavioral aspects of 5xFAD transgenic mice in elevated plus maze, Y maze and Morris water maze tests. Moreover, BZD reduced the protein levels of BACE1 and PS1, resulting in a reduction of Aβ plaques. We also identified a beneficial effect of BZD on oxidative stress by attenuating MDA levels and SOD activity in the brains of 5xFAD mice. Together, these results indicate that BZD produces a dose-dependent positive effect on 5xFAD transgenic mouse model by decreasing APP processing and Aβ plaques, and by ameliorating oxidative damage. BZD may play a protective role in the cognitive and anxiety impairments and may be a complementary therapeutic option for AD.

Gypenosides (GP) are a type of traditional Chinese medicine (TCM) extracted from plants and commonly applied for treatment of metabolic diseases. This study aims to explore the effects of GP extracts on alleviating non-alcoholic fatty liver disease (NAFLD). In this experiment, C57BL/6 J mice were randomly assigned into normal diet control (ND), HFHC (high-fat and high-cholesterol) and HFHC + GP (GP) groups. Mice in HFHC group were fed HFHC diet combined with fructose drinking water for 12 weeks to induce the animal model of NAFLD, followed by ordinary drinking water until the end of the experiment. In the HFHC + GP group, mice were fed HFHC diet combined with fructose drinking water for 12 weeks, followed by GP-containing drinking water till the end. Mouse body weight was measured weekly. After animal procedures, mouse liver and serum samples were collected. It is shown that GP administration reduced body weight, enhanced the sensitivity to insulin resistance (IR) and decreased serum levels of ALT, AST and TG in NAFLD mice. In addition, GP treatment alleviated steatohepatitis, and downregulated ACC1, PPARγ, CD36, APOC3 and MTTP levels in mice fed with HFHC diet. Furthermore, GP treatment markedly improved intestinal microbiota, and reduced relative abundance ratio of Firmicutes / Bacteroidetes in the feces of NAFLD mice. Our results suggested that GP alleviated NAFLD in mice through improving intestinal microbiota.

康泉方是笔者课题组长期临床实践总结的有效治疗良性前列腺增生(benign prostatic hy-perplasia,BPH)的自拟中药复方.本文通过阐述康泉方组方特色与中医治疗BPH理论的契合点,并结合康泉方的实验和临床研究成果,总结分析康泉方治疗BPH的中医思路.整体而言,康泉方具有补益肾精、化瘀通络、清热解毒、通利水道的功效,补肾不留邪,驱邪不伤正,希冀能够对临床中医药治疗前列腺增生有所启迪和借鉴.

目的 对厦门市207例疲劳性亚健康状态者应用疲劳量表-14(FS-14)进行调查分析,并初步了解不同中医证候及体质类型的疲劳状况.方法 采取调查问卷的方法,方便选取于2015年6月—2017年3月对在厦门大学附属第一医院及厦门大学附属中山医院就诊的207例疲劳性亚健康状态者,进行疲劳量表-14(FS-14)评分及分析.得分按疲劳总分(TF)、躯体疲劳(PF)、脑力疲劳(MF)分别记录.结果 ①不同性别比较:男性TF(8.34±2.61)分,女性TF(8.23±2.63)分;不同性别的FS-14评分差异无统计学意义(t=0.302,P>0.05).② 不同婚姻状况者比较:已婚者TF(8.44±2.64),未婚者TF(7.69±2.45)分;不同婚姻状况者FS-14评分差异无统计学意义(t=1.800,P>0.05).③不同体检结果者比较:体检结果部分指标异常者TF(8.82±2.07)分,MF(2.88±1.26)分高于体检结果完全正常者TF(8.01±2.81)分,MF(2.22±1.69),差异无统计学意义(t=2.336,3.177,P<0.05).④不同受教育程度者比较:受教育程度初中及以下者TF(10.53±2.29)分,PF(6.73±1.10)分,MF(3.80±1.66)分,得分最高,与其他受教育程度者得分差异有显著性(F=5.719,F=4.159,F=4.656;P<0.01).⑤不同季节比较:春季TF(8.58±2.90)分,PF(5.96±1.66)分,MF(2.64±1.81)分,春季得分最高,但四季差异无显著性(F=0.562,F=0.634,F=0.705,P>0.05).⑥不同中医证型比较:心脾两虚型TF、PF最高(10.10±2.96)分,(6.90±1.10)分,肺脾气虚型MF最高(4.00±1.00)分,但各证型得分差异无统计学意义(P>0.05).⑦不同偏颇体质比较:特禀质MF(4.00±0.82)分,湿热质MF(3.35±1.41)分,阳虚质MF(3.20±1.92)分,这3项高于其他体质,差异有统计学意义(F=2.001,P<0.05).结论 体检结果部分指标异常者,虽未达到疾病的诊断标准,机体已出现机能失调,疲劳的症状更为明显.与中医学认为亚健康状态是"机体阴阳失衡、气血失调、脏腑功能失和"的观点是一致的.不同教育程度及不同偏颇体质的疲劳特点有所不同,可以通过提高人群健康素养、调理中医体质等方面进行疲劳性亚健康干预.

目的 对厦门市207例疲劳性亚健康状态者进行调查,分析这一群体的中医证候类型分布及体质特点,为建立适合本地区的疲劳性亚健康状态者的中医药干预手段提供依据.方法 根据《亚健康中医临床指南》《亚健康临床指南》,采取调查问卷对厦门市207例疲劳性亚健康状态者进行中医证候资料收集,并进行中医辨证及体质辨识.结果 (1)共收集到12种证候类型,按频率由高到低排序前五位依次为:脾虚湿困型31.9％,肝郁脾虚型16.4％,湿热蕴结型11.6％,气血两虚8.2％,气虚血涩7.7％.(2)共辨识10种中医体质类型,平和体质1例(0.5％),偏颇体质206例(99.5％);偏颇体质按频率由高到低排序前五位依次为:痰湿质32.9％,气虚质21.3％,气郁质15.5％,阴虚质9.2％,湿热质8.2％,痰湿质最高.结论 厦门市207例疲劳性亚健康状态者的中医证型及体质分布具有本地区特点,可以为建立适合本地区特点的中医药干预手段提供依据.

Acupuncture and moxibustion proved to be very effective in chronic atrophic gastritis (CAG). According to the Chinese traditional medicine theory, chronic diseases have an influence on the function of liver and kidney. However, there is little research to demonstrate this theory. This study is aimed at assessing the 1H NMR-based metabolic profiling in liver and kidney of CAG rats and comparing the difference between electroacupuncture and moxibustion treatment. Male SD rats were subjected to CAG modeling by intragastric administration of mixture of 2% sodium salicylate and 30% alcohol coupled with compulsive sporting and irregular fasting for 12 weeks and then treated by electroacupuncture or moxibustion at Liangmen (ST 21) and Zusanli (ST 36) acupoints for 2 weeks. A 1H NMR analysis of liver and kidney samples along with histopathological examination and molecular biological assay was employed to assess and compare the therapeutic effects of electroacupuncture and moxibustion. CAG brought characterization of metabolomic signatures in liver and kidney of rats. Both electroacupuncture and moxibustion treatment were found to normalize the CAG-induced changes by restoring energy metabolism, neurotransmitter metabolism, antioxidation metabolism, and other metabolism, while the moxibustion treatment reversed more metabolites related to energy metabolism in liver than electroacupuncture treatment. CAG did have influence on liver and kidney of rats. Both of these treatments had good effects on CAG by reversing the CAG-induced perturbation in liver and kidney. For regulating the energy metabolism in liver, the moxibustion played more important role than electroacupuncture treatment.

目的 探讨返流性食管炎(肝胃不和型)采取中医宏观辨证结合微观辨证治疗的临床效果.方法 研究对象取2014年1月12日～2017年6月8日我院66例反流性食管炎(肝胃不和型)患者,根据不同治疗方案分为两组.两组均实施基础治疗,在此基础上对照组予以中医宏观辨证治疗,观察组予中医宏观辨证结合微观辨证治疗.观察两组临床效果.结果 观察组总有效率为90.91％,显然高于对照组的69.70％,P<0.05.结论 在反流性食管炎(肝胃不和型)治疗中,中医宏观辨证结合微观辨证效果较佳,可有效控制患者病情.