OBJECTIVE:To evalue the utilization of fluoroquinolones in a third-grade class-A infectious disease hospital after the implementation of intervention measures. METHODS:The utilization of fluoroquinolones in the hospital in Mar.,Apr.,Oct. and Dec. during 2007-2012 were analyzed retrospectively in terms of DDDs and AUD. RESULTS:The DDDs of fluoroquinolones decreased from 2 132 in the 4 months of 2007 to 615 in those of 2012;and AUD fell to 0.92 DDDs/100 persons/day in 2012 from 4.64 DDDs/100 persons/day in 2007;the proportion of hospitalized patients administrated with fluoroquinolones decreased from 14.85% in 2007 to 2.36% in 2012,decreasing by 84.10%. The consumption sum of fluoroquinolones decreased by 75.52%,and DDC of that decreased from 2.62 yuan in 2007 to 0.44 yuan in 2012,decreasing by 83.20%. The AUD of whole hospital by DDDs/ 100 outpatient-services and by DDDs/100 hospitalization day showed good correlation with statistical significance(r=0.99,P 0.05). The DDDs and AUD of fluoroquinolones in Oct. and Dec. were lower than in Mar. and Apr. of same year. CONCLUSIONS: With the intervention measures,combined with effective hospital infection control,the reduction of fluoroquinolones consumption is progressive,stable and obvious.

OBJECTIVE To continuously evaluate nosocomial infections in gastroenterological units of an infectious disease hospital.METHODS The incidence of nosocomial infections(NIs) in gastroenterological units from Jan 2007.to Dec 2008.was prospectively surveyed.RESULTS All 4343 cases were involved during the surveillance,of which 394 patiend acquired NIs.And the average incidence of NIs was 3.030 cases per 1000 admitted patient-day.457 case-times attacked,the case-times incidence of NIs was 3.515 case-times per 1000 admitted patient-days.The more frequent NI sites were spontaneous bacterial peritonitis(SBP,23%),blood stream infection(BSI,20%),upper respiratory tract infection(URTIs,20%) and lower respiratory tract infection(LRTIs,17%),which accounted to 80% of NIs.Nosocomial LRTIs or BSI were the two leading causes of death assoliated with Nis.The NI incidence in a unit mainly admitting liver failure was the highest 5.02‰,in which BSI 1.65 and 1.08‰ were the highest also.CONCLUSION Respiratory tract infection,SBP and BSI are the major NI of infectious disease hospital on the Chinese traditional infectious disease isolation and prevention strategy.The mortality is higher among patients with nosocomial LRTIs and BSI than other NIs.

目的:评价抗菌药物管理策略对医院内抗菌药物使用影响.方法:2006-2008年间建立抗菌药物合理使用指导小组、推进感染控制计划、制定针对性的抗菌药物使用指南、展开教育培训、推行前瞻性抗菌药物使用监测、对临床抗菌药物使用的支持指导与反馈等.结果:咪唑类、抗真菌类、氟喹诺酮类、第三代头孢菌素和含酶抑制剂的β-内酰胺类的收治患者人均使用频度降幅排在前列.同时常用的非限制使用的一线药物使用构成比例增加,包括β-内酰胺霉敏感青霉素类、大环内酯类、第二代头孢菌素、四环素类、氨基糖苷类、磺胺类排在前列.医院抗菌药物使用量逐年递减,持续效果显著.结论:系统而有效的抗菌药物管理机制是抗菌药物合理使用的重要保障.