OBJECTIVE:To evalue the utilization of fluoroquinolones in a third-grade class-A infectious disease hospital after the implementation of intervention measures. METHODS:The utilization of fluoroquinolones in the hospital in Mar.,Apr.,Oct. and Dec. during 2007-2012 were analyzed retrospectively in terms of DDDs and AUD. RESULTS:The DDDs of fluoroquinolones decreased from 2 132 in the 4 months of 2007 to 615 in those of 2012;and AUD fell to 0.92 DDDs/100 persons/day in 2012 from 4.64 DDDs/100 persons/day in 2007;the proportion of hospitalized patients administrated with fluoroquinolones decreased from 14.85% in 2007 to 2.36% in 2012,decreasing by 84.10%. The consumption sum of fluoroquinolones decreased by 75.52%,and DDC of that decreased from 2.62 yuan in 2007 to 0.44 yuan in 2012,decreasing by 83.20%. The AUD of whole hospital by DDDs/ 100 outpatient-services and by DDDs/100 hospitalization day showed good correlation with statistical significance(r=0.99,P 0.05). The DDDs and AUD of fluoroquinolones in Oct. and Dec. were lower than in Mar. and Apr. of same year. CONCLUSIONS: With the intervention measures,combined with effective hospital infection control,the reduction of fluoroquinolones consumption is progressive,stable and obvious.

目的分析传染病医院检出的产超广谱β内酰胺酶(ESBLs)大肠杆菌和肺炎克雷伯菌的流行规律。方法收集2006年1月～2011年3月某传染病医院微生物室感染者标本中培养出的非重复的产ESBLs大肠杆菌和肺炎克雷伯菌,应用Eviews 5软件建立时间序列自回归差分平均移动模型。结果 2006～2010年产ESBLs大肠杆菌和肺炎克雷伯菌每月流行强度呈右偏态分布,中位数为0.162株/千住院日(最小值为0株/千住院日,最高值0.952株/千住院日),发生趋势呈轻微上升(斜率>0,P=0.019 0)。排除惟一一个收治除病毒性肝炎以外法定传染病病房检出产ESBLs细菌后,趋势平稳(斜率>0,P=0.662)。时间序列求和自回归平均移动模型(ARIMA)(0,0,2)较好的拟合了产ESBLs大肠埃希菌、肺炎克雷伯菌的流行趋势,用该模型对2011年1、2、3月份进行预测,误差为8.41%。结论该院产ESBLs肠杆菌流行趋势总体平稳。时间序列ARIMA模型可用于对医院耐药菌流行的监测和预测。

近年来,笔者应用桃红四物汤口服加阴道局部用药治疗输卵管阻塞性不孕45例,并与单用桃红四物汤治疗者进行对照比较.现报告如下.

2000年4月至2003年4月,我们应用自制中药除早定心汤辅助治疗早搏患者100例,取得满意疗效.现报告如下.

2000年5月-2002年5月我们采用中医治疗80例慢性咽炎,收到满意疗效,报告如下.