Objective To detect the secretion level of interleukin-12(IL-12) and interleukin-23(IL-23) in the vaginal of vulvovaginal candidiasis patients and to investigate their relationship with the pathogenesis of varying degree of vulvovaginal candidiasis.Methods The level of the IL-12p70 and IL-23p19 in the vaginal secretion from vulvovaginal candidiasis patients were detected by ELISA and compared with that from normal controls.Results The vaginal secretion level of IL-12 p70 and IL-23p19 in varying degree of serious vulvovaginal candidiasis were lower than that in normal control group and there were statistical differences between the four groups (P0.05);the level of IL-12 p70 in severe vulvovaginal candidiasis group and recurrent vulvovaginal candidiasis group were lower than that in control group (P0.05);the level of IL-23 p19 in recurrent vulvovaginal candidiasis group was lower than that in control group (P0.05).Conclusion The abnormal secretion of the IL-12 and IL-23 cytokines might participate in the pathogenesis,severity and the recrudescence of vulvovaginal candidiasis.

为了解Doula分娩对产妇分娩方式和新生儿的影响,选择2002年3月～7月住院的正常足月产妇220例作为Doula组,并与2001年住院的正常足月产妇220例进行比较观察.结果,220例Doula分娩产妇的剖宫产率、新生儿窒息发生率明显低于对照组(P＜0.05).认为Doula分娩可以降低剖宫产率,减少围产儿窒息率,使顺产率大大提高.

为探讨水针疗法分娩镇痛的疗效及对母儿的影响,将100例产妇随机分为观察组和对照组,观察组产妇宫口开大3cm以上进入活跃期后选择第五腰椎棘突旁开2cm,向下2cm,四点皮内注入注射用水0.5ml,观察组不予处理,观察两组镇痛效果、产程时间、分娩方式、产时出血量及新生儿Apgar评分等情况.结果观察组镇痛效果总有效率达88%,高于对照组,差异有极显著性(P＜0.01).观察组第一产程及总产程时间均短于对照组(P＜0.05),产时出血量少于对照组(P＜0.05).两组分娩方式及对新生儿影响均无差异(P＞0.05).认为水针疗法用于分娩镇痛有一定疗效且方法简单易行,对母儿无影响,值得产科推广应用.

Objectives To research the effective does of estngen on preventing the postmen opausal osteoporosis or the isteioirisis women who received gysterectomy and ovariectomy.Methods 120 patients were given different does of estrogen and had been visited for two years in orden to study the of Serum Calciun and phosphorus and the density of bone.Results To the group of estrogen 0.625mg/day and 1.25mg/day,the of serum Calcium and phosphorus significantly decreased.The group of more lower dose of estrogen the losed bone was significant in(P＜0.01)。Conclusions Estrogen 0.625mg day can Prevent Postmenopausal osteoporosis,the effect of more lower dosage is not as good as the precious one.at the same time the followmg visit and safety check are needed.

Objective: To evaluate the outcome of fetus with abnormal S/D index under the clinical situations of pregnant hypertension, intrauterine growth retardation (IUGR), umbilical twine and fetal distress. Methods: The systolic/diastolic peak values(S/D index) of umbilical arterial blood flow of 600 pregnant women were measured using instrument SRF 608. Results: When the ratio of S/D reached≥90th%, the abnormality is considered over contrasting with normal pregnant women. S/D index≥90th% of gravida with hypertension, IUGR, umbilical twine and fetal distress were significantly higher than that of the normal control group (P0.01). However, the incidence of newborn asphyxia in abnormal gravida was significantly higher than that of normal gravida. Conclusion: Test of arterial S/D ratio is of important role in dealing with patients and evaluating the fetal prognosis.

为了解妊娠期糖尿病患者产后糖尿病的发生率及其高危因素,随访分析复查28例曾患妊娠期糖尿病患者,经口服75g葡萄糖耐量试验检查,按1980年WHO糖尿病诊断标准分组,同时对各组相关因素进行比较.12例(42.86%)发展为糖尿病(DM),其中4例(14.28%)在产后42天内明确诊断,10例(35.71%)糖耐量异常(IGT),6例(21.43%)正常;与IGT组、正常组相比,DM组妊娠期糖尿病确诊孕周明显提前(P<0.05).结果提示妊娠期糖尿病患者是Ⅱ型糖尿病的高危人群,产后应定期随访,以便及早诊断糖尿病.

Objective:To investigate the clinical effect of Gonadotropin-releasing hormone (GnRH)on inducing ovulation.Methods:Twenty four anovulated infertile women were injected GnRH,among them 15 infertilers were performed GnRH stimulating test before inducing ovulation.Results:Twelve cases respanses with GnRH stimulating test were normal and ovulated,2 cases showed hyperreaction;ovulation rate was 87.50%(21/24),pregnancy rate 29.17%(7/24),4 cases experinced term labor,2 cases were in pregnancy over 6 months,1-case natural abortion on day 38. Conclusions:Intramuscular injection GnRH is of economical,safe,convenient and easy popularization adventages,and therefore is an effective method of inducing ovulation.

目的:探讨妊娠期巨幼红细胞性贫血的原因,对母儿的影响及治疗.方法:对我院1996年1月1日～1998年12月31日收治住院的26%例孕产妇进行回顾性分析.结果:巨幼细胞性贫血患者20例,发生率为0.74%,Hb＜60g/L6例,＜80g/L9例,＜100g/L5例,并发妊高征5例,低蛋白血症6例,肾病综合征1例,胃溃疡出血2例,胎膜早破4例,双胎2例.共娩出新生儿22例,重度贫血致死胎1例,成活21例.结论:巨幼细胞性贫血常发生在妊娠后期,孕期加强营养,及时治疗可纠正贫血,减少并发症的发生.

分析1988～1998年妊娠合并心脏病118例临床资料,结果显示患病率1.01%,孕产妇死亡率25‰,围产儿死亡率60.3‰,两者死亡率明显高于同期非心脏病孕产妇及围产儿死亡率.因此必须加强心脏病孕产妇的产前监护,正确判断心功能情况,预防心衰发生,适时终止妊娠,可以获得良好结局.

目的探讨超声及宫颈粘液评分(CMS)在未破裂卵泡黄素化综合征(LUFS)诊断中的价值.方法应用阴道超声及CMS对26例不孕妇女31个月经周期进行连续监测.结果有7个周期发生LUFS,发生率为22.58%,5例LUFS患者有2例重复发生,再发生率40%,围排卵期CMS持续7天达15分,且下降缓慢;黄体中期血清泌乳素(PRL)水平明显高于正常排卵周期妇女(P＜0.05),孕酮降低,但无统计学差异(P＞0.05).结论黄体中期PRL的隐匿性增高可能与LUFS的发生密切相关,定期B超监测结合CMS是诊断LUFS实用和可靠的方法.