Background:Segmental bone defect is a challenging clinical problem that often requires autologous bone grafting, which has limitations such as donor site morbidity and insufficient supply. Bone tissue engineering aims to create functional bone substitutes that can mimic the properties and processes of native bone. However, the discrepancy between in vitro and in vivo conditions hinders the successful translation of bone tissue engineering from animal models to human applications. Organoids, such as muscle pouch-based models, are emerging as promising tools that can closely resemble the osteogenic niche and overcome some of the limitations of conventional in vitro models. Methods:In this study, we explored two distinct muscle-biomaterial based bone induction models: an in vivo heterotopic implantation model and a novel ex vivo muscle pouch-based coral-derived macroporous construct organoid model. They both utilized the coral-derived constructs, specifically 13 % hydroxyapatite/calcium carbonate (13 % HA/CC) as the biomaterial. We implanted 72 coral-derived devices into rats' rectus abdominis muscle, divided equally between in vivo and ex vivo groups. Samples were harvested at 15, 30, and 60 days for molecular and histological analyses. We assessed the relative gene expression of angiogenesis markers (Vegfa and Col4a1) and osteogenesis signaling and structural markers (Runx2, Bmp2, Ocn and Alp) using qRT-PCR. We analyzed tissue morphogenesis, angiogenesis and induction of bone formation by H&E and modified Goldner's Trichrome staining. Immunostaining was further used to detect the expression and localization of OCN, VEGFA and CD31 in both in vivo and ex vivo models. Results:We demonstrated that ex vivo muscle pouch-based coral-derived macroporous construct organoid model supported tissue survival up to 60 days with compromised tissue ingrowth compared to the in vivo model. Primary vascular structures formed at the tissue-scaffold interface in the organoid system with persistent up-regulation of Vegfa and Col4a1, while comprehensive angiogenesis took place with early up-regulation of Vegfa and Col4a1 in vivo. Proper bone formation was absent in both the ex vivo and in vivo models, but the in vivo models showed an up-regulation of Bmp2 and Alp in early phase and a delayed Ocn expression on day 30. The ex vivo model showed connective tissue formation, comprehensive OCN deposition, and gene expression patterns mimicking in vivo trends but with some distinctions. Conclusions:The ex vivo muscle pouch-based coral-derived macroporous construct organoid model in this study can partially recapitulate angiogenesis and osteogenesis as compared to the in vivo model. However, key molecular signaling events that regulate these processes remained inactive. The study demonstrated that activating these events could enable the establishment of an ex vivo tissue-based vascularized model. The translational potential of this article:This study partly elucidated the molecular signaling events involved in the development of an ex vivo tissue-based osteogenic organoid that closely resembled its in vivo counterpart. This would facilitate the development of well vascularized artificial bone grafts for treating segmental bone defects.

目的 比较机器人辅助与传统手术治疗股骨转子间骨折的疗效.方法 本研究为前瞻性随机对照研究,共纳入2021年1月至2022年6月在上海交通大学医学院附属仁济医院创伤骨科接受手术治疗的股骨转子间骨折患者50例,机器人辅助组25例,其中男9例,女16例;年龄53～86岁,平均(71.6±9.5)岁.传统手术组25例,其中男13例,女12例;年龄51～85岁,平均(72.4±11.0)岁.机器人辅助组在天玑骨科机器人辅助下置入拉力螺钉,传统手术组以常规手术方式置入拉力螺钉.记录两组患者拉力螺钉导针穿刺次数、拉力螺钉置入过程透视次数、术中出血量、手术时间等.术后记录两组患者尖顶距(tip-apex distance,TAD)及拉力螺钉位置优良率,术后完成12个月随访,记录髋关节功能评分及并发症发生情况.结果 机器人辅助组TAD值为(13.70±1.91)mm,传统手术组为(15.77± 2.57)mm,两组比较差异有统计学意义(P=0.002);机器人辅助组拉力螺钉位置优良率为100％,传统手术组为72％,两组比较差异有统计学意义(P=0.004).在拉力螺钉置钉过程中,机器人辅助组导针穿刺次数为(1.0±0.2)次,传统手术组为(2.3±1.2)次,两组比较差异有统计学意义(P＜0.001);机器人辅助组透视次数为(4.4±0.6)次,传统手术组为(5.4±1.2)次,两组比较差异有统计学意义(P=0.001).两组患者手术时间、术中出血量、术后12个月髋关节功能评分差异无统计学意义(P＞0.05).结论 机器人辅助定位可以提高股骨转子间骨折手术中拉力螺钉置入的精确度并减少术中穿刺及透视造成的损伤.

Purpose:Delayed skin healing in diabetic wounds is a major clinical problem. The tRNA-derived small RNAs (tsRNAs) were reported to be associated with diabetes. However, the role of tsRNAs in diabetic wound healing is unclear. Our study was designed to explore the tsRNA expression profile and mine key potential tsRNAs and their mechanism in diabetic wounds.Methods:Skin tissues of patients with diabetic foot ulcers and healthy controls were subjected to small RNA sequencing. The role of candidate tsRNA was explored by loss- and gain-of-function experiments in HUVECs.Results:A total of 55 differentially expressed tsRNAs were identified, including 12 upregulated and 43 downregulated in the diabetes group compared with the control group. These tsRNAs were mainly concentrated in intercellular interactions and neural function regulation in GO terms and enriched in MAPK, insulin, FoxO, calcium, Ras, ErbB, Wnt, T cell receptor, and cGMP-PKG signaling pathways. tRF-Gly-CCC-039 expression was upregulated in vivo and in vitro in the diabetic model. High glucose disturbed endothelial function in HUVECs, and tRF-Gly-CCC-039 mimics further harmed HUVECs function, characterized by the suppression of proliferation, migration, tube formation, and the expression of Coll1a1, Coll4a2, and MMP9. Conversely, the tRF-Gly-CCC-039 inhibitor could attenuate high-glucose-induced endothelial injury to HUVECs.Conclusion:We investigated the tsRNAs expression profile in diabetic foot ulcers and defined the impairment role of tRF-Gly-CCC-039 in endothelial function in HUVECs. This study may provide novel insights into accelerating diabetic skin wound healing.

Background: The early recovery of hip function after hip fracture surgery values more attention, especially for patients with delayed surgery of longer than 48 h. We aim to evaluate the associations of in-hospital surgical waiting time with the functional outcomes [Harris Hip Score (HHS), Parker Mobility Score (PMS), and EuroQol 5 dimensions VAS (visual analogue scale) score (EQ-5D VAS)] in elderly patients who sustained hip fractures. Materials and methods: Data on sociodemographic and clinical factors were prospectively collected using a multicenter hip fracture registry system. Participants in the cohort underwent a 12-month follow-up investigation. After adjusting potential confounders identified by the directed acyclic graphs, the associations between surgical waiting time longer than 48 h and functional outcomes were estimated by log-binomial regression and multivariable linear regression models with generalized estimating equations. Results: Of 863 survival participants with available functional data at 12 months after surgery, an increased risk was obtained from receiving surgery after 48 h and the poor functional outcomes (HHS<80: relative risk (RR)=1.56, 95% CI: 1.00-2.51; PMS<7: RR=1.49, 95% CI: 1.13-2.01; EQ-5D VAS<80: RR=1.97, 95% CI: 1.57-2.47). In-hospital waiting time greater than 48 h were time-invariantly associated with lower PMS during recovery (-0.44 units 95% CI: -0.70 to -0.18). In addition, delayed surgery was time-varying associated with HHS and EQ-5D VAS. Conclusions: The associations between in-hospital waiting time and postoperative functional score suggest that delayed surgery can lead to poor functional outcomes, especially in patients waiting longer than 72 h from injury. Delayed surgery mainly impacted hip function and mobility recovery with a slower speed in early recovery of the first 3 months. More attention should be paid to mechanisms behind the associations between delayed surgery on general healthy status.

INTRODUCTION:Fractures of the anterior process of the calcaneus (APC) are easily overlooked in clinical practice. Most patients have good to excellent clinical outcome after conservative treatment, while some patients may have persisting symptoms and unfavorable functional outcomes. The aim of this study was to identify the risk factors associated with unfavorable functional outcome after conservative treatment in APC fractures. METHODS:All patients presenting with APC fractures and receiving conservative treatment from April 2019 to April 2020 were retrospectively assessed. The primary outcome measurement was the ankle joint function assessed using Karlsson Scoring System at 2 years post-injury. The risk factors associated with unfavorable functional outcomes (Karlsson score ≤ 80) were evaluated by logistic regression analysis. RESULTS:In total, 84 patients were included with a mean age of 40 years. 26 (31%) patients presented with unfavorable functional outcome at 2 years post-injury. In multivariate logistic regression, concomitant fractures of talonavicular (TN) joints and older age were significantly associated with unfavorable functional outcome (p<0.05). Patients with concomitant fractures of TN joints had an odds ratio of 3.623 for unfavorable functional outcome. The optimal cutoff age for an unfavorable outcome was ≥ 47.5 years, with an odds ratio of 5.010. CONCLUSION:Most patients with APC fractures achieved good to excellent results when treated conservatively. Attention should be paid to those with concomitant fractures of TN joints and with age ≥ 47.5 years, which might lead to unfavorable functional recovery. LEVEL OF EVIDENCE:IV; case series.

Fractures of the anterior process of the calcaneus (APC) are easily overlooked in clinical practice. Most patients have good to excellent clinical outcome after conservative treatment, while some patients may have persisting symptoms and unfavorable functional outcomes. The aim of this study was to identify the risk factors associated with unfavorable functional outcome after conservative treatment in APC fractures. All patients presenting with APC fractures and receiving conservative treatment from April 2019 to April 2020 were retrospectively assessed. The primary outcome measurement was the ankle joint function assessed using Karlsson Scoring System at 2 years post-injury. The risk factors associated with unfavorable functional outcomes (Karlsson score≤80) were evaluated by logistic regression analysis. Eighty-four patients were included with a mean age of 40 years. Twenty-six (31 %) patients presented with unfavorable functional outcome at 2 years post-injury. In multivariate logistic regression, concomitant fractures of talonavicular (TN) joints and older age were significantly associated with unfavorable functional outcome (p < 0.05). Patients with concomitant fractures of TN joints had an odds ratio of 3.623 for unfavorable functional outcome. The optimal cutoff age for an unfavorable outcome was ≥ 47.5 years, with an odds ratio of 5.010. Most patients with APC fractures achieved good to excellent results when treated conservatively. Attention should be paid to those with concomitant fractures of TN joints and with age ≥ 47.5 years, which might lead to unfavorable functional recovery. IV; Case series.

Background Fractures of the lateral process of the talus (LTPF) are rare and only rarely are associated ligamentous injuries. The injury mechanism is commonly considered to be similar with ankle sprains, where excessive varus of the hindfoot leads to avulsion fractures of the lateral process of the talus. However, previous cadaveric studies have suggested that LTPF was more likely to be caused by eversion or external rotation force with dorsiflexion of the ankle. But no clinical evidence has been provided. Case presentation Two patients presented to the emergency department with ankle pain after ankle eversion or external rotation. Physical examination revealed tenderness and swelling on both medial and lateral sides of the ankles. Plain radiographs and computed tomography revealed LTPF and medial soft tissue swelling, and magnetic resonance imaging confirmed a discontinuity of the deltoid ligament in Case 1. Surgical exploration revealed rupture of the superficial layer of the deltoid ligaments with intact deep layer in both patients. Treatment included fixation of the lateral process of the talus with headless compression screws and repair of deltoid ligaments. Both patients achieved excellent clinical outcomes 1 year post injury. Conclusion There are many possibilities of the injury mechanism of LTPF. These two cases provided clinical evidence that eversion or external rotation force, in addition to inversion, was also an important mechanism of LTPF.

股骨颈骨折是一种常见的髋关节骨折,内固定治疗适用于所有无移位骨折以及青壮年移位骨折.然而,术后 10%～20%患者会发生内固定失败,需行二次手术,即使骨折愈合,股骨颈短缩也非常常见,并影响患者髋关节功能.近年来,许多学者对股骨颈骨折术后并发症的高危因素和预防措施进行了深入研究,该文就股骨颈骨折内固定术后并发症研究进展进行综述.

Pilon骨折是临床较难处理的骨折之一,通常由高能量损伤引起,骨折粉碎程度高,软组织损伤重,手术切口容易出现皮肤和软组织坏死、感染及裂开等并发症.很多Pilon骨折患者合并腓骨远端骨折,手术治疗常需要做双切口,切口并发症发生率高.该文结合参考文献及作者临床工作经验,对如何处理合并腓骨远端骨折的闭合性Pilon骨折双切口及降低切口并发症发生风险进行综述.

目的 探讨"秦氏疼痛方"联合单次小剂量地塞米松治疗踝关节骨折后急性软组织损伤的临床疗效.方法 选取2019年8月至2021年3月在我院住院治疗的符合标准的踝关节骨折患者200例,通过简单随机分组将患者分为生理盐水对照组(盐水组)、地塞米松对照组(地米组)、"秦氏疼痛方"对照组(疼痛方组)及"秦氏疼痛方"联合地塞米松治疗组(联合治疗组).所有患者入院后,均给予抬高患肢、制动固定作为基础治疗,并在规定时间内对各组患者实施干预措施.比较4组患者在分组治疗前、伤后24 h、伤后48 h患肢的肢体周径差、血清炎症及创伤指标(包括IL-6、TNF-α、CK)水平、患肢张力性水疱及术后切口感染发生率.结果 伤后24 h及48 h时,地米组、疼痛方组和联合治疗组的肢体周径差均明显小于盐水组(P<0.05);伤后48 h时,联合治疗组明显小于地米组和疼痛方组(P<0.05).伤后24 h及48 h时,地米组、疼痛方组和联合治疗组的血清炎症和创伤指标(IL-6、TNF-α、CK)均明显小于盐水组(P<0.05);伤后48 h时,联合治疗组明显小于地米组和疼痛方组(P<0.05).伤后48 h时,地米组、疼痛方组和联合治疗组的张力性水疱发生率均明显小于盐水组(P<0.05),联合治疗组明显小于地米组和疼痛方组(P<0.05);在整个随访期间,各组间切口感染率差异无统计学意义(P>0.05).结论 相比单用地塞米松或单用疼痛方治疗踝关节骨折后的急性软组织损伤,疼痛方联合单次小剂量地塞米松在减轻患者的肢体肿胀程度、降低张力性水疱发生率及改善血清创伤和炎症指标方面效果更佳,且切口感染发生率并无明显增加;该中西医结合用药方案效果优于单用中药或单用西药.

Objective:To investigate the outcomes of the surgical treatment of fracture of the first metatarsal base with plantar plate via the first metatarsal medial approach.Methods:A retrospective study was conducted of the 12 patients who had been treated for fracture of the first metatarsal base from January 2016 to December 2018 at Department of Trauma Orthopaedics, Renji Hospital. They were 8 men and 4 women, with an average age of 39.6 years (from 27 to 54 years). The fracture affected the left foot in 5 cases and the right foot in 7. Their fracture of the first metatarsal base and tarsometatarsal joint instability were fixated by plantar plate via the first metatarsal medial approach, and reduction and fixation was also conducted via a dorsal incision when other metatarsotarsal joint injuries were combined. Postoperative X-ray follow-ups were performed regularly. The American Orthopedic Foot and Ankle Society (AOFAS) midfoot scores, visual analogue scale (VAS) pain scores and complications were recorded at the final follow-up.Results:All the patients were followed up for 12 to 19 months (mean, 15.1 months). Primary incision healing was observed in all the 12 patients. No complications like skin necrosis, infection or neurovascular lesion occurred. Fracture union was achieved in all the 12 patients after 12 to 14 weeks (average, 12.6 weeks). At the final follow-up, all the patients could walk with full weight-bearing, the plantar flexion and dorsiflexion of the ankle and the muscle strengths of varus and valgus were normal, and the X-ray film showed that reduction of the tarsometatarsal joint was not lost. At the final follow-up, the AOFAS midoot scores ranged from 82 to 96 (mean, 88.9) and the VAS scores from 0 to 3 (mean, 1.2).Conclusion:Plantar plate fixation via the first metatarsal medial approach can result in satisfactory outcomes for fractures of the first metatarsal base, especially for those with a major fracture fragment at the metatarsal planter side.

Bacterial infection and severe wound inflammation are two primary harmful problems that bring harm to the human body and may cause death when a large-scale skin defect occurs. Thus, developing an effective and quick wound healing strategy for curing skin damage and trauma is vital. This study has developed a multifunctional PLA/gelatin/ZnO nanofiber aerogel with a three-dimensional structure through electrospinning and freeze-drying technology for wound healing. It has validated that the nanofiber aerogel has an excellent antibacterial property and biocompatibility. Meanwhile, benefiting from its three-dimensional nanofiber structure, the PLA/gelatin/ZnO nanofiber aerogel possesses good water absorption and air permeability. In vivo experiments have determined that the PLA/gel/ZnO nanofiber aerogel scaffolds effectively promote skin infection’s wound healing and enhance angiogenesis that is practical with increasing ZnO concentration.

目的 探讨中药"秦氏疼痛方"外敷治疗后肢急性软组织损伤大鼠模型的抗炎作用及其机制.方法 成年雄性SD大鼠40只,随机分成正常对照组(10只,直接生理盐水外敷)、模型对照组(10只,急性压榨伤造模后生理盐水外敷)、扶他林乳剂对照组(10只,急性压榨伤造模后扶他林乳剂外敷)、"秦氏疼痛方"治疗组(10只,急性压榨伤造模后"秦氏疼痛方"外敷);分别进行炎症因子IL-1β、IL-6、TNF-α的测定;IL-1β、IL-6、TNF-α和NF-κB/p65的mRNA含量测定;IκBα和NF-κB蛋白水平测定.结果 "秦氏疼痛方"治疗组的IL-1β、IL-6、TNF-α水平均显著低于模型对照组(P<0.05);该组的IL-1β、IL-6、TNF-α和NF-κB/p65的mRNA含量以及细胞核内NF-κB蛋白含量均显著低于模型对照组(P<0.05);该组的IκBα蛋白水平显著高于模型对照组(P<0.05).结论 外用中药"秦氏疼痛方"具有明显的炎症抑制作用,其作用机制可能与抑制NF-κB信号通路,从而抑制炎症因子的基因表达有关.

Abstract Background Simultaneous dislocation of the radial head and distal radio-ulnar joint without fracture (Criss-Cross Injury) in an adult patient is rarely reported in previous studies. The pathological changes and injury patterns have not been clearly demonstrated. Case presentation A 26-year-old woman presented with acute pain of the right wrist and elbow after a fall from cycling. Physical examination revealed an unstable elbow and wrist joint. Plain radiographs showed volar dislocation of the radial head and dorsal dislocation of the distal radius without associated fracture, forming a criss-cross appearance of the ulna and radius on the lateral radiograph. MRI images confirmed partial rupture of the proximal interosseous membrane from its dorsal attachment on the radius, as well as partial rupture of the medial collateral ligament. Conservative treatment failed because the radiocapitellar joint and distal radio-ulnar joint could not be simultaneously reduced. Surgical exploration revealed a highly unstable radial head, but the annular ligament was found to be intact. Manual force was applied to reduce the radial head and a percutaneous K-wire was used to stabilize the proximal radioulnar joint with the forearm in full supination. After surgery, the elbow was immobilized in 90° flexion by a long arm cast for 4 weeks. The K-wire was removed at 6 weeks postoperatively. At 18 months postoperatively, the patient had regained a full range of flexion and extension, with normal supination and a slight limitation in pronation. Conclusions The proximal IOM, especially the dorsal band, was injured in Criss-Cross injuries, while the central part of the IOM remained intact. This injury pattern distinguished itself from Essex-Lopresti injury, which mainly involves rupture of the central band of the IOM.

Background: For proximal humeral fractures (PHFs), locking intramedullary nails and locking plates have been widely used. However, few reports have been published on the therapy of complex PHFs accompanying humeral shaft fractures. Therefore, we performed this research to analyze the effectiveness of locking intramedullary nails and locking plates in the management of proximal humeral fractures involving the humeral shaft. Material/Methods: We retrospectively reviewed 40 cases diagnosed with proximal humeral fractures involving the humeral shaft fixed with either locking intramedullary nails or locking plates with at least of 2 years' follow-up. Clinical data were obtained from the medical records. Follow-up data included the Constant-Murley score, American Shoulder and Elbow Surgeons score (ASES), visual analog scale score (VAS), and the relative strength of the supraspinatus and deltoid muscles. Results: In total, 19 locking plate patients and 21 locking intramedullary nail patients were analyzed. The average follow-up period was 35 months in the locking plate group and 34 months in the locking intramedullary nail group. There were obvious differences in the intraoperative blood loss, time of operation, and the length of operative incision between the 2 groups (p<0.05). There were no significant differences between the groups in Constant-Murley score, ASES, VAS, or the relative strength of supraspinatus and deltoid muscles. Conclusions: For PHFs involving the humeral shaft, both locking plates and locking intramedullary nails can achieve satisfactory functional results in the long-term follow-up assessment. The locking intramedullary nail group was superior with regards to intraoperative blood loss, time of operation, and length of incision.

由于新型冠状病毒肺炎(COVID-19)潜伏期长,早期症状无特异性,以往针对严重急性呼吸综合征冠状病毒(SARS-CoV)的筛查和防护手段已经不能满足COVID-19疫情控制的需求,必须对COVID-19进行全新的认识并采取特殊的处理流程.由于骨科创伤、出血及疼痛等急性症状的掩盖,COVID-19疫情容易被忽略,使得创伤骨科门急诊亦存在一定的风险和隐患.为了规范创伤骨科门急诊患者的收治,加强创伤骨科医护人员的防护,本文对COVID-19感染的特点及防治原则、疫情期间创伤骨科门急诊的管理、创伤骨科病房和手术室的防控策略、医护人员COVID-19感染防控知识培训进行阐述,为创伤骨科患者的救治以及医护人员的防护提供依据.

目的 探讨依托考昔对大鼠绝经后骨质疏松性骨折愈合的影响.方法 选择雌性、7月龄SD大鼠36只,经腹正中切口行双侧卵巢去势手术,常规饲养3个月后制作双侧股骨骨折模型,然后克氏针顺行髓内固定.随机将成模大鼠分为长期用药组、短期用药组、对照组,每组12只.长期用药组每天依托考昔溶液5.4 mg/kg灌胃1次,连续6周;短期用药组每天依托考昔溶液5.4 mg/kg灌胃1次,连续灌胃1周后,等容量生理盐水连续灌胃5周;对照组每天等容量生理盐水连续灌胃6周.内固定术后1、2、4周,各组随机取3只,断颈处死,取双侧股骨骨折端骨痂组织,HE染色,观察骨折端骨痂组织形态学变化.内固定术后6周,断颈处死剩余大鼠,取出双侧股骨,利用万能材料力学实验机,采用三点弯曲法检测股骨骨折愈合处最大载荷和弹性载荷.结果 股骨骨折端骨痂组织形态学观察可见,长期用药组骨生成和转化过程缓慢,内固定术后4周骨小梁纤细、排列紊乱且可见坏死细胞;短期用药组停止用药后骨生成和转化的抑制作用消失,至内固定术后4周骨小梁表现接近对照组.内固定术后6周,长期用药组股骨骨折愈合处最大载荷、弹性载荷均低于对照组和短期用药组(P均<0.05),而对照组与短期用药组比较差异均无统计学意义(P均>0.05).结论 长期应用依托考昔能够延迟和抑制大鼠绝经后骨质疏松性骨折愈合,并能使骨折愈合强度降低,而短期应用对骨折愈合的影响不大.

We investigated the outcome of conservative treatment and potential causes for clavicle stress fractures following the clavicular hook plate fixation. Six cases of clavicle stress fractures were retrospectively reviewed. All the stress fractures occurred near the medial end of the hook plates. The average interval between the hook plate fixation and the clavicle stress fractures was 28.3 days (range, 18 to 60 days). The mean follow-up was 27 months (range, 15 to 42 months). Fracture union was achieved in all 6 cases. The most proximal screws in the hook plates were found to be eccentric in the clavicular midshaft in 5 cases. At the final follow-up, the average Constant and Murley scores of the operated shoulders were 91.7 (range, 83 to 96). Clavicle stress fractures could be treated conservatively with satisfactory results. Attention should be paid to the position of the most proximal screws in the hook plates.

高等医学院校培育的是未来的医务工作者,其价值观和职业道德关系着广大患者的健康、医疗卫生事业的发展及社会的和谐稳定,运用社会主义核心价值观对医学生进行教育具有非常重要的现实意义.将社会主义核心价值观教育融入医学临床教学中,并对其教学现状进行思考.

Essex-Lopresti损伤是指桡骨头骨折合并下尺桡脱位及骨间膜损伤,通常由前臂受轴向暴力导致.该损伤发病率低,诊疗难度高,若诊疗不及时,通常导致前臂轴向不稳定,从而引起患者肘关节及腕关节的功能障碍.近年来,随着对前臂稳定性的理解加深及内固定器械的发展,关于Essex-Lopresti损伤的诊断及治疗方案得到了越来越多的关注及研究.该文就Essex-Lopresti损伤的诊断及治疗进展作一综述.