The prevalence of post-COVID syndrome in patients treated on an outpatient basis ranges from 10 to 35 %; it can reach 80 % in patients with severe coronavirus infection. It is currently hypothesized that long-COVID may be due to both the direct effects of the SARS-CoV-2 virus and the biopsychosocial effects of COVID-19.The aim. To study the characteristics of damage to the central nervous system and mental sphere in patients with comorbid post-COVID syndrome.Materials and methods. To study the clinical features of the course of post-COVID syndrome, 98 patients who had suffered COVID-19 were examined. Of these, 18 (18.4 %) were men, 80 (81.6 %) were women. The mean age in the group was 56.05 ± 1.27 years. The examination program included a questionnaire, clinical examination, pulse oximetry, and assessment of exercise tolerance using the Borg scale. Statistical processing was carried out using the Statistica software package, version 6 (StatSoft Inc., USA). The results of the study are presented as a median, upper and lower quartiles. After analyzing the compliance of the studied indicators with the law of normal distribution (Shapiro – Wilk test), the groups were compared using the Wilcoxon test for pairwise comparison of related samples. Differences were considered statistically significant at p < 0.05.Results. Our studies of comorbidity and complications after COVID-19 infection revealed the most frequent involvement of three systems in the pathological process: cardiovascular, nervous and endocrine. Metabolic syndrome was detected in 67 % and involvement of the cardiovascular system was detected in 48.8 % of those examined.One of the main manifestations of post-COVID syndrome is damage to the central nervous system and mental sphere in the form of mild cognitive and emotional-volitional disorders with asthenodepressive and anxiety-depressive disorders.Conclusion. The health status of patients after COVID-19 is significantly lower than that of the general population. The study results indicate an urgent need to study the pathogenesis of long COVID and develop effective interventions to reduce the risk of its development.

Abstract—The aim of this study was to identify the relationship between the changes in certain immune system parameters (cytokines and neuronal antibodies) and the distribution of the level of constant brain potential (LCP) in patients with occupational neurosensory hearing loss (NHL). We examined 55 males with occupational NHL formed under the influence of aviation noise and 34 relatively healthy males of comparable ages. As a result of correlation analysis, we found that the higher the concentration is of proinflammatory IL-1β, which is the first to be involved in the body’s reaction by regulating the nonspecific and specific immune response, the higher the LCP of the inter-hemisphere frontal asymmetry of energy metabolism (Fd–Fs) is. In contrast, an increase in TNF-α concentration was accompanied by a decrease in the LCP in the left frontal lead (Fs). These results can indicate the important role of IL-1β and TNF-α in the regulation of interhemispheric activity during hyperpolarization of neuronal membranes in the frontal parts of the brain and activation in the frontal parts of the brain; they also confirm that cytokine regulation of the immune response occurs at the level of entire body. We also showed the deficiency of some relationships and the appearance of new negative relationships between the level of antibodies (AB) to proteins: V-gated Ca-channel, Chol-R, Ser-R, and the LCP in the right and left parietal regions (Pd, Ps), AB to GABA-R, Glu-R, and the LCP in the left parietal region (Ps), ABs to Glu-R with parameters of inter-hemisphere frontal asymmetry of the LCP (Fd–Fs), which indicates an important role of neuroautoimmune reactions in the development of brain energy metabolism disorders. The LCP characteristics that correlate with immunochemical parameters reflect not only neurophysiological mechanisms but also characterize the functional state of the adaptive systems of the body in general. In the future, this can be used in practice to develop new methods for diagnosing various conditions.

The development of vibration disease (VD) is based on the stagnant excitation response that arises mainly in the sympathetic part of the autonomic nervous system, the hypothalamic region, and cortical areas of the brain and leads imbalanced endocrine regulation and metabolic insufficiency. VD is due to a combined effect of local and general vibration and is thought to be a membrane-associated pathological process, membranes of the vascular endothelium being the most vulnerable. It is therefore of importance to study the relationship between topography of direct current (DC) potentials, which integrally reflect the membrane potentials of neurons, glia, and the blood–brain barrier, and serum concentrations of pro- and anti-inflammatory cytokines. The aim of the study was to compare the changes in serum cytokine concentrations and the brain DC potential distribution in patients with VD due to local and general vibrations. The study involved 28 patients who were diagnosed with stage II VD due to occupational exposure to vibration, lacked exposure to vibration at the time of the study, and had no comorbid pathology that could affect cytokine metabolism. A control group included 15 men without occupational exposure to vibration. The serum concentrations of IL-2, IL-4, IL-8, and IFN-γ were determined by the enzyme-linked immunosorbent assay (ELISA). The DC-potential level was recorded using neuro-energy mapping. Statistical analyses included the Shapiro–Wilk W-test, Mann–Whitney U-test, and Spearman’s rank correlation. The VD patients compared with the controls showed a moderately elevated DC-potential level in the central (p = 0.04), left central (p = 0.02), and right temporal (p = 0.03) leads. The IL-2 concentration was found to correlate with the DC potential in the left central (rs = 0.47), right parietal (rs = 0.37), and occipital (rs = 0.38) regions of the brain. The IL-4 concentration correlated with the DC potential in the right (rs = 0.41) and left (rs = 0.45) frontal regions and the temporal (rs = 0.39) and central (rs = 0.51) interhemispheric gradients. The IL-8 concentration correlated with the DC potential in the right (rs = 0.41) and left (rs = 0.43) frontal regions and the central (rs = 0.38) interhemispheric gradient. IFN-γ correlated with the DC potential of the left frontal (rs = 0.41) region and the central (rs = 0.42) interhemispheric gradient. An increase in DC potential in the frontal (right and left), right temporal, occipital, central, and right parietal regions of the brain was associated with IL-8 and IFN-γ overproduction in VD. Based on the correlations, higher energy metabolism in the anterior brain regions was associated with activation of the neuroinflammatory process due to overproduction of IL-4 and IL-8. An increase in IL-2 concentrations was associated with a higher CD-potential level in the posterior regions of the brain.

The aim . To identify neuropsychological signs of a decrease in higher mental functions associated with professional exposure to physical factors. Materials and methods . The study involved 40 patients with vibration disease caused by local vibration (Group 1), 50 patients with vibration disease caused by combined exposure to local and general vibration (Group 2), 71 civil aviation pilots with an established diagnosis of occupational sensorineural hearing loss (Group 3), and 38 healthy men (Group 4, control group). Methods of neuropsychological testing were used. Results . In Groups 1–3 the state of functioning of the cognitive sphere is represented by a mildly pronounced nature of impairments. The results of MMSE and FAB tests in patients of Groups 1–2, when compared with Group 4, determine a decrease in the functional activity of the frontal lobes and subcortical structures (25 (24–27), 25 (22–26), 15 (14–16) and 15 (13–16) points respectively). The most informative feature associated with the fact of occupational exposure to local vibration is the indicator of long-term memory (F = 9.41; р = 0.003); with combined impact of local and general vibration – short-term memory (F = 11.0; р = 0.001); with aircraft noise – objective gnosis (F = 8.48; р = 0.001). The obtained features make it possible to track with a high degree of accuracy the development of a decrease in cognitive functions in this contingent (86.1 %, 84.8 % and 72.1 % respectively). Conclusion . Common signs of changes in the cognitive sphere and lesions of the brain structures in patients with vibration disease are a decrease in praxis, impressive speech, for occupational sensorineural hearing loss – the lack of analytical-synthetic and conceptual thinking, object and finger gnosis, characterizing the inferiority of the functioning of the frontal and parietal regions of the left hemisphere.

The aim of the study was to identify the peculiarities of neuropsychological indices disorders depending on changes in the level of constant potential in patients with occupational diseases as a result of physical factors.Materials and methods. The study involved 60 patients with vibration disease caused by local vibration (group I), 106 patients with vibration disease caused by combined exposure to local and general vibration (group II), 101 civil aviation pilots with an established diagnosis of professional sensorineural hearing loss (group III), and 50 healthy men (group IV, comparison group) who were not exposed to vibration and noise due to the specifics of their professional activities. Methods of neuro-energy mapping and neuropsychological testing were used.Results. In groups I–II, compared with group IV, an increase in local levels of constant potential (DC-potential level) in the central, right temporal, and central frontal parts of the brain (2.3 (6.5–3.8) mV; –0.3 (–2.1–2.1); 2.1 (–3.4–6.8) and –0.3 (–3.1–4.3); –2.24 (–6.4–3.8); 0.9 (–3.1–8.5) mV at p = 0.005, 0.007 and 0.004 respectively). Differences in the values of DC-potential level gradients in individuals of group III when compared with group IV reached the level of significance in the central, temporal, occipital leads relative to the central frontal (–5.0 (–13.1–3.8); –4.1 (–9.4–5.1); –2.1 (–10.9–6.6); –6.3 (–15.3–1.8) and 2.9 (–3.0–10.6); 2.2 (–4.5–13.8); 5.6 (–7.6–14.1); –1.4 (–7.5–3.9) mV at p = 0.008; 0.009; 0.009, and 0.007 respectively). Cognitive disorders in patients of groups I–III when compared with group IV correspond to a mild disorder of dynamic, constructive praxis and expressive speech (1.40 (0–1,6); 1.43 (0–1,7); 1.2 (0–1,5) and 0.3 (0–1); 0.2 (0–1); 0.06 (0–1) points at p = 0.008, 0.008 and 0.009 respectively).Conclusions. A common neurofunctional sign of a mild impairment of the cognitive sphere in occupational diseases caused by physical factors is an increase in direct current potential level in the frontal-central and parieto-occipital regions, predominantly of the left hemisphere of the brain.

The aim of the study was to assess changes in serum concentrations of pro- and anti-inflammatory cytokines in patients with vibration disease (VD). Methods. In total, 28 patients with VD associated with the combined effects of local and general vibration comprised the study group while 24 men were included in the reference group with no exposure to vibration in their professional activities. Serum concentrations of IL-2, IL-4, IL-8, IFN-y) were measured by enzyme-linked immunosorbent assay. The severity of neuroenergy exchange was assessed using the neuroenergy mapping method based on measuring the levels of constant potential (DC-potential level). Data were analyzed using Shapiro-Wilk test, Student test, Mann-Whitney test, Fisher's angular transformation method and Spearman's rank correlation. Results. The proportion of study participants with increased brain DC-potential level was greater (67.9 %) among patients with VD (p = 0.001). The concentration of IL-8 was 24.29 (14.42-65.16) pg / ml in the VD-group vs. 14.35 (6.24-19.14) pg / ml. in the comparison group. Concentration of IFN-y - was 21.38 (1.68-94.28) pg / ml. in the VD-group vs. 0.01 (0.01-0.28) pg / ml in the reference group. We observed significant correlations between the levels of IL-4, IL-8, TNF-γ and DC-potential (rs = 0.61; 0.55; 0.57, respectively) suggesting their role in disruption of the processes of neuroenergy exchange. Conclusions. More than two thirds of patients with VD have an increased DC-potential level and greater concentrations of IL-8 and TNF-y. Disrupted functioning of the mechanisms of cytokine regulation seems to be associated with neuuroenergy exchange and may activate neuroinflammatory processes.

The aim of the study was to assess constant potential levels (CP level) in patients with vibration disease (VD) in combination with metabolic disorders. Methods. Measurements were taken in three gorups: Group I (n = 94) - patients with VD, Group II (n = 42) - patients with VD and metabolic syndrome (MS), Group III (n = 31) - patients with VD and Type 2 diabetes (DM2), Group IV (n = 14) - patients with DM2 and V (n = 50) - reference group. Data were analyzed using Shapiro-Wilk, Mann-Whitney tests and discriminant analysis. Results. In groups I-IV, the percentage of individuals with altered neuroenergetic activity was higher than in the experimental group (p = 0.001; 0.003; 0.01; 0.009, respectively). CP level in group I prevailed in the central, in group II - in the left central, right temporal, in group III - in the left central, central, in group IV - in the right frontal, central, and left parietal leads when compared with group V at p < 0.01. CP level decrease in the anterior cortex (frontal, temporal: 16.6 (15-18) mV, 14.7 (12-17) mV, 17.6 (16-20) mV respectively), and its amplification in the posterior (Central, parietal: 20.4 (16-25) mV, 18.2 (14-20) mV, 23.3 (17-28) mV respectively) at p < 0.01 was diagnosed in patients of groups II-IV. As a result of discriminative analysis, two signs were identified in groups I and III: the values of CP level indicators in the left temporal and right central leads. Conclusions. Disorders of neuroenergy exchange in patients with VD in combination with MS and DM2 are manifested by an increase in CP level in the centrotemporal areas, with DM2- in the frontal-central-parietal areas. The signs of neuroenergetic mapping in patients with VD, associated with the fact of DM2 presence as a concomitant pathology are: an increase in the CP level in the right central and its decrease in the left temporal leads.

The aim of the study was to identify the characteristics of energy metabolism of the brain according to neuroenergy mapping in patients with hand-arm vibration syndrome (HAVS) and occupational sensorineural hearing loss (SNHL). Methods. 45 patients with HAVS associated with the combined effects of local and general vibration, and 71 patients with SNHL of professional origin were examined. The comparison group was represented by 38 men who were not exposed to the studied factors in their professional activities. The method of neuroenergy mapping was used, based on measuring of constant potential level. Results. Increased values of level of constant potential were observed in 62 % of patients with HAVS, 39 % of patients with SNHL, 31 and 52 % of patients, respectively, had a normal average level of neurometabolism, 7 and 9 % had reduced values of the constant potential level. An increase in metabolic intensity in relation to the average constant potential level in patients with HAVS was determined in the central (p = 0.027), right temporal (p = 0.043) regions. Patients with SNHL demonstrated an increase in bipolar indices in the central lead (Fpz-Cz = -5.0 (-13.1...3.8) mV) (p = 0.003), temporal right (Fpz -Td = -2.1 (-10.9...6.6) mV) (p = 0.014), temporal left (Fpz-Ts = -6.3 (-15.3...1.8) mV) (p = 0.031), occipital (Pz-Oz = -4.2 (-9.4...5.1) mV) (p = 0.022) regions of the brain associated with a decrease in constant potential level in frontal areas. According to the results of a discriminative analysis, the most informative neurometabolic signs in patients with HAVS were the indicators of constant potential level in the central lead (Cz, F = 9.672), in patients with SNHL - in the central parietal (Pz, F = 12.816). Conclusions. Functional disorders of the brain were observed in 69 % of the examined with HAVS and 48 % with SNHL; they were represented by increased energy exchange mainly in the central and temporal sections. Neurometabolic signs peculiar to HAVS were an increase in constant potential level of centralized lead and a decrease in the Td-Ts interhemispheric ratio; for SNHL, an increase in the left parietal, central parietal, and occipital divisions.

Objective. To identify the features of cognitive impairments (CI) in patients with alcoholic (AE) and dyscirculatory (DE) encephalopathies. Materials and methods. The study included 32 patients with DE and 30 with AE. Along with clinical observations, patients underwent computerized electroencephalography (EEG), recording of cognitive event-related potentials, and neuropsychological testing. Results and conclusions. The pathologies studied here showed both common and distinct signs in the clinical picture, in the emotional-personality domain, and impairments to cognitive processes. Common features of encephalopathies of different etiologies were CI and asthenic syndrome; AE was characterized by hyposthenic and DE by mixed (hyper- and hyposthenic) syndromes. The EEG showed that changes in bioelectrical activity in DE were predominantly located in the occipital-parietal areas of the cortex, while in AE they were located in the temporal and occipital-parietal areas. CI in DE and AE consisted of disorders to categorial thinking, long-term memory, reciprocal coordination, and digital gnosis, pointing to dysfunction of the frontal and parietal lobes of the left hemisphere, hippocampus, and corpus callosum. The indexes of the δ, β1, and β2 rhythms were discriminating features of CI in AE and DE.

Research objective identification of the peculiarities of indicators of audiological examination, registration of somatosensory induced potentials (SSSP), level of constant potential (LCP) and neuropsychological testing in persons of flight composition (LLS) of civil aviation exposed to intra-cabin noise, depending on the degree of expression of professional neurosensory noise (ONIHL).PATIENTS AND METHODS:Thresholds of acoustical sensitivity, levels of perception of shepotny, informal conversation, UPP, characteristic of SSVP, neuropsychological features at 45 patients with easy degree of PNST (LONIHL) and at 50 - with moderate degree of ONIHL (UONIHL) are studied.RESULTS:LCP in the left frontal (Fs), central dark (Pz) leads increased in persons with ONIHL, and the inter-peak interval of the N13-N20 characterizing the central conduct time increased. The FAB, unlike the LONIHL, is characterized by deterioration of cognitive activity in the form of easily pronounced decrease of visual memory functions, expressive speech, FAB scale value indicating priority dysfunction of frontal, dark-occipital lobes, subcortical cerebral structures.CONCLUSION:Neurofunctional markers in UONIHL are the reduction of the indicators of the interfamily relations on the frontal department, conceptual thinking, visual image memory, expressive speech, MMSE and FAB tests, the increase of LCP in the left temporal, central dark, occipital right central N13-N20, inter-peak N25.

Цель исследования - выявление особенностей распределения уровня постоянного потенциала (УПП) у пациентов с вибрационной болезнью (ВБ) в сочетании с метаболическими нарушениями. Методы. Обследуемые распределены на группы: I (n = 94) - с ВБ, II (n = 42) - с ВБ, отягощенной метаболическим синдромом (МС), III (n = 31) - с ВБ, отягощенной сахарным диабетом 2 типа (СД2), IV (n = 14) - с СД2, V (n = 50) - группа сравнения. Применены методы статистического анализа с определением W-критерия Шапиро - Уилка, U-критерия Манна - Уитни, дискриминантный анализ. Результаты. В I-IV группах доля лиц с измененной нейроэнергетической активностью выше, чем в группе сравнения (р = 0,001; 0,003; 0,01; 0,009 соответственно). В I группе УПП преобладал в центральном, во II - в левом центральном, правом височном, в III - в левом центральном, центральном, в IV - в правом лобном, центральных, левом теменном отведениях при сопоставлении с V группой при р < 0,01. У пациентов II-IV групп диагностировано снижение УПП в передних отделах коры (лобных, височных: 16,6 (15-18) мВ, 14,7 (12-17) мВ, 17,6 (16-20) мВ соответственно), его увеличение в задних (центральных, теменных: 20,4 (16-25) мВ, 18,2 (14-20) мВ, 23,3 (17-28) мВ соответственно) при р < 0,01. В результате дискриминантного анализа в I и III группах выявлено два признака: значения показателей УПП в левом височном, правом центральном отведениях. Выводы. Нарушения нейроэнергообмена у пациентов с ВБ в сочетании с МС и СД2 проявляются увеличением УПП в височно-центральных областях, при СД2 - в лобно-центрально-теменных отделах. У пациентов с ВБ, отягощенной СД2, увеличивается значение УПП в правом центральном и снижается в левом височном отведениях.

Comparative analysis of the subpopulations of lymphocytes in patients with vibration disease (VB) from the effects of local vibration revealed the features of the immune response, characterized by increasing the absolute amount of CD3 + -, CD4 + -, CD8 + - lymphocytes and decreased the percentage of CD20 + -, CD25 + -lymphocytes. In patients with VB from the effects of combined vibration, an increase in the absolute number of CD3 + -, CD4 + -, CD8 + -, CD16 + -, CD20 + -, CD25 + -, CD95 + -lymphocytes was observed, which indicates the activation of lymphocyte apoptosis under conditions of pronounced stimulation of the immune system. A decrease in the level of HSP70 in the serum of patients with VB from exposure to local vibration indicates its accumulation inside the cell and the protection of the processes of biosynthesis and the structural integrity of proteins in the damaged cell due to B-lymphocytes.

Objective. Neurophysiological and neurochemical indicators of trainee workers exposed to mercury and vinyl chloride over time. Purpose – to study the dynamics of changes in neurophysiological and neurochemical parameters in workers exposed to mercury and vinyl chloride. Methods. 131 trainees exposed to mercury and vinyl chloride were examined. All patients underwent clinical neurological examination, electroencephalography, determination of neurochemical parameters of catecholamines, their metabolites and neurotrophic factors in dynamics. Results. In the course of dynamic observation of trainee workers in contact with mercury and vinyl chloride, clinical symptoms worsened with an increase in emotional and personal disorders, an aggravation of cognitive potential and a staged involvement of brain structures in the pathological process according to computer electroencephalography. Under the influence of mercury on neurochemical parameters, its predominant effect on the change in the level of norepinephrine in the dynamics of the examination was established, due, first of all, to the change in its biotransformation into an active metabolite of adrenaline and inactive normetanephrine, an increase in the level of neurotrophic factor CNTF in the dynamics of the examination and a decrease in the levels of NT-3 and BDNF. Under the influence of vinyl chloride, an increase in the levels of adrenaline and norepinephrine, as well as the coefficients of biotransformation of the latter, was noted in dynamics. Field of application: occupational pathology, neurology, toxicology. Conclusion. When exposed to both mercury and vinyl chloride, changes are noted in the dynamics of observation in the field of emotional and cognitive impairments, as well as bioelectric activity of the brain. In addition, the content of catecholamines, primarily norepinephrine, due to the modification of its biotransformation, is more pronounced upon exposure to mercury. Deviations in the content of neurotrophic factors (CNTF, BDNF, and NT-3) are important in the development of disorders and/or compensatory-adaptive reactions only with chronic effects on the body of mercury.

Objective. Neurophysiological and neurochemical indicators of trainee workers exposed to mercury and vinyl chloride over time. Purpose – to study the dynamics of changes in neurophysiological and neurochemical parameters in workers exposed to mercury and vinyl chloride. Methods. 131 trainees exposed to mercury and vinyl chloride were examined. All patients underwent clinical neurological examination, electroencephalography, determination of neurochemical parameters of catecholamines, their metabolites and neurotrophic factors in dynamics. Results. In the course of dynamic observation of trainee workers in contact with mercury and vinyl chloride, clinical symptoms worsened with an increase in emotional and personal disorders, an aggravation of cognitive potential and a staged involvement of brain structures in the pathological process according to computer electroencephalography. Under the influence of mercury on neurochemical parameters, its predominant effect on the change in the level of norepinephrine in the dynamics of the examination was established, due, first of all, to the change in its biotransformation into an active metabolite of adrenaline and inactive normetanephrine, an increase in the level of neurotrophic factor CNTF in the dynamics of the examination and a decrease in the levels of NT-3 and BDNF. Under the influence of vinyl chloride, an increase in the levels of adrenaline and norepinephrine, as well as the coefficients of biotransformation of the latter, was noted in dynamics. Field of application: occupational pathology, neurology, toxicology. Conclusion. When exposed to both mercury and vinyl chloride, changes are noted in the dynamics of observation in the field of emotional and cognitive impairments, as well as bioelectric activity of the brain. In addition, the content of catecholamines, primarily norepinephrine, due to the modification of its biotransformation, is more pronounced upon exposure to mercury. Deviations in the content of neurotrophic factors (CNTF, BDNF, and NT-3) are important in the development of disorders and/or compensatory-adaptive reactions only with chronic effects on the body of mercury.

Introduction. Issues of studying the central origins and development of оccupational pathology in the faces of flight personnel define a need for the application of neurophysiological and neuropsychological methods of research. Material and methods. The levels of constant potential (LCP), characteristics the somatosensory caused potentials (SSVP), neuropsychological features in 95 patients with оccupational neurosensory deafness (ONSD) and 35 cases in a group of comparison are studied. Methods of the statistical analysis with a definition of W-of criterion of Shapiro-Uilka, Mann-Whitney›s U-criterion, coefficient of correlation of Spirmen, the discriminant analysis are applied. Results. in ONSD at patients the quantity of cases with the increased values of average LCP were established to prevail significantly in comparison with those in patients of a group of comparison (39% and 13% respectively, р = 0.03), strengthening of neuropower exchange in right and left frontal, central, left central, left parietal, right temporal assignments, increase in duration of the latent period of N18, N30 components are registered (р < 0.05). The condition of the cognitive sphere was characterized by the easily expressed violations of functions of analytical and synthetic thinking, оral-aural memory, visual, long-term memory, reciprocal coordination, impressive speech. Correlation connection between the index of N13-N20 and indices characterizing a condition of long-term memory, reciprocal coordination, the expressional speech is established (rs=0.45; 0.28; 0.28 at р =0.008; 0.04; 0.03 respectively), an index the between hemispheres of the relations Fd-Fs and latency of P25 and N30 (rs = 0.53 and 0.29 at р =0.009; 0.02 respectively). Diagnostic signs of brain deficiency at patients with ONSD were indices of visual gnosis, reciprocal coordination, LCP in right central, central parietal assignments of a brain, duration of the latent period of N30, N18-N20 (F=9.14; 5.43; 6.08; 4.41 4.77; 4.34 respectively). Conclusions. Violations of power metabolism in the frontal and central and parietal and temporal assignments of a brain, a functional condition of the central carrying-out structures, disorganization of cognitive activity were established to be a consequence of the impact of aviation noise and the reason of brain deficiency.

Introduction. The importance of attracting to predict the development of hand-arm vibration syndrome (HAVS) nonspecific indices of violations of the basic functional systems, for which the dose or exposure dependences can be clearly established, is shown. There is shown the importance of attracting non-specific indices of violations of the main functional systems of the body, for which dose or exposure dependencies can be clearly established to predict the development of vibrational disease (VD) due to a local vibration. Material and methods. The studies were carried out on the information array of personalized indices of the functional systems in aircraft production workers exposed to local vibration. There was used a multiplicity of exceeding the maximum dose of vibration as an index of the vibration effect during the work. Information-entropy modeling was used to predict the risk of changes in functional systems formation. Results. Analysis of calculations in different variants of diagnostic models allowed drawing a conclusion that the pathological indices of the main activity of the brain and thyroid system made the greatest contribution (82.6%) to HAVS formation among the studied combinations. In the model with the consideration of the indices of the main activity of the brain and the thyroid system, an increase in the equivocation of the system to almost 100% were and by 3 times increasing differences between the coefficients of redundancy characterizing the relative organization of the system in the norm and pathology were noted. Conclusion. The conducted studies have allowed substantiating the high importance of non-specific indices of the pathogenesis of HAVS (Central nervous system and thyroid systems), which opens up opportunities to attract them to the structure of the model, taking into account the dose of local vibration. It is proposed to consider the expansion of the information base with the involvement in the model, along with indices of the specific link of the pathogenesis of HAVS and indices of its nonspecific link.