Hg2+ is one of the most toxic heavy metals, posing a serious threat to the human body and the environmental ecosystem. In order to detect Hg2+ rapidly, accurately, and sensitively, a kind of boron, nitrogen, and sulfur co-doped carbon dots (B,N,S-CDs) were synthesized by a simple, economical, and direct hydrothermal method. The average size of the prepared B,N,S-CDs is 2.7 +/- 0.7 nm, and the high photoluminescence quantum yield is 67.6%. Furthermore, due to the efficient quenching effect of Hg2+, such B,N,S-CDs are considered to serve as an efficient fluorescence sensing platform for label-free and sensitive detection of Hg2+ with a detection limit of 72 nM. The selectivity experiments reveal that the B,N,S-CDs are selective and specific for Hg2+ even in the presence of other interfering substances. Most importantly, the Hg2+ sensing platform based on B,N,S-CDs can be successfully applied to the determination of Hg2+ in tap water and real lake water samples. This stable and inexpensive carbon material exhibits excellent sensitivity and selectivity, potentially suitable for Hg2+ monitoring in environmental applications.

Dion-Jacobson (DJ) structured quasi-2D perovskites are promising candidates for new generation gain medium due to their excellent photoelectric performance, super environmental, and structure stability. The isolated carrier recombination with inhomogeneous mixed phase is detrimental in enhancing amplified spontaneous emission (ASE) of optically pumped DJ phase quasi-2D perovskites lasers. Here, in 1.3-propanediamine (PDA)-based DJ perovskites, the carrier dynamic behavior from the pristine sample to the Cremophor EL (Cre EL) treated sample is unraveled. Remarkably, the Cre EL treated sample displays a well-proportioned large n domain distribution, resulting in an increased radiation-state density and hence enhancing collaboration emitting between carriers. The improved collaboration emitting promotes carriers' fast relay radiation, resulting in a higher ASE performance with a threshold reduced from 11.7 to 4.8 mu J/cm2, mu J/cm 2 , optical gain coefficient increased from 775 to 1559 cm-1 - 1 and degree-of-polarization (DOP) improved from 0.59 to 0.98. Our findings suggest that the development of DJ structured quasi-2D perovskite laser gain medium should target facilitating fast carrier co-radiation recombination. (c) 2024 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement

Photo-responsive metal complexes, which connect certain photo-switches with the distinctive metal ions, have aroused extensive interest in the fields of optoelectronic functional applications. Upon photoisomerization, these metal complexes exhibit dynamically tunable photophysical properties in terms of their absorption ability and range, emission color and intensity, photoisomerization rate, mechanical property, and so on. This review will provide an overview of the recent advances in photo-responsive metal complexes, including small molecules, metal-based macrocycles and supramolecular polymers. Moreover, the responsive mechanisms and design strategies, along with the applications of these photo-responsive metal complexes in optoelectronic devices are also discussed. Finally, the challenges and perspectives on future synthesis and extensive applications of photo-responsive metal complexes are also presented. This review shall offer important guidelines for designing novel photo-responsive metal complexes with controllable responsive behaviors for advanced optoelectronic applications.

Metal lead perovskite (MHP) single crystals (SCs) with extraordinary optical properties are promising candidates for high-performance SC-based perovskite light-emitting diodes (SC-PeLEDs). However, the heating process involved in traditional methods to initiate crystal nucleation and growth inevitably induces massive defects in MHP SCs, leading to inferior electroluminescence performance and poor operational stability of the SC-PeLEDs. Preparation of low-defect thin MHP SCs for high-performance SC-PeLEDs remains a formidable challenge. Here, a facile pre-nucleation strategy is developed to enable room-temperature (RT) growth of high-quality MAPbBr(3) (MA(+) = CH3NH3+) SCs. By avoiding the detrimental effect of high growth temperature, the MAPbBr(3) SCs prepared at RT show improved crystallinity with lower trap-state density, giving rise to higher photoluminescence quantum yield and uniform fluorescence. Consequently, the MAPbBr(3)-based SC-PeLEDs achieve a high external quantum efficiency up to 9.7%, along with an ultrahigh luminance of 126 800 cd m(-2), which is among the highest for MAPbBr(3)-based SC-PeLEDs. Moreover, the SC-PeLEDs demonstrate remarkably high operational stability with half-lifetimes as long as 594 min and 33.2 min at initial luminances of approximate to 1000 cd m(-2) and approximate to 10 000 cd m(-2), respectively. The work has excellent universality and paves the way toward the fabrication of high-performance SC-PeLEDs for future lighting, display, and laser applications.

目的 探讨长链非编码RNA(LncRNA)在LADA和T2DM中的表达,并预测LncRNA作用的靶向基因,为LADA和T2DM的诊断及鉴别诊断提供基因表达谱.方法 选取2017年7月至2018年6月于吉林大学第二医院内分泌科就诊的DM患者或正常糖耐量(NGT)人群,分为T2DM组、LADA组及NGT组,每组各4例.采用高通量测序检测,挑选表达差异有统计学意义的LncRNA构建基因表达谱.结果 与NGT组比较,T2DM组LncRNA 68763个表达上调,28523个表达下调;LADA组LncRNA 68748个表达上调,28538个表达下调.各组LncRNA表达差异显著.在有统计学意义的数据中选取2个差异倍数最高的LncRNA(LncRNA ENST00000602845-NCBP2、LncRNA ENST00000364558-HECTD4)进一步分析,并通过GO、KEGG通路分析预测LncRNA的靶基因功能.结论 LADA、T2DM患者LncRNA表达谱与NGT人群存在明显差异,可能通过多种机制参与发病.

目的 探讨LADA患者外周血环状RNA(circRNA)的差异性表达及LADA的发病机制.方法 选取2019年2～4月于吉林大学第二医院内分泌科治疗的12例LADA患者(LADA组),另选取同期我院健康体检者12名为正常对照(NC)组.通过高通量测序筛选出差异性表达的环状RNA表达谱,应用qRT-PCR验证circRNAs的显著失调.通过基因本体论和基因组途径富集分析,预测失调circRNAs的潜在功能.结果 高通量测序共发现992个差异表达的circRNAs,其中209个表达上调,783个表达下调,严格筛选出2个最显著表达的circRNAs(hsa_circ_100670302、hsa_circ_0035809),其中hsa_circ_100670302上调倍数为2.64,hsa_circ_0035809下调倍数为2.68.应用qRT-PCR对差异性表达的circRNA进行验证,均差异有统计学意义(P<0.05),与测序结果一致,可能与IR、免疫防御相关.结论 hsa_circ_100670302、hsa_circ_0035809可能阐明糖尿病的部分发病机制,成为临床诊治LADA新的分子靶点.

研究发现人类基因组可以被广泛转录成大量与疾病发生发展密切相关的非编码RNA（ncRNA）,其中环状RNA是一种内源性非编码RNA,参与人体病理生理过程调控,目前已有多项研究证明环状RNA（circRNA）在糖尿病的发生和发展过程中起着重要的调控作用。1环状RNA真核生物信息的传递过程主要为DNA转录成RNA并翻译成蛋白质。研究表明,人类基因组中至少有90%的DNA序列是被转录成RNA的,但仅有1.5%的DNA序列用于编码蛋白质,大部分的DNA序列则被转录成了非编码RNA。环状RNA是一种内源性非编码RNA,circRNA没有

正>糖尿病是由多种原因引起的一类以慢性高血糖为特征的代谢性疾病,近年来,糖尿病的患病率在迅速上升,根据国际糖尿病联合会的糖尿病图谱,世界上大约有4亿人患有2型糖尿病,每年有1000万人被诊断患有糖尿病[1]。按现行的分类标准,糖尿病主要分为1型糖尿病(T1DM)、2型糖尿病(T2DM)、妊娠期糖尿病等特殊类型糖尿病。有些T1DM患者发生在成年期,即成人迟发性自身免疫性糖尿病(laten-

一、土地承包经营权入股农民专业合作社的现实问题 土地承包经营权入股农民专业合作社是指在不改变土地所有权的性质和土地的农业用途的前提下,土地承包经营权人(主要是家庭承包的承包方,即农户)以通过家庭承包方式设立的土地承包经营权或通过其他方式承包(招标、拍卖、公开协商等方式承包农村土地)并经依法登记取得土地承包经营权证或者林权证等证书设立的土地承包经营权,按数量和年限作价出资或与货币、实物等其他出资形式并存参与组建农民专业合作社的行为.

约定违约金高具有多重功能,如预估损失、促进履行、增加确定性、排除或限制证明责任、减少诉讼、降低交易成本等.约定违约金虽属合同自由领域,然法律往往对其进行特别规制,学界对此有赞同和反对两种观点.《合同法司法解释》(二)第29条规定了以实际损失的1.3倍作为判断约定违约金是否过高的标准.尽管该标准有明显优势,但其不能有效促进履约或预估损失,降低了确定性,强加了本欲回避的证明责任,额外增加了交易成本和诉讼概率,混淆了商事合同与消费者合同的不同需求,具有明显的内在缺陷.立法有必要回应对约定违约金是否过高的一体性判断标准,并区别对待商事合同和消费者合同,严格解释“过分高”的标准.

目的 探讨α-硫辛酸联合甲钴胺片治疗老年糖尿病性周围神经病变(DPN)的临床效果及不良反应.方法 DPN的老年2型糖尿病患者112例,年龄62～78岁,其中男64例,女48例,随机分为对照组50例,研究组62例,每组患者均普及糖尿病基础教育并给予降糖治疗,严格控制血糖及其波动范围,其中对照组给予甲钴胺片口服,研究组在对照组的基础上加用硫辛酸胶囊口服,观察疗程为12 w.评价治疗前后患者临床感觉及相关体征的变化.结果 研究组总有效率显著高于对照组(P<0.05),治疗后研究组治疗效果明显优于对照组(P<0.05).治疗期间两组均未出现明显不良反应.结论 α-硫辛酸联合甲钴胺治疗DPN更能减轻临床症状,加快神经传导速度,获得更满意的效果且安全性高,可作为治疗DPN的常规临床用药.

表观遗传学是研究在基因的核苷酸序列不发生改变的情况下,基因发生了可遗传的表达的一门新兴学科。其机制主要包括DNA甲基化,组蛋白修饰,代谢记忆,RNA介导的基因沉默,染色质重塑及基因组印记等。糖尿病是以高血糖及胰岛素缺乏为特征的一种多因素的慢性代谢性疾病,与基因及环境因素相关 [1] 。近几年,越来越多的研究表明,可以用表观遗