Approximately 10 million individuals worldwide are affected by Parkinson’s disease. As a chronic and progressive movement disorder, it imposes a heavy economic burden on both patients and society. Focused ultrasound shows great potential for treating Parkinson’s disease owing to its noninvasive and multifunctional nature. This study aimed to explore the utilization of ultrasound in managing Parkinson’s disease by enhancing drug delivery via disruption of the blood–brain barrier, employing neuroregulatory techniques to mitigate symptoms, and ablating specific pathological brain nuclei for precise therapeutic intervention. This study aimed to delineate the underlying mechanisms of these therapeutic interventions, evaluate the current state of research, and explore opportunities for future development.

BACKGROUND:The diagnosis of Parkinson's disease (PD) lacks reliable biomarkers. This study investigated substantia nigra (SN) elasticity using shear wave elastography (SWE) as a novel diagnostic tool for PD. OBJECTIVES:To investigate the role of SN elasticity values in the diagnosis of PD and their correlation with disease severity, duration, and iron metabolism indicators. METHODS:This study included PD patients diagnosed and treated at Tongji Hospital's Neurology Department and healthy controls from January 2021 to December 2022. SWE was used to measure the elasticity of the SN and surrounding midbrain regions. Differences in elasticity between the two groups were analyzed, along with correlations between SN elasticity and age, hyperechoic area of SN, iron metabolism markers, and disease duration. RESULTS:A total of 90 patients with PD and 106 healthy controls who could undergo transcranial ultrasound elastography were enrolled. The PD group demonstrated significantly elevated SN elasticity values (20.43 ± 3.94 kPa vs. 10.72 ± 1.86 kPa, P < 0.001) compared with controls. The SN elasticity value demonstrated higher classification performance with an area under the curve (AUC) of 0.96 (95% CI: 0.87-0.98) compared with the hyperechogenic area of SN (AUC: 0.884, 95% CI: 0.85-0.92). The elasticity values of the SN in the PD group were positively correlated with disease duration (r = 0.503, P < 0.001). CONCLUSIONS:SN elasticity values are a promising classification biomarker for PD, showing a significant association with disease duration and improving classification performance. These findings highlight the potential of biomechanical properties in neurodegenerative disease assessment and call for further validation in larger cohorts. © 2025 International Parkinson and Movement Disorder Society.

OBJECTIVE:Complete resection of malignant gliomas is often challenging. Our previous study indicated that intraoperative contrast-enhanced ultrasound (ICEUS) could aid in the detection of residual tumor remnants and the total removal of brain lesions. This study aimed to investigate the survival rates of patients undergoing resection with or without the use of ICEUS and to assess the impact of ICEUS on the prognosis of patients with malignant glioma.METHODS:A total of 64 patients diagnosed with malignant glioma (WHO grade HI and IV) who underwent surgery between 2012 and 2018 were included. Among them, 29 patients received ICEUS. The effects of ICEUS on overall survival (OS) and progression-free survival (PFS) of patients were evaluated. A quantitative analysis was performed to compare ICEUS parameters between gliomas and the surrounding tissues.RESULTS:The ICEUS group showed better survival rates both in OS and PFS than the control group. The univariate analysis revealed that age, pathology and ICEUS were significant prognostic factors for PFS, with only age being a significant prognostic factor for OS. In multivariate analysis, age and ICEUS were significant prognostic factors for both OS and PFS. The quantitative analysis showed that the intensity and transit time of microbubbles reaching the tumors were significantly different from those of microbubbles reaching the surrounding tissue.CONCLUSION:ICEUS facilitates the identification of residual tumors. Age and ICEUS are prognostic factors for malignant glioma surgery, and use of ICEUS offers a better prognosis for patients with malignant glioma.

Background Many studies have suggested that the optic nerve sheath diameter (ONSD) measured by transorbital ultrasound could reflect the increased intracranial pressure (ICP). However, whether the optic nerve subarachnoid space width (ONSASW) could evaluate the increased ICP, and whether it has better diagnostic value for the increased ICP than ONSD are lack of knowledges. Methods Patients with brain injury undergoing ICP monitoring after external ventricular drainage surgery were enrolled. Within 48 hours post-surgery, ONSDI/ONSDE (ONSD including/excluding the dura mater) and OND (optic nerve diameter) were measured via transorbital ultrasound at 3mm behind the retina. The ONSASW was defined as the difference between ONSDI/ONSDE and OND (i.e., ONSDI-OND/ONSDE-OND). Patients were categorized into increased ICP and normal ICP groups based on invasive ICP measurements. The differences of the ONSASW between the two groups were compared, and ROC curve analysis was used to assess its diagnostic value for increased ICP. Results A total of 70 patients (including 17 patients with increased ICP and 53 patients with normal ICP) were ultimately included in the study. Significant differences were observed in ONSDI, ONSDI-OND, and ONSDE-OND between the increased and normal ICP groups (all p < 0.05). Additionally, it was determined that ONSDI, ONSDI-OND, and ONSDE-OND exhibited diagnostic value for increased ICP (all p < 0.001), with ONSDI-OND demonstrating superior performance with an area under the curve (AUC) of 0.806. Conclusions The ONSASW (especially defined as ONSDI-OND) is not only associated with increased ICP, but also possesses superior diagnostic value for increased ICP in brain-injured patients compared to ONSD.

The monitoring of intracranial pressure (ICP) and detection of increased ICP are crucial because such increases may cause secondary brain injury and a poor prognosis. Although numerous ultrasound parameters, including optic nerve sheath diameter (ONSD), width of the crural cistern (WCC), and the flow velocities of the central retinal artery and middle cerebral artery, can be measured in patients after hemicraniectomy, researchers have yet to determine which of these is better for evaluating ICP. This study aimed to analyze the correlation between ICP and ultrasound parameters and investigate the best noninvasive estimator of ICP. This observational study enrolled 50 patients with brain injury after hemicraniectomy from January 2021 to December 2021. All patients underwent invasive ICP monitoring with microsensor, transcranial, and ocular ultrasound postoperatively. We measured the ONSD including the dura mater (ONSDI), the ONSD excluding the dura mater, the optic nerve diameter (OND), the eyeball transverse diameter (ETD), the WCC, and the flow velocities in the central retinal artery and middle cerebral artery. Then, we calculated the ONSDI-OND (the difference between ONSDI and OND) and ONSDI/ETD (the ratio of ONSDI to ETD). Patients were divided into a normal ICP group (n = 35) and an increased ICP group (≥ 20 mm Hg, n = 15) according to the ICP measurements. Correlations were then assessed between the values of the ultrasound parameters and ICP. The ONSDI, ONSDI-OND, and ONSDI/ETD were positively associated with ICP (r = 0.455, 0.482, 0.423 and p = 0.001, < 0.001, 0.002, respectively), whereas the WCC was negatively associated with ICP (r = − 0.586, p < 0.001). The WCC showed the highest predictive power for increased ICP (area under the receiver operating characteristic curve [AUC] = 0.904), whereas the ONSDI-OND and ONSDI also presented with acceptable predictive power among the ONSD-related parameters (AUC = 0.831, 0.803, respectively). The cutoff values for increased ICP prediction for ONSDI, ONSDI-OND, and WCC were 6.29, 3.03, and 3.68 mm, respectively. The AUC of the combination of ONSDI-OND and WCC was 0.952 (95

BACKGROUND One-fourth of Parkinson's disease (PD) patients suffer from cognitive impairment. However, few neuroimaging markers have been identified regarding cognitive impairment in PD. OBJECTIVE This study aimed to explore the association between third ventricular width by transcranial sonography (TCS) and cognitive decline in PD. METHOD Participants with PD were recruited from one medical center in China. Third ventricular width was assessed by TCS, and cognitive function was analyzed by the Mini-Mental State Examination (MMSE). Receiver operating characteristic (ROC) analysis and Cox model analysis were utilized to determine the diagnostic and predictive accuracy of third ventricular width by TCS for cognitive decline in PD patients. RESULT A total of 174 PD patients were recruited. Third ventricular width was negatively correlated with MMSE scores. ROC analysis suggested that the optimal cutoff point for third ventricular width in screening for cognitive impairment in PD was 4.75 mm (sensitivity 62.7%; specificity 75.6%). After 21.5 (18.0, 26.0) months of follow-up in PD patients without cognitive impairment, it was found that those with a third ventricular width greater than 4.75 mm exhibited a 7.975 times higher risk of developing cognitive impairment [hazard ratio = 7.975, 95% CI 1.609, 39.532, p = 0.011] compared with patients with a third ventricular width less than 4.75 mm. CONCLUSION Third ventricular width based on TCS emerged as an independent predictor of developing cognitive impairment in PD patients.

Objective To investigate the value of routine intraoperative ultrasound (IU) and intraoperative contrast-enhanced ultrasound (ICEUS) in the surgical treatment of brain tumors, and to explore the utilization of ICEUS for the removal of the remnants surrounding the resection cavity. Methods In total, 51 patients who underwent operations from 2012 to 2018 due to different tumors in the brain were included in this study. The clinical data were evaluated retrospectively. IU was performed in all patients, among which 28 patients underwent ICEUS. The effects of IU and ICEUS on tumor resection and recurrence were evaluated. Semiquantitative analysis was performed to compare ICEUS parameters of the brain tumor with those of the surrounding tissue. Results In total, 36 male and 15 female patients were included in this study. The average age was 43 years (range: 14–68 years). The follow-up period was from 7 to 74 months (mean follow-up 32 months). IU was used in all patients, and no lesion was missed. Among them, 28 patients underwent ICEUS. The rate of total removal of the ICEUS group (23/28, 82%) was significantly higher than that of the IU group (11/23, 48%) ( P <0.05). The recurrence rate of ICEUS and IU was 18% (5/23), and 22% (5/28), respectively, and the difference did not reach statistical significance ( P >0.05). The semiquantitative analysis showed that the intensity and the transit time of microbubbles reaching the lesions were significantly different from the intensity and the transit time of microbubbles reaching the surrounding tissue ( P <0.05) and reflected indirectly the volume and the speed of blood perfusion in the lesions was higher than those in the surrounding tissue. Conclusion ICEUS is a useful tool in localizing and outlining brain lesions, especially for the resection of the hypervascular lesions in the brain. ICEUS could be more beneficial for identifying the remnants and improving the rate of total removal of these lesions than routine intraoperative ultrasound.

Glioblastoma (GBM) is the most aggressive brain tumor, which owns the characteristics of high recurrence, low survival rate and poor prognosis because of the existence of blood brain barrier (BBB) and complicated brain tumor microenvironment. Currently, immunotherapy has attracted much attention on account of favorable therapeutic effect. In this study, we designed a cRGD-modified cancer cell membrane (CM) coated calcium carbonate nanoparticle to deliver interleukin-12 messenger RNA (IL-12 mRNA@cRGD-CM-CaCO3 NPs). The cRGD-modified CM as the shell can endow the nanoparticles with BBB crossing and tumor homing/homotypic targeting effect in the brain tumor microenvironment. IL-12 mRNA-loaded calcium carbonate nanoparticles as the core allow synergistic immunotherapy of necroptosis-induced immune response and IL-12 mRNA transfection under ultrasound irradiation. The as-prepared biomimetic nanoparticles showed superior target and immunotherapeutic outcomes, suggesting that this biomimetic nanoplatform provides a feasible strategy for promoting BBB-penetrating and antitumor immunity.

患儿男，3岁3个月(产前检查正常)，因"活动后乏力1年余，加重伴口唇发绀16 d"入院。患儿父母述其活动后乏力1年余，半月前因"感冒"后症状加重，出现活动后气喘伴口唇发绀，无其他任何不适。于当地医院行超声检查示右房右室增大、肺动脉高压，予以对症支持治疗后病情有所缓解，为进一步诊治而来我院。查体：生命体征平稳，无阳性发现。实验室检查：乙肝、丙肝等相关病原学检查阴性；天冬氨酸转氨酶84 U/L，直接胆红素8.7 μmol/L；余血常规及凝血功能等正常。超声心动图示：右心扩大(右心房横径25 mm，右心室横径31 mm)，肺动脉压力增高(肺动脉主干内径18 mm)，三尖瓣中度反流，流速4.5 m/s，压差80 mmHg(1 mmHg＝0.133 kPa)。肝脏超声：门静脉主干及其肝内分支缺失(图1A)，脾静脉及肠系膜上静脉(图1B)相互汇合为一主干(图1C)，经肝尾叶直接汇入右房(图1D)。肺动脉血管增强CT+体层像+三维重建示：肺动脉未见明显栓塞征象，肺动脉主干增宽(20 mm)，右心扩大。肝脏门静脉CT血管成像+三维重建结果示：肝脏由肝动脉供血，门静脉缺失，肠系膜上静脉(SMV)与脾静脉(PV)汇合后注入右心房(图1E，F)，考虑Ⅰ型Abernethy畸形可能。临床诊断：Abernethy畸形，Ⅰb型。

Objective To evaluate the role of intraoperative ultrasound (IoUS) in the microsurgical treatment of intramedullary ependymoma and astrocytoma of the spinal cord.Methods A retrospective review was performed on 78 cases of intramedullary ependymoma and 34 cases of intramedullary astrocytoma which were treated microsurgically between January 2010 and May 2018 at Department of Neurosurgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology.All cases of ependymoma or astrocytoma were divided into IoUS group (44 cases of ependymomas,18 cases of astrocytomas) and control group(34 cases of ependymomas,16 cases of astrocytomas) according to whether IoUS was employed during operation.All patients were followed up in the clinic or by telephone to assess tumor recurrence and spinal function recovery by radiographic reexamination and Modified McCormick Scale (MMS),which were then compared between IoUS and control group in ependymomas and astrocytomas,respectively.The accuracy of intraoperative ultrasound in evaluating the gross total resection (GTR) rate was also evaluated.Results No significant differences were observed in age,sex,presenting symptoms,MMS or spinal cord segment of tumor location between IoUS and control groups in ependymoma or astrocytoma (all P ＞ 0.05).Compared with control group in ependymoma,the IoUS group had slightly higher GTR rate [97.7％ (43/44) vs.91.2％ (31/34)],slightly higher rate of good outcomes in terms of spinal function [36.4％ (16/44) vs.32.4％ (11/34)] and slightly lower incidence of complications [8.8％ (3/44) vs.11.8％ (4/34)],which,however,were not significantly different (all P ＞0.05).For astrocytoma,the IoUS group had significantly higher GTR rate [16/18 vs.9/16,P ＜ 0.05] and longer median PFS [84.0(67.5-100.5) months vs.75.0 (52.0-98.0) months,P ＜ 0.05] compared with control group.The IoUS group had slightly higher rate of good outcomes in terms of spinal function [3/18 vs.2/16,P ＞ 0.05]and slightly lower incidence of complications [0/18 vs.2/16,P ＞ 0.05] compared with control group.However,those differences were not significant (P ＞ 0.05).Postoperative enhanced MRI was used as the gold standard for verification of GTR.The accuracy rate of IoUS for prediction of GTR was 97.7％ (43/44)in ependymoma and 14/16 in astrocytoma.Conclusion The intraoperative ultrasound technique could facilitate the real-time and accurate judgement of tumor resection extent,which might have greater application value in the astmcytoma.

Objective To analyze the application value and clinical experience of intraoperative ultrasound in microsurgical resection of supratentorial cavernous malformations.Methods From March 2018 to March 2019,31 patients with supratentorial cavernous malformations were operated with assistance of intraoperative ultrasound in our hospital.Intraoperative ultrasound could clearly show the locations and sizes of the lesions,and relations of lesions with surrounding structures to choose appropriate surgical routes.The degrees of resection were judged and complications were recorded.The patients were followed up for 3-6 months,and modified Rankin scale (mRS) was used to evaluate the prognoses.Results In these 31 patients,35 cavernous hemangiomas were diagnosed by MR imaging before surgery;33 lesions were removed surgically,and the other two lesions located in the contralateral side of the operative field were not removed.The accuracy of intraoperative ultrasound guiding the lesions was up to 100％.There were no postoperative infections or deaths.During follow-up,mRS score of 28 patients was 0;the other 3 patients with postoperative neurological impairment recovered partially during follow-up.Conclusion With the help of real-time monitoring of intraoperative ultrasound and location technique of small pieces of hemostatic yam,patients with supratentorial cavernous malformations could acquire satisfactory prognosis through meticulous microsurgery.

Abstract Substantia nigra (SN) hyperechogenicity measured by transcranial sonography (TCS) is a promising biomarker for Parkinson disease (PD). The aim of this study was to explore the diagnostic accuracy of SN hyperechogenicity (SN+) for differentiating PD from essential tremor (ET). A total of 119 patients with PD, 106 ET patients and 112 healthy controls that underwent TCS from November 2016 to February 2019 were included in this single-center retrospective case–control study. Two reviewers who were blinded to clinical information independently measured the SN+ by TCS imaging. The diagnostic sensitivity, specificity, and accuracy of TCS imaging were evaluated between the PD and healthy controls and between patients with PD and ET. Interrater agreement was assessed with the Cohen κ statistic. TCS imaging of the SN+ allowed to differentiate between patients with PD and ET with a sensitivity (91.6% and 90.8%) and specificity (91.5% and 89.6%) for readers 1 and 2, respectively. Interobserver agreement was excellent (к = 0.87). In addition, measurement of the SN+ allowed to differentiate between patients with PD and healthy subjects with a sensitivity (91.6% and 90.8%) and specificity (88.4% and 89.3%) for readers 1 and 2, respectively. Interobserver agreement was excellent (к = 0.91). Measurement of SN+ on TCS images could be a useful tool to distinguishing patients with PD from those with ET.

Objective:To explore the relationship between the changes of midbrain raphe nucleus echo and blood trace metals, non-motor symptoms in patients with Parkinson′s disease (PD).Methods:A total of 177 patients with PD were recruited from Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology from November 2017 to December 2019. Their non-motor symptoms were assessed by a series of PD-related scales. All subjects completed transcranial color-coded sonography, and were divided into two groups according to the continuity of raphe nucleus echo. The difference of trace metals in peripheral blood and the scores of non-motor symptoms were analyzed.Results:The serum iron level of PD patients in the continuous echo of raphe nucleus group (117 cases; 15.33 （11.30, 18.93） μmol/L) was higher than that of the discontinuous group (60 cases; 12.52 （4.15, 16.00） μmol/L, t=-2.294, P=0.022), so was the scores of Scale for outcomes in PD for Autonomic Symptoms (34.00 （28.00, 39.00） vs31.00 （26.25, 36.00）， t=-2.044, P=0.041). There was no significant difference in the level of serum copper, hemoglobin, ceruloplasmin, and the scores of Movement Disorder Society Unified Parkinson′s Disease Rating Scale, Parkinson′s Disease Sleeping Scale, 39 items Parkinson′s Disease Questionnaire, Hamilton Depression Rating Scale and Hamilton Anxiety Rating Scale between the two groups. Conclusion:There was significant difference in serum iron levels and the scores of SCOPA-AUT between the two groups, but no difference in depression, sleep, and daily living ability.

To determine the diagnostic performance of transcranial sonography (TCS) in assessing increased echogenic area of the substantia nigra (SN) in patients with Parkinson's disease (PD). Institutional review board approval was obtained for this retrospective study. A total of 278 PD patients (mean age: 64.7 ± 9.8 y, 100 women) and 300 healthy control patients (mean age: 63.6 ± 9.3 y, 97 women) were referred for TCS assessment of SN hyper-echogenicity (SN+) from June 2016 to December 2018. Two sonographers independently measured the sizes of the echogenic areas of the SN by TCS imaging in both PD patients and healthy controls. The diagnostic sensitivity, specificity and accuracy of TCS imaging were compared between PD patients and healthy controls. Inter-rater agreement was assessed with the Cohen's κ statistic. The sensitivity, specificity and accuracy of readers 1 and 2, respectively, for the identification of SN+ in TCS were 90.3% and 89.6% (251 and 249 of 278), 89.3% and 88.3% (268 and 265 of 300) and 89.8% and 88.9% (519 and 514 of 578). Inter-observer agreement was excellent (к = 0.84). The area under the receiver operating characteristic curve (AUC) for differentiation of PD patients from healthy controls was 0.92 for reader 1 and 0.91 for reader 2. Cutoff values of 0.20 and 0.21 cm2 were derived from the assessments performed by readers 1 and 2, respectively. We defined 0.20 cm2 as the optimal cutoff value because it had a higher AUC. TCS is a promising diagnostic technique and can be very helpful in differentiating PD patients from healthy individuals.

A systematic review and meta-analysis were conducted to evaluate the diagnostic accuracy of substantia nigra hyper-echogenicity by transcranial sonography (TCS) for the diagnosis of Parkinson's disease (PD). PubMed, Embase and the Cochrane Library were electronically searched from inception to June 2018 for all relevant studies. The methodological quality of each study was evaluated by two independent reviewers, who used the Quality Assessment of Diagnostic Accuracy Studies 2 tool. Articles reporting information sufficient to calculate the sensitivity and specificity of TCS to diagnose PD were included. Statistical analysis included data pooling, heterogeneity testing, sensitivity analyses and forest meta-regression. Thirty-nine studies (3123 participants with PD) were analyzed. The pooled sensitivity and specificity of TCS were 0.84 (95% confidence interval: 0.81-0.87) and 0.85 (0.80-0.88), respectively, for differentiating PD from normal controls or participants with other parkinsonian syndromes. In the secondary outcome, PD participants exhibited a significant increase in substantia nigra areas than either normal controls (0.14 [0.12-0.16], p < 0.0001) or participants with other parkinsonian syndromes (0.11 [0.08-0.13], p < 0.0001). This meta-analysis revealed the high diagnostic performance of TCS in differentiating patients with PD from both normal controls and participants with other parkinsonian syndromes.

目的 分析早产儿不同程度脑损伤的超声表现,探讨早产儿脑损伤发生的临床相关影响因素.方法 对我院新生儿科收治的210例早产儿行颅脑超声检查,分析早产儿不同程度脑损伤的超声表现,以及不同胎龄、不同出生体质量、不同分娩方式早产儿脑损伤的发生情况.结果 210例早产儿中,颅脑超声表现正常30例,轻度脑损伤106例,重度脑损伤57例,其他异常17例.胎龄<30周(36例)、30～32周(74例)、33～34周(67例)、35～36周(33例)早产儿重度脑损伤者分别为18例、26例、11例、2例;与胎龄<30周和30～32周早产儿比较,胎龄33～34周和35～36周胎儿重度脑损伤发生率均显著降低(均P<0.05).出生体质量<1500 g(79例)和≥1500 g(131例)早产儿重度脑损伤者分别为29例和28例;与出生体质量<1500 g早产儿比较,出生体质量≥1500 g早产儿重度脑损发生率显著降低(P<0.05).剖宫产、经阴道分娩早产儿重度脑损伤发生率比较差异无统计学意义.结论 早产儿脑损伤的发生及程度可能与胎龄和出生体质量有关,颅脑超声为早期诊断早产儿脑损伤提供了重要依据.

目的 总结术中超声引导切除小脑桥臂海绵状血管瘤的经验.方法 回顾性分析2016年7月～2017年7月在术中超声定位引导下经颅入路手术切除的2例小脑桥臂海绵状血管瘤的临床资料,并结合文献进行分析.结果 2例均获全切除,无手术死亡,术后无神经功能障碍,无其它手术并发症,随访1.5～2年无复发.结论 经颅入路手术是桥臂海绵状血管瘤合适的选择,术中超声引导可帮助定位肿瘤,指导切除肿瘤,并获得良好预后.

目的:探讨对接受PICC置管术的患者定期进行彩超检查对控制其血栓形成的意义.方法:对在华中科技大学同济医学院附属同济医院接受PICC置管术的152例患者的临床资料进行回顾性分析.将其中定期接受彩色多普勒超声检查的82例患者作为A组,将其余70例仅在出现明显不适症状后才接受彩色多普勒超声检查的患者作为B组.对两组患者中发生血栓的患者均进行常规的溶栓治疗.然后比较两组患者血栓的发生情况、进行溶栓治疗的效果和留置PICC导管的时间.结果:两组患者血栓的总发生率相比,差异不具有统计学意义(P>0.05).A组患者中发生3～5级血栓患者的占比低于B组患者,差异具有统计学意义(P<0.05).A组患者治疗的总有效率高于B组患者,其留置PICC导管的时间长于B组患者,差异具有统计学意义(P<0.05).结论:对接受PICC置管术的患者定期进行彩超检查能够控制其血栓的形成,延长其置管的时间.

目的 分析彩色多普勒超声评价锁骨下动脉窃血综合征(SSS)患者椎动脉血流改变情况.方法 选取2012年9月～2019年4月收治的46例SSS患者,患者入院后均实施彩色多普勒超声检查,分析患者的椎动脉血流动力学变化.结果 窃血程度与锁骨下动脉狭窄程度呈正相关(r＝0.754,P＝0.000),患侧、健侧不同窃血程度的椎动脉收缩期峰值流速(Vp)、搏动指数(PI)差异明显(P＜0.05),健侧Ⅲ期窃血椎动脉Vp、PI＞Ⅱ期＞Ⅰ期＞无窃血(P＜0.05),患侧Ⅲ期窃血椎动脉的Vp、PI＜Ⅱ期＜Ⅰ期＜无窃血(P＜0.05),患侧椎动脉Ⅰ、Ⅱ、Ⅲ期窃血的Vp、PI均低于健侧(P＜0.05),无窃血患侧与健侧Vp、PI比较差异不显著(P＞0.05).结论 SSS患者窃血程度与锁骨下动脉狭窄程度有关,且患侧窃血程度越严重,健侧椎动脉血流动力学速度越快,彩色多普勒超声可对SSS椎动脉的血流动力学进行准确的评价.