Abstract Background Pelvic solitary fibrous tumor is a rare spindle-cell tumor arising from mesenchymal tissue, usually benign. However, its malignant form is an extremely rarer, and more aggressive disease. Our review of previous literature found that it has not been reported in adolescents younger than 18 years. Herein, we describe a case of pelvic giant solitary fibrous tumor with rectum and bladder invasion in a 16-year-old girl and summarize the diagnosis and treatment experience to further improve the existing management of solitary fibrous tumor. Case Description Retrospectively analyzed a 16-year-old girl admitted to our department with irregular menstruation and increased menstrual bleeding for 2 months. A computed tomography scan of the abdomen demonstrated an 11.2×7.5×8.9 cm isodense space-occupying lesion in the pelvis. Contrast-enhanced computed tomography showed heterogeneous enhancement, which was considered a tumor of mesenchymal origin. Pelvic mass resection, bladder repair, and right ureteral stent placement were performed. It was confirmed that the mass invaded the upper rectal and the right bladder wall during the operation. After complete resection of the tumor, malignant solitary fibrous tumor was diagnosed in combination with histopathology and immunohistochemistry. The patient survived well with no tumor metastasis or recurrence in 4 months of postoperative follow-up. Conclusion This case report suggests that pelvic solitary fibrous tumor is rarely seen clinically. Because of its non-specific clinical manifestation and imaging, definite diagnosis is mainly based on histopathology and immunohistochemistry. Complete resection of the tumor is the first-line treatment, and most patients have a good prognosis.

胃印戒细胞癌(SRC)因其细胞膜表面葡萄糖转运蛋白-1 低水平表达导致对18 F-FDG 摄取低, PET/CT显像假阴性较多,临床易漏诊误诊.近期收治胃印戒细胞癌术后腹膜转移 1 例,PET/CT检查显像假阴性,现报道如下.

The involvement of long non-coding RNAs (lncRNAs), differentially expressed genes and signals in prostate cancer (PCa) continues to be a subject of investigation. This study determined effects of LOC100996425 on human PCa by targeting hepatocyte nuclear factor 4A (HNF4A) via the AMPK/mTOR pathway. PCa and adjacent normal tissues were obtained to characterize expression pattern of LOC100996425, HNF4A and the AMPK/mTOR pathway-related genes. Then, the target gene of LOC100996425 was determined with lncRNA target prediction website and further verification was obtained through luciferase assay and ribonucleoprotein immunoprecipitation. After that, PCa cells were introduced with LOC100996425, HNF4A, siLOC100996425 or siHNF4A to explore the specific significance of LOC100996425 and HNF4A in PCa. The mechanism associated with AMPK/mTOR pathway was investigated using AMPK inhibitor or activator. LOC100996425 was up-regulated, while HNF4A was down-regulated in the PCa tissues. HNF4A was a target gene of LOC100996425. PCa cells transfected with either siLOC100996425 or HNF4A displayed reduced rates of PCa cell proliferation and migration while elevating cell apoptosis. HNF4A overexpression reversed the promotive effect of LOC100996425 overexpression on PCa. The activation of AMPK pathway involved in the cancer progression mediated by LOC100996425. Down-regulation of LOC100996425 retards progression of PCa through HNF4A-mediated AMPK/mTOR pathway.

RATIONALE:Adult intussusception is rarely observed, accounting for about 5% of all cases of intussusception. Most ileal lipomas are asymptomatic and do not need any special treatment. Herein, we describe a case with ileocolic intussusception caused by ileal lipoma. PATIENT CONCERNS:A 27-year-old woman complaints of intermittent abdominal pain for 10 days. DIAGNOSIS:Abdominal computed tomography demonstrated ileocolic intussusception. Colonoscopy revealed a spherical polypoid lesion with surface capillary rising from the lateral wall of the ileum. A diagnosis of ileocolic intussusception was made. INTERVENTIONS:The patient underwent primary resection of the intussuscepted intestine after which an end-to-end anastomosis was performed. OUTCOMES:Histopathology report confirmed a 4.5 cm × 3.5 cm lipoma in the terminal ileum. The patient was discharged on a postoperative day 9 without complications. LESSONS:We describe the difficulties in diagnosis and treatment of this rare cause of intussusception and review the literature on adult intussusceptions. The ileal lipoma is a very rare cause of ileocolic intussusception. Abdominal CT and colonoscopy are important for the diagnosis of intussusception and abdominal lipomas. Surgical resection remains the treatment of choice.

Alternative splicing (AS) occurs in nearly all human genes and abnormal AS has a close association with cancer. Serine and arginine‑rich splicing factor 6 (SRSF6), a canonical member of the serine/arginine‑rich protein family, has been characterized as an important regulator of AS. However, the role of SRSF6 in regulating AS in cancers has remained to be fully elucidated. In the present study, the median expression of SRSF6 in tumors was determined to be higher compared with that in matched normal tissues in 13 out of 16 cancer types from The Cancer Genome Atlas. To investigate the biological effects of SRSF6 overexpression, an SRSF6‑overexpression model of HeLa cells was constructed and it was revealed that SRSF6 overexpression resulted in significantly higher apoptosis and lower proliferation compared to control cells. Transcriptome analysis indicated that overexpression of SRSF6 in cancer cells induced large‑scale changes in transcriptional expression levels and AS. Two groups of cervical cancer tumor samples in which SRSF6 was differentially expressed were then selected to analyze potential SRSF6‑regulated AS. It was determined that the pattern of SRSF6‑regulated AS in clinical samples was similar to that in cancer cells and AS genes were enriched in DNA damage response (DDR) pathways, including DNA repair and double‑strand break repair via homologous recombination. Furthermore, AS events regulated by SRSF6 were validated using reverse transcription‑quantitative PCR. The present results highlighted that SRSF6 is able to trigger the activation of DDR pathways via regulation of AS to influence cancer progression. These results markedly expand the current understanding of the mechanisms underlying SRSF6‑mediated gene regulation and suggest the potential use of SRSF6 as a therapeutic target in cancer.

In this study, we have successfully developed a simvastatin (SMV) and miR-21i-loaded poly (D,L-lactide-co-glycolide)/polyethylenimine (PLGA/PEI) nanoparticles (NP) to enhance the therapeutic efficacy in gastric cancers. The nanoparticles were characterized for in vitro physicochemical and biological assays and pharmacokinetic study was performed in rats. CLSM/FACS results clearly showed the ability of SMV/miR-21i-loaded PLGA/PEI NP (PPN-S21i) to deliver the combinational therapeutics of SMV and miR-21i to the cancer cells. Combination of SMV+miR-21i showed significantly lower cell viability compared to that of free SMV. Our results clearly highlight the importance of simultaneous interaction of SMV+miR-21i and that it could significantly decrease the cell proliferation in BGC-823, SGC-7901 and HGC-27 gastric cancer cells while it was significantly less cytotoxic to normal gastric mucosa cells (GES-1). Cell apoptosis of SMV+miR-21i was significantly higher compared to that of individual drug or miRNA. Finally, pharmacokinetic analysis revealed that PPN-S21i significantly prolonged the blood circulation time of SMV compared to that of free SMV indicating the potential of carrier system. Overall, results clearly indicate that the combination of SMV+miR-21i (gene + drug therapy) might provide a valuable strategy for the clinical management of gastric cancers.

Emerging evidence has shown that the long noncoding RNA urothelial carcinoma-associated 1 (UCA1) plays a tumor-promoting role in colorectal cancer, while miR-28-5p shows tumor-inhibitory activity in several tumor types. However, the mechanisms both of these in colon cancer progression are still unknown. In this work, the detailed roles and mechanisms of UCA1 and its target genes in colon cancer were studied. The results showed that UCA1 was upregulated in colon cancer tissues when compared with the adjacent nonhumorous tissues, as well as in the various colon cancer cell lines, but the expression of miR-28-5p showed an opposite trend. Furthermore, a high UCA1 level in colon cancer tissues is positively associated with the tumor size and advanced tumor stages. Functional assays revealed that both UCA1 knockdown and miR-28-5p overexpression could inhibit colon cancer cell growth and migration. Further mechanistic studies indicated that UCA1 knockdown played tumor suppressive roles in SW480 and HT116 cells through binding with miR-28-5p. We also, for the first time, identified HOXB3 as the target gene of miR-28-5p and that HOXB3 overexpression could mediate the functions of UCA1 in cell proliferation and migration of colon cancer cells. In conclusion, our data provided evidence for the regulatory network of UCA1/miR-28-5p/HOXB3 in colon cancer, suggesting that UCA1, miR-28-5p, and HOXB3 are the potential targets for colon cancer therapy.

This study discusses the influences of early-stage movement nursing of hospital-community-home(HCH) nutrient management mode on nutritional status and prognosis of patients with gastrointestinal malignant cancer. Malnutrition is one of common complications for malignant tumor patients. The study indicates that HCH nutrient management mode is a new mode of grading nutrient management. With the bidirectional circulation and seamless connection among the hospital, community and home, nutrient management from the hospital to home has already gotten some effect in tumor patients.

目的 探究珠子参汤剂对脑胶质瘤U87细胞增殖和凋亡的影响,并对其分子机制进行初步探究.方法 将脑胶质瘤U87细胞随机分为空白组(A组)、珠子参汤荆低剂量组(B组)、珠子参汤剂中剂量组(C组)、珠子参汤剂高剂量组(D组).用MTT检测细胞增殖情况,流式细胞仪和TUNEL染色检测细胞凋亡情况,Real-time PCR检测细胞内Bcl-2 mRNA、Bax mRNA和Caspase-3 mRNA水平,Western blotting检测细胞内p-PI3K蛋白、p-AKT蛋白的水平.结果 与A组比较,C、D组细胞存活率显著降低(P＜0.05);B、C、D组Bcl-2 mRNA表达水平显著降低,B、C组Bax mRNA与Caspase-3 mRNA水平显著升高(P＜0.05);B、C、D组p-PI3K蛋白与p-AKT蛋白表达水平显著降低(P＜0.05).与B组比较,C、D组细胞存活率显著降低(P＜0.05);D组Bcl-2 mRNA表达水平显著降低,Bax mRNA与Caspase-3 mRNA水平显著升高(P＜0.05);p-PI3K蛋白与p-AKT蛋白表达水平显著降低(P＜0.05);与C组比较,D组细胞凋亡率、Bax mRNA水平显著升高,而Bcl-2 mRNA表达水平、p-AKT蛋白表达水平显著降低(P＜0.05).结论 珠子参汤剂可以抑制脑胶质瘤U87细胞增殖、细胞凋亡,其机制可能与珠子参汤剂调控PI3K/AKT信号通路有关.

目的 分析急性脑出血患者血清细胞间黏附分子1(ICAM-1)、细胞纤维连接蛋白(cFN)水平与炎性因子的相关性及预后危险因素.方法 选取2017年10月—2018年10月吉林大学第二医院神经外科诊治急性脑出血患者126例作为脑出血组,其中存活104例(存活亚组),死亡22例(死亡亚组),另选取同期在医院体检的健康志愿者50例作为健康对照组.比较2组血清ICAM-1、cFN水平及与炎性因子的相关性,分析患者死亡的危险因素.结果 脑出血组患者各个时间点的血清ICAM-1、cFN、肿瘤坏死因子-ɑ(TNF-ɑ)、白介素-1β(IL-1β)、C反应蛋白(CRP)水平均高于健康对照组(F/P=4319.339/0.000、3692.312/0.000、3862.029/0.000、621.021/0.000、899.166/0.000);患者发病3 d时的血清ICAM-1、cFN、TNF-ɑ、IL-1β、CRP水平最高,高于发病1、5 d(F/P=90.498/0.000、589.890/0.000、185.613/0.000、10.920/0.001、11.634/0.001);Pearson分析结果显示,血清ICAM-1、cFN与TNF-ɑ、IL-1β、CRP均呈正相关(ICAM-1:r/P=0.532/0.007、0.489/0.012、0.581/0.000;cFN:r/P=0.453/0.024、0.422/0.041、0.501/0.010);死亡亚组和存活亚组临床资料比较显示,血肿量、GCS评分、ICAM-1、cFN、TNF-ɑ、IL-1β、CRP差异均有统计学意义(P均<0.05),多因素Logsitic回归分析结果显示,血肿量以及血清ICAM-1、cFN、CRP水平是急性脑出血患者死亡的独立危险因素(P<0.05).结论 急性脑出血患者血清ICAM-1、cFN水平与炎性因子呈正相关,血肿量以及血清ICAM-1、cFN、CRP水平是急性脑出血患者死亡的独立危险因素.

Background: Colorectal cancer (CRC) is one of the gastrointestinal tumors. MTAP gene has a close relationship with the tumor and the NF-kappa B pathway has been reported to be related with multiple diseases. This study was mainly focused on the role of MTAP and NF-kappa B pathway in the development of colorectal cancer. Methods: Thirty pairs of colorectal tumor and tumor-adjacent tissue specimens were collected from our hospital and expression of MTAP was detected. RT-PCR was applied to test the mRNA expression of MTAP in five CRC cell lines of normal colonic cell line NCM460 (SW480, SW620, HCT116, HT29, and LoVo) and tumor tissues to examine metastasis. Relative expression of the NF-kappa B pathway in both high and low MTAP expression LoVo cell lines was analyzed though Western blot. Western blot and immunofluorescence were used to detect inhibition of LoVo cell growth though suppression of the NF-kappa B pathway by MTAP. Finally, flow cytometry and immunofluorescence tests were applied to determine cell apoptosis by suppressing the NF-kappa B pathway through MTAP. Results: These data show that the expression of MTAP is lower in CRC cell lines when compared with the normal colonic cell line (P<0.05). In addition, the metastasis CRC tissues also showed lower expression of MTAP than the non-metastasis CRC tissues. Ectopic expression of MTAP and RNA interference significantly reduced cell proliferation through the inhibition of NIK and enhanced cell apoptosis of CRC cells. Therefore, MTAP plays an important role in development of CRC by targeting NIK. Conclusion: Downregulation of MTAP leads to activation of the NF-kappa B pathway and the malignant phenotype of CRC.

目的 探讨D型人格对帕金森病(Parkinson's disease,PD)患者生活质量的影响.方法 便利抽样收集2015年11月至2018年2月期间在吉林大学第二医院诊治的175例PD患者作为研究对象,借助D型人格量表-14进行D型人格鉴定,并将其分为D型人格组和非D型人格组.应用非运动症状量表进行非运动症状评估,应用帕金森病调查问卷-39评估患者生活质量,应用多元线性逐步回归分析生活质量与D型人格的关系.结果 在175例参与者中,D型人格组62例(35.4％),该组低收入家庭、运动波动的患者比例较高,且生活质量总分及各领域评分均高于非D型人格组(均P<0.05);多元线性逐步回归分析显示D型人格与PD患者生活质量总分呈正相关(P<0.05).结论 D型人格的PD患者的生活质量水平显著下降.因此,掌握PD患者的D型人格特征对于制定护理策略、提高患者生活质量具有一定的指导意义.

RATIONALE:Adult intussusception is rarely observed, and the clinical manifestations are very atypical. The most common symptom is abdominal pain, while the incidence of hematochezia is relatively low. We report two cases of adult intussusception secondary to small intestinal tumors with gastrointestinal hemorrhage as the main symptom.PATIENT CONCERNS:Two men aged 19 and 54 years were successively referred to our department due to intermittent hematochezia. The hemoglobin levels of the two patients declined progressively, and conservative treatment was ineffective.DIAGNOSES:The first patient underwent an abdominal computed tomography angiography examination, which showed that the intestine and its mesentery were tortuous, suggesting an intra-abdominal hernia or intussusception. The second patient underwent an abdominal computed tomography examination, which suggested a high possibility of an intussusception. The two patients were diagnosed as adult intussusception caused by small intestinal tumors.INTERVENTIONS:Emergency laparoscopic explorations were performed. Enteroenteric intussusceptions caused by ileal tumors were found during surgery. Reduction of the intussusceptions and resection of the ileal tumors were performed.OUTCOMES:The patients recovered well after surgery, and postoperative pathology showed that the tumors were a vascular hamartoma polyp and a lipoma.LESSONS:Adult intussusception is very rare, particularly with gastrointestinal hemorrhage as the main symptom. Isolated hamartoma polyp is a rare cause of intussusception in adults. The clinical manifestations of adult intussusception are very atypical, and thus, making a preoperative diagnosis is difficult. Abdominal CT or CTA is an effective diagnostic method for adult intussusception. For adult patients with gastrointestinal hemorrhage caused by intussusceptions, active surgery should be performed when conservative treatment is not effective. Laparoscopic surgery is a safe and effective treatment for adult intussusceptions caused by benign diseases.

BACKGROUND:Emerging evidence indicate that miRNAs play an important role on gastric cancer (GC) progression via regulating several downstream targets, but it is still partially uncovered. This study aimed to explore the molecular mechanisms of GC by comprehensive analysis of mRNAs and miRNA expression profiles.METHODS:The mRNA and miRNA expression profiles of GSE79973 and GSE67354 downloaded from Gene Expression Omnibus were used to analyze the differentially expressed genes (DEGs) and DE-miRNAs among GC tissues and normal tissues. Then, targets genes of DE-miRNAs were predicted and the DE-miRNA-DEG regulatory network was constructed. Next, function enrichment analysis of the overlapped genes between the predicted DE-miRNAs targets and DEGs was performed and a protein-protein interactions network of overlapped genes was constructed. Finally, RT-PCR analysis was performed to detect the expression levels of several key DEGs and DE-miRNAs.RESULTS:A set of 703 upregulated and 600 downregulated DEGs, as well as 8 upregulated DE-miRNAs and 27 downregulated DE-miRNAs were identified in GC tissue. hsa-miR-193b-3p and hsa-miR-148a-3p, which targeted most DEGs, were highlighted in the DE-miRNA-DEG regulatory network, as well as hsa-miR-1179, which targeted KNL1, was newly predicted to be associated with GC. In addition, NCAPG, which is targeted by miR-193b-3p, and KNL1, which is targeted by hsa-miR-1179, had higher degrees in the PPI network. RT-qPCR results showed that hsa-miR-148a-3p, hsa-miR-193b-3p, and hsa-miR-1179 were downregulated, and NCAPG and KNL1 were upregulated in GC tissues; this is consistent with our bioinformatics-predicted results.CONCLUSIONS:The downregulation of miR-193b-3p might contribute to GC cell proliferation by mediating the upregulation of NCAPG; as additionally, the downregulation of miR-193b-3p might contribute to the mitotic nuclear division of GC cells by mediating the upregulation of KNL1.

Objective: To discuss the anatomic variation of celiac axis influencing the D2 radical operation for distal gastric cancer and its significance. Method: A retrospective analysis on the anatomic variation of celiac axis influencing operation found in 163 cases of D2 radical resection for distal gastric cancer was made. Result:4 cases of anatomic variation of celiac axis influencing operation was found from the 163 cases, 1 case is common hepatic artery originated from left gastric artery, 1 case is left gastric artery was deficiency by 3 branch stomach arteries originating from common hepatic artery, and 2 cases are left gastric artery independently originated from aorta abdominals. With popularization of standardization of gastric cancer operation, it is necessary to excise the routine lymph nodes in the surrounding blood vessels of celiac axis such as those beside celiac artery and left gastric artery, in front of common hepatic artery, etc. in D2 radical operation for distal gastric cancer, However, the typical type in the celiac axis accounts for 75% [1], and the rest blood vessels all variate in different ways, leading to the risks of damaging the blood vessels and influencing the blood supply in operation. During February 2013 to February 2015, our department totally performed standard D2 radical operation for 163 cases with distal gastric cancer, and found 4 cases with coeliac trunk blood vessel variation influencing operation. Following is a summary of our experience as follows: 1. Clinical data and method 1.1 General materials The 163 patients with distal gastric cancer who underwent standard D2 radical operation in the surgical department of stomach, intestine, colorectum and anus in China-Japan Friendship Hospital Affiliated to Jilin University during February 2013 to February 2015 were selected as research objects, to observe the variation in the branches originating from the coeliac trunk in D2 radical operation. The included cas-es all underwent gastroscopy and pathological examination after hospitalized to clari-fy the diagnosis. Wherein, there were 94 male cases, 69 female cases, whose age was 32-76 and average age was 59.8.

Increasing evidence shows that microRNAs (miRNAs) are a novel class of gene regulators, and play a vital role in tumor development and progression. MicroRNA-27a (miR-27a) was previously reported dysregulated expression in human carcinoma, including gastric cancer (GC). However, till now, the mechanism that miR-27a functions as an oncogene is still not well known. As we all known, there are two isoforms of mature miR-27a, miR-27a-5p and miR-27a-3p. In this study, we figure out the link between miR-27a-3p and RUNX1 and the overexpression of miR-27a-3p markedly promote gastric cancer cell proliferation, invasion, and migration in vitro. We also describe that miR-27a-3p have effect on the EMT process. Furthermore, miR-27a-3p repressed RUNX1 expression by directly binding to 3-untranslated region (UTR) of RUNX1 in gastric cancer, and the inverse correlation was observed between the expressions of miR-27a-3p and RUNX1 mRNA in primary GC tissues. In turn, the restoration of RUNX1 led to suppressed proliferation, invasion, and migration of GC cells. In vivo, miR-27a-3p promotes tumor growth of GC. Taken together, these results suggested that the miR-27a-3p/RUNX1 axis promotes GC progression by directly downregulating RUNX1 expression and may be employed as a novel prognostic marker and therapeutic target in the management of gastric cancer.

In order to investigate the mechanism of celecoxib and whether long non-coding RNAs (lncRNAs) were involved in the effects of celecoxib treatment in NCI-N87 cells, NCI-N87 cells were treated with 15, 30 and 60 µM celecoxib and an MTT assay was performed to assess cell viability. Following treatment with 15 µM celecoxib, the cell cycle and apoptosis were analyzed by flow cytometry, and the mRNA levels of lnc-SCD-1:13, lnc-PTMS-1:3, cyclooxygenase-2 (COX-2), integrin α3 (ITGA3) and DSH homolog 1 (DVL1) were detected by reverse transcription quantitative PCR (RT-qPCR) in NCI-N87 cells. MTT analysis demonstrated that celecoxib significantly inhibited cell viability in treated cells compared with untreated cells. Flow cytometry analysis revealed that, compared with untreated cells, the percentage of cells in the G0/G1 phase was significantly increased, and the percentage of cells in the S and G2 phase was decreased. In addition, the percentage of early and late apoptotic cells was increased in cells treated with 15 µM celecoxib compared with the control. RT-qPCR analysis also demonstrated that the mRNA levels of lnc-SCD-1:13, lnc-PTMS-1:3, ITGA3 and DVL1 were increased following treatment with celecoxib (15 µM; P<0.05). However, there were no significant differences in the expression of COX-2 mRNA between cells treated with celecoxib (15 µM) and untreated cells. The present study demonstrated that a low dose of celecoxib may be involved in regulating cell growth independent of COX-2 in NCI-N87 cells. Furthermore, ITGA3 and/or DVL1 co-expressed with lnc-SCD-1:13 and lnc-PTMS-1:3 may be associated with the effects of treatment with a low dose of celecoxib in NCI-N87 cells.

Low-grade gliomas (LGGs) are associated with neurological disability. The present study used microRNA (miRNA) expression profiles to identify risk miRNAs for potential prognosis of cerebral LGGs. miRNA expression profiles and clinical data from 408 patients with cerebral LGGs were obtained from the Cancer Genome Atlas database. Risk miRNAs were identified by plotting Kaplan-Meier curves and Cox proportional hazard regression analysis with the survival and KMsurv packages in R. A regulatory network of miRNA-targets was constructed, followed by gene ontology (GO) function and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis using the Database for Annotation, Visualization and Integrated Discovery. A protein-protein interaction (PPI) network of miRNA targets was built using Search Tool for the Retrieval of Interacting Genes software, and sub-pathway identification was performed using the iSubpathwayMiner package in R. In total, 39 miRNAs had significant effect on survival curves. Following the Cox analysis and construction of miRNA-targets regulatory network, hsa-miRNA (miR) -326 was identified to regulate 397 target genes. Additionally, targets of miR-326 were primarily enriched in the GO terms of cell proliferation, epithelial growth factor receptor and nerve growth factor signaling pathways. Additionally, son of sevenless homolog 1 (SOS1), neuroblastoma RAS viral oncogene homolog (NRAS), vitamin D receptor (VDR) and mothers against decapentaplegic family member 3 (SMAD3) were most enriched in the PPI network. Targets of miR-326 were primarily enriched in sub-pathways including sphingolipid metabolism and arachidonic acid metabolism, in which sphingomyelin synthase 1 (SGMS1) and hematopoietic prostaglandin D synthase (HPGDS) were screened out. Hsa-miR-326 was identified as a risk miRNA for prognosis and may improve the outcome prediction of patients with cerebral LGG. This miRNA may regulate cancer cell proliferation by targeting SOS1, NRAS, VDR, SMAD3, SGMS1 and HPGDS.

原发性十二指肠肿瘤（PTD）是指发生在十二指肠各个部位的肿瘤,不包括胰头、胆总管末端及Vater壶腹部的肿瘤。PTD分为原发性十二指肠良性肿瘤（PBTD）与原发性十二指肠恶性肿瘤（PMTD）。PTD发病率小于胃肠道肿瘤的1%,其中PBTD占PTD发病率的25% [1] 。PMTD好发于中年人,男性多于女性,好发于十二指肠降段乳头区。因为十二指肠与胆总管、胆囊、胰腺、下腔静脉、肠系膜上动、静脉等重要结构毗邻,使PTD缺乏特

目的 探讨远端胃癌D2根治术中影响手术的腹腔干变异及其意义. 方法 回顾性分析2013年2月～2015年2月我科收治的163例胃癌D2根治术中发现的影响手术的腹腔干变异情况.结果 163例中发现影响手术的腹腔干变异4例,1例肝总动脉起源于胃左动脉,1例胃左动脉缺失由肝总动脉发出3只胃分支动脉替代,2例胃左动脉起独立源于腹主动脉. 结论 远端胃癌根治术时应考虑到腹腔干血管变异的可能,小心解剖变异血管,避免损伤脏器的血供.