Introduction:The oncogenic role of lncRNA LUADT1 has been investigated only in lung cancer.This study aimed to investigate the role of LUADT1 in oral squamous cell carcinoma (OSCC).Patients and Methods: The expression levels of LUADT1 in paired OSCC and non-tumor tissues from OSCC patients were determined by RT-qPCR.A 5-year follow-up study was performed to analyze the prognostic value of LUADT1 for OSCC.Dual-luciferase assay and overexpression experiments were performed to assess the interactions among LUADT1, miR-34a and GASL1.Cell proliferation was analyzed by cell proliferation assay.Results: In this study, we found that LUADT1 was upregulated in OSCC and predicted poor survival.LUADT1 was predicted to interact with miR-34a, which was confirmed by dualluciferase activity assay.However, overexpression experiments showed that they did not affect the expression of each other.Interestingly, overexpression of LUADT1 resulted in upregulation of GAS1, a target of miR-34a.Cell proliferation assay revealed that overexpression of LUADT1 and GAS1 resulted in promoted cell proliferation.MiR-34a played an opposite role and reversed the effects of LUADT1 overexpression.Conclusion: LUADT1 may promote OSCC proliferation by regulating miR-34a/GAS1 axis.

Using anthropometry,we analyzed a number of the dermatoglyphic characteristics in 202 patients suffering from depression(140 females,62 males),compared with 310 normal(or control) cases(231 females,79 males) from the Tianjin-based Han people.Differences were analyzed using t test or χ2 test with the SPSS 17.0 statistical software.Results showed that there were no significant differences in a-b RC and the incidence of the true patterns at the hypothenar and area I2,I3,I4 in both hands of depressed patients.Fingerprint pattern occurrence rates of the whorl and radial loop increased(P<0.01),whereas ulnar loop occurrence decreased(P<0.01),and in palmar FA(fluctuating asymmetry) values of a-b RC increased(P <0.01),atd angle enlarged(P <0.01),variation I type of simian line and wrinkles-palm were more common(P <0.01) in patients with depression.

目的 探讨抑郁症患者的指纹特征.方法 采用体质测量法,分析天津汉族抑郁症患者202例(女性140例,男性62例)正常者310例(女性231例,男性79例)指纹类型及指纹白线出现率,比较其差异.结果 抑郁症患者组斗型纹出现率高于对照组,差异极显著(P＜0.001);双手一般斗型纹数≥6的出现率与正常对照组存在极显著性差异(P＜0.01);桡箕、帐弓出现率显著高于对照组,尺箕、双箕斗出现率显著低于对照组;女性患者各指指纹白线出现率显著高于对照组(P＜0.001),男性患者指纹白线出现率均高于对照组,中指、环指、小指差异具显著性(P＜0.05).结论 一般斗型纹、指纹白线出现率增加可能是抑郁症的重要指纹特征之一.