Paraproteinemic polyneuropathy accounts for up to 30% of chronic demyelinating polyneuropathies. The aim of this study was to determine the clinical and neurophysiological patterns of the nosology compared with chronic inflammatory demyelinating polyneuropathy (CIDP). We examined 30 patients with PNP against a background of monoclonal gammopathy (16 with monoclonal gammopathy of undetermined significance (MGUS) and 14 with hemoblastosis) and 30 patients with CIDP. The history, neurological status and results of stimulation electroneuromyography were evaluated. A number of significant differences were recorded which suggest paraproteinemia in patients with demyelinating PNP. Nevertheless, immunofixation electrophoresis is currently the only method of the disease verification.

POEMS-syndrome (Polyneuropathy, Organomegaly, Endocrinopathy, M-protein, and Skin Changes) is a rare nosological form occurred in patients with paraproteinemic hemoblastosis. Chronic progressive sensory-motor polyneuropathy is a key syndrome of the disease and it is a common reason for referral to neurologist. The paper presents data about POEMS-syndrome and own case reports with the analysis of disease features and results of examination.