Ether-based electrolytes are widely used in lithium metal batteries (LMBs) due to their excellent compatibility with the lithium metal anode (LMA). However, their poor oxidation resistance significantly limits their operational conditions. In this study, we introduce a breakthrough in the design of multifunctional additive-2,4-bis(2-fluoroethoxy)-tetrafluorocyclotriphosphazene (DFEPN)-that overcomes the critical limitations of ether-based electrolytes in LMBs. Leveraging its highly fluorinated molecular structure, DFEPN resolves the long-standing issue associated with the poor oxidation stability in ether-based electrolytes. Remarkably, the fluoroethoxy functionality of DFEPN was found to be compatible with LMA and to regulate the Li+ solvation structure through steric effects, demonstrating an innovation path of molecular design for LMBs. On top of that, the fluorinated cyclotriphosphazene ring was recognized to be able to stabilize the cathode interface via a unique dual-protection effect on both electrode-electrolyte interfaces. By incorporating DFEPN into the conventional Dimethoxyethane/1,3-Dioxolane ether-based electrolyte system, the Li/LiFePO4 full battery exhibits a dramatic leap in performance, i.e., its cycle life surges from severe degradation within merely 75 cycles with only 27.5% capacity retention to 200 cycles with an exceptional 96.4% capacity retention. This study advances the industrial use of LMBs and makes them one step closer to practical implementation.

Clinicians often concurrently tackle critical challenges including emergency hemorrhage, secondary infection, and the elusive tracking of biodegradation of conventional hemostatic agents for complex wounds. Here, we report an intelligent hemostatic sponge (spCS@AIE) by incorporating aggregation-induced emission (AIE) nanoparticles with short-wave infrared (SWIR) fluorescence and photodynamic properties into a chitosan matrix through several weak interactions in a self-assembled manner. This multifunctional platform enables rapid hemostasis, strong antibacterial and anti-inflammatory activity, and real-time monitoring of wound healing and sponge degradation through SWIR fluorescence. The synergistic effect of photodynamic properties by AIE nanoparticles and the cationic nature of chitosan also result in efficient antibacterial rates of 98.8 and 91.7% against Escherichia coli (E. coli) and methicillin-resistant Staphylococcus aureus (MRSA), respectively. The sponge here also accelerates oral wound healing within 21 days and fully degrades within 11 days. This work advances hemostatic materials by combining therapeutic efficacy with diagnostic capability, offering a comprehensive solution for wound management and bridging the material innovation with clinical practice.

African swine fever virus (ASFV) poses a severe threat to the global swine industry, demanding rapid on-site diagnostics due to the lack of an effective vaccine. Existing laboratory-based methods, such as PCR and ELISA, are limited by cost, complexity, and infrastructure requirements, hindering their use in resource-limited settings. Colorimetric assays offer a promising alternative for instrument-free, rapid detection, but conventional reliance on fragile and expensive natural enzymes such as horseradish peroxidase (HRP) is problematic. This research addresses this need by developing a highly sensitive colorimetric sensor for ASFV based on a two-dimensional (2D) MoSe2@Fe-MOF nanozyme. This composite nanozyme leverages a synergistic effect: Fe-MOF provides abundant peroxidase-like (POD-like) active sites, while integrated MoSe2, a p-type semiconductor, enhances charge transfer at the heterojunction. This synergy boosts the catalytic oxidation of the chromogenic substrate TMB, resulting in a vibrant blue color signal (the "ON" state). To achieve specific ASFV detection, the nanozyme surface is functionalized with antibodies targeting the p72 major capsid protein. Upon capturing ASFV, the resulting immuno-complex generates significant steric hindrance, physically blocking catalytic sites and impeding substrate access. This inhibition significantly reduces TMB oxidation, leading to a decrease in color development and absorbance (the "OFF" state). This efficient signal modulation enables the sensor to achieve a remarkably low limit of detection of 0.22 TCID50/mL in just 15 min, offering a rapid, cost-effective, and reliable solution for on-site ASFV diagnostics.

Heteroatom doping and carbon coating are essential techniques for improving the conductivity and reaction kinetics of intercalation-type anode materials in lithium-ion batteries. However, it is difficult to achieve heteroatom doping and carbon coating at the same time through simple processes. Here, we propose a simple method to simultaneously achieve carbon-coating and P/S/N triple-doping by introducing polyphosphazene (PZS) as precursor. We first prepare PZS-coated titanium-based metal-organic frameworks (MIL-125), which can be readily converted into phosphorus/sulfur/nitrogen (P/S/N) co-doped carbon-coated titanium dioxide (TiO2) nanocomposites (PSN-C@TiO2@C) by simple calcination under an inert atmosphere. The heteroatom doping and carbon hybridization synergistically enhance the conductivity and ion diffusion of the PSN-C@TiO2@C, which not only change the local charge density of the nanocomposite, but also generate more active sites. Benefiting from the above advantages, the well-designed PSN-C@TiO2@C anode exhibits significantly improved specific capacity and rate performance, maintaining high reversible specific capacities of 272.2 mA h g-1 after 1000 cycles at 1000 mA g-1 and 141.1 mA h g-1 after 2000 cycles at 5000 mA g-1. This study presents a novel simplified method for multi-element-doping and carbon-coating, which can be generally applied for developing advanced electrode materials for energy storage application.

Objective Wind speed measurement is critical in fields such as energy exploration and environmental monitoring. In coal mine safety, accurately detecting micro-airflow from goaf leakage is essential for preventing gas accumulation and spontaneous combustion. Traditional electrical sensors face challenges in harsh, explosive-prone environments due to electromagnetic interference and safety concerns. Fiber optic sensing technology, with its intrinsic safety and immunity to electromagnetic interference, offers a promising alternative. This study focuses on developing a high-performance fiber-optic hot-wire anemometer based on the photothermal conversion effect of cobalt-doped fiber, specifically targeting the need for precise micro-wind-speed detection in coal mine goafs. Methods The principle of photothermal conversion in doped fiber was investigated, identifying non-radiative relaxation of excited ions as the primary heat source. Theoretical analysis based on thermodynamics was conducted to elucidate the factors influencing the photothermal effect in cobalt-doped fiber. Simulations were performed to study the temperature distribution under different pump wavelengths and fiber lengths. Following the sensing element design, a fiber Bragg grating (FBG) wind speed sensor was fabricated using cobalt-doped fiber, and a complete optical fiber wind speed sensing system was constructed. A series of experiments were carried out to characterize the sensor, including tests on pump absorption coefficients, photothermal-induced wavelength drift, and wind speed response sensitivity. Results and Discussions COMSOL Multiphysics simulations revealed that the highest temperature within the cobalt-doped fiber under 980 nm and 1480 nm pump irradiation occurs near the fusion point with the single-mode fiber. Increasing the pump power raised the maximum fiber temperature. The photothermal effect was more pronounced under 1480 nm pump light, leading to a higher internal temperature and a more significant FBG wavelength shift. Experimental characterization of a 10 mm cobalt-doped fiber segment showed that the absorption coefficients for both 980 nm and 1480 nm pump light decreased with increasing input power, with the coefficient for 1480 nm being significantly higher than that for 980 nm. This higher absorption correlates with greater heat generation, consistent with theoretical expectations. The FBG wavelength drift exhibited a linear increase with pump power. Wind tunnel tests using a 1480 nm pump showed that the FBG center wavelength shifted towards shorter wavelengths as wind speed increased. A higher pump power resulted in a larger overall wavelength drift and enhanced sensitivity at low wind speeds. At a pump power of 160 mW, the sensor demonstrated high sensitivity in the low wind speed range, with the sensitivity decreasing as wind speed increased due to enhanced convective cooling. Conclusions The influencing factors of the photothermal conversion effect in cobalt-doped fiber were analyzed theoretically. A highly sensitive optical fiber micro-wind-speed sensor was developed based on this effect and tested comprehensively. The results confirm significant photothermal conversion in cobalt-doped fiber for both 980 nm and 1480 nm pump lasers, with a notably higher absorption coefficient (up to 16.58 dB/cm) for the 1480 nm pump. The fabricated sensor exhibits high sensitivity in the low wind speed range, reaching 1634 pm/(m & centerdot;s(-1)) at a wind speed of 0.35 m/s, demonstrating excellent capability for micro-wind detection. This work provides an effective sensing solution for applications such as air leakage detection in coal mine goafs.

Spatial heterogeneity at electrode/electrolyte interfaces critically influences the electrochemical performance and degradation of lithium-ion batteries, yet the respective contributions of surface morphology and interfacial chemistry to localized electrochemical kinetics remain...

Chronic diabetic wounds featuring interlocked biofilm infection, vascular damage, and oxidative stress, demand smart nanomedicines that dynamically respond and concurrently address these pathologies. Here, a coordination-disparity-driven strategy is used to construct a copper-cerium heterogeneous dual-single-atom on carbon dots (CeCu DSAEs). Theory and experiment show that Ce-Cu d-f orbital hybridization suppresses Ce aggregation, elevates the Ce3+ fraction to 55.07%, and reduces the peroxidase-like reaction energy barrier to 0.44 eV. Atomic-level electronic regulation endows CeCu DSAEs with exceptional, switchable cascade catalysis. Upon integration with glucose oxidase (GOx), the resulting CeCu@GOx nanoplatform performs pH-programmed, microenvironment-adaptive catalytic therapy: in the infection stage, Ce-mediated hydrolytic disruption of biofilms achieves 89% matrix breakdown, followed by hetero Fenton-like bactericidal activity with >99.999% reduction; in the reparative stage, the catalyst switches to reactive oxygen species scavenging (90% clearance) and enhances angiogenesis (+299%). In diabetic mice, CeCu@GOx achieves 96% wound closure by day 11, with 2.19-fold collagen densification and 2.8-fold neovascularization. Transcriptomics confirms inflammatory pathway suppression and tissue regeneration activation. This work introduces an integrated all-in-one therapeutic strategy for chronic diabetic wounds and establishes a paradigm for designing adaptive nanozymes by tuning interatomic electron interactions via orbital coupling, providing generalizable principles for next-generation smart responsive biomaterials.

ABSTRACT Thoracic aortic dissection (TAD) is a highly lethal cardiovascular disease, yet its accurate diagnosis and effective treatment remain challenging due to poor imaging contrast and insufficient specificity. Leveraging the overexpressed reactive oxygen species (ROS) in TAD, we reported a hypochlorous acid (HClO)‐activatable molecular probe DT‐PZ. It enables two‐stage self‐amplifying fluorescence imaging (chemical activation and then physical aggregation) and light‐independent therapy on a single chemical entity. The probe initially exhibits quenched fluorescence via photoinduced electron transfer (PET). Two pathways can turn on the fluorescence via chemical activation: (1) oxidation by HClO blocks PET and turns on the emission; (2) photo‐triggered radicals generation of HClO (via chloride ions or myeloperoxidase) to activate neighboring probes, creating self‐amplifying fluorescence. Upon accumulation at the lesion site, the physical aggregation caused by the aggregation‐induced emission effect further amplifies the fluorescence signals. This two‐stage fluorescence amplification mechanism enables TAD visualization within 2 min in vivo. For therapy, the phenothiazine scavenges excess ROS during non‐illuminated periods, down‐regulates the NF‐κB/P65 signal pathway, and up‐regulates eNOS and P‐Akt expressions, protecting endothelial homeostasis and then improving murine survival from 50% to 90%. Collectively, DT‐PZ synergizes self‐amplifying fluorescence imaging with light‐independent antioxidation/anti‐inflammatory therapy, holding great promise for managing deep‐seated cardiovascular diseases.

Lithium-rich manganese-based layered oxides with high capacity are regarded as highly attractive cathodes for high-energy-density lithium-ion batteries. However, the redox reactions in this cathode usually generate highly reactive singlet oxygen and electrolyte-derived free radicals during high-voltage cycling, which accelerate electrolyte oxidative decomposition and trigger cascading side reactions, leading to a rapid capacity fade. Herein, we report a targeted scavenging strategy employing a hindered amine-functionalized triblock binder to trap singlet oxygen and free radicals, improving the long-cycle stability of the cathodes. The amino groups (N-H) in the hindered amine structure can continuously scavenge singlet oxygen and generate nitroxide radicals (N-O·). Both the parent N-H groups and the resulting N-O· radicals further act as effective traps for free radicals derived from electrolyte decomposition, stabilizing the interfacial stability and transport kinetics of the cathode under 4.8 V. Consequently, the full cell with this binder exhibits a significantly reduced capacity decay rate of 0.175% per cycle over 200 cycles. Our work provides a viable solution for enhancing the cycling stability of lithium-rich manganese-based cathodes, promoting the development of high-energy-density lithium-ion batteries.

Deep-tissue bacterial infections progress rapidly and recur frequently, while current primary treatment—systemic antibiotics are hampered by poor intralesional exposure, dose-dependent toxicity, and resistance. Thus, precision targeting and mitigating drug resistance have emerged as key breakthroughs for therapeutic efficacy enhancement. Here we reported a biomimetic nanotherapeutic platform—MMZI, that integrated indocyanine green (ICG)-loaded zeolitic imidazolate framework-8 (ZIF-8) with Methicillin-resistant Staphylococcus aureus (MRSA)-preactivated macrophage membrane to enable precise, antibiotic-free phototherapy. In situ encapsulation of ICG within ZIF-8 suppressed aggregation-caused quenching, improved photostability, and boosted photothermal conversion efficiency (PCE) to 47.3% while achieving a 30-fold increase in reactive oxygen species (ROS) generation compared to free ICG. The macrophage membrane cloak, optimized by bacterial preconditioning, conferred immune evasion, biocompatibility, and pathogen-specific affinity which promoted selective accumulation at infected foci and improved bioavailability. Upon near-infrared (NIR) irradiation, MMZI triggered a localized heat/ROS burst that achieved >99% in-vitro bactericidal performance via synergistic photothermal/photodynamic therapies (PTT/PDT). In subcutaneous abscess model, MMZI reduced lesion area by 94.03% (0.29 versus 4.86 mm2 in PBS control) and alleviated suppression of tissue repair and angiogenesis, evidenced by a 7-fold increase in Ki67-positive cells and a 6.3-fold increase in CD31-positive vessels. In vivo experiments confirmed the negligible organ toxicity and favorable hemocompatibility of MMZI. By coupling biological recognition with metal-organic framework nanotechnology, MMZI circumvented conventional delivery bottlenecks in deep-seated infections and established a robust, spatiotemporally controllable paradigm for on-demand phototherapy with substantial translational promise.

Organic radicals are highly important, but it is still challenging to produce air-stable and photo-induced radicals. Herein, a series of triarylamine derivatives (compounds 1-6) is designed to tune their molecular stacking and then their capability in photo-induced electron transfer and radical stabilization. It is noted that, in contrast to the other compounds, a robust hydrogen-bonded crystal network is observed in compound 1 with parallel alignments in two dimensions. This network is beneficial to alter its electronic and spatial structures, leading to enhanced inter-molecular electronic transfer. This can finally facilitate the rapid photo-response and high radical stability. As observed, upon irradiation, compound 1 exhibits a fast radical generation in solution (5-min to saturation), showing a 22.5-folds enhancement in near-infrared absorption and 8-folds increase in emission. Remarkably, these radical signals can also be obtained in crystals and detected in the solid state even after one month. Interestingly, it also exhibits efficient fluorescence emission in the NIR region, also high capability to generate reactive oxygen species and heat under irradiation. Therefore, as a proof of concept, these radical-based nanoparticles are prepared via nanoprecipitation for fluorescence imaging and photo-therapy simultaneously both in vitro and in vivo, highlighting their great potential in phototheranostics.

Agents to combine functions simultaneously are highly needed but still challenging in synergistic therapy. Particularly, capabilities to deplete glutathione (GSH) in tumors and monitor their process are also important. Therefore, platinum(II) metallacycles are prepared by using aggregation-induced emission active ligands. Despite their similar structures, high emission for Mh1 is obtained (PLQY = 49.2%) in solids, but a PLQY of only 6.8% is recorded for Mh2. NIR emission in Mh2 can be turned-on in depleting GSH by releasing emissive ligands. Also, both type I and type II reactive oxygen species (ROS) are obtained in Mh2 nanoparticles. Due to the depletion of GSH and generation of ROS, oxidative stress in immunogenic cell death can be induced. By combining chemotherapy and photoimmunotherapy, synergistic therapy in vivo is obtained for Mh2-NPs to well inhibit the tumor growth, also showing antitumor immune effects in distant tumors. The work here provides some guidelines in designing the multi-functional agents, showing the great potentials in efficient cancer therapy.

Stabilizing Li metal anodes remains a central challenge due to the difficulty of establishing the stable electrode/electrolyte interface, arising from dynamic potential fluctuations within the inner Helmholtz plane. Here, we propose a preoccupancy-guided interfacial regulation strategy that decouples electric-field effects from interfacial reduction processes. A Schiff-base polymer with terminal C-F fragments spontaneously establishes a preferential surface-normal orientation across the inner Helmholtz plane, thereby defining a preoccupied and spatially confined interfacial environment that suppresses solvent access to the Li surface. Coupled with the electron-withdrawing effect of its fluorinated moieties, the interfacial electronic environment is modulated, facilitating the preferential formation of a LiF-rich interphase on Li metal. Meanwhile, the abundant F/N coordination sites in the unreacted polymer serve as a soft organic outer layer that accelerates Li-ion desolvation and diffusion. Benefiting from these features, the fine-tuned solid electrolyte interphase integrates chemical stability, mechanical robustness, and efficient Li-ion transport, enabling the fabricated 4.81 Ah pouch cell to deliver an energy density of 502.43 Wh kg-1 and maintain ∼90.06% of its initial capacity after 240 cycles. Our findings reveal that precise tuning of the chemical environment within the inner Helmholtz plane effectively suppresses uncontrolled electrochemical-derived interphase formation, paving the way toward the rational design of a stable Li metal/electrolyte interface.

Biofilm-infected wounds remain a major clinical challenge, as biofilm infections and persistent inflammation hinder conventional therapies from dynamically adapting to the evolving wound microenvironment. Herein, a smart hydrogel dressing (HCOC) is successfully developed for programmed and pH-responsive therapy by integrating humic acid (HAs)-encapsulated ultrasmall mixed-valence copper nanozymes (Cu5.4O) into an oxidized alginate-carboxymethyl chitosan network. In the acidic biofilm-infected phase (pH < 6.5), the HAs shells aggregate, controllably releasing Cu5.4O to initiate chemodynamic therapy (CDT), while simultaneously enabling HAs-mediated photothermal therapy (PTT). This synergistic CDT/PTT achieves exceptional antibacterial efficacy, eradicating > 99.99% of Methicillin-Resistant Staphylococcus aureus and Escherichia coli and dispersing 87.46% of biofilms. As the wound pH rises post-infection (pH ≥ 7.0), HAs dissolves, liberating more Cu5.4O nanozymes, which switch to potent antioxidant modes—scavenging > 90% of reactive oxygen species—and promoting M2 macrophage polarization by suppressing NF-κB and activating Wnt/β-catenin signaling. In vivo, HCOC combined with NIR irradiation accelerates infected wound healing, achieving 91.65% closure within 7 days, significantly enhancing angiogenesis (∼90 CD31+ cells/field), and boosting M2 macrophage infiltration (∼110 CD163+ cells/field). This work establishes a paradigm-shifting platform for precision wound management through microenvironment-responsive sequential therapy.

Abstract Photosensitizers in nanocrystals have emerged as promising avenues for immune stimulation through enhanced reactive oxygen species (ROS) generation relative to their amorphous structures. However, their rigid molecular packing severely restricts the molecular variations necessary for stimuli-responsive conversion in the crystalline state, resulting in challenges for these nanocrystals to undergo dynamic and on-demand immune regulation, particularly under the tumor microenvironment (TME) stimulation. Herein, we address this challenge by developing 2TZP, a photosensitizer engineered with a synergistic proton-capturing motif that confers a narrow pH response range within the TME. This design enables a specific and complete acid-triggered nanocrystal-to-nanocrystal (NCNC) transformation, from hexagonal prism to cuboid prism, directly activated by TME (pH 6.5) with a narrow response range of 0.70 pH units. This process involves significant conformational distortion, subtle rotation, and slippage within the preserved crystalline lattice, which is favored by sensitive responsiveness, sufficient free volume, and crystal lattice similarity before and after nanocrystal transformation. Crucially, this mechanism serves a dual purpose. It intensifies the twisted intramolecular charge transfer (TICT) effect, boosting intersystem crossing (ISC), while simultaneously unveiling latent RNA binding to form an electron reservoir pump and thereby enhancing ROS generation. Thus, the transformed 2TZP nanocrystals further potentiate their ability to target the nucleolus, causing oxidative damage to the nucleolus and leading to pronounced nuclear disruption and enhanced dsDNA leakage. This then effectively ensures potent, on-demand activation of the cGAS-STING immune pathway while concurrently inducing robust immunogenic cell death (ICD) under an acidic TME. This work not only demonstrates a model of NCNC transformation within the TME, but also establishes a design principle to couple structural regulation with dynamic, on-demand function amplification for potential photoimmunotherapy.

ABSTRACT The metal‐reduction‐induced dechlorination coupling (MR–DC) strategy enables the first successful synthesis of an all‐inorganic crosslinked phosphazene network (aPN) from hexachlorocyclotriphosphazene (HCCP) under mild reaction conditions. Using Cu as a model, the resulting Cu–aPN (copper‐embedded all‐inorganic phosphazene network) retains the intrinsic N3P3 backbone and exhibits an amorphous structure where Cu species are uniformly anchored at dense P/N coordination sites of the network. Time of flight secondary ion mass spectrometry (TOF‐SIMS) and X‐ray diffraction (XRD) reveal a gradual CuCl‐to‐CuO phase conversion during ammonia treatment, which effectively ensures the structural stability of the phosphazene framework. In 1 M KOH, Cu–aPN delivers an overpotential of 280 mV at 10 mA cm−2 and a Tafel slope of 48 mV dec−1, markedly outperforming Ga–aPN. In situ Raman and density functional theory (DFT) analyses indicate stronger Cu–P/N coordination coupling that lowers the *OH formation barrier (0.39 vs. 0.88 eV for Ga). This MR–DC route furnishes a general and versatile pathway for constructing metal‐embedded all‐inorganic phosphazene frameworks with tunable coordination environments for advanced electrocatalytic applications.

Background The escalating economic threat of Lumpy skin disease (LSD) demands rapid, point-of-care diagnostic tools that overcome the limitations of conventional methods. Current nanozyme-based assays are often limited by their reliance on unstable hydrogen peroxide (H2O2). Our goal was to engineer a potent, H2O2-free oxidase-like (OXD-like) nanozyme to enable a simpler and more robust point-of-care immunoassay for the LSD virus (LSDV). Results A bimetallic manganese-cobalt metal-organic framework (MnCo-MOF) was synthesized, where strategic cobalt doping unlocked potent intrinsic OXD-like activity for direct colorimetric reactions. An immunoassay was developed by conjugating specific antibodies to the MnCo-MOF surface. The target LSDV ORF-122 protein obstructed the nanozyme's active sites and triggered particle aggregation, inhibiting the catalytic signal. This method detected the ORF-122 protein with a limit of detection (LOD) of 0.0355 μg/mL in just 10 min and demonstrated excellent specificity. Significance This study presents the first H2O2-free nanozyme immunoassay for a key LSDV protein, providing a practical tool for on-site disease surveillance. It establishes a powerful design strategy—unlocking potent OXD-like activity in bimetallic MOFs—that offers a robust blueprint for a new generation of field-deployable diagnostics for diverse biomedical and environmental targets.

ABSTRACT Radioresistance remains a pivotal factor in the failure of esophageal squamous cell carcinoma (ESCC) therapy. Here we report a hyaluronic acid‐modified, polyphosphazene‐based self‐scaffold nanoradiosensitizer (HDiSeH) that addresses the limitations of single‐organelle targeting. HDiSeH exhibited uniform nanoscale morphology, ultrahigh dihydromyricetin (Di) loading (77.8%), and tumor microenvironment‐relevant pH/reactive oxygen species (ROS)/X‐ray responsive release. In ESCC cells, HDiSeH markedly enhanced radiosensitivity, increasing γ‐H2AX foci, suppressing DNA damage repair, and abolishing clonogenic survival. Mechanistically, HDiSeH remodeled mitochondria‐associated membranes (MAMs), inducing robust endoplasmic reticulum stress (CHOP up 4.8‐fold) and a cytosolic Ca 2+ surge (10.2‐fold), which drived mitochondrial Ca 2+ overload (4.8‐fold), a burst of mitochondrial ROS (9.7‐fold), loss of mitochondrial membrane potential, and bioenergetic collapse (ATP to 40.3% of control), culminating in mitochondria‐dependent apoptosis. In a KYSE‐150 xenograft mouse model, HDiSeH demonstrated good biological safety and sensitized tumors to radiotherapy. Specifically, radiotherapy combined with high‐dose HDiSeH achieved potent tumor growth inhibition (89.0%) and significantly extended median survival with favorable tolerability. Overall, our study advances a radiosensitization paradigm that targets inter‐organelle communication to build an endogenous signal amplification network, offering an efficient and safe strategy to overcome ESCC radioresistance.

Precise monitoring of cancer treatment at the subcellular level remains a critical challenge. Therefore, a lysosome-specific AIE nanoprobe integrating stimulated emission depletion (STED) imaging and photodynamic therapy is reported here. The probe enables real-time visualization of lysosomal dynamics and reactive oxygen species (ROS)-mediated apoptosis, offering a powerful platform for high-resolution imaging-guided cancer diagnosis and treatment.