Objective To observe the content changes of superoxide dismutase(SOD) and malondialdehyde(MDA) and discuss the cerebral protective effect of yidalaphon for the patients with acute traumatic brain injury.Methods 48 patients with acute brain trauma in our hospital from December 2010 to December 2012 were randomly divided into observation group(24 cases) and control group(24 cases),the two groups were treated with craniotomy and routine treatment.The observation group was given yidalaphon(30 mg) by intravenous infusion,and completed within half an hour,continuous for 4 days.The concentration of serum SOD and MDA among the treatment(T0),surgery completed(T1),postoperative 2 d(T2),postoperative 2 d(T3),postoperative 4 d(T4) were monitored.Results The two sets of SOD activity was activity increased in T1,T2,T3,T4 compared with T0(P<0.05),and the activity of SOD between T1,T2,T3,T4 in observation group were significantly higher than that in the control group(P<0.05);the MDA concentration of T1,T2,T3,T4 in the two groups were decreased significantly compared with T0(P <0.05),but MDA concentration of T1,T2,T3,T4 in observation group was significantly lower than that of control group(P<0.05).Conclusion Yidalaphon can increase the activity of SOD,decreased the concentration of MDA and it can improves the prognosis of patients with acute traumatic brain injury and their quality of life,it is worth to be applied in clinical.
目的 探讨改良外伤大骨瓣开颅术治疗重型脑外伤的临床效果.方法 对标准外伤大骨瓣的切口、骨瓣进行改良,用于65例重型脑外伤患者的手术治疗.结果 按GOS评分,术后3个月进行随访:良好40例,中残5例,重残9例,植物生存3例,死亡8例,无一例发生脑脊液漏、脑嵌顿、颅内感染.结论 改良外伤大骨瓣是治疗重型脑外伤安全有效的手术方式.
目的观察改良人工硬脑膜成形术在脑外伤减压术中硬脑膜缺损的修复效果。方法对88例脑外伤减压术硬脑膜缺损患者分别采用改良人工硬脑膜修补术(A组,46例)和传统颞肌—硬脑膜缝合术(B组,42例)治疗。观察硬脑膜修复效果及并发症发生情况。结果两组均能达到满意修复脑膜缺损目的。两组术后脑脊液漏、皮下积液、伤口感染等发生率近似(P>0.05),A组手术用时较短(P<0.05),术后癫痫发生率明显低于B组(P<0.05)。结论采用改良人工硬脑膜成形术修复脑外伤减压术中硬脑膜缺损效果好、安全。
小儿颈部大血管损伤临床少见,本院近期收治1例,现报道如下. 临床资料 2例均为男性,年龄分别为8岁和5岁,均为玩耍时不慎绊倒,手中所持锐器刺中颈部致伤,均表现为大量出血(当地医院未敢处理),于伤后约1 h入院.
弥漫性轴索损伤(Diffuse axonal injury,DAI)是一种原发性脑损伤,以其死亡率和致残率高而引起广大医疗工作者的关注,目前已成为神经外科医师治疗和研究的热点.笔者回顾分析我院自2003年6月至2005年7月收治的46例,就其诊断、分级和治疗分析如下:
本科1998-06～2004-01共收治128例重型颅脑损伤,其中66例采用静脉注射结合腰穿注射地塞米松治疗收到了良好的疗效,现报道如下.
