ObjectiveThe incidence of coronary heart disease (CHD) is progressively increasing on an annual basis. Dyslipidemia constitutes a significant pathogenic factor in CHD, exerting a substantial influence on its onset and progression. Consequently, precise and effective lipid management is crucial for the prevention and cure of CHD. This study aims to examine the risk factors, therapeutic approaches, current research status and emerging trends in lipid management related to CHD.MethodWe searched for publications on lipid management of coronary heart disease from 01/01/2014 to 12/31/2023 in Web of Science and performed bibliometrics using CiteSpace, VOSviewer, Scimago Graphica, Gephi and R Studio.ResultsA total of 6,027 related articles were retrieved from the Web of Science database. After screening, 5,954 articles were included. Journal of Clinical Lipidology and Atherosclerosis were the journals with the most publications and citations, respectively. In this discipline, the United States has the largest number of publications, research institutions, citations, and collaborative partnerships. The burst keywords include sex difference, heterozygote familial hypercholesterolemia, PCSK9, lipid peroxidation, fish oil, monoclonal antibody, insulin sensitivity, and gene, etc.ConclusionResearch on CHD indicates that risk factors influencing lipid levels encompass sex, genetics, PCSK9, and lipid peroxidation. There has been a growing trend in investigating the underlying mechanisms of these factors. Recent research hotspots have concentrated on disease prevention, prognosis, specific treatments for CHD, the development of new pharmaceuticals, and the molecular mechanisms of action. Future research is likely to continue focusing on more precise treatment protocols and the exploration of novel mechanisms.

BackgroundCoronary microvascular disease (CMVD), particularly ischemia with non-obstructive coronary arteries (INOCA)-related CMVD, is associated with recurrent angina, impaired quality of life, and an increased risk of adverse cardiovascular outcomes. Although recognition of this condition is increasing, treatment options remain limited, and many patients continue to have symptoms despite conventional medical therapy. Acupuncture has shown potential as an adjunctive therapy for angina-related symptoms and other cardiovascular conditions. However, high-quality evidence for INOCA-related CMVD remains scarce. This trial aims to evaluate the efficacy and safety of acupuncture as an adjunct to conventional medical therapy in patients with INOCA-related CMVD.MethodsThis prospective, single-center, randomized, sham-controlled, parallel-group pilot trial will recruit 60 participants with INOCA-related CMVD at Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China. Eligible participants will be randomly assigned in a 1:1 ratio to an acupuncture group or a sham acupuncture group. Both groups will continue guideline-directed conventional medical therapy. The acupuncture group will receive true acupuncture at Dabao (SP21), Neiguan (PC6), Danzhong (CV17), Xinshu (BL15), and Geshu (BL17), while the sham group will receive non-penetrating sham acupuncture at the same acupoints with the same schedule. Treatment will be given three times weekly for 4 consecutive weeks, followed by a 4-week follow-up. The primary outcome is the response rate at week 4, defined as the proportion of participants with an increase of at least 5 points in the Seattle Angina Questionnaire summary score from baseline. Secondary outcomes include changes in SAQ scores, angina attack frequency, EuroQol 5-Dimension 5-Level questionnaire, traditional Chinese medicine syndrome score, nitric oxide, endothelin-1, and high-sensitivity C-reactive protein. Additional assessments include Clinical Global Impression–Improvement, expectancy and credibility assessments, and blinding assessment. Safety evaluation includes monitoring adverse events and serious adverse events throughout the trial.DiscussionThis pilot trial will provide preliminary evidence on the safety and potential efficacy of acupuncture for INOCA-related CMVD and may help clarify its effects on angina-related health status, quality of life, and selected endothelial and inflammation-related markers. The findings are expected to inform future larger multicenter confirmatory trials.Clinical Trial RegistrationInternational Traditional Medicine Clinical Trial Registry (http://itmctr.ccebtcm.org.cn/), Identifier ITMCTR2026000515.

BACKGROUND:A growing body of clinical evidence points to an association between hypertension and anxiety, but the mechanisms by which the two occur are unclear. This article aims to explore possible common influences and associations between hypertension and anxiety. METHODS:We searched for publications on hypertension and anxiety from January 01, 2004 to December 31, 2022 in Web of Science and performed bibliometrics using CiteSpace, VOSviewer, Scimago Graphica and Gephi. RESULTS:A total of 3216 related articles were retrieved from the Web of Science database. After screening, 3051 articles were included. The number of published articles has increased over the past 19 years. The United States has more researches in this area and has strong collaborative relationships with other countries, which gives it some credibility and authority. The words that appear in the burst keywords are gender, age, obesity, depression, panic disorder, pregnancy induced hypertension, coronary heart disease, chronic kidney disease, and pituitary adrenal axi, which are co-related with hypertension and anxiety. CONCLUSION:There is a link between hypertension and anxiety, and the 2 influence each other, usually in a positive way. Common influences on hypertension and anxiety include age, gender, obesity, depression, panic attacks, pregnancy, coronary heart disease and chronic kidney disease. Recent research hotspots have focused on population aging and comorbidities. Future research hotspots are likely continue to focus on influencing factors, clinical research and prognosis.

The metabolic score for visceral fat (METS-VF), which integrates measures of visceral adiposity, insulin resistance, and demographic variables, serves as a composite indicator of metabolic health. However, the association between METS-VF and atrial fibrillation (AF) risk is unclear. This study aimed to investigate the prospective association between METS-VF and incident AF within the UK Biobank cohort. A total of 400,668 participants from the UK Biobank were included in the analysis. Flexible parametric survival models were applied to estimate hazard ratios (HRs) and 95

OBJECTIVE:To screen the target population with symptomatic bradyarrhythmia for pharmacotherapy. METHODS:This study use database from clinical trial that use Yuanjiang decoction, a traditional Chinese medicinal prescription. Eligible participants were recruited and treated with Yuanjiang decoction (composed of 6 Chinese herbal medicines), 200 mL twice daily. Cross-contingency analysis, logistic regression analysis, interaction analysis, discriminant analysis and 10-fold cross validation methods were used to establish discriminant model. RESULTS:This study concluded that the clinical treatment of bradyarrhythmia has a clear effect. Low minimum heart rate, high maximum heart rate are risk factors that affect the efficacy. Patients with only one comorbid disease did not significantly affect the efficacy, but patient with two or more diseases of coronary heart disease, hypertension, paroxysmal atrial fibrillation, premature ventricular contraction and premature atrial contraction at the same time did not have a good effect. Using the discriminant analysis method to establish a efficacy prediction model, y = 0.07 X 1 + 0.16 X 2 - 0.65 X 3 - 1.12 X 4 - 0.71 X 5 - 0.75 X 6 - 0.91 X 7 (X1 = 24 h mean heart rate, X2 = minimum heart rate, X3= coronary heart disease, X4 = paroxysmal atrial fibrillation, X5 = premature ventricular contraction, X6= sinus block, X7 = atrioventricular block). CONCLUSION:Our model based on the clinical features of patients with bradyarrhythmia. Should be useful aid for predicting pharmacotherapy response and could screen the optimal pharmacotherapy target.

Background:Autophagy is essential for the homeostasis and function of the cardiovascular system. Citespace is a visual analysis software developed in the context of scientometrics and data visualization. The purpose of this study is to use Citespace software to conduct bibliometric and visual analysis of the research on autophagy in cardiovascular diseases, identify the current status, hot spots and trends in this field, help researchers clarify the future research focus and direction of autophagy in cardiovascular diseases, and provide more positive and broader ideas for the treatment and drug development of cardiovascular diseases.Methods:In the Web of Science Core Collection database to download the data from 2004 to 2022 regarding autophagy in cardiovascular research. CitespaceV was used to collect the research status, hotspots and development trends for visual analysis.Results:The 3568 articles were published by 547 authors from 397 institutions in 75 countries. From 2004 to 2021, the annual publications increased over time. The top 3 productive nations were China, the United States, and Germany. The leading institution was China's Fudan University. The most cited paper is Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). The research hotpots include monitoring methods for autophagy activity, changes in autophagy levels in different types of cardiovascular diseases, autophagy signal transduction mechanism in cardiovascular diseases, etc.Conclusion:Bibliometric analysis provided valuable information for autophagy research in cardiovascular disease, which is full of opportunities and challenges. The research of autophagy in the field of cardiovascular diseases is still worthy of in-depth exploration. A challenge with autophagy-targeted therapies is their dichotomy in which the goal is to target maladaptive autophagy while maintaining a baseline level of cell survival to optimize a beneficial outcome. It is necessary for scientists to develop new methods to evaluate the level of autophagy from basic application to human body and reveal the signaling mechanism of autophagy in different types of cardiovascular diseases.

Background The independent causality of periodontal disease on atrial fibrillation (AF) and the modifiable risk factors mediating the pathogenesis remain unclear. Method First, to confirm the independent causality, this study underwent the bidirectional and multivariable Mendelian Randomization (MR) underlying the genome-wide association studies (GWAS) of periodontal disease (87497 cases/259234 controls) from the FinnGen and AF (55114 cases/482295 controls) from AFGen. Then, the two-step Mendelian randomization evaluated the mediating role and proportions of 25 candidate factors. Result Periodontal disease was associated with a higher risk of AF with an odds ratio of 1.16 ([95% CI, 1.027–1.314], p = 0.017), independently of dental caries and pulp and periapical disease. Reversely, there is no causation of AF on periodontal disease status. Using the two-step MR, we identified 5 out of 25 candidate mediators as statistically significant; sorted by the mediation proportion, including weight (30.3%), IL-17 (17.2%), TNF (14.08%), coronary atherosclerosis (13.4%) and hypertension (11.6%). Conclusion Our findings preliminarily demonstrated the genetic causality between periodontal disease and atrial fibrillation. For patients suffering from periodontal disease status, it is noted that maintaining oral hygiene, accepting standardized periodontal treatment, and managing body weight are crucial targets for controlling the disease progression towards AF.

In recent years, spatial transcriptomics (ST) research has become a popular field of study and has shown great potential in medicine. However, there are few bibliometric analyses in this field. Thus, in this study, we aimed to find and analyze the frontiers and trends of this medical research field based on the available literature. A computerized search was applied to the WoSCC (Web of Science Core Collection) Database for literature published from 2006 to 2023. Complete records of all literature and cited references were extracted and screened. The bibliometric analysis and visualization were performed using CiteSpace, VOSviewer, Bibliometrix R Package software, and Scimago Graphica. A total of 1467 papers and reviews were included. The analysis revealed that the ST publication and citation results have shown a rapid upward trend over the last 3 years. Nature Communications and Nature were the most productive and most co-cited journals, respectively. In the comprehensive global collaborative network, the United States is the country with the most organizations and publications, followed closely by China and the United Kingdom. The author Joakim Lundeberg published the most cited paper, while Patrik L. Ståhl ranked first among co-cited authors. The hot topics in ST are tissue recognition, cancer, heterogeneity, immunotherapy, differentiation, and models. ST technologies have greatly contributed to in-depth research in medical fields such as oncology and neuroscience, opening up new possibilities for the diagnosis and treatment of diseases. Moreover, artificial intelligence and big data drive additional development in ST fields. Spatial transcriptomics (ST) technologies and application prospects. (1) Imaging-based approaches, including in situ sequencing (ISS)—where transcripts are amplified and sequenced in tissue—and ISH-based approaches—where imaging probes are sequentially hybridized in tissue. (2) NGS-based techniques, in which positional information is encoded onto transcripts prior to NGS sequencing.

A growing body of research indicates the promising potential of vaccines in both preventing and treating atherosclerosis (AS). To gain a comprehensive understanding of the current research landscape and emerging trends in this field, this study conducted a bibliometric analysis of publications on AS vaccines using the Web of Science Core Collection (WoSCC) database, based on the “bibliometric” R package and VOSviewer software. From 1991 to 2024, a total of 462 publications were identified in the WoSCC. The United States appeared as the leading contributor in terms of both total publications and citations. The Vaccine journal exhibited the highest publications output. Nilsson J from the Lund University in Sweden was the author with the most published articles, total citations and Hirsch index (H-index). Keywords analysis and thematic maps analysis revealed the passive immunotherapy (AS protective antibodies vaccines) was a hot mature theme, the active immunotherapy (AS antigens vaccines) was an emerging and booming theme, while the efficacy and safety of AS vaccines was a niche and well-developed theme. These findings offered valuable insights into the AS vaccination and provided guidance for future research in this domain.

The vascular endothelial growth factor (VEGF) family plays a major role in tumors and ophthalmic diseases. However, increasingly more data reported its potential in regulating lipids. With its biological functions mainly expressed in lymphatic vessels, some factors in the families, like VEGF-A and VEGF-C, have been proved to regulate intestinal absorption of lipids by affecting chylous ducts. Other effects, including regulating lipoprotein lipase (LPL), endothelial lipase (EL), and recombinant syndecan 1 (SDC1), have also been confirmed. However, given the scant-related studies, further research should be conducted to examine the concrete mechanisms and provide pragmatic ways to apply them in the clinic. The VEGF family may treat dyslipidemia in specific ways that are different from common methods and concurrently contribute to the treatment of other metabolic diseases, like diabetes and obesity.

Objectives To summarize the measures and rules of Chinese medicine (CM) and provide reference for clinical application in the prevention and treatment of coronavirus disease (COVID-19). Methods The data source was from CM COVID-19 prevention and treatment programs on government websites and official media websites of the different provinces and cities. The search lasted from December 8, 2019 to March 10, 2020. Main variables were medication frequency and combinations of medicines. Cluster analysis and complex network analysis were used by prevention and treatment stage and by area. Results Among 27 CM diagnosis and treatment plans, 203 therapeutic prescriptions were enrolled, of which the top 4 herbs were: Radix glycyrrhizae, Semen armeniacae amarum, Herba ephedrae, and Herba agastachis, respectively. The core combinations were Herba ephedrae and Semen armeniacae amarum. Forty-eight preventive formulae were identified. Ten herbs, including Radix Astragali seu hedysari, Radix glycyrrhizae, Radix saposhnikoviae, Flos lonicerae, etc. were most frequently used. The core prescription of CM compatibility was Radix astragali seu hedysari, Radix glycyrrhizae, and Radix saposhnikoviae, which is the main component of Yu Ping Feng San. There were 45 prevention and treatment prescriptions in East China; the most used CM was Radix glycyrrhizae, Herba agastachis, Pericarpium citri reticulatae, and Gypsum fibrosum. Fifty prescriptions were identified in North China. According to CM analyses, Herba agastachis, Semen armeniacae amarum, Herba ephedrae, and Poria were most frequently used. Conclusions CM for COVID-19 prevention mainly focuses on improving human immunity; for treatment, prescription focuses on clearing the lungs and removing dampness. Prescriptions vary with regions, perhaps due to climatic and environmental differences, which help clinicians to quickly make CM plans and treat patients according to clinical status, further minimizing resource wastage.

Takotsubo cardiomyopathy (TTC) is often acute with a high mortality rate and is subject to relapse. Meanwhile, its complex pathogenesis has attracted increasing attention. To learn more about TTC, CiteSpace V.5.7 R5W was used in this study to analyze the research status, hot spots, and trends in TTC before 2020. The keywords, co-citation references, as well as country and institution distribution were explored. A total of 2,349 papers were reviewed. The United States, Italy, and Germany were the main countries studying TTC and had good cooperation relationships. The Mayo Clinic topped the institution list, but the rate of inter-institutional cooperation was not high. Research hotspots include disease features, auxiliary diagnostic methods, epidemiology, and pathophysiological mechanisms, and the latest ones are complications related to prognosis, such as cardiovascular abnormalities caused by myocardial infarction and normal or non-obstructive coronary arteries (MINOCA), atrial fibrillation, stroke, cancer, and COVID-19. In conclusion, the research of TTC is in a hot development period. Our research will help clinicians and researchers to better understand TTC and its research status by providing a foundation for research objectives. In doing this, our research will help to provide better scientific management, diagnosis, and treatment for patients with TTC, which will in turn improve the prognosis of this condition.

CD36作为清道夫受体,在动脉粥样硬化相关的脂质代谢及氧化应激过程均起重要作用.现就CD36在动脉粥样硬化形成过程中对血管平滑肌细胞、微血管内皮细胞、单核/巨噬细胞和血小板活化相关氧化应激过程影响的研究现状进行综述,为临床动脉粥样硬化的治疗提供新的角度和思路.

目的 研究骐龙血脉健方对载脂蛋白E基因敲除小鼠(ApoE-/-)动脉粥样硬化(AS)模型的血脂水平、主动脉CD36蛋白表达及血清Ox-LDL的影响.方法 8周龄健康雄性ApoE-/-小鼠40只,按随机数表法分为模型组、阿托伐组、骐龙血脉健方大、中、小剂量组,每组8只,均给予高脂饮食饲养14周,构建高脂血症小鼠模型.阿托伐组给予阿托伐他汀钙片溶液灌胃,中药干预组分别予骐龙血脉健方颗粒剂大(临床用量20倍)、中(临床用量10倍)、小(临床用量5倍)相应剂量灌胃14周.选取8周龄雄性C57BL/6J野生型小鼠8只作为空白组,给予正常饲料喂养.14周末检测血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)水平,ELISA法检测血清氧化低密度脂蛋白(Ox-LDL)水平.分离主动脉,油红染色,检测斑块面积占全动脉内膜面积的比值;蛋白印迹法检测主动脉CD36蛋白表达.结果 与空白组相比,模型组TC、TG、LDL-C水平显著升高(P<0.01);与模型组比较,阿托伐组TC、TG、LDL-C水平明显降低(P<0.01),骐龙血脉健方大剂量组TC、TG、LDL-C水平明显降低(P<0.01),骐龙血脉健方中、小剂量组TC水平显著降低(P<0.01),TG、LDL-C降低不明显(P>0.05);大剂量组TC水平低于阿托伐组(P<0.01),而TG水平高于阿托伐组(P<0.05);中、小剂量组TC水平与阿托伐组无明显差异(P>0.05).与空白组相比,模型组AS斑块面积与内膜总面积比值显著升高(P<0.05);与模型组相比,阿托伐组和骐龙血脉健方大剂量组AS斑块面积与内膜总面积比值明显降低(P<0.05);与阿托伐组相比,大剂量组AS斑块面积与内膜总面积比值无明显变化(P>0.05).与空白组相比,模型组Ox-LDL水平显著升高(P<0.01);与模型组相比,阿托伐组、骐龙血脉健方大剂量组、中剂量组Ox-LDL水平均降低(P<0.05),其中大剂量组降低最为明显(P<0.01);与阿托伐组相比,大、中剂量组Ox-LDL水平无明显变化(P>0.05).与空白组相比,模型组主动脉CD36蛋白表达明显升高(P<0.01);与模型组相比,阿托伐组主动脉CD36蛋白表达有所减少(P<0.05),骐龙血脉健方大剂量组主动脉CD36蛋白表达明显减少(P<0.01);与阿托伐组相比,骐龙血脉健方大剂量组主动脉CD36水平无明显变化(P>0.05).结论 骐龙血脉健方可有效改善高脂饮食ApoE-/-小鼠血脂水平,减轻动脉粥样硬化程度,其机制可能与降低血清Ox-LDL水平、下调主动脉CD36蛋白表达有关.

目的 评价丹参川芎嗪注射液治疗心绞痛的疗效及其对血脂水平的影响。方法 计算机检索CochraneLibrary、Pubmed、Embase、知网、万方、维普等数据库，检索时限均为建库至2021年2月19日。由2名研究者独立筛选文献、提取资料并评价偏倚风险，采用Review Manager 5.3软件进行meta分析。结果 共纳入16项研究，包括1 631例患者。Meta分析结果显示，与西药常规疗法相比，联合丹参川芎嗪注射液治疗心绞痛总疗效[OR=3.88,95%CI（2.80,5.37）,P＜0.000 01]更好。血清总胆固醇水平[MD=–1.08,95%CI（–1.36，–0.81）,P＜0.000 01]、甘油三酯水平[MD=–0.52,95%CI（–0.66，–0.37）,P＜0.000 01]、低密度脂蛋白水平[MD=–0.74,95%CI（–0.94，–0.55）,P＜0.000 1]低于对照组；高密度脂蛋白水平高于对照组[MD=0.28,95%CI（0.20,0.36）,P＜0.000 01]。不良反应发生率亦低于对照组[OR=0.57,95%CI（0.30,1.08）,P=0.008]。结论 联合使用丹参川芎嗪注射液治疗心绞痛疗效明确，能有效改善血脂且不增加不良反应发生率。

目的 观察骐龙血脉健方对载脂蛋白E基因敲除(ApoE-/-)小鼠动脉粥样硬化(AS)模型的主动脉功能、血小板反应蛋白-1(TSP-1)表达、血小板(PLT)CD36表达率及活化率的影响.方法 将40只健康8周龄雄性ApoE-/-小鼠随机分为模型组、立普妥组及中药大剂量组、中药中剂量组、中药小剂量组,每组8只,给予高脂饮食饲养14周;以8周龄雄性C57BL/6J野生型小鼠8只为空白组,给予正常饲料喂养.立普妥组给予阿托伐他汀钙片溶液灌胃,中药大剂量组、中剂量组、小剂量组分别予骐龙血脉健配方颗粒大剂量(临床20倍量)、中剂量(临床10倍量)、小剂量(临床5倍量)灌胃14周.造模结束前3 d,使用动物超声系统检测腹主动脉收缩末期内径(Ds)、舒张末期内径(Dd).14周末取材,摘眼球取血,分离主动脉,蛋白印迹法检测TSP-1蛋白表达;流式细胞术检测血小板CD36表达率及活化率.结果 与空白组比较,模型组腹主动脉Ds及Dd均明显减小(P<0.01),TSP-1蛋白表达、血小板CD36表达率、血小板活化率明显升高(P<0.01).与模型组比较,立普妥组与中药大剂量组主动脉Ds、Dd均明显增大(P<0.01),中药小剂量组、中药中剂量组主动脉Ds明显增大(P<0.01);立普妥组与中药大剂量组、中药中剂量组主动脉TSP-1水平明显降低(P<0.05或P<0.01);立普妥组与中药大剂量组血小板CD36表达率明显降低(P<0.05),而中药中剂量组、中药小剂量组血小板CD36表达率与模型组比较差异均无统计学意义(P>0.05);立普妥组与中药大剂量组血小板活化率明显降低(P<0.05),而中药中剂量组、中药小剂量组血小板活化率与模型组比较差异均无统计学意义(P>0.05).结论 骐龙血脉健方可有效改善ApoE-/-小鼠腹主动脉功能,并可能通过TSP-1/CD36途径调节血小板活化程度.

目的:对有关穿心莲的文献进行可视化分析,研究其近20年来的热点及进展过程.方法:以中国知网(CNKI)为来源数据库,检索以穿心莲为主题的文献,运用可视化文献分析软件(CiteSpace)V和CNKI自带的计量可视化分析工具进行文献数、作者、机构和关键词的共现分析及可视化表达.结果:研究穿心莲的主要人员有韩光、万遂如、何瑞、张文成、杜红、詹若挺、徐海伟、潘见等;主要机构有广州中医药大学、河南大学、广东药科大学、成都中医药大学、华中科技大学、北京中医药大学等;主要研究方向有抗感染、糖尿病、心血管疾病、抗肿瘤、保肝、质控方法等.近年来受到关注较多的研究热点是细胞凋亡、生物膜、核因子κB(NF-κB)信号通路、糖尿病.结论:研究穿心莲的学术团队局限在各机构中,而各研究机构之间合作较少;细胞凋亡、生物膜、NF-κB、糖尿病将继续成为研究热点.

Abstract Objective: Andrographis paniculata (Burm.f.) Nees is a medicinal plant that has been traditionally used as an anti-inflammatory and antibacterial remedy for several conditions. Andrographolide (AG), the active constituent of A. paniculata (Burm.f.) Nees, has anti-lipidic and anti-inflammatory properties as well as cardiovascular protective effects. The present study aimed to explore the effects of AG on the progression of atherosclerosis and to investigate related mechanisms via network pharmacology. Materials and methods: Compound-related information was obtained from the PubChem database. Potential target genes were identified using STITCH, SwissTargetPrediction, Bioinformatics Analysis Tool for Molecular mechANism of Traditional Chinese Medicine, and Comparative Toxicogenomics Database. Genes involved in atherosclerosis were obtained from DisGeNet and compared with AG target genes to obtain an overlapping set. Protein–protein interactions were determined by STRING. Gene ontology (GO) analysis was performed at WebGestalt, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment was analyzed using Metascape. The final network showing the relationship between compounds, targets, and pathways was constructed using Cytoscape. After that, oxLDL-induced RAW264.7 cells were used to further validate a part of the network pharmacology results. Result: Eighty-one potential AG target genes were identified. PPI, GO, and KEGG enrichment revealed genes closely related to tumor progression, lipid transport, inflammation, and related pathways. AG improves the reverse cholesterol transport (RCT) through NF-κB/CEBPB/PPARG signaling in oxLDL-induced RAW264.7 cells. Conclusion: We successfully predict AG’s potential targets and pathways in atherosclerosis and illustrate the mechanism of action. AG may regulate NF-κB/CEBPB/PPARG signaling to alleviate atherosclerosis.

目的 分析近16年长QT综合征研究相关领域的研究现状、热点及动态前沿.方法 以Web of Science(WOS)核心合集数据库为数据来源,利用CiteSpace软件对近16年长QT综合征相关研究进行可视化分析,探讨相关研究的国家/机构、期刊、作者及关键词进行文献计量学分析.结果 共检索680篇SCI文献,类型以期刊为主.最高产文量的国家是美国,机构是梅奥医学中心,发文量最多的期刊是HEART RHYTHM,被引频次最高的期刊是CIRCULATION,发文量最多的作者是MICHAEL J ACKERMAN,被引频次最高的作者是SCHWARTZ PJ.该领域的研究热点是:①长QT综合征易感基因相关的临床分类;②该病遗传变异机制及基因通路;③长QT综合征与其他疾病的相关性.结论 本研究为了解长QT综合征相关研究提供了新的视角,为研究长QT综合征的国家和机构、热点话题和研究前沿提供了有价值的信息.

目的 通过对中西医结合治疗心力衰竭随机对照试验的相关文献进行可视化分析,探索该领域的研究现状、研究热点及趋势.方法 检索中国期刊全文数据库(CNKI) 1992年-2020年相关文献839篇,筛选后将786篇文献数据导入CiteSpace 5.6 R1软件,对作者、机构、关键词进行可视化分析.结果 通过对知识图谱进行分析后发现,在中西医结合治疗心力衰竭随机对照试验领域研究作者方面存在大量分散作者,至今未出现有影响力的核心作者.主要研究机构也较为分散,未形成稳定高产的研究团队.热点关键词包括中西医结合疗法、心力衰竭、疗效、心功能、对照治疗观察、冠心病、肺心病、充血性心力衰竭等,并形成9个聚类.结论 中西医结合治疗心力衰竭随机对照试验相关文献的发文量呈上升趋势,通过对关键词分析发现急性重症心力衰竭的治疗是近年来的研究重点和研究趋势.