Cardiovascular disease has become one of the main causes of human death. In addition, many cardiovascular diseases are accompanied by a series of irreversible damages that lead to organ and vascular complications. In recent years, the potential therapeutic strategy of natural antioxidants in the treatment of cardiovascular diseases through mitochondrial quality control has received extensive attention. Mitochondria are the main site of energy metabolism in eukaryotic cells, including myocardial and vascular endothelial cells. Mitochondrial quality control processes ensure normal activities of mitochondria and cells by maintaining stable mitochondrial quantity and quality, thus protecting myocardial and endothelial cells against stress. Various stresses can affect mitochondrial morphology and function. Natural antioxidants extracted from plants and natural medicines are becoming increasingly common in the clinical treatment of diseases, especially in the treatment of cardiovascular diseases. Natural antioxidants can effectively protect myocardial and endothelial cells from stress-induced injury by regulating mitochondrial quality control, and their safety and effectiveness have been preliminarily verified. This review summarises the damage mechanisms of various stresses in cardiomyocytes and vascular endothelial cells and the mechanisms of natural antioxidants in improving the vulnerability of these cell types to stress by regulating mitochondrial quality control. This review is aimed at paving the way for novel treatments for cardiovascular diseases and the development of natural antioxidant drugs.

李敬孝教授认为,心悸的病因病机为肝、脾、肺、肾等脏腑功能失调损及心之气血阴阳,病机关键是肾阳虚衰,肝郁气滞,水瘀结肺,脾虚失养.李敬孝教授临证以心为本,从肝、脾、肺、肾论治心悸,以温肾、清肝、消肺、补脾为治疗原则.李敬孝教授基于中医学整体观思想、辨证论治及对五脏的生理特点的认识,采用了温、清、消、补四法安抚五脏以养心安神定悸.

升陷汤为治疗大气下陷证的代表方,临床多用于治疗因大气下陷所导致的脏腑疾病.心血管疾病的病因病机是胸中大气下陷,为升陷汤的主治病证,故临床常用于治疗冠状动脉粥样硬化性心脏病、心力衰竭、心律失常、心脏神经官能症、心肌病、低血压病等.临床研究发现,升陷汤可改善血管内皮功能;扩张血管,改善缺血再灌注损伤;改善心律失常,纠正心力衰竭,抑制心室重构等作用.升陷汤治疗心血管疾病时,要根据症状及疾病发展的不同阶段,随证加减.由于本方剂型为汤剂,服用及携带不便.今后应开发新剂型,以满足临床需要.

李敬孝教授认为心气亏虚是心悸发病的内因和始发因素,肝郁血虚、心肾不交、心阳不振、心胆气虚、脾胃失和是其常见病因.李教授治疗心悸以益气养心,补益肝肾为主,擅长以心为本,从肝肾论治,顾护胃气调阴阳,自拟珍蒲宁心汤,该方“养心温肾疏肝以定悸,活血化瘀与健脾理气并行”,旨在以心为本,从肝肾论治,为心悸的临床治疗提供更多的指导思路.李老师强调临证之时不可局限于常见证候类型,应四诊合参,八纲辨证,一人一方.

李敬孝教授根据多年的临证经验,认为稳定型心绞痛的病机为本虚标实,本虚为心阴亏虚,心气不足,标实为气滞、血瘀、痰浊.在治疗上以补益心气,滋养心阴为本,兼顾以理气、活血、化瘀、化痰、理气,配合宁心安神.本文介绍了李敬孝教授对稳定型心绞痛病因病机的认识,并总结了李教授的治疗经验.

李敬孝教授对失眠有独到的见解和丰富的临床经验,其认为失眠的主要病机为心失所养,阳不入阴.本文介绍李敬孝教授运用自拟失眠汤治疗失眠的临床经验,并阐述李敬孝教授治疗失眠的相关学术观点.

李敬孝教授认为不寐病位主要在心,与肝脾肾相关,文章通过分析总结其运用柴胡加龙骨牡蛎汤治疗不寐方证机理和治疗不寐典型医案,证实柴胡加龙骨牡蛎汤治疗不寐有效性,通过四诊合参,准确辨证,灵活应用本方进行临证加减,善调情志,治疗上多疏肝理气,重镇安神以治疗失眠.李教授通过临床经验发现,情志因素不仅会导致失眠,还会增加高血压的发病率,故嘱患者要善调情志,内外兼治,以增加治病疗效.

Cervical cancer is the world's most common female genital tumors of malignant tumors, great harm to women's physical and mental health,and the younger trend is more obvious.Chinese medicine have a unique view on the cause of cervical cancer pathogenesis,development and treatment.For a long time,Chinese medicine in the treatment of cervical cancer is quite effective,more and more attention from all walks of life,the prospects are good. Now the role of Chinese medicine in the treatment of cervical cancer and its mechanism to do a review,expect the future of Chinese medicine treatment of cervical cancer clinical practice and research to provide some reference and inspiration.

Objective:To observe the clinical effects of Zishen Yutai Pill combined with progesterone injection in the treatment of threatened abortion.Methods:A total of 60 cases of 4 to 9 gestational weeks of threatened abortion patients in our hospital were randomly divided into treatment group and control group,with 30 cases in each.The control group was given daily intramuscular in-jection of progesterone injection 40 mg.The treatment group was given the Chinese herbal medicine Zishen Yutai pill on the basis of the control group.Two groups were 7 days for a course of treatment,with a total of 3 courses.The levels of serum chorionic gonado-tropin(β-HCG),progesterone(P)and estradiol(E2)were measured before and after treatment for 1,2 and 3 weeks.TCM syn-dromes before and after treatment were compared.The clinical efficacy of different age,gestational age and spontaneous abortion in the treatment group was compared with that in the treatment group.Results:The comprehensive effect of the treatment group and the control group was 90% and 77% respectively.The therapeutic effect of the treatment group was significantly higher than that of the control group(P<0.05).The levels of β-HCG,P and E2in the serum of the two groups were significantly higher than those before treatment(P<0.01).The subjects in the two groups were significantly higher than those in the control group(P<0.01). The levels of serum β-HCG and E2were not significantly different between the two groups(P>0.05).After 1,2 and 3 weeks of treatment,the levels of progesterone(P)increased significantly(P<0.01).There was no significant difference in the total effec-tive rate of the subjects with different age groups,gestational age and spontaneous abortion in the treatment group(P>0.05). Conclusion:The clinical curative effect of Zishen Yutai Pill combined with progesterone injection on the treatment of threatened a -bortion is not significantly correlated with the age,gestational age and spontaneous abortion of pregnant women.The improvement of TCM symptoms is very significant,and the levels of P were significantly increased.

目的 系统评价眼针治疗失眠的临床疗效.方法 中文文献检索万方数据库、中国知网数据库(CNKI)、重庆维普中文科技期刊数据库(VIP)、中国生物医学文献数据库(CBM),外文文献检索PubMed和Cochrane图书馆.文献检索从建库到2017年3月31日,语种为中英文.纳入眼针加基础治疗与基础治疗或口服药治疗比较治疗失眠或不寐的随机对照试验文献.使用Cochrane系统评价手册进行偏倚风险评估,运用RevMan 5.3软件进行Meta分析.通过比较两种效应模型结果进行敏感性分析,研究个数在10个及以上的Meta分析采用倒漏斗图对发表偏倚的存在进行检验.结果 共纳入8项,涉及研究675例失眠病人,试验的方法学质量部分偏低.Meta分析结果显示:治疗组与对照组比较,中医证候有效率相对危险度(RR)、95％可信区间(95％CI)为1.29[1.13,1.48];中医证候积分均方差(MD) (95％ CI)为-2.86[-3.44,-2.28];失眠疗效RR(95％ CI)为1.20[1.06,1.35];匹兹堡睡眠质量指数(PSQI)积分MD(95％ CI)为-2.55[-3.53,-1.58];睡眠状态自评量表(SRSS)评分MD(95％ CI)为-2.84[-3.81,-1.88].描述不良反应的1项研究中,治疗组无不良反应发生,对照组发生不良反应3例,均症状轻微且治疗结束停药后好转,未提及有严重不良反应的发生.结论 眼针治疗失眠可提高中医证候有效率,降低中医证候及匹兹堡睡眠质量指数积分,降低睡眠状态自评量表评分,改善失眠疗效.

Vitamin D (VD) and vitamin C (VC) have been recognized as essential elements for human health. Animal models, especially mouse models, have been widely used in the study of VD and VC. This study is to investigate how VD and VC interact at molecular level using whole genome expression profiles from spleens of 111 mouse strains and livers from 40 mouse strains. We first identified the genes that are closely correlated to vitamin D receptor (Vdr) and gulonolactone oxidase (Lgo). We next analyzed the potential molecular pathways of Vdrand Lgo correlated genes and examined how these two sets of pathways are connected in liver and spleen. Our results indicated that Vdrand Lgo associate to distinct groups of genes. While most of genes are not the same, a few of them are associated to both Vdrand Lgo. Our gene network construction suggests that there are interactions between Vdrand Lgopathways. Our work laid down the foundation for future study of the interactions between VD and VC and revealed the potential bias when using animals for the study of VD or VC, as humans do not produce VC.

通过李敬孝教授用升陷汤治疗胸痹(气虚型)的临床医案,阐述李教授相关学术观点.李教授认为胸痹(气虚型)主要病机为胸中大气下陷,常有夹瘀.升陷汤以大剂量黄芪配合人参补气,升麻配合桔梗升提,知母益气清热,知母合桔梗润肠通便.本方补虚力量较强,适合气虚型胸痹的治疗.

This paper discusses the feasibility of introducing big data into Chinese medicine constitution research on ovarian cancer.Taken into account these problems,such as lack of effective screening and diagnostic methods in early stage of ovarian cancer,complexity and variety of Chinese medicine constitution of ovarian cancer,limitations of the traditional random sampling approach and other issues,it proposes the advantages of thinking and technology of big data in Chinese medicine constitution research on ovarian cancer,which aims to achieve the early screening and prevention of ovarian cancer by big data of Chinese medicine constitution.

高血压左心室肥厚为心室适应性肥厚,属代偿性机制,早期可归属为“头痛”“眩晕”等范畴;后期为“胸痹”“中风”“喘证”“水肿”等范畴,为本虚标实.单味药治疗有蛇床子素、丹参、黄芪、三七等可降低血压、心质量指数、心肌MDA含量和血及心肌FFA含量等;中药复方如复方钩藤降压片、半夏白术天麻汤、复方丹参滴丸、心可舒胶囊、扶阳益心膏等,不仅拥有良好的降低收缩压、舒张压作用,而且能有效逆转左心室室间隔厚度、左心室后壁厚度和左心室质量指数以及减轻血管增殖并降低尿微量白蛋白的作用.未来期望病名病机及辨证分型形成共识,多方位深层次研究中医药作用机制.

要提高机关党组织思想政治工作的效率, 必须坚持以人为本的原则, 尊重人,理解人,深入研究干部员工的思想、心理问题及成因, 针对工作中存在的问题和不足, 针对形势的变化和干部员工的思想动态, 采取科学、 灵活的方式方法,切实增强思想政治工作的科学性、创新性和实效性.

民主生活会是党内政治生活的一项重要制度.坚持和加强这一制度,对于健全党内民主,搞好党内监督,解决领导班子内部矛盾,增进干部团结,提高党员修养,充分发挥集体领导作用,提高班子战斗力都有着十分重要的现实作用和意义.

新形势下, 基层党支部发挥战斗堡垒作用必须从实际出发, 要站在推进党的建设新的伟大工程的高起点上, 把保证和促进各项工作、 推进和实现事业跨越式发展, 作为检验基层党支部工作成效和战斗力的重要标准. 要以建设开拓型的支部班子、学习型的党员队伍、长效型的工作机制、管理型的基础工作、文化型的思想阵地、 务实型的党内活动为目标, 逐步将党支部建设成为适应现代化管理和服务要求, 形成严密的组织体系和高效的管理体系, 促进新形势下基层党支部充分发挥战斗堡垒作用.

目的：观察原络通经针法治疗中、轻度抑郁症疗效的临床疗效。方法：把符合纳入标准的患者随机分为观察组和对照组，两组入选患者均口服百忧解，观察组采用原络通经针法治疗，对照组采用十一五教材常规选穴治疗，连续治疗4周。分别在治疗前和治疗后1个月对患者进行汉密尔顿抑郁量表（ HAMD）24项评分，并根据减分率评估两组的疗效分布。结果：治疗后两组患者汉密尔顿量表得分有显著性差异（ P＜0．05）。观察组总有效率为83．34％，对照组总有效率为70％，两组之间疗效分布情况有显著性差异。结论：原络通经针法较传统针刺方法更能有效地改善轻、中度抑郁患者症状。

目的：探讨中药白芨胶[1]对动物移植性肝癌治疗前后影像学比较。方法：选择新西兰大白兔40只，介入技术及动物分组处理参照Lindell等的肝动脉插管方法，将40只荷瘤兔随机分为四组，每组10只，分别为生理盐水加碘油组注射剂量1．5ml／kg；5－FU加碘油组注射剂量0．35mg／kg；白芨胶加碘油热灌注组注射剂量10 mg／kg；白芨提取液加碘油热灌注组注射剂量10 mg／kg。将四组家兔治疗前、后CT影像进行比较。结果：白芨胶加碘油组肝动脉化疗栓塞术能抑制兔VX2肝移植瘤的生长，对肿瘤的抑制作用更明显。结论：白芨具有良好的血管栓塞作用，使用安全，简易，对荷瘤兔肿瘤生长有抑制作用；白芨能抑制肿瘤增殖，使瘤体缩小，是一种理想的栓塞剂。

目的：总结近年来人中穴治疗的疾病，为临床医生提供借鉴。方法：检索相关数据库，对针刺人中穴所治疗的同类文献进行总结。结果：人中穴在急性腰扭伤、三叉神经痛、急症、神经精神疾病方面疗效确切。结论：人中穴疗效可靠，可以广泛应用。