Objective To investigate and analyze the current status,risk factors and clinical characteristics of venous thrombosis in women during pregnancy and puerperium.Methods A retrospective analysis was made in 139 women who was objectively diagnosed with venous thrombosis in 11 medical units in 9 provinces and cities（10 third-class hospitals,1 second-class hospital）from January 1,2018 to December 31,2018.The clinical data of 139 pregnant and puerperal women was analyzed（1 of the 139 patients had incomplete clinical data,so only 138 patients were included in the later analysis）.According to the time of venous thrombosis,they were divided into two groups:pregnancy and puerperium,and the current status,risk factors and clinical characteristics of venous thrombosis were analyzed retrospectively.Results（1） The incidence of venous thrombosis during pregnancy and puerperium varied from 0.09‰ to 5.89‰.（2） Among the 138 cases of venous thrombosis,there were 33 pregnant women（23.9%） and 105 women（76.1%） in the puerperium.Among the risk factors related to thrombosis,inactivity or dehydration,age≥35 years,pregnancy comorbidities and surgical procedures during pregnancy or puerperium excluding perineal sutures) accounted for 34.1%（47/138）,32.6%（45/138）,32.6%（45/138）,and 22.5%（31/138）.Caesarean section accounted for 92.4%（97/105） in patients with puerperal thrombosis,and only 10.1%（14/138） of patients had no associated risk factors.（3） Thrombosis during pregnancy or puerperium was dominated by lower extremities deep vein thrombosis（73.2%,101/138）.Deep vein thrombosis is more common in the left lower extremity（73.3%,74/101）,and10.0%（2/20） of patients with superficial vein thrombosis of upper extremities had deep vein thrombosis,while 57.1%（8/14）of patients with superficial vein thrombosis of lower extremities had deep vein thrombosis.（4）Four（2.9%）patients in this study had pulmonary embolism（4/138）,1 case occurred in the second trimester,1 case occurred in the third trimester,and 2 cases occurred in the puerperium;3 cases survived after positive treatment and 1 case died.Conclusion During pregnancy and puerperium,it is necessary to screen all women for risk factors of venous thrombosis in order to identify high-risk patients early and provide necessary preventive or therapeutic measures.

为探究丹皮酚(paeonol,Pae)调控miR-106a-5p/第10号染色体缺失的磷酸酶及张力蛋白同源物(phosphatase and ten-sion homologue deleted on chromosome 10,PTEN)通路对白血病细胞增殖和凋亡的影响,采用双荧光素酶报告基因分析法验证miR-106a-5p对PTEN的靶向作用.用不同浓度Pae处理K562细胞,分别构建miR-106a-5p抑制表达和经Pae处理的miR-106a-5p过表达或PTEN抑制表达K562细胞株,qRT-PCR检测miR-106a-5p和PTEN的mRNA表达水平;Western blotting检测PTEN、细胞周期素D1(CyclinD1)、Bcl-2、p21和Bax蛋白表达水平;MTT法检测K562细胞增殖能力;FACS检测细胞凋亡率.结果显示,PTEN是miR-106a-5p的靶基因,miR-106a-5p负向调控PTEN的表达;Pae处理可抑制K562细胞的增殖,促进其凋亡,并可抑制白血病细胞rniR-106a-5p、CyclinD1和Bcl-2的表达,促进PTEN、Bax和p21的表达(均P＜0.05);同时,抑制miR-106a-5p表达可抑制K562细胞增殖,促进其凋亡(均P＜0.05);miR-106a-5p过表达或抑制PTEN表达均可部分逆转Pae对K562细胞增殖凋亡的影响(有P＜0.05).由此,Pae通过下调miR-106a-5p/PTEN信号通路蛋白抑制白血病细胞增殖,促进其凋亡.

目的 探讨无透视下腹主动脉球囊阻断术在凶险性前置胎盘剖宫产术研究.方法 回顾性分析内蒙古医科大学附属医院产科2014年01月～2017年11月收治的37例凶险性前置胎盘孕妇,观察组剖宫产术中放置腹主动脉球囊阻断,对照组剖宫产术中未放置腹主动脉球囊阻断.观察指标包括两组之间的术中出血量(mL)、输悬浮去白细胞红细胞量(mL)、输新鲜冰冻血浆量(mL)、子宫切除率.结果 观察组的术中出血量平均值是725.00±580.04 mL、平均输悬浮去白细胞红细胞量为328.57±474.63 mL、平均输新鲜冰冻血浆量为158.57±258.09 mL、子宫切除率为3/1(21.43％),两组之间比较,差异有统计学意义(P<0.05).结论 无透视下腹主动脉球囊阻断术可有效控制凶险性前置胎盘的术中出血量,减少输血量,降低子宫切除率.

目的:观察蒙药蓝刺头对去卵巢骨质疏松(osteoporosis,OP)模鼠血清骨碱性磷酸酶(bone alkaline PhosPhatase,BALP)、抗酒石酸酸性磷酸酶(tartrate-resistant acid phosphatase,TRACP)调节作用、股骨头形态变化,阐明蒙药蓝刺头防治绝经后骨质疏松(postmenoPausal osteoPorosis,PMOP)部分机制,为蒙医药"补暖补精-清镇赫依-固骨质壮骨"治法防治PMOP科研提供实验依据,为本病临床防治提供新思路.方法:通过去势制备PMOP鼠模;后5 d宫颈涂片观察脱落细胞,30 d后选用各组造模大鼠2只,切除子宫HE观察,确定造模是否成功;90 d后应用蒙药蓝刺头高、中、低浓度,强骨胶囊相应浓度、己烯雌酚灌胃90 d;采血后处死剖取大鼠双侧股骨,测血清BALP、TRACP,行左侧股骨头甲苯胺蓝染色,观察形态变化;显微CT右侧股骨骨密度(bone density,BMD)计量学指标分析.结果:去卵巢后大鼠子宫脱落细胞明显减少、皱缩,假手术组呈现大量聚集细胞,造模成功.血清BALP、TRACP表达、左侧股骨头甲苯胺蓝染色观察破骨细胞(OC)骨吸收陷窝数量,蒙药蓝刺头中剂量组具有明显抑制BALP、TRACP表达、提高BMD抗PMOP作用(P<0.05).结论:大鼠经去卵巢后,血清BALP、TRACP明显增高;一定剂量蒙药蓝刺头可降低大鼠血清BALP、TRACP,降低骨OC骨吸收陷窝数量,具抑制骨吸收、促成骨特性,提高BMD,为运用蒙医"补暖补精-清镇赫依-固骨质壮骨"理论防治OP明确部分作用机制,提供实验依据.

近年来,女性阴道微生态状况越来越受到重视,女性阴道环境复杂,通过以乳杆菌为主的多种菌群的相互作用,而维持阴道微生态的动态平衡.孕期是女性的一个特殊时期,由于激素水平以及全身各系统发生一定程度改变,可能使阴道内相关菌群发生改变,造成包括菌群抑制、霉菌性阴道炎、滴虫性阴道炎等阴道微生态失衡的情况出现,最终导致早产、胎膜早破、新生儿感染等不良妊娠结局的发生,对母儿及其家庭造成不良影响.本文就孕期阴道微生态改变与妊娠不良结局的相关性进行综述.

目的 探讨缩宫素欣母沛联合子宫下段止血带捆绑在前置胎盘剖宫产患者术中的应用.方法 将2015年1月～2018年12月在我院收治的前置胎盘患者80例.按随机数表法分为两组,对照组采用缩宫素欣母沛.观察组在对照组止血方式基础上采用子宫下段止血带捆绑.观察两组止血效果.结果 观察组术后各时间点子宫出血量均明显少于对照组,差异有统计学意义,P<0.05;24h SOD、CAT水平高于对照组;ROS、MDA水平低于对照组,差异有统计学意义(P<0.05);与对照组比较观察组并发症发生率差异无统计学意义(P>0.05).结论 缩宫素欣母沛联合子宫下段止血带捆绑可降低前置胎盘剖宫产患者术中及术后出血量,安全性较高.

目的:观察超声引导射频消融联合米非司酮治疗子宫肌瘤对患者子宫功能的影响,旨在指导未来安全有效的子宫肌瘤治疗方法.方法:回顾性收集2017-06～2019-06期间本院收治的子宫肌瘤患者96例病历资料,按照治疗方式不同将其分为两组,将子宫肌瘤剔除术+米非司酮治疗患者51例纳入对照组,将超声引导射频消融+米非司酮治疗患者45例纳入观察组.术后用药4周为1个疗程,用药3个疗程.抽取患者治疗前、治疗3个疗程后静脉血,检测血清性激素[促黄体生长素(LH)、雌二醇(E2)、促卵泡生长激素(FSH)]水平,采用彩色多普勒超声诊断仪检测治疗前、治疗3个疗程后患者子宫内膜厚度、子宫体积及子宫内膜各血流参数[血流指数(FI)、血管化指数(Ⅵ)、血管化血流指数(VFI)],并对比上述检各项检测指标.结果:两组治疗前后LH、E2、FSH水平的变化,对照组较治疗前均明显升高(P＜0.05),观察组较治疗前均无变化(P＞0.05),且均低于对照组,差异有统计学意义(P＜0.05);两组治疗后子宫内膜厚度均较治疗前增加,子宫体积较治疗前缩小,且观察组子宫内膜厚度大于对照组,子宫体积小于对照组,差异有统计学意义(P＜0.05);治疗后,两组FI、VI、VFI、VFI值均较治疗前升高,且观察组高于对照组,差异有统计学意义(P＜0.05).结论:超声引导射频消融联合米非司酮治疗子宫肌瘤,更利于患者术后性激素水平的调节,患者子宫内膜血流改善、子宫内膜厚度增加、子宫体积缩小,不仅不会对患者子宫功能带来不理影响,在一定程度上更利于术后子宫恢复.

目的 探讨复方红衣补血口服液联合乳酸亚铁治疗妊娠期缺铁性贫血的临床疗效.方法 选取2017年1月—2018年6月内蒙古医科大学附属医院收治的妊娠期缺铁性贫血患者94例,随机分为对照组和治疗组,每组各47例.对照组口服乳酸亚铁片,2片/次,3次/d.治疗组在对照组的基础上口服复方红衣补血口服液,10 mL/次,3次/d.两组患者均治疗4周.观察两组患者临床疗效,同时比较治疗前后两组患者临床症状缓解时间、妊娠结局及外周血红细胞参数、网织红细胞参数和铁代谢指标.结果 治疗后,对照组临床治愈率为65.96％,显著低于治疗组的82.98％,两组比较差异具有统计学意义(P<0.05).治疗后,治疗组临床症状缓解时间均显著短于对照组(P<0.05).治疗后,治疗组剖宫产率和低体质量儿出生率显著低于对照组(P<0.05).治疗后,两组患者外周血未成熟网织红细胞比率(IRF)、可溶性转铁蛋白受体(sTFR)和sTFR/血清铁蛋白(SF)水平显著下降(P<0.05),血红细胞计数(RBC)、血红蛋白(Hb)、红细胞平均体积(MCV)、红细胞平均血红蛋白(MCH)、单个网织红细胞平均血红蛋白浓度(CHCMr)和SF水平显著升高(P<0.05),且治疗组外周血这些指标水平的改善幅度明显(P<0.05).结论 复方红衣补血口服液联合乳酸亚铁治疗妊娠期缺铁性贫血可以促进铁代谢,改善红细胞的发育,缓解临床症状,提高临床治愈率.

孕期在胎盘产生的激素参与和神经内分泌的影响下,孕妇体内各系统发生一系列生理变化以适应胎儿生长发育的需要并为分娩做准备.妊娠期血液处于高凝状态.由于孕期血液处于高凝状态,产后胎盘剥离面血管内迅速形成血栓,是预防产后出血的另一重要机制.血浆D-二聚体是血浆交联纤维蛋白的特殊降解产物,在各种血栓形成性疾病及生理性高凝状态时均有增高,是反映体内纤溶活性的特异性分子标志物.相关文献支持,孕期血浆D-二聚体指标检测有助于诊断妊娠及分娩期并发症.血流处于持续的病理性高凝状态,并有继发性纤溶的可能,形成血栓前状态,引起子宫局部组织和胎盘形成微血栓,子宫内膜及胎盘血流灌注不足,引起胎盘组织缺血缺氧坏死,最终导致妊娠期高血压疾病、胎盘早剥、反复流产、早产、死产、FGR、弥散性血管内凝血(DIC)及产后大出血等不良妊娠结局.严重威胁孕产妇及围产儿的生命安全.妊娠期生理正常值及疾病的诊断不同于非孕期.积极预防妊娠不良结局的发生是高危妊娠管理的重要任务.

Objective To investigate the role of p16,Ki-67 and human papilloma virus(HPV)type in the shunt treatment of cervical intraepithelial neoplasia (CIN) Ⅱ. Methods The paraffin block on file and the pathological results from loop electrosurgical excision procedure (LEEP) of 377 CIN Ⅱpatients diagnosed with colposcope examination accompanied by cervical high-risk HPV infection in the Affiliated Hospital of Inner Mongolia Medical University of Obstetrics and Gynecology Department from January 2014 to October 2016 were collected. The paraffin sections were stained with p16 and Ki-67 immunohistochemistry. The correlation between the expression of p16 and Ki-67 in biopsy tissues and the pathological results after LEEP was analyzed.HPV type and pathological results after LEEP were also analyzed.Results LEEP postoperative pathological grade in 337 cases of CINⅡpatients was divided into two groups(＜CINⅡ and ≥CINⅡ). There was no statistical difference in age between the two groups (t = 3.078, P = 0.063). There were statistical differences in the expressions of p16+and Ki-67+between the two groups[3.6 %(8/233) vs. 88.5 % (92/104), χ 2=235.54,P<0.001; 3.0 %(7/233) vs. 76.9 % (80/104), χ 2= 197.63, P< 0.001]. There was a statistical difference in HPV infection type between the two groups (χ2= 12.713, P = 0.005). The sensitivity and specificity of p16+and Ki-67+for LEEP postoperative≥CINⅡ was 88.89 % vs.77.78 % and 95.96 % vs.95.80 % respectively. There was a statistical difference in group type of p16 and Ki-67 in both groups (χ2=304.28, P< 0.001). The sensitivity of p16+Ki-67+was 90.73 % and the specificity was 98.74 % in CINⅡpatients for LEEP postoperative. Conclusions The expressions of p16 and Ki-67 can guide the colposcopic biopsy for the treatment of CINⅡ. For CINⅡpatients with p16+Ki-67+, the active treatment should be taken. Close observation needs to follow for p16 and Ki-67 single negative or double negative patients. Active treatment should be performed for CINⅡpatients with HPV16 type infection in CINII. Age can not be used as the basis for the patients with shunt CINⅡ.

子痫前期是影响孕产妇生命健康的常见病因.主要病理表现为全身小血管痉挛,通过尿钙检测可以对其疾病的发生起到监测作用;同时子痫前期患者由于凝血与纤溶平衡失调,导致异常高凝状态,通过监测凝血因子、D-二聚体及血浆白蛋白的改变也可以探究病情的发生及发展.故而联合各项敏感指标来监测孕产妇的血栓前状态,可以指导临床治疗,并且起到降低孕产妇的严重并发症及改善母儿预后的作用.在此讨论可以预测子痫前期的几种指标.

近年来随着剖宫产率的上升,甚至二胎政策放开后凶险性前置胎盘的发生率明显上升.凶险性前置胎盘的治疗重点是在最短时间内及时有效控制出血情况.大多数文献报道,腹主动脉球囊阻断术可以缩短手术时间,减少术中、术后出血量,降低子宫切除率,保留生育能力,术后恢复快,但仍然存在释放球囊后继续出血的风险,可能需要其他方法 止血,术后形成血栓等并发症的可能.有些学者认为,无X线引导定位下,利用解剖标志及手法进行腹主动脉球囊阻断术取得较好的效果,值得在临床应用中推广.

目的:探讨瘢痕子宫阴道试产成功的影响因素.方法:前瞻性系列研究.选取2015-01～2017-12期间我院妇产科产检并分娩的剖宫产术后瘢痕子宫再次妊娠产妇300例,其中符合剖宫产后阴道试产(TOLAC)指征且有TOLAC意愿的产妇120例,180例自愿选择选择性重复剖宫产术(ERCD),对比TOLAC成功和失败产妇的临床资料,Logistic回归分析影响TOLAC成功的危险因素.TOLAC成功产妇作为阴道分娩组(VBAC组),TOLAC失败转剖宫产术及自愿选择选择性重复剖宫产术(ERCD)产妇作为ERCD组,比较两组产妇临床资料及不良事件发生率.结果:有TOLAC意愿的产妇共120例,试产成功98例,占81.67％,失败22例,占18.33％.TO-LAC成功组和失败组产妇年龄、距离上次剖宫产手术时间、既往有阴道分娩史、新生儿未存活率比较,差异无统计学意义(P>0.05),成功组年龄<40岁、孕周<36wk、新生儿体重<3500 g的几率分别为73.47％、65.31％、89.80％高于失败组的45.45％、36.36％、59.09％,差异有统计学意义(P<0.05);多因素Logistic回归分析显示,年龄、新生儿体重是影响瘢痕子宫再次妊娠产妇TOLAC成功的重要因素.VBAC组孕次少于ERCD组,差异有统计学意义(P<0.05),其余比较差异无统计学意义(P>0.05);两组均未出现子宫破裂,且产后出血≥500 mL、胎儿窘迫几率比较,差异无统计学意义(P>0.05);VBAC组产后24 h出血量少于ERCD组,产褥感染率为2.04％低于ERCD组的8.91％,差异有统计学意义(P<0.05).结论:严格把握TOLAC指征情况下,瘢痕子宫再次妊娠产妇TOLAC成功率较高,其中年龄>40岁、新生儿体重≥3500 g是影响阴道试产成功的重要危险因素;与ERCD相比,VBAC可减少产后24 h出血量,降低产褥感染率,且不会增加子宫破裂风险.

女性生殖道感染是常见的妇科疾病之一.正常情况下,女性生殖道内存在一个相对稳定的微环境,当内分泌激素水平、生殖道内的PH变化时,生殖道内的微环境也会改变.妊娠期作为女性的一个特殊生理时期,体内激素水平发生巨大变化,容易导致下生殖道的炎症.而下生殖道炎症是引发早产的重要危险因素之一,故本文对妊娠期阴道微生态环境与早产的关系进行研究及评价,为指导妊娠期阴道炎症的临床诊治、降低早产发生率提供依据.

目的 探讨中孕期胎盘植入孕产妇发生不良妊娠结局的相关危险因素.方法 回顾性分析2010年1月～2017年1月内蒙古医科大学附属医院产科56例中孕期胎盘植入患者的临床资料.结果 中孕期胎盘植入患者严重不良妊娠结局的发生率为28.6％ (16/56).单因素分析显示,年龄、孕次、产次、流产次数、剖宫产次数、产前阴道出血次数、人工辅助生殖技术、终止妊娠的孕周、胎盘植入类型、未规律产检、宫腔感染、产前多学科团队参与、和合并胎盘低置是中孕期胎盘植入患者发生不良妊娠结局的相关危险因素(P＜0.05);多因素logistic回归分析显示,剖宫产次数(OR=2.213)、宫腔感染(OR=1.606),合并胎盘低置(OR=-1.834)是中孕期胎盘植入患者发生不良妊娠结局的独立危险因素.结论 中孕期胎盘植入患者发生不良妊娠结局的独立危险因素是剖宫产次数、宫腔感染和胎盘低置.

Objective:Studying the effects of Mongolian echinops on some indexes of ovariectomied rats,the estrogen receptor α and β mRNA to search for the mechanism of drug action.Methods:It selected 84 female Wistar rats which are 4 months old in the study,they were randomly divided into 7 groups:shamed operations group,model group,Qianggu capsule group,diethylstilbestrol group,Mongolian echinops at high、medium、low dose groups.every group had twelve rats.Prepared model reference to the literature,shamed operations group were shamming operated;which removed a little amount of adipose tissue around ovarian.Others were removed bilateral ovarian.Then,it fed rats for 90 days in the normal conditions.And it gived rats corresponding drug orally,intragastrically.It separated rats bilateral tibial bone,and to tissue the estrogen receptor α and β mRNA expression of rats by RT-PCR method.Results:The Mongolian medicine Echinops can improve the general condition of ovariectomized rats significantly.Among the group of diethylstilbestrol,model group and Echinops high group,which improved expression ERα,ERβ mRNA.Echinops dose drug of middle can increase expression of ERβ mRNA than the diethylstilbestrol.There is no difference between the Echinops dose group and strong bone capsule group,the expression of ER mRNA.Conclusion:Echinops can raise expression of ovariectomized rats ERα and ERβ.In short,it is possible to specify Echinops treated osteoporosis.Therefore,Mongolian Echinops may promote bone formation,adjusted the coupling of bone resorption and reduced the rate of bone turn over to reache combating the PMOP.

Objective:To investigate the study of abdominal aorta balloon occlusion without fluoroscopy in cesarean section of central placenta previa. Methods:The data of 36 patients with central placenta previa from obstetrics and gynecology in the Affiliated Hospital of Inner Mongolia Medical University from January 2016 to January 2017 were analyzed retrospectively. Observation group:20 patients with central placenta previa underwent abdominal aortic balloon preset and occlusion,and the control group:16 patients with central placenta previa who did not have abdominal aortic balloon occlusion. Results:Compared with the control group 1181. 25 ± 1208. 83mL, the blood loss in the observation group was 490. 00±497. 52mL,the difference was statistically significant(P=0. 026),and the blood loss in the observation group was significantly reduced. The observation group and the control group of uterus resection rate was 10%( 2/20 ) and 43 . 75%( 7/16 ) , the difference was statistically significant(P = 0.026),the observation group significantly decreased the rate of hysterectomy. Conclusion:Application of abdominal aorta balloon occlusion without fluoroscopy can effectivelycontrol bleeding in central placenta previa during operation,reduce the uterus resection rate.

Objective:To analyze the clinical characteristics of pregnant patients with pulmonary hypertension,and explore manner and timing of their delivery. Methods:To retrospective analyze 32 cases of pulmonary hypertension of pregnancy 2010 to 2014 in the department of obstetrics of our hospital. Result:According to pulmonary artery systolic pressure 32 patients were divided into mild group(30~40 mmHg)18 cases,moderate group(41~69 mmHg)9 cases,severe group(≥70 mmHg)5 cases. Perinatal child mortality 3 cases, maternal mortality 3 cases, early pregnancy embryo stop education 2 cases, second trimester stillbirth 2 cases, the rest discharge after childbirth and heart function improved. Conclusion:The higher pulmonary artery pressure,the worse maternal heart function and maternal outcomes. according to the patient the timing of termination of pregnancy should be integrated to determine,caesarean section to terminate the pregnancy is a safer way.

AIM:To investigate the value of fetal heart rate mo?nitoring combined with umbilical cord blood flow S/D value in the prediction of fetal distress. METHODS: A total of 200 cases of term pregnant women admitted into Affiliated Hospital of Inner Mongolia Medical University from January 2014 to December 2015 were treated by fetal heart rate monitoring combined with umbilical blood monitoring test. The results of two kinds of detection meth?ods and joint detection were predicted. RESULTS:Fetal distress rate of combined detection was 33.5%;Fetal distress rate of fetal heart monitoring was 27.0%;Fetal distress rate of umbilical blood monitoring test was 22.0%. Fetal distress rate of combined detec?tion was higher than that of the other two kinds of detection means, with statistically significant difference(P<0.05). There was no statistically significant difference between fetal heart moni?toring and umbilical blood monitoring test( P>0.05); Accordance rate of fetal heart monitoring was 58.0%, which was slightly high?er than 66. 0% of umbilical blood flow monitoring test, with no statistical significant difference ( P>0.05 ) . CONCLUSION:Combined detection excludes the interference of various factors in the single detection. It greatly improves diagnostic rate of fetal dis?tress, and makes up for the deficiency of single detection. It helps providing evidence for the early prediction of fetal distress.

Objective:To investigate the significance of fetal heart monitoring,umbilical cord blood flow S/D value in predicting fetal distress in high risk pregnancy. Methods:in our hospital from September 2013 to September 2015 in our hospital 200 cases of high-risk singleton pregnancy pregnancy, all pregnant women underwent antenatal fetal heart monitoring and umbilical blood flow detection. The prediction results of two kinds of means for contrast detection and joint detection. Results:S/D<3and fetal heart monitoring reaction type comparison,the difference was not significant;the S/D value is more than 3 and the fetal heart monitoring without response. There is no significant difference,P>0. 05;fetal heart monitoring abnormal amniotic fluid of 7 Apgar, turbidity, low birth weight infants were significantly higher than normal. The comparison between the two,P<0. 05;S/D value of abnormal amniotic fluid turbidity,7Apgar, low birth weight infants were significantly higher than those of normal subjects,two,P<0. 05;combined detection of neonatal prognosis rate was 36%, significantly higher than the other two kinds of detection methods,P<0. 05;fetal heart Monitoring the incidence of adverse prognosis was 26%,the umbilical cord blood flow was 21%,and there was no sig-nificant difference between the two types of test results,P>0. 05. Conclusion:the combined detection of the interference of various factors in the single monitoring,improve the prognosis of newborns with poor diagnostic rate,make up for the lack of a single detection,help to provide a basis for the early pre-diction of neonatal prognosis.