Objective To evaluate the clinical efficacy and safety of Huzhen Qingfeng Capsule（HZQFC） in the treatment of acute gouty arthritis patients with damp-heat accumulation syndrome（DHAS）.Methods A randomized, double-blind, placebo-controlled, multicenter, superiority testing clinical trial was performed. A total of 480 acute gouty arthritis patients with DHAS were collected from 14 hospitals across China.They were randomly assigned to the treatment group（360 cases） and the control group（120 cases） using SAS Software at 3 :1 by stratified block randomization. Patients in the treatment group took HZQFC, while those in the control group took HZQFC simulators. All patients took 4 capsules each time, 3 times a day, for a total of 3days. The visual analogue scale（VAS） of pain, TCM syndrome score, the disappearance rate of each symptom, erythrocyte sedimentation rate（ESR）, C-reactive protein（CRP）, blood routines（white blood cell count）, and the incidence of adverse events were observed before and after treatment. Results Of 480 subjects, 438were included in the full analysis set（FAS） for efficacy analysis. There were 325 cases in the treatment group with 35 cases dropped off（including 2 cases with adverse events, 29 lost to follow-ups, 2 cases violating the protocols, and 2 cases withdrawn from the trial due to lack of efficacy）. There were 113 cases in the control group with 7 cases dropped off（including 2 cases lost to follow-ups and 5 cases violating the protocols）. The VAS score and difference of pain in the treatment group on the third day were better than those in the control group, and the differences were statistically significant（t =7.241, t =6.452, P＜0.01）. The total effective rate of TCM syndrome in the treatment group was 91.4%（297/325）, better than that [68.1%（77/113）] in the control group with statistical difference（χ~2=7.184, P＜0.01）. The TCM syndrome scores and differences of the treatment group on the third day were better than those of the control group, and the differences were statistically significant（t =7.126, t =6.417, P＜0.01）. In terms of the disappearance rate of 9 individual symptoms, including joint pain, joint swelling, joint fever, joint skin color, mobility inconvenience, joint tenderness, fever, thirst, restlessness, the disappearance rate of the treatment group was higher than that of the control group except fever（P＜0.01）.After 3 days of treatment there were no significant differences in ESR, CRP, or WBC count between the two groups（P＞0.05）. The incidence of adverse events during the treatment was 24.4%（87/357） in the treatment group and 24.8%（30/121） in the control group, and the difference was not significant（χ~2=0.009,P＞0.05）.Conclusions HZQFC effectively relieved joint pain of acute gouty arthritis patients with DHAS, with shorter onset time. But its safety was comparable to placebos. So the clinical application was safe.

采用经颅重复针刺法联合芒针透刺治疗桡神经麻痹,效果显著.该文分享验案1则,以期为桡神经麻痹的治疗提供新的治疗思路与方法.

[目的]研究火针辅以腧穴埋线对中风上肢痉挛患者痉挛程度(MAS)和上肢运动功能(FMA)的影响.[方法]文章选取2019年1月—2021年2月在黑龙江中医药大学第二附属医院针灸五病房住院的中风上肢痉挛患者120例,按照随机数字表法分为治疗组和对照组,各60例.对照组给予火针治疗,治疗组在对照组火针针灸治疗的基础上辅以腧穴埋线治疗,两组患者共治疗4周.检测患者MAS、FMA、神经功能缺损评分标准(CSS)、γ-氨基丁酸(GABA)、甘氨酸(Gly)、焦虑自评量表(SAS)、日常生活活动能力(ADL)指标,统计治疗效果.[结果]治疗后,CSS、SAS评分均低于治疗前,FMA、Gly、GABA、ADL评分均高于治疗前,差异有统计学意义(P<0.05);治疗后治疗组MAS评分等级优于对照组,CSS、SAS评分均低于对照组,FMA、Gly、GABA、ADL及临床疗效优于对照组,差异有统计学意义(P<0.05).[结论]火针辅以腧穴埋线对中风上肢痉挛患者治疗痉挛程度、上肢运动功能的效果明显,能降低患者痉挛程度,提高患者上肢运动功能.

[目的]观察芒针对刺神阙与曲泉穴治疗脑卒中后尿潴留的临床疗效.[方法]将70例脑卒中后尿潴留患者随机分为治疗组和对照组,每组各35例.2组患者均给予基础治疗,对照组给予常规针刺治疗,治疗组给予芒针对刺神阙与曲泉穴治疗.6 d为1个疗程,2个疗程之间间隔1 d,连续治疗2个疗程.治疗2周后,评价2组临床疗效,观察2组患者治疗前后膀胱最大容量及残余尿量的变化情况,比较2组患者治疗前后中医症状积分的变化情况.[结果](1)治疗后,2组患者的膀胱最大容量、残余尿量均明显改善(P<0.05),且治疗组在改善膀胱最大容量、残余尿量方面明显优于对照组,差异有统计学意义(P<0.05).(2)治疗后,2组患者的排尿无力、小腹坠胀、倦怠乏力及总分均明显改善(P<0.05),且治疗组在改善排尿无力、小腹坠胀、倦怠乏力及总分方面明显优于对照组,差异有统计学意义(P<0.05).(3)治疗组总有效率为82.86％(29/35),对照组为71.43％(25/35).治疗组疗效优于对照组,差异有统计学意义(P<0.05).[结论]芒针对刺神阙与曲泉穴治疗脑卒中后尿潴留,能明显改善患者的临床症状,有效改善患者的膀胱功能,疗效显著.

目的 寻找一种可以减轻逆行腓肠神经营养血管皮瓣传统手术方式后的蒂部肿胀畸形的方法,以求改善足踝部的功能和外观.方法 在传统手术方式的基础上,对皮瓣的蒂部进行改良,改良方式为切断蒂部近端上旋转轴点的皮肤,从畸形部分的近处到远处、浅处到深处进行分离,由浅入深分离至到深层皮下筋膜组织时停止,由近及远分离至旋转轴点时停止,使近端蒂部"猫耳"样畸形的皮肤变成真皮层皮片.结果 该例患者的皮瓣完全成活,创面完全愈合.皮瓣不会有"猫耳"样的畸形,也不会有明显的肿胀,功能和外观均较好.结论 该蒂部改良方式能有效地减轻术后皮瓣的肿胀畸形,使足踝部恢复正常的功能,并改善足踝部的外观.

原发性三叉神经痛是临床上最常见的神经痛,其论治方法较多.该文运用芒火针特色疗法治疗原发性三叉神经痛,效果颇佳.

目的:以脑栓通胶囊为对照,评价天丹通络胶囊用于脑梗死恢复期(中风中经络风痰瘀血痹阻脉络证)的安全性和有效性.方法:采用随机、双盲单模拟、阳性药、多中心临床研究,研究周期为2016年12月28日至2019年4月12日.计划纳入352例脑梗死恢复期,中医辨证属中风中经络风痰瘀血痹阻脉络证的患者,按3∶1的比例随机分为试验组与对照组.试验组给予天丹通络胶囊口服,5粒/次,3次/日;对照组同时服用脑栓通胶囊模拟剂与脑栓通胶囊,脑栓通胶囊3粒/次,3次/日,脑栓通胶囊模拟剂2粒/次,3次/d.连续服药12周,随访至发病后180 d.以日常生活活动(ADL)能力量表(Barthel指数)评分为主要疗效指标;次要疗效指标神经功能缺损评分[国立卫生研究院卒中量表(NIHSS)],改良Rankin量表(mRS),中医证候疗效,新发血管性事件患者的比例.并观察治疗过程中实验室指标变化及不良反应发生率.结果:实际入组389例患者,脱落30例,脱落率7.71％;纳入全分析数据集374例,纳入安全集分析377例.与对照组比较,试验组主要疗效指标Barthel指数评分总分,Barthel指数评分≥75分的百分率均有所升高,但差异无统计学意义;与对照组比较,试验组次要疗效指标发病后180 d mRS评分≤2分的百分率明显升高(P＜0.05);中医证候疗效与对照组比较,试验组愈显率高于对照组(P＜0.05);研究期间,试验组未出现新发血管事件,发生率0.00％;对照组发生1例,发生率1.09％,与对照组比较,试验组新发血管事件比例差异无统计学意义.结论:天丹通络胶囊与脑栓通胶囊治疗脑梗死恢复期(中风中经络风痰瘀血痹阻脉络证)疗效确切,与脑栓通胶囊比较,天丹通络胶囊在改善神经功能缺损、促进神经功能恢复及中医证候疗效更显著,试验期间新发血管事件比例及不良事件发生率两组差异无统计学意义,且试验组无严重不良事件发生.

目的 探究后循环缺血性眩晕患者采用芒针联合甲磺酸倍他司汀治疗的临床效果.方法 纳入该院2018年1—12月收治的90例后循环缺血性眩晕患者,按随机数字表法分为治疗组1、治疗组2和观察组,各30例.治疗组1采用芒针治疗,治疗组2口服甲磺酸倍他司汀治疗,观察组采用芒针联合甲磺酸倍他司汀治疗.比较三组的治疗效果.结果 观察组的治疗总有效率为96.67％,高于治疗组1的73.33％及治疗组2的70.00％,组间差异有统计学意义(P<0.05).治疗后,观察组的DARS评分、DHI-S评分均低于治疗组1及治疗组2,组间差异有统计学意义(P<0.05).治疗后,观察组的右椎动脉平均血液流速、基底动脉平均血液流速及左椎动脉平均血液流速均快于治疗组1及治疗组2,组间差异有统计学意义(P<0.05).结论 芒针联合甲磺酸倍他司汀治疗后循环缺血性眩晕患者的效果显著,可有效改善眩晕,加快血液流速,具有临床推广应用价值.

目的 观察芒针治疗中风后呃逆的临床疗效.方法 选取42例患者,随机分为治疗组和对照组,其中对照组单纯使用毫针针刺治疗,治疗组在对照组的基础上加以芒针针刺治疗.治疗后,比较与分析两组结果 .结果 治疗组的有效率明显高于对照组,差异具有统计学意义(P<0.05).结论 芒针治疗中风后呃逆是一种有效的治疗方法 .

梅核气是一种以喉中明显异物感,但无器质性病变为症状特点的疾病.应用芒针透刺,疏通气血,配以情绪疏导,临床疗效显著.

目的 探究治疗中风后假性延髓麻痹的高效疗法.方法 32例患者随机分为治疗组、对照组各16例.基础治疗方案相同,治疗组接受火针疗法和康复训练;对照组接受普通针刺疗法和康复训练.2组患者治疗每周6d,连续4周为1疗程.结果 治疗组有效率93.7％,对照组87.5％.火针组疗效明显高于对照组(P<0.05).结论 火针疗法较普通针刺有更优的临床效果.

目的:观察常规治疗基础上采用夹脊穴穴位埋线联合电针治疗格林巴利综合征的临床疗效.方法:将48例格林巴利综合征患者随机分为治疗组和对照组,每组24例.2组均予基础治疗,对照组联合电针治疗,治疗组联合夹脊穴穴位埋线及电针治疗.2组均治疗1个月.比较2组患者治疗前后四肢肌力、神经传导速度及日常生活活动能力变化情况,并评估临床疗效.结果:治疗组总有效率100.0％,明显优于对照组的87.5％(P<0.01);2组患者治疗后四肢肌力、神经传导速度及日常生活活动能力(ADL)评分均较治疗前明显改善(P<0.01),且治疗组改善情况明显优于对照组(P<0.01).结论:常规治疗基础上采用夹脊穴穴位埋线联合电针治疗对格林巴利综合征患者肢体运动功能及神经修复有显著的促进作用,能明显改善患者生活活动能力.

对近5年来假性延髓麻痹中医治疗方法的文献进行了查阅、分析和整合,从非药物疗法和中药治疗方面对该病分析论述.非药物类的治疗方法又分为常规针刺治疗方法和特殊针刺治疗方法,常规针刺疗法主要是体针,特殊针法治疗包括项针、舌针、电针、芒针、火针、放血疗法.与非药物治疗相比较,中药治疗应用比较少,主要因为假性延髓麻痹患病时临床表现为吞咽困难这一特点.非药物治疗更为广泛,且患者的疗效和预后效果更佳,操作便捷,副作用小.假性延髓麻痹的中医疗法,突出了中医药治疗延髓麻痹的优势.虽然祖国医学对该病疗效显著,但对该病的临床研究方法和数据分析方面仍需深入探索.

Objective: To explore the clinical efficacy of point-to-point electro-needling back-shu points with elongated needle in the treatment of chronic fatigue syndrome (CFS). Methods: 60 cases of CFS were randomly divided into the treatment group (n = 30) and the control group (n = 30). The treatment group was treated with point-to-point electro-needling with elongated needle; the control group was treated with ordinary acupuncture. After three courses of the treatment, scores of fatigue scale and SF-20 were compared between the two groups to evaluate the clinical efficacy. Results: After three courses of the treatment, the scores of fatigue scale were decreased in the two groups (P ＜ 0. 01); of which the treatment group was superior to the control group (P ＜ 0. 05). The scores of secondary accompanied symptoms, such as decreased memony and concentration, swollen and painful lymph nodes, headache, and sleep disorder, were significantly lowered after the treatment in the treatment group (P ＜ 0. 01); of which the scores in the treatment group was significantly lower than those in the control group (P ＜ 0. 05). There were statistical differences in SF-20 score and clinical efficacy between the two groups after the treatment (P ＜ 0. 05). Conclusion: The curative effect of point-to-point needling back-shu points with elongated needle is better than ordinary acupuncture when treating CFS.

Objective To observe the clinical efficacy of fire-needle therapy in treating deglutition disorders due to pseudobulbar palsy in the remission stage of stroke. Methods Sixty-two eligible subjects were divided into a fire-needle group and a rehabilitation group by a simple randomization method at a ratio of 1:1. The two groups received same basic intervention; in addition, the fire-needle group received fire-needle treatment, while the rehabilitation group received rehabilitation training. The two groups of subjects all received a 3-week treatment and were evaluated by the dysphagia severity rating scale (DSRS), modified Mann assessment of swallow ability (MMASA) and Kubota Toshio swallow test (KTST) before and after the intervention. The complications and adverse events occurred during the trial were recorded. The data were statistically analyzed. Results At the third week, the DSRS, MMASA and KTST scores changed significantly compared with the baseline in both groups ( P <0.05), and the changes in the fire-needle group were more significant than those in the rehabilitation group ( P <0.05). The between-group comparison at the third week showed that the therapeutic efficacy in the fireneedle group was superior to that in the rehabilitation group ( P <0.05). Conclusion Fire-needle therapy can obviously change the DSRS, MMASA and KTST scores in pseudobulbar palsy in the remission stage of stroke, and significantly enhance the therapeutic efficacy of the treatment of deglutition disorders in this stage.

Objective To observe the clinical efficacy of acupuncture at the three nasal acupoints plus bloodletting at Suliao (GV 25) in treating rosacea.Method Sixty rosacea patients were randomized into a treatment group and a control group, 30 cases each. The treatment group was intervened by acupuncture at the three nasal acupoints plus bloodletting at Suliao (GV 25), while the control group was intervened by ordinary medication. The skin lesion scores of the two groups were observed before and after 4-week treatment, and the clinical efficacies were also compared. Result The skin lesion scores were significantly changed after respectively 2, 3 and 4 weeks of treatment in both groups (P<0.05). The skin lesion scores in the treatment group were significantly different from those in the control group respectively after 2, 3 and 4 weeks of treatment (P<0.05). The total effective rate was 93.3％ in the treatment group versus 73.3％ in the control group, and the between-group difference was statistically significant (P<0.05). Conclusion Acupuncture at the three nasal acupoints plus bloodletting at Suliao (GV 25) is an effective approach in treating rosacea.

Objective To observe the clinical efficacy of acupoint thread embedding plus Western medication in treating major epilepsy.Method Sixty epilepsy patients were randomized into a thread embedding group and a Western medication group, 30 cases each. The Western medication group was intervened by Western medication; the thread embedding group was given acupoint thread embedding based on the same Western medication treatment. Seizure frequency, seizure score, general efficacy and the improvement of adverse reactions due to Western medications were analyzed.Result Compared to the Western medication group, the thread embedding group was more effective in controlling seizure frequency (P<0.01), and reducing seizure score (P<0.05) and adverse reactions of Western medications (P<0.05); the general efficacy of the thread embedding group was superior to that of the Western medication group in treating epilepsy (P<0.05).Conclusion Acupoint thread embedding plus Western medication is effective in treating epilepsy, and is superior to the use of Western medication alone.

目的:观察火针治疗慢性湿疹的临床疗效.方法:将60例慢性湿疹患者随机分为治疗组和对照组,治疗组采用火针治疗,对照组采用复方氟米松软膏,治疗结束后对结果进行分析.结果:火针治疗组总有效率为93.3％,优于对照组(P＜0.05).治疗组治疗后VAS评分改善比较优于对照组(P＜0.05).结论:火针治疗慢性湿疹疗效较好.

本文从制备工艺、高低温性能性能、降噪研究、抗老化性能等多个方面论述了我国现阶段对橡胶沥青的研究进展，总结了现阶段橡胶沥青的研究成果和生产、施工工艺。

目的探讨穴位埋线对癫痫大鼠海马神经元氨基酸及细胞凋亡的影响。方法选取50只Wistar大鼠,每组10只,随机分为空白对照组、模型组、穴位埋线组、针刺组、丙戊酸钠组。除空白对照组外,其他4组均用青霉素钠腹腔注射造模,穴位埋线组第1、4、7天重复埋线。第7天模型组、穴位埋线组、针刺组及丙戊酸钠组再一次腹腔注射青霉素钠点燃模型大鼠,所有动物均在第7天治疗后断头取脑,剥离海马。标本切片观察各组大鼠海马神经元形态学改变（原位末端标记法）。并检测海马内谷氨酸（Glu）、?-氨基丁酸（GABA）的含量（高效液相色谱仪）,计算GABA/Glu比值。结果空白对照组大鼠海马神经元细胞正常,阳性凋亡细胞稀疏,模型组、针刺组、穴位埋线组及丙戊酸钠组均可见不同程度海马细胞凋亡现象。与模型组相比,穴位埋线组、针刺组及丙戊酸钠组海马细胞凋亡现象明显降低（P＜0.01）,丙戊酸钠组低于穴位埋线组（P＜0.05）,穴位埋线组低于针刺组（P＜0.05）。模型组海马区兴奋性氨基酸Glu的含量较空白对照组明显增加（P＜0.01）,穴位埋线组、针刺组及丙戊酸钠组与模型组对比海马内Glu的含量明显减少（P＜0.01）,且穴位埋线组及丙戊酸钠组Glu水平少于针刺组（P＜0.05）,穴位埋线组及丙戊酸钠组间无明显差异（P＞0.05）。模型组海马区GABA的含量低于空白对照组（P＜0.01）。穴位埋线组、针刺组及丙戊酸钠组GABA的含量均高于模型组（P＜0.01）,穴位埋线组、丙戊酸钠组及针刺组间GABA含量无明显差异（P＞0.05）。模型组GABA/Glu比值低于空白对照组（P＜0.01）,穴位埋线组、针刺组、丙戊酸钠组GABA/Glu比值高于空白对照组（P＜0.01）,穴位埋线组、丙戊酸钠组及针刺组间GABA/Glu比值无明显差异（P＞0.05）。结论重复穴位埋线可明显阻止癫痫大鼠海马神经元细胞凋亡的发生发展并可通过调节脑内兴奋性与抑制性氨基酸的水平而发挥抗癫痫作用。