This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal).This article has been retracted at the request of the Editor-in-Chief.Following the concerns raised about the background pattern of the Western Blots from Figures 1C and 3D, the corresponding author has contacted the journal to request the retraction of the article. Given the comments of Dr Elisabeth Bik regarding this article “This paper belongs to a set of over 400 papers (as per February 2020) that share very similar Western blots with tadpole-like shaped bands, the same background pattern, and striking similarities in title structures, paper layout, bar graph design, and - in a subset - flow cytometry panels”, the journal requested the authors to provide the raw data. However, the authors were not able to fulfil this request and therefore the Editor-in-Chief decided to retract the article.

目的:探讨用中西医结合疗法治疗冠心病稳定型心绞痛伴高同型半胱氨酸血症的临床效果.方法:将2016年9月至2017年9月期间在济宁医学院附属医院就诊的60例冠心病稳定型心绞痛伴高同型半胱氨酸血症患者作为研究对象.将这60例患者平均分为西医疗法组和中西医结合疗法组.为西医疗法组患者使用常规的西医疗法进行治疗,为中西医结合疗法组患者使用常规的西医疗法和血府逐瘀汤进行治疗.然后,比较两组患者的中医证候积分、血清同型半胱氨酸(Hcy)的水平和心绞痛症状缓解的总有效率.结果:治疗后,与西医疗法组患者相比,中西医结合疗法组患者的中医证候积分和血清Hcy的水平均更低,其心绞痛症状缓解的总有效率更高,P<0.05.结论:用中西医结合疗法治疗冠心病稳定型心绞痛伴高同型半胱氨酸血症的效果显著,可有效地降低其血清Hcy的水平,缓解其心绞痛的症状.

基质金属蛋白酶（MMP）－9又称为明胶酶 B，在病理状态下其表达上调，可降解细胞外基质，使斑块纤维帽厚度变薄，斑块变得不稳定。光学相干断层扫描技术（OCT）可清晰显示患者冠脉内斑块脂质含量及纤维帽厚度，并且分辨率可达到10μm，结果与组织学检查高度一致〔1〕。本研究分析冠心病患者血浆中 MMP－9与斑块纤维帽厚度之间的关系。

目的:探讨动脉粥样硬化中钾通道Kv1.3阻断剂抗hKv1.3 E314抗体对巨噬细胞分化的影响.方法:培养THP-1单核细胞,给予佛波酯100 μg/L诱导72 h使其分化为巨噬细胞.将巨噬细胞洗涤后重新接种在6孔板中,分为A组、B组和C组:A组加入LPS 10 ng/L和IFN-γ 20 μg/L诱导24 h使其分化;B组给予E314抗体(300 nmol/L)在37℃孵育2h后加入LPS 10 ng/L和IFN-γ 20 μg/L诱导24 h使其分化;C组细胞不做任何处理.倒置相差显微镜下观察细胞形态学变化;流式细胞术鉴定巨噬细胞分型;ELLISA检测细胞上清液中IL-10、IL-12表达水平.结果:经流式细胞术鉴定:A组细胞iNOS抗体强阳性,为M1型;B组细胞CD206抗体强阳性,为M2型;C组流式结果为阴性.ELLISA结果显示A组IL-12表达水平高于B组(P＜0.05),A组IL-10表达水平低于B组(P＜0.05).结论:体外诱导巨噬细胞分化,炎性因子促使其向M1型分化,具有促进炎症反应的作用;加入Kv1.3通道阻断剂后,炎性因子同样诱导分化的巨噬细胞会向M2型抗炎方向发展.通过阻断巨噬细胞上的Kv1.3通道可以促进巨噬细胞向着具有抗炎作用的M2型巨噬细胞分化.

目的:探讨血浆可溶性血栓调节蛋白(soluble thrombmodulin,sTM)与支架术后冠状动脉(冠脉)内皮化的相关性,为临床ADP受体拮抗剂的用药时间提供参考.方法:分析2013-06-2014-08济宁医学院附属医院心内科收治的32例冠脉支架植入术后12～18个月无支架内再狭窄的冠心病患者的临床资料,对以上32例患者的34支血管35个支架进行光学相干断层成像(OCT)检查,根据OCT显示的支架小梁内皮化的程度将以上患者分为完全内皮化组和非完全内皮化组,同时选择18例正常成人作为对照组.采用ELISA的方法测定以上各组人群外周血sTM水平,并分析sTM的改变与支架术后冠脉内皮化之间的相关性.结果:非完全内皮化组、完全内皮化组和对照组血浆内sTM的水平分别为(7.98±1.43)μg/L、(5.25±1.62)μg/L和(5.21±1.55)μg/L,非完全内皮化组血浆内sTM的水平明显高于完全内皮化组和对照组(P＜0.05),完全内皮化组血浆sTM因子水平与对照组之间无显著性差异(P＞0.05).血浆sTM水平与支架小梁暴露数目呈正相关(r=0.723,P＜0.05).结论:血浆sTM与冠脉支架植入术后支架小梁暴露数目呈正相关,可为临床ADP受体拮抗剂的使用提供参考.

目的:探讨趋化因子RANTES与冠心病及斑块易损性之间的关系.方法:行冠状动脉(冠脉)造影患者149例,其中急性心肌梗死急诊PCI 49例(AMI组),不稳定心绞痛50例(UAP组),稳定心绞痛50例(SAP组).采用双抗体夹心酶联免疫吸附法(ELISA法)检测血清趋化因子RANTES的浓度,其中20例(UAP组11例,SAP组9例)应用光学相干断层成像(OCT)技术测定斑块纤维帽厚度.结果:①各组血清中趋化因子RANTES浓度差异有统计学意义(均P＜0.01);②应用RANTES判断急性冠脉综合征患者的ROC下面积为(0.951±0.022),大于应用高敏C反应蛋白(hs-CRP)判断的ROC下面积(0.916±0.030)(P＜0.05);③UAP组中趋化因子RANTES的浓度与斑块纤维帽厚度呈负相关(r=-0.821,P＜0.01);④逐步多重线性回归分析显示,趋化因子RANTES是预测斑块易损性的独立危险因素.结论:趋化因子RANTES是一种独立的、能够有效预测冠脉斑块易损性的生物标记物,较hs-CRP具有更高的早期诊断和判断预后的价值.

目的研究急诊经皮冠状动脉介入术(PCI)对不同年龄段急性心肌梗死(AMI)患者生活质量的影响。方法将124例AMI患者按年龄分为青年组(年龄≤44岁)、中年组(年龄45～59岁)和老年组(年龄≥60岁),比较各组的一般资料、冠脉血管病变情况及心肌梗死多维度量表评分。结果青年组的危险因素以高脂血症、阳性家族史、吸烟史及饮酒史为主,冠脉血管病变以单支病变为主,合并高血压病、糖尿病较少,急诊PCI治疗后,患者心肌梗死多维度量表评分显著降低,生活质量明显提高。中年组、老年组多合并高血压病、糖尿病、冠脉血管病变以多支病变为主,急诊PCI治疗仅能开通罪犯血管,患者心肌梗死多维度量表评分降低,生活质量有所改善,但不如青年组改善明显。结论急诊PCI可改善不同年龄段AMI患者的生活质量,以青年组改善最明显。

Aim To investigate whether von Willebrand factor(vWF) can predict endothelialization after coronary stent implantation. Methods Optical coherence tomography(OCT) images were obtained in 32 diseased coronary vessels with 34 stents in 30 patients with coronary artery disease who had no restenosis on follow up angiography at 12~18 months post drug-eluting stent(DES).Patients with complete endothelialization of the struts were considered as complete endothelialization group,patients with incomplete endothelialization of the DES struts were considered as incomplete endothelialization group,patients with angiographily diagonased nomal coronary were selected as the control group.For all the patients blood was drawed from elbow venous after operation,then plasma vWF levels of the three groups were tested. Results The plasma vWF levels of incomplete endothelialization group were significantly higher than the complete endothelialization group and the control group(29.13±8.47 μg/L vs 13.81±1.04 μg/L and 12.83±1.13 μg/L,P<0.05),the plasma vWF levels had no significant difference in the complete endothelialization group and the control group(P>0.05). Conclusions Our study confirms that the plasma vWF level has certain reference value in predicting endothelialization after coronary stent implantation.To some extent,the plasma vWF level can guide how long the antiplatelet therapy should be continued for the patients with coronary artery disease who had DES implanted.

目的 探讨非ST段抬高型心肌梗死(NSTEMI)合并高血压、糖尿病经皮冠状动脉腔内介入(PCI)治疗时机.方法 选择95例行PCI治疗的NSTEMI患者,合并高血压53例,其中早期行PCI治疗28例,择期行PCI治疗25例；合并糖尿病42例,其中早期行PCI治疗22例,择期行PCI治疗20例.比较早期与择期PCI治疗患者住院期间主要不良心脏事件及随访6个月反复心绞痛症状、再发心肌梗死、冠脉血运重建、心衰等情况.结果 合并高血压的NSTEMI患者早期行PCI近期预后及随访6个月的预后好于择期行PCI治疗；合并糖尿病的NSTEMI患者早期行PCI治疗近期预后较择期PCI治疗预后差.结论 对于合并高血压病的NSTEMI患者应早期积极行PCI治疗,合并糖尿病的NSTEMI患者择期PCI治疗更安全可靠.

Objective:To analysis the relationship between pregnancy associated plasma protein-A(PAPP-A) and vulnerable plaque in coronary artery disease.Method:There were 20 cases in ACS group and 19 in SAP group.The levels of PAPP-A were determined by enzyme linked immunosoebent assay(ELISA),and OCT was used to measure the fibrous cap thickness of coronary artery atherosclerotic plaques.Result:The levels of PAPP-A in ACS group were significantly higher than those in SAP group([48.71±18.90]ng/L∶[18.93±11.11]ng/L,P0.01).Fibrous cap thickness of plaques in ACS group were thinker than those in SAP group([45.44±18.25]μm∶[90.74±24.54]μm,P0.01). The levels of PAPP-A(r=-0.778,P0.01) were correlated negatively with fibrous cap thickness in ACS patients.Gradually(Stepwise) multiple linear regression analysis identified that PAPP-A predicted vulnerability as an independent risk factor.Conclusion:PAPP-A,as an independent and effective marker,can predict the risk of coronary disease and vulnerable plaque.