查阅近年来采用香砂六君子汤治疗消化系统疾病的相关文献,从慢性胃炎、消化性溃疡、功能性消化不良、胃肠功能障碍、腹泻、糖尿病胃轻瘫、胃食管反流病、肝硬化、化疗后消化道反应9个方面进行总结和归纳,认为香砂六君子汤可广泛应用于脾胃气虚、痰阻气滞证之消化系统疾病的治疗,但应统一制定临床应用标准.

目的:观察中药泡足对糖尿病足溃疡的疗效。方法:对67例糖尿病足溃疡患者在换药的基础上,进行辨证用药泡足和辨证施护。结果:有效率94%,截肢率1.5%。结论:中药泡足提高了有效率,降低了截肢率,减轻了患者的经济负担。

Aim To discuss the effective methods on diabetes pyogenic infection of skin.Methods 96 diabetes pyogenic infection of skin sufferers who have come to our department to change dressings were randomly divided into two groups,on the basis of the TCM drugs wash and gradual debridements.The treatment group made use of diabetic sores No.1 and diabetic sores No.2,meanwhile the control group used the sterile dauze soaked in gentamycin,anisodamine,Normal insulin and nomal saline for topical application.Results The efficiency of the treatment group is 98% while the efficiency of the conrtol group is 87%.Compared with the control group,time that the treatment group spent was obviously shorter.Conclusion The traditional Chinese medicine dressings have better effects on the treatment of wounds of the diabetes pyogenic infection of skin.

Objective: To observe the clinical effects,toxicity or side reactions of Furong Ointment in treating deep abscess by external application.Methods: One hundred and ninety-one cases of deep abscess were randomized into study group(116 cases) and control group(75 cases).The study group was treated with Furong Ointment in the infected places externally and evenly,being replaced once daily.A treatment course was one week.The control group was treated with Jinhuang Powder in the infected places externally and evenly.The application and treatment course were the same as those of the study group.One week later,the pain relief,the fever retrogression,the hemogram recovery and local mass dissipation were observed.The overall therapeutic effects and the therapeutic effects of single disease in both groups were evaluated separately,and the local and systemic toxicity or side reactions in both groups were observed also.Results: There were no significant difference in the rates of fever retrogression and hemogram recovery between the two groups;but there were significant difference in the rates of pain relief and local mass dissipation between the two groups(P0.01),the total effective rate of the study group being statistically higher than that of the control group(P0.05).The total effective rates of periappendiceal abscess,deep muscle abscess and abdominal residual abscess after operation in the study group were not statistically different from those in the control group.The local and systemic toxicity or side reactions were low in both groups and the differences between the two groups were not significant(P0.05).Conclusion: Furong Ointment has a fine clinical effect in treating deep abscess by the external application with no obvious local and systemic toxicity or side reactions.

Objective: To observe the clinical effect and toxicity of Furong ointment in treating superficial soft-tissue infection by external application.Methods: Three hundreds and forty cases of superficial soft tissue infection were randomly divided into study group(220 cases) and control group(120 cases).The study group and control group were treated with Furong ointment and Jinhuang powder in the infected places externally and evenly,respectively,dressing changing daily and treatment course being one week.At the end of treatment course,the local mass dissipation,the inflamed retrogression,the opening sore healing and the fever retrogression were recorded.The overall effect and the single disease effect of the two groups were evaluated separately,and the local and systemic toxicity of the two groups were observed separately.Results:The opening sore healing and the fever retrogression of the two groups had not significant difference,but local mass dissipation and the inflamed retrogression of the two groups had a better clinical curative effect,and the difference was significant(P0.01).The total effective rate of the study group was better than that of the control group and the difference was significant(P0.01).The total effective rates of furuncle and gangrene had no significant difference between two groups.But the total effective rates of carbuncle and erysipelas of the study group were significantly higher than those of the control group(P0.05,P0.01).The local toxic-side reactions of two groups were low and the difference was not significant(P0.05).There were no significant systemic toxic-side reactions in the two groups(P0.05).Conclusion: Furong ointment has a fine clinical effect in treating the superficial soft-tissue infection by the external application without obvious local and systemic toxicity.

Objective: To investigate the relationship between the syndrome type of traditional Chinese medicine(TCM) and clinical stage and the expression of estrogen receptor(ER),progesterone receptor(PR) and C-erbB-2 oncoprotein in breast cancer.Methods: Ninety-five cases of breast cancer with conformed pathological test and intact data were selected,and differentiated into 3 syndrome types,namely,the stagnation of the liver-qi and phlegm stasis,the disturbance of Chong and Ren channels and the weakened body resistance and the heating of pathogens.The expression of ER,PR and C-erbB-2 were analysed using immunohistochemistry method.Results: Of 95 cases,71 belonged to the syndrome of the stagnation of the liver-qi and phlegm stasis,occupying 74.74%;9 to the syndrome of the disturbance of Chong and Ren channels,occupying 9.47%;15 to the syndrome of the weakened body resistance and the heating of pathogens,occupying 15.79%.The patients in stage Ⅰ and stage Ⅱ mostly belonged to the syndrome of the stagnation of the liver-qi and phlegm stasis.The proportion of the weakened body resistance and the heating of pathogens in stage Ⅲ and stage Ⅳ was higher than that of the stagnation of the liver-qi and phlegm stasis and the disturbance of Chong and Ren channels.There was no significant difference in the positive rate of ER between the stagnation of the liver-qi and phlegm stasis and the disturbance of Chong and Ren channels(P=0.074);but the positive rate of ER in the stagnation of the liver-qi and phlegm stasis was significantly different from that in the disturbance of Chong and Ren channels(P=0.022).There was no significant difference in the positive rate of PR and C-erbB-2 expression among 3 types.Conclusion: Breast cancer in early stage mostly belongs to the syndrome of the stagnation of the liver-qi and phlegm stasis,and in late stage to the weakened body resistance and the heating of pathogens.The expression of ER in the syndrome of the stagnation of the liver-qi and phlegm stasis was higher than that in the syndrome of the disturbance of Chong and Ren channels.And there was no marked relation between the expression of PR and C-erbB-2 and TCM syndrome type.

目的:观察中西医结合治疗急性胆道感染的临床疗效。方法:将68例患者随机分成2组,对照组33例采用抗生素为主治疗,治疗组35例应用疏肝利胆,通里攻下中药联合抗生素治疗。7d为1个疗程。结果:治疗组在缓解症状体征方面优于对照组（P＜0.01或0.05）;2组在抗生素应用时间、住院时间、肝脏功能恢复时间的比较差异均有显著性（P均＜0.05）,治疗组优于对照组;2组治疗有效率比较差异无显著性（P＞0.05）。结论:中西医结合治疗急性胆道感染可迅速缓解症状、体征,减少抗生素应用,加速肝脏功能的恢复,缩短住院时间。中药在治疗急性胆道感染中有较好的作用。

目的:了解中医药治疗乳腺增生病的实验研究概况。方法:从建立动物模型、药效研究和机理研究3个方面对中医药治疗乳腺增生病的近年文献进行综述。结论:中医药治疗乳腺增生病的作用机理是调节神经网,从而达到治疗目的。

目的探讨脾切除治疗小儿肝豆状核变性合并脾功能亢进的有效性及安全性。方法回顾分析30例小儿肝豆状核变性合并脾功能亢进而行脾切除的临床资料,对手术前后血细胞和免疫球蛋白的变化进行比较。结果全部患者术后白细胞及血小板恢复至正常,手术前后免疫球蛋白比较差异无统计学意义。结论脾切除是小儿肝豆状核变性合并脾功能亢进的主要治疗措施,它能保证患儿继续驱铜治疗。只要充分地进行围手术期处理,脾切除是有效的、可行的、安全的。

目的:针对腹部手术后胃瘫发生的原因,探讨中医治疗胃瘫的新方法。方法:42例患者随机分成2组,治疗组22例经置入输出襻空肠或十二指肠内的胃管或营养管应用中药和营养液治疗,对照组20例单用西药治疗,观察胃肠动力恢复的时间,检测治疗前及治疗后1周营养状况指标,并对其效果进行分析。结果:42例均治愈,治愈时间14~30d。无再次手术。但2组胃动力恢复时间、营养状况指标的比较有显著性差异（P＜0.05）。治疗组优于对照组。结论:中药治疗胃瘫疗效确切,胃瘫治疗可以采用非手术治疗。

目的 观察中西医结合治疗重症急性胰腺炎(SAP)的疗效.方法 SAP患者41例随机分为中药组与对照组,均予西医治疗,中药组加服中药;对两组排气(便)情况、中转手术、治疗后并发症、住院时间、死亡数进行分析.结果 中药组的各种并发症(大出血、胰腺假性囊肿、消化道瘘、胰腺脓肿)发生率低于对照组,两组经治疗后在排气(便)时间、中转手术例数、住院时间等方面差异显著.结论 中西医结合治疗SAP效果良好.

目的:探讨中药消核冲剂对乳腺小叶增生大鼠乳腺组织及性激素等的影响。方法:采用苯甲酸雌二醇联合黄体酮肌注30d造模,分空白对照组、病理模型组、消核冲剂组和三苯氧胺组,治疗30d,结束后测定各组大鼠乳头直径变化,血清雌激素、孕激素、雌激素/孕激素及催乳素、一氧化氮等指标,并观察大鼠第2、第3对乳房组织病理切片变化,采用免疫组化SP法观测第2、第3对乳腺中ER、PR表达情况。结果:经中药消核冲剂治疗后大鼠乳头直径、乳腺缩小(P<0.01);血清雌激素水平显著降低(P<0.05);能降低大鼠血清孕激素(P<0.05),催乳素含量明显降低(P<0.01);光镜下乳腺小叶数目、小叶腺泡数明显减少,腔内分泌物减少。结论:消核冲剂对雌激素引起大鼠乳腺增生病有较好的疗效。

Objective: To observe the effects of traditional Chinese prescription for invigorating the spleen and purging the gastrointestinal tracts on the cellular immune function and intestinal mucosal barrier function in early postoperative patients with gastric cancer.Method: Sixty gastric cancer patients with operation indication were randomized into the observation group and the control group.Thirty patients were dripped with traditional Chinese prescription for invigorating the spleen and purging the gastroinstestinal tracts via the silicon catheters intubated into small intestine on the first postoperative day for 7 days,while the other 30 patients of the control group were dripped with 9.0 g/L normal saline on the first postoperative day,and the course of treatment was the same as that of the observation group.The observation parameters included cellular immune function,such as serum interleukin-2(IL-2),soluble interleukin-2 receptor(sIL-2R) and interleukin-12(IL-12) and intestinal mucosal permeability,such as lactulose and mannitol excretion ratio in urine as well as serum endotoxin before and after surgery.Result: The IL-2 level of the observation group increased significantly,while the level of sIL-2R decreased obviously as compared with that of the control group seven days after operation(P0.05).The levels of IL-2,sIL-2R and IL-12 of the observation group were obviously improved seven days after operation as compared with those one day before operation.While the above-mentioned indexes of the control group showed no significant difference between seven days postoperative and one day preoperative(P0.05).The excretion ratio of urine L/M of the observation group five days after operation was significantly lower than that of the control group(P0.01).But there was no significant difference in the observation group between five days postoperative and one day preoperative(P0.05).While the urine L/M excretion ratio obviously increased five days after operation as compared with that one day before operation.The ET level of the observation group three days after operation significantly decreased as compared with that of the control group(P0.01).The ET level of the observation group did not increased obviously three days after operation as compared with that one day before operation,while there was significant difference in the serum ET level of the control group between three days postoperative and one day preoperative.Conclusion: The early application of traditional Chinese prescription for invigorating the spleen and purging the gastrointestinal tracts in treating postoperative patients with gastric cancer can improve the cellular immune function and help the improvement of intestinal mucosal permeability and protect gut barrier function.

OBJECTIVE:To explore the regulation and clinical significance of intestinal dripping of Jianpi Tongli (JPTL) Chinese herbs on levels of serum cytokines, such as interleukin-2 (IL-2), soluble interleukin-2 receptor (sIL-2R) and interleukin-12 (IL-12) in treating patients with gastric cancer (GC) at early post-operational stage. METHODS:Sixty patients with GC were randomly divided into two groups, i. e. the studied group (n = 30), treated with JPTL Chinese herbs, and the control group (n = 30) treated with normal saline. The medication was started from the 1st day after operation by intestinal dripping daily, 7 days as one course. Levels of IL-2, sIL-2R and IL-12 were observed before and after operation. RESULTS:Significant difference was seen on the 7th day post-operation between the studied and the control group, mainly in aspects of obvious increase of IL-2 and decrease of sIL-2R (P <0.05), no significant difference in IL-12 was found (P >0.05) though there was certain improvement. Compared with pre-operation of the same group, significant difference was found in the studied group in the increased IL-2 and IL-12 and decreased sIL-2R on the 7th day post-operation, while no significant difference in these indexes was found in the control group (P >0.05), though certain improvement was shown. CONCLUSION:Early intestinal dripping of JPTL Chinese herbs to post-operational patients with GC could improve their immune function, which was of important significance in early preventing the severe complications, improving the prognosis, and elevating the survival rate.

目的:观察食管癌术后早期肠内营养对免疫功能的影响.方法:30例食管癌患者随机分为治疗组(早期肠内营养组)和对照组(普通输液组)各15例,术后24小时治疗组应用赫力广行肠内营养支持8天,对照组常规输液治疗.术前和术后第一天、第九天测定IgA、IgG、IgM及T淋巴细胞亚群,观察肠功能恢复时间及不良反应.结果:术后第九天治疗组免疫指标较对照组迅速恢复,两组比较差异有显著性(P<0.05).结论:食管癌患者术后早期肠内营养支持可以恢复和改善机体的免疫功能.

目的 :观察益气通腑法治疗食管贲门癌术后气虚气滞证的临床疗效。方法 :以益气通腑方治疗 4 7例食管贲门癌术后气虚气滞证患者 ,与 4 0例术后常规处理的对照组比较。结果 :治疗组证候疗效愈显率、总有效率分别为 6 3.83%和 95 .74 % ,对照组愈显率、总有效率分别为 30 .0 0 %和70 .0 0 % ,两组比较 ,差异有显著性 （P ＜0 .0 1 ）。两组 1周后证候积分均有减低 ,治疗组与对照组比较 ,差异有显著性 （P ＜0 .0 1 ）。治疗组术后排气时间、留置胃管时间与对照组比较 ,差异有显著性 （P ＜0 .0 1 ）。术后并发症发生率治疗组为 8.5 1 % （4 /4 7） ,对照组为 30 .0 0 % （1 2 /4 0 ） ,二者相比 ,差异有显著性 （P ＜0 .0 1 ）。结论 :益气通腑法能改善食管贲门癌术后气虚气滞证的症状和促进术后恢复。

乳腺增生病(hyptroplasia of mammarygland,HmG)是非肿瘤性、非炎症性的乳腺上皮增生性疾患.又称为乳腺结构不良(mammary.dysplasia).属于中医"乳癖"范畴.其发病率占乳房疾病的75%,约占育龄妇女的40%.发病年龄集中于20～50岁,45～50岁达到高峰,50岁以后发病率急骤下降.一般认为与女性内分泌失调有关.由于性腺器官卵巢的功能发生紊乱,体内黄体素分泌减少,而雄激素相对增多,使乳腺导管及乳腺小叶上皮发生随月经来潮而出现的增生和复旧不全.国内外专家认为,此病癌变率占10%～20%,发生乳癌的危险比健康妇女高1.4～2.5倍.因此防治本病有着重要的临床意义和广阔的应用前景.近年来,中医药治疗乳腺增生有了较大发展,治疗方法多样,取得较好疗效.现就乳腺增生病的中医治疗情况综述如下.

目的 :观察脾亢脾切除术后虚热证辨证治疗的疗效。方法 :以益气养阴补血中药治疗 35例脾亢脾切除术后虚热证患者为试验组 ,与 4 1例术后常规处理的对照组比较 ;观察治疗前及治疗 1周后证候积分值变化、术后体温恢复正常时间、术后留院时间。结果 :试验组治疗后证候积分下降值为 （8.2 3± 7.5 8） ,对照组为 （14 .5 6± 8.2 7） ,2组比较有非常显著差异 （P ＜0 .0 0 1） ;试验组治愈率为 2 5 .7% ,显效率为 6 5 .7% ,对照组分别为 4 .9%、2 6 .3% ,2组比较均有显著性差异 （P ＜0 .0 5或 0 .0 1） ;试验组术后体温恢复正常时间、术后留院时间分别为 （7.71± 3.0 6 ）d和 （11.2 0± 2 .2 2 ）d,对照组分别为 （10 .85± 3.15 ）d和 （13.39± 2 .39）d ,2组间比较均有显著性差异 （P ＜0 .0 0 1）。结论 :益气养阴补血中药对脾亢脾切除术后虚热证的治疗有较好疗效。

目的 探讨肝豆状核变性 （肝豆 ）合并脾功能亢进 （脾亢 ）患者行脾切除的手术指证及可行性。方法 总结分析 1991年 1月至 2 0 0 1年 1月 12 4例肝豆合并脾亢患者脾切除病例 ,比较术前与术后 2周外周血细胞变化。结果 术后全血细胞明显升高 （P ＜0 0 5～ 0 0 0 1）。结论 肝豆合并脾亢行脾切除治疗适应证明确 ,术后疗效满意。持续驱铜和加强围手术期保肝治疗是手术成功的重要保证

Objective To evaluate the effect of Chinese medicinal herbs on digestive function, nutritional status, immune function and complication rate in patients after total gastrectomy. Methods : Thirty-nine patients performed total gastrectomy were divided into two groups and had their small intestine intubated for administering medicine postoperatively. Twenty-one of them belonged to the treated group and had Chinese medicinal herbs dripped into their small intestine intraluminally during the early postoperative stage, while the 18 cases in the control group were dripped with 0.9% sodium chloride. Results : The digestive function of the treated group recovered rapidly, and the nutritional status and immune function improved markedly as compared with those of the control group (P<0.01-0.05). Conclusion : Early application of Chinese medicinal herbs after total gastrectomy could promote the digestive function to recover to normal, and improve the nutritional status and immune function. And occurrence of complication was reduced.