Aim:To understand the mental health status of editors of Henan academic journals and to analyze the in-fluencing factors so as to provide a reference for carrying out targeted preventive measures.Methods: On-the-job editing staffs of 75 academic journals in Henan Province were enumerated by cluster sampling and SCL-90 scale was used for ques-tionnaire survey. Descriptive analysis,independent sample t test,one-way ANOVA, multiple linear regression analysis of the questionnaire results were used for analysis.Results: The SCL-90 scores for editors of Henan academic journals were (145.05 ± 48.62),higher than the national norm(P<0.001). There was a significant difference in SCL-90 scores be-tween different gender,editors with different job title,times of physical exercises per week,and different sleeping time per day(P<0.05). Multiple linear regression analysis showed that business group(β= -7.831,P=0.017), the times of physical exercises per week(β= -14.419,P=0.001) and daily sleeping time(β= -16.136,P=0.011) were the main impacts of editors′mental health. Conclusion:There are some mental health problems in editors of academic journals in Henan Province. The leaders of academic journals should pay close attention to the mental health education of editors. Edi-tors themselves should adjusting their moods timely.

[目的]探讨河南省学术期刊编辑人员的工作能力现状及其影响因素.[方法]采用工作能力指数量表对河南省80种学术期刊的277名编辑人员进行抽样调查,采用描述性分析、独立样本t检验、单因素方差分析和多重线性回归分析对问卷结果进行统计描述.[结果]河南省学术期刊编辑人员的工作能力总分为38.22±5.19,处于较好水平,但是工作能力为极好水平的编辑人员仅为49人,不足本次调查人员的五分之一;不同性别、年龄、学历、月收入、平均每年外出培训次数、平均每周锻炼身体次数及每天睡眠时间的学术期刊编辑人员工作能力的差异具有统计学意义(P＜0.05);性别(β=2.362,P＜0.001)、年龄(β=-1.285,P＜0.001)、每周锻炼身体次数(β=0.776,P=0.002)、每天睡眠时间(β=2.627,P＜0.001)是编辑人员工作能力的主要影响因素.[结论]河南省学术期刊编辑人员的工作能力整体处于较好水平,但是还有进一步提升的空间.每周锻炼身体3次以上和每天睡眠时间保持8～10 h的编辑人员能够保持较好的工作能力.

按需印刷出版是近年来随着数字出版的发展而出现的新的印刷出版模式,它具有即时印刷、绿色环保、节省仓储成本、永不绝版等优点,符合编辑出版业可持续发展的要求.高校学报是高等学校编辑出版的重要学术期刊,在目前的情况下,一方面不断发展并被广泛应用的数字化印刷技术为其开展按需印刷出版提供了可能;另一方面高校学报的发行现状、自身属性和特点也符合按需印刷出版的要求.因此,从不断完备的数字化出版环境出发,按需印刷出版将是高校学报未来的发展方向.

高校学报是科研人员发表科研成果的重要阵地之一,也是开展国内外学术交流的重要平台.大数据时代的到来使得高校学报的发展形势十分严峻,也对高校学报编辑的职业素养提出了新的挑战.本文通过分析大数据时代高校学报对编辑的要求,提出了高校学报编辑应培养的职业素养以及培养职业素养的方法,试图从高校学报编辑的职业素养修炼上寻找高校学报应对大数据时代的突破口,也为高校学报编辑的成长提供方向.

目的:探讨重症手足口病(HFMD)的主要危险因素,为其早期识别、及时治疗提供参考依据.方法:应用Meta分析对1990-2014年国内外关于重症HFMD患者危险因素的病例-对照研究进行综合分析,经异质性检验,分别采用固定效应模型和随机效应模型进行相对危险度(OR)值合并,计算其95％可信区间(95％CI),并进行敏感性分析及发表偏倚评估.结果:共纳入文献19篇,病例(重症HFMD患者)2 868例,对照(轻症HFMD患者)6 676例.异质性检验,重症HFMD危险因素对应文献异质性检验I2值分别为,年龄≤3岁70％、居住地为农村0％、发病至入院时间≥3 d23％、肠道病毒71型(EV71)感染75％、发热≥38.5℃0％、持续发热时间≥3 d 14％、精神萎靡0％、高血糖(≥6.11 mmol·L-1)51％,各危险因素合并OR及其95％CI分别为2.90 (2.14～3.94)、2.21 (1.66～2.93)、2.02 (1.46～2.79)、2.90 (1.24～6.81)、3.13 (1.99～4.94)、5.48 (3.56～8.45)、4.25 (2.45～7.37)和2.87 (1.49～5.52).敏感性分析,固定效应模型和随机效应模型计算结果一致.发表偏倚评估,无明显发表偏倚.结论:农村低龄婴幼儿、就医延迟、EV71感染、持续高热、精神萎靡和血糖水平升高可能是重症HFMD患者发病的主要危险因素.

大数据不仅仅指海量的数据资源,更强调的是这些数据之间的相互关系,能够掌握和运用好这些内在的联系是大数据时代对出版人提出的新挑战.大数据背景下的新型出版需要一个变革、发展的过程,是挑战也是机遇,大学出版社应该一方面坚持自身的宗旨,出精品力作,提升核心竞争力;另一方面,加强学习新技术,培养创新思维型人才,为新型出版奠定坚实的基础.

Aim: To identify the risk factors associated with cardiopulmonary failure( CPF) in infants with severe hand-foot-mouth disease(HFMD), and develop a reliable prediction system for it. Methods: Logistic regression was used to examine the relationship between risk factors and CPF. The predictive effect of the model was evaluated. Results: In the multivariable analysis, 4 variables [age≤24 months(OR = 2. 619, 95% CI = 1. 609 - 4. 262), days of fever > 3 d(OR =4. 167, 95% CI = 2. 591 - 6. 703, hyperglycaemia( OR = 8. 235, 95% CI = 4. 356 - 15. 571) and leucocytosis( OR =2. 661, 95% CI = 1. 695 - 4. 178)] in the risk evaluation model remained independent predictors of CPF. When the pre-diction was performed based on the existing data using the present model, the sensitivity, specificity and consistency of the model were 67. 4% (31 / 46), 85. 7% (78 / 91) and 79. 5% (109 / 137), respectively. Conclusion: The forecasting model was a quantitative and effective tool for predicting CPF in infants with severe HFMD.

综合性高校学报正面临严峻的发展瓶颈，迫于体制等原因，改革不能一概由“全”向“专”转型突破。在互联网时代，特色办刊、优先数字出版、多媒体融合、新媒体技术等成为综合性学报突破瓶颈寻求发展的路径。

目的：探讨舒肝解郁胶囊治疗肝硬化并轻、中度抑郁症的临床疗效及安全性。方法2012‐01—2013‐12我院收治的肝硬化并轻、中度抑郁症患者89例，随机分为治疗组42例，对照组47例，治疗组在常规治疗基础上给予舒肝解郁胶囊治疗。治疗前、治疗后1、2、4、6周采用汉密尔顿抑郁量表（HAMD）、Child‐Pugh评分评定治疗效果并观察其不良反应。结果2组患者HAMD评分随治疗时间变化，治疗组 HAMD评分下降幅度高于对照组（F组间＝17.447，P＝0.000；F交互＝17.447，P＝0.000；F组间＝4.684，P＝0.03）；2组患者治疗后Child‐Pugh评分差异无统计学意义（t＝1.873；P＝0.067）。结论舒肝解郁胶囊可有效改善肝硬化并轻、中度抑郁症患者的抑郁症状，不良反应较少。

确定课程目标，从临床护理需要探讨人体解剖内容、确定授课重点、编写体现护理特色与目标的教材，以体现护理特色；提出基础和临床相结合突出专业应用、科学和人文相结合突出素质教育、知识学习和能力培养相结合突出能力培养的教学方法。

Aim: To analyze the epidemic characteristics of influenza in Henan Province from 2010 to 2013 . Methods: Descriptive epidemiological method was used to analyze the surveillance data of influenza in Henan Prov-ince from 2010 to 2013.Geographic distribution of influenza was analyzed by the public health geographic information system, and seasonal characteristics of influenza were analyzed using circular distribution.Results: A total of 34 721 cases of influenza were reported in all from 2010 to 2013 in Henan Province.The average annual incidence rate was 9.213 7 per 100 000.Four patients died, and the mortality rate was 0.12‰.The incidence rate of influenza rose year by year.Most cases were mainly distributed in eastern and southern areas of Henan Province .The epidemic perk periods were from September to next April.The incidence rate for males(9.820 4 per 100 000) was significantly higher than that for females(6.572 9 per 100 000)(χ2 =1 342.417,P<0.001).Children under 10 years old and the elderly were the high risk groups.Three outbreaks were reported.Conclusion:Influenza is mainly sporadic in Henan Province, disease surveillance should be strengthened in school, and the vaccination should be strengthened in high-risk groups.

Objective To investigate the situation of drug resistance and the risk factors of infections caused by extended-spectrum beta-lactamase(ESBLs)-producing enterobacteriaceae. Methods Multivariable logistic regression analysis was performed on the risk factors of ESBLs production and drug resistance of Escherchia coli and Klebsiella pneumoniae isolated from patients during2009 to 2013. Results From January 2009 to December 2013, the isolations of Escherchia coli and the ESBLs-producing strains were respective 2307, 1015(43.99%), and the isolation of Klebsiella pneumoniae was 2510, 333(13.26%). The drug resistance rates of the ESBLs- producing Escherchia coli and Klebsiella pneumonia to all the tested antibiotics except carbapenems and complex preparations containing enzymes inhibitors. In the multivariate logistic regression analysis, 4 variables [age≥60 years old(OR= 2.673, 95% CI: 1.548-4.615, days of hospitalization ≥2 weeks(OR= 2.559, 95% CI: 1.296-5.054), invasive treatment(OR=3.022, 95%CI: 1.993-4.583), application of antimicrobial(OR=2.739, 95%CI: 1.584-4.738) ] were identified for independent factors. Conclusion The ESBLs-producing strains were still at high level. The prevention and control measures against ESBLsproducing enterobacteriaceae should be made reasonably apply antimicrobial, emphasize bacteris-free operation technology, and control the days of hospitalization.

Aim: To examine the potential effects of meteorological factors on the hand-foot-mouth disease ( HFMD) epidemic, so as to explore the method to prevent and control HFMD .Methods:The daily incidence and weather surveil-lance data were provided by Erqi Center for Disease Control and Prevention and Zhengzhou Meteorological Administration respectively.The correlation between the meteorological parameters and the weekly number of HFMD in Erqi District were analyzed with Spearman′s rank correlation tests with and without time-lag.Time series modeling was carried out using mult-ivariate SARIMA models when there was significant predictor meteorological variable .Results:HFMD was prevalent from March to July and peaks in April and May .Spearman′s rank correlation test indicated that average atmospheric temperature at lag 2 weeks (rS =0.248, P<0.05), maximum atmospheric temperature at lag 2 weeks (rS =0.170, P<0.05) and minimum atmospheric temperature at lag 2 weeks ( rS =-0.223, P<0.05) were correlated with the weekly number of HFMD.Average atmospheric temperature at lag 2 weeks was identified as a significant predictor for the weekly number of HFMD.SARIMA(1,1,0) (0,1,0) 52 associated with average atmospheric temperature at lag 2 weeks were developed and validated for description and predication of the weekly number of HFMD .The goodness of fit [ stationary square R( R2 )=0.797] and the predictive power [root mean square error(RMSE)=11.573] of the model were enhanced by the inclusion of climatic variable to forecast the number of HFMD in the year 2014 compared with the univariate model ( R2 =0.833, RMSE=10.611).Conclusion:Temperatures affect the occurrence of HFMD , and might be used as meteorological pre-dictors for the epidemic of HFMD in this region .

pathological changes of corneal tissue lesions after different periods of fungal keratitis .Methods:Forty C57BL/6 mice mod-els were inoculated with a culture stick simulated clinical corneal scratches which caused fungal infections .On the 1st,3rd, 5th,7th and 14th day, infectious corneas were observed and given clinical scoring by slit-lamp biomicroscope,and then the mice were killed to make corneal stretched preparation .After immunofluorescence staining , the corneal tissue were ob-served with laser scanning confocal microscope .Results:The clinical scoring increased sharply on the 1st,3rd and 5th day after inoculation and peaked on the 5th day, then decreased on the 7th and 14th days.On the 1st day,the eye limbal tissue had neutrophil infiltration ,corneal limbal vascular dilatation and congestion and other significant acute inflammatory chan -ges.On the 3rd day,there were limbal corneal neovascularization buds , and neutrophil infiltration to gather corneal ulcer le-sions.On the 5th day neutrophil infiltration further aggravated and invasive corneal stroma radial growth of new blood ves -sels could be seen .On the 7th day neutrophil infiltration was still severe , neovascularization obvious grew to the central&nbsp;cornea ulcer lesions,and luminal enlargement could be found on the 14th day neutropenia decreased significantly , and neo-vascularization atrophy reduced .Conclusion:An animal model of aspergillus keratitis has been successfully established . The key time window is the 5th day during the inflammation process of fungal keratitis .

中国知网研制的“学术不端文献检测系统”(AMLC)在编辑初审稿件时其检测结果会出现文字复制比为0和＞40％这2种特殊情况.文章分析导致这2种检测结果的原因是:AMLC检测不出来的论文文字隐性重复以及论文文字复制比＞40％的论文中的格式性语言的重复、实验方法或操作步骤的重复,疾病的病理生理机制、治疗方案、结果判定(或疗效)标准的重复,以及统计学处理描述的重复,并给出比较具体的解决方案.建议编辑人员在处理上述情况时不完全依赖检测结果,要根据不同情况区别对待,利用专业知识区分有无抄袭以及抄袭与不当引用,正确使用AMLC提供的结果.

引文分析是利用数学及统计学方法以及比较、归纳和抽象等逻辑方法对科学期刊、论文、著者等各种分析对象的引证与被引证进行分析，以揭示其数量特征和内在规律的一种文献计量学分析方法。

To explore the association of rs 2293152 polymorphism of single transducer and activator of transcrip-tion-3 (STAT3) gene with the susceptibility of obesity in Henan Han population .Methods:The single nucleotide polymor-phisms of STAT3 gene rs2293152 in 379 obese and 391 controls were detected by restriction fragment length polymorphism . The relation between STAT3 polymorphism and obesity was estimated by logistic regression model .Gene-environment inter-action was evaluated by non-parametric multifactor dimensionality reduction ( MDR ) model.Results: The genotype (CG+CC) and GG frequency of rs2293152 between case and control group had statistical difference (χ2 =4.712, P=0.029).Further analysis revealed that genotype (CG+CC) of STAT3 gene rs2293152 polymorphism increased the risk of obesity after adjusting age, gender etc (adjusted OR=1.391;95%CI:1.009-1.919).Gene-environment interaction a-nalysis presented a best model consisted of two factors (rs2293152 and smoking) (P<0.05).Conclusion:STAT3 gene rs2293152 polymorphism is associated with the risk of obesity , and there may be significant interaction between rs2293152 polymorphisms and smoking .

针对护理专业的特点,在人体解剖学实验课教学过程中不但要加强对人体正常结构的感性认识,切实联系临床,而且也要注重对理性认识的提升,紧扣护理专业的培养目标,精选教材内容,充实教学手段和方法。该文从突出临床护理应用特色为切入点,注重培养学生临床思维能力和操作能力,培养学生的哲学理性思维能力等方面探讨如何提高护理专业人体解剖实验教学质量。

<正>参考文献是作者在撰写文章时引用的有关资料,包括专著、报刊、学位论文等,它标识了文章中引用资料的来源,是作者对他人研究成果的引用和借鉴,在文章中具有非常重要的作用,是

鉴于参考文献不容忽视的重要作用,其著录准确性已受到编辑出版界的广泛重视[1-4],某些期刊编辑部已采取适当的核查措施来提高参考文献著录的准确性[5-6],并取得了一定的效果[7-8],但不少医学期刊的文后参考文献仍存在许多明显的不规范著录情况.