Background: An unprecedented coronavirus disease 2019 (COVID-19) wave occurred in China between December 2022 and January 2023, challenging the efficacy of the primary series of COVID-19 vaccines. The attitudes toward future COVID-19 booster vaccines (CBV) after the massive breakthrough infection among healthcare workers remain unknown. This study aimed to explore the prevalence and determinants of future CBV refusal after the unprecedented COVID-19 wave among healthcare workers. Methods: Between 9 and 19 February 2023, a cross-sectional nationwide online survey was conducted using a self-administered questionnaire vaccine among healthcare workers in China. Sociodemographics, profession, presence of chronic medical conditions, previous COVID-19 infection, attitudes towards future CBV, and reasons for future CBV refusal were collected. We estimated odds ratio [OR] with 95% confidence interval [CI] using a multivariable logistic regression model to explore the factors associated with future CBV refusal. Results: Among the 1618 participants who completed the survey, 1511 respondents with two or more doses of COVID-19 vaccines were analyzed. A total of 648 (41.8%) of respondents were unwilling to receive a future CBV. Multivariable logistic regression analysis revealed the association of CBV refusal with profession (vs. other staff, physician-adjusted OR 1.17, 95%CI 0.79–1.72, nurse-adjusted OR 1.88, 95%CI 1.24−2.85, p = 0.008), history of allergy (adjusted OR 1.72, 95%CI 1.05–2.83, p = 0.032), a lower self-perceived risk of future COVID-19 infection (p < 0.001), and a lower belief in CBV effectiveness (p = 0.014), safety (p < 0.001), and necessities for healthcare workers and the public (p < 0.001, respectively). Conclusions: Our findings highlight that a considerable proportion of healthcare workers were against a future booster dose after an unprecedented COVID-19 wave. Self-perception of future COVID-19 risk, and potential harm or doubtful efficacy of vaccines are the main determinants. Our findings may help public health authorities to establish future COVID-19 vaccination programs.

Background Greenness exposure is beneficial to human health, but its potential mechanisms through which the risk for metabolic syndrome (MetS) could be reduced have been poorly studied. We aimed to estimate the greenness-MetS association in southeast China and investigate the independent and joint mediation effects of physical activity (PA), body mass index (BMI), and air pollutants on the association. Methods A cross-sectional study was conducted among the 38,288 adults based on the Fujian Behavior and Disease Surveillance (FBDS), established in 2018. MetS was defined as the presence of three or more of the five components: abdominal obesity, elevated triglyceride, reduced high-density lipoprotein cholesterol (HDL-C), high blood pressure, and elevated fasting glucose. The residential greenness exposure was measured as the 3-year mean values of the normalized difference vegetation index (NDVI) and enhanced vegetation index (EVI) within the 250, 500, and 1,000 meters (m) buffer zones around the residential address of each participant. Logistic regression models were used to estimate the greenness-MetS association. The causal mediation analysis was used to estimate the independent and joint mediation effects of PA, BMI, particulate matter with an aerodynamic diameter of 2.5 μm (PM2.5), particulate matter with an aerodynamic diameter ≤ 10 μm (PM10), nitrogen dioxide (NO2), and sulfur dioxide (SO2). Results Each interquartile range (IQR) increase in greenness was associated with a decrease of 13% (OR = 0.87 [95%CI: 0.83, 0.92] for NDVI500m and OR = 0.87 [95%CI: 0.82, 0.91] for EVI500m) in MetS risk after adjusting for covariates. This association was stronger in those aged < 60 years (e.g., OR = 0.86 [95%CI: 0.81, 0.92] for NDVI500m), males (e.g., OR = 0.73 [95%CI: 0.67, 0.80] for NDVI500m), having an educational level of primary school or above (OR = 0.81 [95%CI: 0.74, 0.89] for NDVI500m), married/cohabitation (OR = 0.86 [95%CI: 0.81, 0.91] for NDVI500m), businessman (OR = 0.82 [95%CI: 0.68, 0.99] for NDVI500m), other laborers (OR = 0.77 [95%CI: 0.68, 0.88] for NDVI500m), and non-smokers (OR = 0.77 [95%CI: 0.70, 0.85] for NDVI500m). The joint effect of all six mediators mediated about 48.1% and 44.6% of the total effect of NDVI500m and EVI500m on the MetS risk, respectively. Among them, BMI showed the strongest independent mediation effect (25.0% for NDVI500m), followed by NO2 and PM10. Conclusion Exposure to residential greenness was associated with a decreased risk for MetS. PA, BMI, and the four air pollutants jointly interpreted nearly half of the mediation effects on the greenness-MetS association.

Whether intravenous thrombolysis provides additional benefits before direct endovascular treatment (dEVT) in acute ischemic stroke remains unclear. We aimed to compare the functional and safety outcomes of dEVT to endovascular treatment with bridging using intravenous thrombolysis (BT) in acute ischemic stroke. This meta-analysis included currently available eligible randomized clinical trials (RCTs) by searching in the PubMed, EMBASE, Cochrane Central Register, and the International Stroke Conference and European Stroke Organisation Conference posted abstracts. The six included RCTs yielded 2334 participants (mean age, 69.8 years [SD, 11.4]; women, 44.3%; 1164 in dEVT group and 1170 in BT group). We found not significantly different 90-day functional outcomes of modified Rankin scale (mRS 0 − 2, odds ratio [OR] 0.93, 95%CI 0.79 − 1.09; mRS 0 − 1, OR 0.99, 95%CI 0.82 − 1.18), mortality (OR 1.08, 95%CI 0.86 − 1.35), and symptomatic intracranial hemorrhage (OR 0.72, 95%CI 0.49 − 1.07) for patients in dEVT and BT group. Patients treated with dEVT were less likely to experience successful recanalization (OR 0.72, 95%CI 0.57 − 0.92, p = 0.009) and any intracranial hemorrhage (OR 0.81, 95%CI 0.68 − 0.97, p = 0.02). There were no significant differences regarding procedural complications between the two groups. This meta-analysis showed no significant differences in 90-day functional outcomes or mortality between dEVT and BT, but a lower possibility of successful recanalization and intracranial hemorrhage for dEVT.

Objective The objective of this study was to investigate the association between previous stroke and the risk of severe coronavirus disease 2019 (COVID-19). Methods We included 164 (61.8 ± 13.6 years) patients with COVID-19 in a retrospective study. We evaluated the unadjusted and adjusted associations between previous stroke and severe COVID-19, using a Cox regression model. We conducted an overall review of systematic review and meta-analysis to investigate the relationship of previous stroke with the unfavorable COVID-19 outcomes. Results The rate of severe COVID-19 in patients with previous stroke was 28.37 per 1,000 patient days (95% confidence interval [CI]: 10.65–75.59), compared to 3.94 per 1,000 patient days (95% CI: 2.66–5.82) in those without previous stroke (p < 0.001). Previous stroke was significantly associated with severe COVID-19 using a Cox regression model (unadjusted [hazard ratio, HR]: 6.98, 95% CI: 2.42–20.16, p < 0.001; adjusted HR [per additional 10 years]: 4.62, 95% CI: 1.52–14.04, p = 0.007). An overall review of systematic review and meta-analysis showed that previous stroke was significantly associated with severe COVID-19, mortality, need for intensive care unit admission, use of mechanical ventilation, and an unfavorable composite outcome. Conclusion Previous stroke seems to influence the course of COVID-19 infection; such patients are at high risk of severe COVID-19 and might benefit from early hospital treatment measures and preventive strategies.

目的 了解福建省2004-2020年成人艾滋病ART患者生存情况及其影响因素.方法 采用回顾性分析方法,收集2004-2020年参与艾滋病ART的18244例成人患者基本情况及可能影响患者ART后生存情况的影响因素等信息,计算治疗患者的全死因病死率、生存时间和生存率,运用COX比例风险模型和分类回归树模型分析治疗患者生存情况的影响因素及不同参数变量对病例生存影响的重要性,并应用ROC曲线评价模型预测效果.结果 截至2020年底,福建省18244例成人艾滋病ART患者中,累计报告1367例患者死亡,全死因病死率为2.14/100人年,5年生存率为0.91;COX比例风险模型显示,婚姻状况为已婚同居或其他、感染途径为异性性传播和其他、末次VL≥1000copies/mL的治疗患者死亡风险较高,而女性、文化程度较高、最近一次CD4细胞水平较高则死亡风险较低;回归树模型显示末次VL水平是艾滋病ART患者生存情况的首要影响因素,ROC曲线下面积为0.64(95％CI:0.62～0.67).结论 福建省成人艾滋病ART人群中,女性、未婚、同性性行为、文化程度较高者死亡风险较低,提高CD4细胞水平、控制病毒复制可以减少死亡和延长生存时间.

Background: The coronavirus disease 2019 (COVID-19) outbreak might have a psychological impact on frontline healthcare workers. However, the effectiveness of coping strategies was less reported. Objectives: We aimed to investigate the sources of stress and coping strategies among frontline healthcare workers fighting against COVID-19. We also performed a literature review regarding the effects of coping methods on psychological health in this population. Methods: We included frontline healthcare workers who completed an online survey using self-made psychological stress questionnaires in a cross-sectional study. We evaluated the association between potential factors and high-stressed status using a logistic regression model. We performed the principal component analysis with varimax rotation for factor analysis. We also performed a systematic review of published randomized controlled studies that reported the effects of coping methods on psychological health in COVID-19 healthcare workers. Results: We included 107 [32 (29–36) years] respondents in the final analysis, with a response rate of 80.5%. A total of 41 (38.3%) respondents were high-stressed. Compared with the low-stressed respondents, those with high-stress were less likely to be male (46.3% versus 72.7%, p = 0.006), nurses (36.6% versus 80.3%, p < 0.001), and more likely to have higher professional titles ( p = 0.008). The sources of high-stress in frontline healthcare workers were categorized into ‘work factor’, ‘personal factor’, and ‘role factor’. A narrative synthesis of the randomized controlled studies revealed that most of the coping methods could improve the psychological stress in healthcare workers during the COVID-19 pandemic. Conclusion: Our findings suggest that some frontline healthcare workers experienced psychological stress during the early pandemic. Effective coping strategies are required to help relieve the stress in this population.

Cadmium (Cd) is one of the most harmful environmental pollutants and has been found to have adverse effects on the gut. However, the toxic effects and potential mechanism of Cd on intestinal epithelial cells (IECs) are poorly understood. This study evaluated the effects of Cd exposure (0, 0.25, 0.5, 1, 2, and 4 mu M) on IEC-6 cells in terms of cell viability and apoptosis, as well as apoptosis-associated gene expression. The results indicated that low doses (0.25- 1 mu M) of Cd exhibited hormetic effects, while high doses of Cd (2 and 4 mu M) reduced cell viability. The apoptotic effect increased in a dose-dependent pattern. Moreover, the mRNA levels of the Bcl-2, Bax and Caspase 3 genes were altered, which was in agreement with their protein expression. Based on sequencing analysis, the expression pattern of the microRNAs (miRNAs) changed significantly in the 2 mu M Cdtreated group. QRT-PCR verified that 7 miRNAs, including miR-124-3p and miR-370-3p, were all upregulated with dose-effect relationship. Besides, transfection of miR-124-3p and miR-370-3p mimics /inhibitor and Bcl-2 siRNA into IEC-6 cells verified that these two miRNAs could regulate Cd-induced apoptosis by targeting Bcl-2. Finally, the direct targeting relationship between miR-370-3p and Bcl-2 gene was confirmed by luciferase reporter assay. Overall, the results demonstrated that Cd exposure could induce apoptosis in IEC-6 cells. The potential mechanism may be interference with the regulation of Bcl-2 gene expression by miR-370-3p and miR124-3p

To investigate the potential prognostic value of Serum cystatin C (sCys C) in patients with COVID-19 and determine the association of sCys C with severe COVID-19 illness. We performed a retrospective review of medical records of 162 (61.7 ± 13.5 years) patients with COVID-19. We assessed the predictive accuracy of sCys C for COVID-19 severity by the receiver operating characteristic (ROC) curve analysis. The participants were divided into two groups based on the sCys C cut-off value. We evaluated the association between high sCys C level and the development of severe COVID-19 disease, using a COX proportional hazards regression model. The area under the ROC curve was 0.708 (95% CI 0.594–0.822), the cut-off value was 1.245 (mg/L), and the sensitivity and specificity was 79.1% and 60.7%, respectively. A multivariable Cox analysis showed that a higher level of sCys C (adjusted HR 2.78 95% CI 1.25–6.18, p = 0.012) was significantly associated with an increased risk of developing a severe COVID-19 illness. Patients with a higher sCys C level have an increased risk of severe COVID-19 disease. Our findings suggest that early assessing sCys C could help to identify potential severe COVID-19 patients.

目的 了解HIV/AIDS病例非在治的影响因素及其原因.方法 采用统一问卷通过面谈/电话随访等方式,对福建省非在治HIV/AIDS病例进行调查,结合国家疾控中心艾滋病综合防治信息系统中相关信息,分析其影响因素.结果 15639例已审核存活病例中,治疗覆盖率达85.2％(13330例),非在治14.8％(2309例),其中已启动治疗非在治状态者占4.4％(694/15639),未启动治疗或未链接者占10.3％(1615/15639).非在治原因中,拒绝治疗原因居首位(33.5％,774/2309),拒绝治疗原因除不详(13.4％)外,以外出居多(8.2％).多因素回归分析结果显示,年龄为15～29岁、男性、文化程度≤小学、外省户籍、传播途径为异性传播或其他、首次CD4检测值＜500个/μL、疾病名称为HIV是非在治的危险因素.结论 拒绝治疗是患者非在治主要原因.15～29岁、男性、文化程度较低、外省户籍、异性传播或其他、首次CD4检测值＜500个/μL、疾病名称为HIV者更易非在治.应加强艾滋病早发现早治疗健康教育,促进更多感染者尽早接受抗病毒治疗,预防并发症,提高生命质量.

Background The long-term functional outcome of discharged patients with coronavirus disease 2019 (COVID-19) remains unresolved. We aimed to describe a 6-month follow-up of functional status of COVID-19 survivors. Methods We reviewed the data of COVID-19 patients who had been consecutively admitted to the Tumor Center of Union Hospital (Wuhan, China) between 15 February and 14 March 2020. We quantified a 6-month functional outcome reflecting symptoms and disability in COVID-19 survivors using a post-COVID-19 functional status scale ranging from 0 to 4 (PCFS). We examined the risk factors for the incomplete functional status defined as a PCFS > 0 at a 6-month follow-up after discharge. Results We included a total of 95 COVID-19 survivors with a median age of 62 (IQR 53–69) who had a complete functional status (PCFS grade 0) at baseline in this retrospective observational study. At 6-month follow-up, 67 (70.5%) patients had a complete functional outcome (grade 0), 9 (9.5%) had a negligible limited function (grade 1), 12 (12.6%) had a mild limited function (grade 2), 7 (7.4%) had moderate limited function (grade 3). Univariable logistic regression analysis showed a significant association between the onset symptoms of muscle or joint pain and an increased risk of incomplete function (unadjusted OR 4.06, 95% CI 1.33–12.37). This association remained after adjustment for age and admission delay (adjusted OR 3.39, 95% CI 1.06–10.81, p = 0.039). Conclusions A small proportion of discharged COVID-19 patients may have an incomplete functional outcome at a 6-month follow-up; intervention strategies are required.

The prevalence and outcomes of patients who had re-activation of coronavirus disease 2019 (COVID-19) after discharge remain poorly understood. We included 126 consecutively confirmed cases of COVID-19 with 2-month follow-up data after discharge in this retrospective study. The upper respiratory specimen using a reverse-transcription polymerase chain reaction test of three patients (71 years [60–76]) were positive within 11–20 days after their discharge, with an event rate of 19.8 (95%CI 2.60–42.1) per 1,000,000 patient-days. Moreover, all re-positive patients were asymptomatic. Our findings suggest that few recovered patients may still be virus carriers even after reaching the discharge criteria.

Leveraging the community of practice recently established through the U S National Institute of Environmental Health Sciences (NIEHS) Disaster Research Response (DR2) working group, we used a modified Delphi method to identify and prioritize environmental health sciences Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and associated Coronavirus Disease 2019 (COVID-19) research questions Twenty-six individuals with broad expertise across a variety of environmental health sciences subdisciplines were selected to participate among 45 self-nominees In Round 1, panelists submitted research questions and brief justifications In Round 2, panelists rated the priority of each question on a nine-point Likert scale Responses were trichotomized into priority categories (low priority;medium priority;and high priority) A research question was determined to meet consensus if at least 69 2% of panelists rated it within the same priority category Research needs that did not meet consensus in round 2 were redistributed for re-rating Fourteen questions met consensus as high priority in round 2, and an additional 14 questions met consensus as high priority in round 3 We discuss the impact and limitations of using this approach to identify and prioritize research questions in the context of a disaster response BACKGROUND: Patients with cardiovascular comorbidities are at high risk of poor outcome from COVID-19 However, how the burden (number) of vascular risk factors influences the risk of severe COVID-19 disease remains unresolved Our aim was to investigate the association of severe COVID-19 illness with vascular risk factor burden METHODS: We included 164 (61 8 ± 13 6 years) patients with COVID-19 in this retrospective study We compared the difference in clinical characteristics, laboratory findings and chest computed tomography (CT) findings between patients with severe and non-severe COVID-19 illness We evaluated the association between the number of vascular risk factors and the development of severe COVID-19 disease, using a Cox regression model RESULTS: Sixteen (9 8%) patients had no vascular risk factors;38 (23 2%) had 1;58 (35 4%) had 2;34 (20 7%) had 3;and 18 (10 9%) had ≥4 risk factors Twenty-nine patients (17 7%) experienced severe COVID-19 disease with a median (14 [7-27] days) duration between onset to developing severe COVID-19 disease, an event rate of 4 47 per 1000-patient days (95%CI 3 10-6 43) Kaplan-Meier curves showed a gradual increase in the risk of severe COVID-19 illness (log-rank P < 0 001) stratified by the number of vascular risk factors After adjustment for age, sex, and comorbidities as potential confounders, vascular risk factor burden remained associated with an increasing risk of severe COVID-19 illness CONCLUSIONS: Patients with increasing vascular risk factor burden have an increasing risk of severe COVID-19 disease, and this population might benefit from specific COVID-19 prevention (e g , self-isolation) and early hospital treatment measures

Objectives: Enlarged perivascular spaces in the basal ganglia (BG-EPVS) share common vascular risk factors with atherosclerosis. However, little is known about the relationship between steno-occlusive middle cerebral artery (MCA) and BG-EPVS. In this cross-sectional study, we aimed to test the hypothesis that severe MCA stenosis or occlusion is associated with increased MRI-visible BG-EPVS. Methods: We retrospectively reviewed 112 patients with a steno-occlusive MCA from Fujian Medical University Union Hospital between January 2014 and December 2018. We rated BG-EPVS, white matter hyperintensities (WMH), and lacunes as markers of cerebral small vessel disease (CSVD) on magnetic resonance image (MRI). The severity of steno-occlusive MCA was assessed by computed tomography angiography (CTA) and was classified into moderate (50-69%), severe (70-99%), and occlusion (100%). We evaluated the association of steno-occlusive MCA for >10 BG-EPVS using logistic regression model adjusted for age, gender, hypertension, MR-visible WMH, and lacunes. We also compared the number of BG-EPVS between the affected side and unaffected side in patients with only unilateral steno-occlusive MCA. Results: In multivariable logistic regression analysis, age (OR = 1.07, 95%CI: 1.03-1.13, p = 0.003), hypertension (OR = 2.77, 95%CI: 1.02-7.51, p = 0.046), severe MCA stenosis (OR = 3.65, 95%CI: 1.12-11.87, p = 0.032), or occlusion (OR = 3.67, 95%CI: 1.20-11.27, p = 0.023) were significantly associated with >10 BG-EPVS. The number of BG-EPVS in the affected side was higher than the unaffected side in patients with severe MCA stenosis (12 [9-14] vs. 8 [6-11], p = 0.001) or occlusion (11 [7-14] vs. 8 [5-11], p = 0.028). Conclusions: BG-EPVS were more prevalent in patients with severe MCA atherosclerosis. Our findings suggest a biological link between severe steno-occlusive MCA and increased BG-EPVS. These results need confirmation in prospective studies.

Background Patients with cardiovascular comorbidities are at high risk of poor outcome from COVID-19. However, how the burden (number) of vascular risk factors influences the risk of severe COVID-19 disease remains unresolved. Our aim was to investigate the association of severe COVID-19 illness with vascular risk factor burden. Methods We included 164 (61.8 ± 13.6 years) patients with COVID-19 in this retrospective study. We compared the difference in clinical characteristics, laboratory findings and chest computed tomography (CT) findings between patients with severe and non-severe COVID-19 illness. We evaluated the association between the number of vascular risk factors and the development of severe COVID-19 disease, using a Cox regression model. Results Sixteen (9.8%) patients had no vascular risk factors; 38 (23.2%) had 1; 58 (35.4%) had 2; 34 (20.7%) had 3; and 18 (10.9%) had ≥4 risk factors. Twenty-nine patients (17.7%) experienced severe COVID-19 disease with a median (14 [7–27] days) duration between onset to developing severe COVID-19 disease, an event rate of 4.47 per 1000-patient days (95%CI 3.10–6.43). Kaplan-Meier curves showed a gradual increase in the risk of severe COVID-19 illness (log-rank P < 0.001) stratified by the number of vascular risk factors. After adjustment for age, sex, and comorbidities as potential confounders, vascular risk factor burden remained associated with an increasing risk of severe COVID-19 illness. Conclusions Patients with increasing vascular risk factor burden have an increasing risk of severe COVID-19 disease, and this population might benefit from specific COVID-19 prevention (e.g., self-isolation) and early hospital treatment measures.

目的 在大脑中动脉狭窄/闭塞的高血压脑梗死患者中,探讨血压成分与基底节区扩大的血管周围间隙之间的相关性.方法 回顾性纳入自2014年1月到2018年12月在福建医科大学附属协和医院经临床、颅脑计算机断层扫描血管造影(CTA)及头颅核磁共振成像(MRI)确诊为大脑中动脉狭窄/闭塞的高血压脑梗死患者49例,根据脑小血管病评估量表对患者头颅MRI上基底节区扩大的血管周围间隙(BG-EPVS)进行评估,将患者分为＞10BG-EPVS和≤10 BG-EPVS组,比较两组患者年龄、性别、收缩压、舒张压、脉压、平均动脉压(MAP)及其他血管相关因素等基线特征.采用Logistic回归分析法,评估血压成分与＞10 BG-EPVS之间的相关性.采用受试者工作特征曲线(ROC曲线)分析法计算收缩压、舒张压、脉压和MAP判断＞10 BG-EPVS的曲线下面积(AUC).结果 自2014年1月到2018年12月,共纳入49例符合入选标准的大脑中动脉狭窄/闭塞的高血压脑梗死患者[年龄(65.1±10.5)岁,男性30例(61.2％)].与≤10 BG-EPVS组患者比较,＞10 BG-EPVS组患者年龄更大[(67.7±8.1)比(60.4±12.7)岁],收缩压[(146.5±12.7)比(137.7±13.2) mm Hg]和MAP[(103.2±9.4)比(97.5±9.6)mm Hg,均P＜0.05]更高.Logistic回归分析显示,在调整年龄因素后,收缩压(OR=1.08,95％ CI 1.01～1.15,P=0.025)和MAP(OR=1.19,95％ CI 1.06～1.34,P=0.003)与＞10 BG-EPVS存在显著相关性.ROC曲线分析显示:收缩压和MAP的AUC分别为0.711(95％ CI 0.551～0.870,P=0.015)和0.710(95％ CI 0.553～0.867,P=0.015);舒张压和脉压的AUC分别为0.629(95％ CI 0.463～0.795,P=0.135)和0.575(95％ CI 0.391～0.759,P=0.384).结论 在大脑中动脉狭窄/闭塞的高血压脑梗死患者中,收缩压和MAP与＞10BG-EPVS存在显著相关性,是判断＞10 BG-EPVS的良好指标,可视为＞10 BG-EPVS的标志物.

AIDS antiviral therapy (ART) has achieved great success.Originaly,AIDS had been regarded as a fatal disease,but it has become a kind of infectious disease that could be cured and administrated.Global HIV / AIDS cases were still up to about 38 million,but more than half have been effectively treated.In addition to drug treatment,at present,some new technologies and new methods,such as genome editing,have also been involved in the treatment of AIDS,and in the humanized animal experiment has shown very good results.There is no doubt that AIDS will eventually be stopped its epidemic.However,with the continuous development of AIDS antiviral treatment,the most fundamental problem is that HIV latent library has become increasingly prominent one,whether molecular therapy and hybrid cure have being developed for AIDS treatment,there are still such problem existence.Great efforts shoud be made to continuously search for new markers of latent viral cells and to reduce the latent pool.In addition,despite the prevention and treatment of AIDS has made great achievements,but the world still produces nearly 6000 cases of HIV/AIDS every day.Therefore,the development of safe and effective vaccine,whether in the field of prevention,or in clinical treatment,has its positive significance.

目的 分析福建省母婴传播艾滋病病毒感染者(HIV)/艾滋病病人(AIDS)及其母亲基本情况.方法 利用中国疾病预防控制信息系统艾滋病综合防治信息系统收集福建省母婴传播HIV/AIDS的基本信息和随访资料并逐一核实其母亲的基本情况,用SPSS 15.0对相关数据进行统计分析.结果 截至2015年12月31日,福建省共发现70例母婴传播病例,11例病例为抱养/弃婴.死亡病例19例,现活51例;现活的51例在2015年100％接受随访管理.在艾滋病综合防治信息系统中共有47例阳性母亲能核实到具体情况,显示阳性母亲文化程度较低,初中以及下文化程度者占89.36％,职业以无业者及农民为主,占74.47％,91.49％的母亲是在患儿出生之后确诊HIV抗体阳性.70例母婴传播病例母亲中外籍女性12例,占17.14％.结论 艾滋病母婴传播对儿童的影响深远,应引起足够的重视,还需加强适龄妇女孕前/孕早期HIV抗体检测、外籍新娘的管理以促进母婴阻断的有效实施.

<span id="ChDivSummary" name="ChDivSummary" class="abstract-text">目的分析福建省性传播艾滋病病毒感染者（HIV）/艾滋病病人（AIDS）生存状况及其影响因素。方法利用中国疾病预防控制信息系统艾滋病综合防治信息系统,收集自1987年福建省报告首例经性传播病例—2014年11月30日病例基本信息和随访资料,采用回顾性队列研究分析相关数据。结果 6 146例研究对象平均生存时间为（189.91±7.58）月,中位生存时间216月;首次确诊HIV抗体阳性时年龄&lt;50组死亡风险低于年龄≥50岁组（P均&lt;0.0001）;大专以上文化程度病例死亡风险低于其他文化水平患者（95%CI=0.20⁰.87,P=0.020）,重点人群、羁押人群发现病例死亡风险低于医疗机构发现病例（P分别为0.010、0.046）;CD4+T淋巴细胞≤500个/μL病例死亡风险高于CD4+T淋巴细胞&gt;500个/μL病例（P均&lt;0.000 1,95%CI=19.04⁸3.03、6.17²8.33、1.89⁸.26）;未治疗组死亡风险高于治疗组（P&lt;0.000 1,95%CI=4.12⁷.21）。结论年龄、文化程度影响HIV/AIDS的生存时间。</span>