BACKGROUND:The gastroscopic examination is a preferred method for the detection of upper gastrointestinal lesions. However, gastroscopic examination has high requirements for doctors, especially for the strict position and quantity of the archived images. These requirements are challenging for the education and training of junior doctors.OBJECTIVE:The purpose of this study is to use deep learning to develop automatic position recognition technology for gastroscopic examination.METHODS:A total of 17182 gastroscopic images in eight anatomical position categories are collected. Convolutional neural network model MogaNet is used to identify all the anatomical positions of the stomach for gastroscopic examination The performance of four models is evaluated by sensitivity, precision, and F1 score.RESULTS:The average sensitivity of the method proposed is 0.963, which is 0.074, 0.066 and 0.065 higher than ResNet, GoogleNet and SqueezeNet, respectively. The average precision of the method proposed is 0.964, which is 0.072, 0.067 and 0.068 higher than ResNet, GoogleNet, and SqueezeNet, respectively. And the average F1-Score of the method proposed is 0.964, which is 0.074, 0.067 and 0.067 higher than ResNet, GoogleNet, and SqueezeNet, respectively. The results of the t-test show that the method proposed is significantly different from other methods (p< 0.05).CONCLUSION:The method proposed exhibits the best performance for anatomical positions recognition. And the method proposed can help junior doctors meet the requirements of completeness of gastroscopic examination and the number and position of archived images quickly.

PurposeOur study aimed to develop a relatively accurate gastric cancer (GC) screening score system for urban residents and to validate the screening efficacy.MethodsThe present study included a derivation cohort (n = 3406) and a validation cohort (n = 868) of urban residents. Applying the full-stack engineering intelligent system platform of Hualian Health Big Data of Shandong University, the clinical physical examination data of subjects were collected. Univariate and multivariate analyses were used to identify risk factors for GC, and subsequently, an optimal prediction rule was established to create three distinct scoring systems.ResultsIn the GC-risk scoring system I, age, plateletocrit (PCT), carcinoembryonic antigen (CEA), glucose, albumin, creatinine were independent risk factors of GC, with scores ranging from 0 to 28 and optimal cut-off was 15.5. The second scoring system consisted of age, PCT, RDW-CV, CEA, glucose, albumin, and creatinine, with scores ranging from 0 to 31. The optimal cut-off point was determined to be 15.5. The scoring system III comprise of age, sex, PCT, RDW CV, CEA, glucose, with scores ranging from 0 to 21 and optimal cut-off was 10.5. All three scoring systems demonstrated excellent discrimination for GC, achieving an AUC of 0.884, 0.89, and 0.876, respectively. In external validation, the AUC values were 0.654, 0.658, and 0.714. Notably, the GC-risk scoring system III exhibited the highest screening efficiency.ConclusionsUrban residents benefited from the effective and verified GC-risk scoring systems, which demonstrated excellent performance in identifying individuals with an elevated risk of GC.

Junctional adhesion molecule 3 (JAM3) can be used as a prognostic marker in multiple cancer types. However, the potential prognostic role of JAM3 in gastric cancer (GC) remains unclear. The purpose of this research was to gauge JAM3 expression and methylation as potential biomarkers for GC patient survival. Through bioinformatics research, we analyzed JAM3 expression, methylation, prognosis, and immune cell infiltrations. JAM3 methylation acts as a negative regulator of JAM3, leading to reduced expression of JAM3 in GC tissues relative to normal tissues. Patients with GC who expressed little JAM3 have a better chance of living a long time free of the disease, according to the Cancer Genome Atlas (TCGA) database. Through univariate and multivariate Cox regression analysis, inadequate JAM3 expression was labeled as an isolated indicator for overall survival (OS). The GSE84437 dataset was also used to confirm JAM3 prognostic role in GC, with consistent findings. A meta-analysis also found that low levels of JAM3 expression were significantly associated with longer OS. Finally, there was a strong correlation between JAM3 expression and a subset of immune cells. According to the TCGA database, low JAM3 expression could predict favorable OS and progression-free-survival (PFS) in GC patients ( P < .05). The univariate and multivariate Cox regression demonstrated that low JAM3 expression was independent biomarker for OS ( P < .05). Moreover, GSE84437 dataset was utilized to verify the prognostic role of JAM3 in GC, and the similar results were reached ( P < .05). A meta-analysis revealed that low JAM3 expression was closely relevant to better OS. Finally, JAM3 expression exhibited a close correlation with some immune cells ( P < .05). JAM3 might be a viable predictive biomarker and likely plays a crucial part in immune cell infiltration in individuals with GC.

Background and objectivesStudies on the effect of sedated endoscopy on adenoma detection rate (ADR) and advanced adenoma detection rate (AADR) remain scarce. The present study aims to determine whether sedation can help improve ADR and AADR.

胃癌风险评估系统是胃癌筛查与早诊早治工作中甄别胃癌高危人群的重要方法.此类系统包括临床变量和血清标志物综合相关评估系统、临床变量相关评分系统、血清标志物相关评分系统、基因多态性位点相关胃癌风险预测系统.研究表明,上述评估系统有助于胃癌筛查与早诊早治,应用价值较高.在现有评估系统的基础上,专家们发现了一些新的风险相关变量,有望建立更加高效、实用的评估系统.本文就近期胃癌风险评估系统在胃癌筛查工作中的研究现状与展望进行综述,旨在为胃癌筛查与早诊早治工作选择实用的评估系统提供参考价值,同时为未来建立更加简单、高效的评估系统提供参考方向.

Objective:To evaluate the new model of group screening combined with opportunistic screening for the diagnosis and treatment of gastric cancer.Methods:Group screening combined with opportunistic screening was used for gastric cancer screening. (1) Group screening. Cluster sampling was used to screen gastric cancer by endoscopy in high-risk population (aged 40-<70 years) of rural residents in Weihai from July 2017 to December 2020, and biopsy was obtained for histopathology if necessary. Main collection parameters included the detection rate of advanced gastric cancer, early gastric cancer and high-grade intraepithelial neoplasia (HGIN). (2) Opportunistic screening. The changes of the detection rates of early gastric cancer in opportunistic screening in 2 hospitals in Weihai area were observed during the same period of time.Results:(1) In group screening, from July 2017 to December 2020, the first batch of 8 000 cases of gastric cancer screening were completed. The cases of advanced gastric cancer, early gastric cancer and HGIN were 36, 28, and 62, respectively. The detection rates of gastric cancer and early gastric cancer were 0.80% (64/8 000) and 43.75% (28/64), respectively. The proportion of early gastric cancer+HGIN who received endoscopic submucosal dissection (ESD) was 77.78% (70/90), and the rate of curative resection was 100.00%(70/70). (2) Opportunistic screening: from July 2017 to December 2020, the annual early gastric cancer detection rates in opportunistic screening in Wendeng District Traditional Chinese and Western Medicine Hospital were 16.67% (1/6), 20.00% (3/15), 23.53% (4/17), and 33.33% (6/18) in the consecutive 4 years, respectively. The annual detection rates of early gastric cancer in opportunistic screening in Ru Shan Peoples Hospital were 14.74% (14/95), 23.80% (60/252), 25.49% (65/255), and 24.04% (50/208), respectively. The detection rates of opportunistic screening for early gastric cancer in hospitals in Weihai city increased year by year.Conclusion:In areas with high incidence of gastric cancer, a certain scale of group screening can lead to a wider range of opportunistic screening, resulting in the increase of the detection rate of early gastric cancer. The new model of diagnosis and treatment of gastric cancer is worth recommendation.

MicroRNA (miR/miRNA)-153, as a novel tumor-related miRNA, has been found to be aberrantly expressed in different types of cancer; however, to the best of our knowledge, the role of miR-153 in gastric cancer (GC) remains unclear. The present study demonstrated that miR-153 expression was markedly decreased in GC, including GC cell lines and culture medium, GC tissues, and serum samples, based on reverse transcription-quantitative PCR, and this was further confirmed by fluorescence in situ hybridization. Transfection with miR-153 mimics inhibited proliferation and migration, and promoted apoptosis in GC cells. The serum expression levels of miR-153 were decreased in 59 patients with GC compared with those of 9 healthy controls, and more decreased in advanced GC compared with early-stage GC, suggesting that miR-153 was associated with tumor progression. Furthermore, serum miR-153 was expressed at significantly lower levels in patients with GC with larger tumor size (≥4 cm; P=0.013), poor differentiation and signet histology (P=0.013), lymph node metastasis (P=0.025) and advanced tumor stage (TNM stage III and IV; P=0.048) compared with patients with a smaller tumor size (<4 cm), well and moderate differentiation, no lymph node metastasis, and TNM stage I and II, respectively. In conclusion, the present study revealed that low miR-153 expression was associated with poor prognosis in GC and miR-153 may potentially act as a tumor biomarker and therapeutic target in GC.

目的 建立"农村居民相对精准胃癌筛查评分系统",并验证评估其筛查效能.方法 选取2019-09-01-2021-06-30参与威海市文登区胃癌普查的40～69岁人群为研究对象,随机分为4组:A组为空白组,不进行任何检测;B组检测H.pylori抗体分型(Ⅰ型强毒力菌株、Ⅱ型弱毒力菌株和阴性菌株);C组检测胃蛋白酶原(PG)、胃泌素-17(G-17);D组检测H.pylori抗体分型(Ⅰ型强毒力菌株、Ⅱ型弱毒力菌株和阴性菌株)、PG及G-17.4组均进行胃镜检查.采用χ2检验比较各组血清学阳性人群胃癌检出率.以胃癌检出率最高组所含血清学指标为例,完善其余组血清学指标,绘制ROC曲线,得出PG、G-17诊断胃癌的最佳临界值,进行单因素、多因素logistic回归分析,建立相对精准胃癌筛查评分系统.结果 共纳入1668名研究对象,A组396名,B组380名,C组388名,D组380名,验证人群124名;将Ⅰ型H.pylori抗体感染、胃蛋白酶原Ⅰ(PGⅠ)≤70μg/L、胃蛋白酶原比值(PGR)≤3和G-17≥7.960 pmol/L定义为血清学阳性,其中血清学阳性人群B组183例,C组58例,D组13例,D组胃癌检出率最高,χ2=22.602,P=0.001.logistic回归分析结果显示,男性、年龄、Ⅰ型H.pylori抗体分型、PGR≤7.325、G-17≥7.960 pmol/L是影响胃癌发生的独立危险因素,均P<0.05;对各危险因素进行赋值,评分系统得分范围为0～22分,当临界值为16分时,ROC曲线下面积最大为0.900,灵敏度为85.7％,特异度为79.0％,高危人群(16～22分)胃癌检出率高于低危人群(0～15分),χ2=49.932,P=0.001.经Hosmer-Lemeshow拟合优度检验后发现,差异无统计学意义(χ2=1.496,P=0.993),表明模型拟合度较好;对124名研究对象进行外部验证,灵敏度、特异度与上述差异无统计学意义.结论 "农村居民相对精准胃癌筛查评分系统"有助于农村居民胃癌高危人群的识别和筛查,可提升胃镜筛查性价比,提高早期胃癌检出率.

Objective To observe the anti-fibrosis effect of tenofovir combined with fuzheng huayu capsule in the treatment of compensatory hepatitis B cirrhosis.Methods Sixty patients with compensatory hepatitis b cirrhosis were randomly divided into observation group and control group.The observation group received tenofovir and fuzheng huayu capsule, while the control group received tenofovir for 30 months.The mean values of ALB,PTA and APRI before and after treatment were compared.The inner diameter of portal vein, thickness of spleen and mean of maximum flow of portal vein before and after treatment were compared in the two groups.Liver hardness test results before and after treatment were compared between the two groups.Results The results of liver function, HBVDNA and HBeAg were compared between the two groups.results after treatment, liver function was normal in both groups, HBVDNA decreased below the detection line, and there were 42% and 36.8% negative HBeAg in the two groups, respectively.The mean values of ALB,PTA and APRI in serum of the two groups were compared before and after treatment.After further comparison, ALB,PTA and APRI of the two groups were all P＜0.05.Comparison of portal vein diameter, spleen thickness and portal vein maximum flow mean before and after treatment in the observation group showed P＜0.05,while comparison of portal vein diameter before and after treatment in the control group showed P＞0.05.Comparison of portal vein diameter, spleen thickness and maximum portal vein flow between the observation group and the control group after treatment showed P＜0.05.After treatment, the mean value of liver hardness test in the two groups was P＜0.05,and the observation group was better than the control group.Conclusion The two methods can improve liver function and antiviral therapy.Tenofovir combined with fuzheng huayu capsule improved liver circulation and liver fibrosis and reduced portal vein pressure in the treatment group, which was better than tenofovir alone.

To assess carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9), platelet distribution width (PDW), neutrophil-to-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR) for gastric cancer’s (GC) diagnostic efficiency, and the use of receiver operating characteristic curves (ROC) combined with logistic regression to evaluate multi-index combination’s diagnostic value of GC. 773 GC patients’ clinical data were retrospectively collected in the Weihai Municipal Hospital, affiliated hospital of Shandong University from April 2018 to May 2021, and selected 2368 healthy physical examination patients during the same period as the control group. A total of 3141 samples was included in this study, including 773 cases in the GC group and 2368 cases in the healthy physical examination group. The results of the overall comparison between groups showed that apart from gender, the age differences, CEA, CA19-9, PDW, NLR, and PLR were statistically significant (P < .001). Spearman ranks correlation analysis’s results showed that CA19-9, CEA, PLR, and NLR were correlated with GC patients’ clinical-stage positively, and the correlation coefficients r was 0.249, 0.280, 0.252, 0.262 (all P < .001), and PDW was correlated with the clinical stage negatively (r = −0.186, P < .001). The ROC curve analysis results of CEA, CA19-9, PDW, NLR and PLR showed that CEA’s diagnostic cutoff value for GC was 3.175 (area under the curve [AUC] = 0.631, 95% CI: 0.606–0.655, P < .001), the CA19-9’s diagnostic cutoff value is 19.640 (AUC = 0.589, 95% CI: 0.563–0.615, P < .001), PDW’s diagnostic cutoff value is 15.750 (AUC = 0.799, 95% CI: 0.778–0.820, P < .001), NLR’s diagnostic cutoff value was 2.162 (AUC = 0.699, 95% CI: 0.675–0.721, P < .001), and PLR’s diagnostic cutoff value was 149.540 (AUC = 0.709, 95% CI: 0.688–0.732, P < .001). The area under the ROC curve for the combined diagnosis of GC with 5 indicators was 0.877 (95% CI: 0.860–0.894, P < .001), which was better than a single indicator (P < .05). The diagnostic efficiency of combined detection of CEA, CA19-9, PDW, NLR, and PLR is better than that of single index detection alone, which can reduce the misdiagnosis rate of GC effectively.

INTRODUCTION: The influence of sedation on the endoscopic detection rate of upper gastrointestinal (UGI) early cancer (EC) and precancerous lesions, including high-grade intraepithelial neoplasia (HGIN) and low-grade intraepithelial neoplasia, has not been assessed. The aim of this research is to assess whether the use of sedation can help improve the detection rate of UGI EC and precancerous lesions. The second objective is to evaluate its potential influencing factors. METHODS: The study includes 432,202 patients from a multicenter database from January 2012 to July 2019. Information on endoscopic findings and histology biopsies was obtained from endoscopy quality-control system. Associations of sedation with the detection rate of EC and precancerous lesions were assessed. RESULTS: The sedation group has a higher detection rate of UGI EC and HGIN compared with the no-sedation group, whereas the detection rate of low-grade intraepithelial neoplasia was similar between the 2 groups. There were more cases examined by using staining, image enhancement, or magnifying techniques in the sedation group (P < 0.001). And, the mean observation time was also longer in the sedation group (P < 0.001). The type 0-IIb esophageal HGIN and EC cases were significantly increased in the sedation group. No significant difference was detected on lesion subtypes for gastric HGIN and EC according to the Paris classification. More gastric HGIN and EC were detected at gastric body in the sedation group (P = 0.001). DISCUSSION: Sedation may improve the endoscopic detection rate of EC and HGIN in the UGI tract probably through enhancing the use of accessary endoscopic techniques, prolonging observation time, and taking more biopsies in different locations (see Visual Abstract, Supplementary Digital Content 2, http://links.lww.com/AJG/B926).

胃癌是我国最常见的恶性肿瘤之一,进展期胃癌5年生存率低于30％,而早期胃癌10年生存率可达90％.但目前我国早期胃癌的诊断率低于10％,大多数胃癌发现时已属晚期,预后较差.因此,亟须寻找一种简单有效的早期胃癌筛查措施,以提高早期胃癌的诊断率.本文就当前胃癌筛查模式的研究进展做一综述.

Objective:To explore the feasibility of endoscopic retrograde appendicitis in the treatment of acute non-perforated appendicitis.Method:Retrieve the pubmed、cochrane Library Control Test Registration Database, Chinese Journal full text Database, Wanfang Database, Weipu Database, from January 2012 to April 2019 related literature on endoscopic retrograde appendicitis and laparoscopic surgery for acute non-perforated appendicitis, the Cochrane collaboration with Rev Man 5.3 edition software for statistical processing, analyze the heterogeneity in data, calculate the OR value OR MD and its 95% confidence interval.Results:16 clinical studies with a total of 1375 patients were enrolled according to the inclusion criteria.Meta analysis showed that endoscopic retrograde appendicitis treatment and laparoscopic surgery for acute non-perforated appendicitis compared the curative effect, endoscopic retrograde appendicitis treatment of shorter hospital stay MD(95%CI)= -2.46(-2.93, -1.99), P<0.05, Lower incidence of complications OR (95%CI) =0.23(0.16 0.33), P<0.05, Short operation time MD(95%CI)=-19.89(-21.8, -17.93), P<0.05, and Postoperative recovery was faster MD(95%CI)= -3.16(-4.13, -2.19), P<0.05.Conclusions:the results of meta-analysis suggest that endoscopic retrograde appendicitis is a safe and feasible method for the treatment of acute non-perforatedre appendicitis, which has many advantages, such as short operation time, short hospitalization time, rapid recovery of patients, fewer complications, and good cosmetic effect, However, at present, this treatment method is not completely popular, and this conclusion needs to be confirmed by large-scale clinical data.

目的 探讨幽门螺杆菌(Helicobacterpylori)急性感染对GES-1细胞凋亡的影响,揭示H.pylori引起GES-1细胞凋亡变化的分子机制.方法 将H.pylori临床分离株SBK与胃上皮细胞GES-1按不同比例(感染复数MOI分别为50∶1和100∶1)共培养24 h,建立H.pylori急性感染模型.采用流式细胞仪分析GES-1的凋亡,通过Western Blot检测凋亡相关蛋白Bcl-xL、Bcl 2、Bax、Caspase-3和NF-κBp65的表达.经H.pylori感染的GES-1细胞为处理组细胞,未经H.pylori感染的GES-1细胞即为对照细胞.使用SPSS 21.0软件对结果进行统计学分析.结果 GES-1细胞经H.pylori处理24 h后,与对照细胞相比,MOI为50∶1(t=11.040,P＜0.001)和100∶1(t=6.936,P=0.002)的细胞凋亡率均明显增加;MOI为100∶1时GES-1细胞的凋亡率明显高于MOI为50∶1(t=4.875,P=0.008).与对照组相比,处理组细胞的Bax、Caspase-3表达明显增高,NF-κB p65表达无明显变化,Bcl-xL和Bcl-2在MOI为50∶1时表达升高,而在100∶1时表达下调.结论 H.pylori急性感染通过改变线粒体途径中凋亡相关蛋白Bax、Bcl-2及Bcl-xL的表达促进GES-1细胞凋亡,且GES-1细胞的凋亡程度与H.pylori的感染复数有关.

INTRODUCTION: Conventional gastrointestinal (GI) endoscopy reports written by physicians are time consuming and might have obvious heterogeneity or omissions, impairing the efficiency and multicenter consultation potential. We aimed to develop and validate an image recognition–based structured report generation system (ISRGS) through a multicenter database and to assess its diagnostic performance. Methods: First, we developed and evaluated an ISRGS combining real-time video capture, site identification, lesion detection, subcharacteristics analysis, and structured report generation. White light and chromoendoscopy images from patients with GI lesions were eligible for study inclusion. A total of 46,987 images from 9 tertiary hospitals were used to train, validate, and multicenter test (6:2:2). Moreover, 5,699 images were prospectively enrolled from Qilu Hospital of Shandong University to further assess the system in a prospective test set. The primary outcome was the diagnosis performance of GI lesions in multicenter and prospective tests. Results: The overall accuracy in identifying early esophageal cancer, early gastric cancer, early colorectal cancer, esophageal varices, reflux esophagitis, Barrett’s esophagus, chronic atrophic gastritis, gastric ulcer, colorectal polyp, and ulcerative colitis was 0.8841 (95% confidence interval, 0.8775–0.8904) and 0.8965 (0.8883–0.9041) in multicenter and prospective tests, respectively. The accuracy of cecum and upper GI site identification were 0.9978 (0.9969–0.9984) and 0.8513 (0.8399–0.8620), respectively. The accuracy of staining discrimination was 0.9489 (0.9396–0.9568). The relative error of size measurement was 4.04% (range 0.75%–7.39%). DISCUSSION: ISRGS is a reliable computer-aided endoscopic report generation system that might assist endoscopists working at various hospital levels to generate standardized and accurate endoscopy reports (http://links.lww.com/CTG/A485).

Background & Goals: We observed that the number of colorectal polyps found intraoperatively was often higher than that encountered preoperatively during elective colonoscopic polypectomy. To evaluate whether more polyps can be detected when they are purposely sought than when they are routinely examined during colonoscopy. Materials and methods: Patients undergoing colonoscopy were randomized into groups A and B. Before colonoscopy was performed, endoscopists were instructed to seek polyps for group A purposely but not for group B. Polypectomy was electively completed. In groups A and B, the cases of elective polypectomy were named groups AR and BR, including groups AR-1 and BR-1, during the first colonoscopy and groups AR-2 and BR-2 during the second colonoscopy for polypectomy, respectively. The following data were calculated: the number of polyps detected (NPD) and the polyp detection rate (PDR) in all cases and the number of polyps missed (NPM) and partial polyp miss rate (PPMR) in the cases of colorectal polyps. Results: A total of 419 cases were included in group A, 421 in group B, 43 in group AR, and 35 in group BR. No significant differences in PDR were found between groups A and B and in PPMR between groups AR-1 and BR-1 (P > .05), although PPMR in group AR-1 was higher than in group AR-2 (P < .05), similar results were found in PPMR between groups BR-1 and BR-2 (P < .05). Conclusion: Purposely seeking for colorectal polyps did not result in more polyps detected compared with routine colonoscopy.

目的:通过研究中西医结合根除幽门螺旋杆菌的作用,增加一种更加有效根除幽门螺旋杆菌的方法,从而改善幽门螺旋杆菌相关疾病症状,预防幽门螺旋杆菌相关疾病的发生.方法:通过比较对照组单纯四联疗法和实验组中西医结合序贯疗法的症状改善的情况,及有关幽门螺旋杆菌的根除情况,综合分析,运用SPSS 22.0软件来进行独立样本的t检验、多种因素的方差分析,卡方检验统计分析.结果:蒲地蓝+苏打水+四联疗法,实验组,比单纯的四联疗法,有更好的症状改善作用,并更高幽门螺旋杆菌的根除效果.结论:临床中,特别对反复发作的胃炎,难活性的幽门螺旋杆菌感染,中西医结合,蒲地蓝+苏打水+四联疗法,根除幽门螺旋杆菌有着良好的作用,值得推广.

Aim: To investigate the evaluation of EUS for the high-risk gastrointestinal precancerous lesions (HRGIPCL) before endoscopic resection. Methods: The patients with HRGIPCL scheduled for endoscopic resection, were randomized to preoperatively performing EUS (Group A) versus without EUS (Group B). Data were prospectively collected as follows: routine endoscopic results, EUS findings, therapeutic maneuvers, resected lesion size, final diagnosis and the grades of therapeutic maneuvers. Results: 116 patients with 156 HRGIPCL were included in Group A and 116 with 140 HRGIPCL in Group B. In terms of routine endoscopic results, resected lesion size (1.84 ± 1.30cm in Group A vs 1.70 ± 0.97cm in Group B) and final diagnosis, no differences were found between two groups (P >0.05). 207 endoscopic mucosal resection (EMR) was performed for 157 patients (114 EMR for 81 patients in Group A vs 93 for 76 in Group B), 14 endoscopic piecemeal mucosal resection (EPMR) for 14 patients (7 in Group A vs 7 in Group B), and 72 endoscopic submucosa dissection (ESD) for 67 patients (32 ESD for 30 patients in Group A vs 40 for 37 in Group B). No significant differences were observed between two groups (P >0.05). 33 adverse events occurred with significant differences between two groups (11 in Group A vs 22 in Group B, P < 0.05). The grades of therapeutic maneuvers in Group A was higher than that in Group B (P < 0.05). Conclusion: It was helpful to be evaluated by EUS for HRGIPCL before endoscopic resection.

胃癌是全球常见的消化道恶性肿瘤之一.我国癌症防治形势十分严峻,每年新发癌症病例约310万,死亡约200万,胃癌发病率达38.36/10万.随着老龄化进程的加快,预计在未来几十年内,我国癌症发病率和死亡率将整体继续呈上升趋势[1].中国癌症防治行动计划现场调研报告显示癌症负担日益加剧,防治体系亟待完善[2].

Colonoscopy is the standard method for colorectal cancer screeing.Colorectal adenomas,as precancerous lesions,can reduce morbidity and mortality in patients with colorectal cancer by early detection and removal of adenomas.However,interval colorectal cancer being detected after recent colonoscopy were associated with missed lesions.