Practical courses in a university are the basic courses to cultivate university students’ professional quality, practical ability and innovative thinking, as well as important carriers to achieve the goal of cultivating talents in higher education. Sticking to the student-centered teaching concept and highlighting problem-oriented instruction, the teaching team of the course of Laboratory Management Innovation Practice implemented teaching reform in terms of teaching idea, instructional design, instructional delivery, and teaching reflection. The reform aimed to guide students to think actively and use brains and hands simultaneously, developing their professional skills, promote their all-round development, and ultimately accomplish the transformation from delivering knowledge to improving abilities in classrooms. The reform practices have achieved good results.

教学质量是高校发展的生命线.教学质量评价需要通过校内师生评价、校外同行评价、社会评价等多方面开展综合评定.“互联网+”的兴起为高校教学质量评价提供了丰富的数字教育资源平台,有助于创新网络化教育服务新模式,完善多方面参与的评教机制.在探索“互联网+”对高校教学质量评价产生的重要影响基础上,分析了评价高校教学质量的关键因素,研究了在“互联网+”背景下高校教学质量评价过程中的理念变化和参评要素变化,有针对性地提出了“互联网+”背景下高校教学质量评价体系设计.

"双带头人"培育工程是高校开展教师党支部建设的创新工程,也是提升基层党组织组织力的重要工程,作者通过调研天津市高校的基本情况,分析了当前高校教师基层党组织存在的一些问题,探索了实施"双带头人"对教师党支部建设的意义和实现途径,以期对提升基层党组织党建工作质量、实现高校内涵式发展等方面起到一定指导意义.

2017年高校毕业生数量将达到795万人,庞大的大学毕业生群体就业问题引起了广泛关注.这其中,大学生在就业地域选择上也呈现出一些新变化和新趋势,存在着一些新问题. 对比研究近两年各高校公开的就业质量报告,聚焦近两年大学生就业区域去向的统计数据,可以看出,大学生就业区域选择具有以下特点: 高校所在地是首选就业地,相应省份是毕业生主要就业区域,在东部高校更为明显 大学毕业生对高校所在地比较熟悉,多数高校在当地都有较好的影响力,这一区域成为大学生就业选择的一个重点考虑.

大数据技术的不断发展对高校教务管理工作产生了深刻影响,对教务管理系统的工作模式、数据获取与研究方式、信息发布与交互途径、教务资源共享机制等提出了新要求和新挑战.高校教务管理工作者要面向大数据时代背景,及时转变工作理念,加强信息化建设,提升教务工作大数据获取、管理、分析、研究和应用意识,不断提升教务管理工作科学化水平.

To achieve a good stealth property and to enhance the uptake by tumor cells, polymeric micelles containing a slightly negatively charged and zwitterionic corona at pH 7.4 (i.e., blood pH) and a positively charged surface at a slightly acidic pH (i.e., tumor extracellular pH) were prepared. The amphiphilic diblock copolymer which was used to prepare the polymeric micelles contains a hydrophilic block comprised of nonionic hydrophilic groups, negatively charged groups (carboxyl groups) and pH-triggered positive charge-generation groups (morpholino groups). The zeta potential of the micelles was found to increase as the pH decreased over the pH range covering the blood and tumor tissue pH ranges, and the corona of the micelles should contain zwitterionic groups. This could be due to that, in the pH range studied, more morpholino groups become protonated as the pH decreased, whereas the carboxyl groups were almost completely deprotonated to form carboxylate anions. Furthermore, by adjusting the molar ratio of morpholino to carboxyl groups, the zeta potential of the polymeric micelles was controlled to achieve a slightly negative value at pH 7.4. Thus, the combination of a slightly negatively charged surface and a zwitterionic corona suggests that these micelles would possess good stealth property. When the pH decreased from 7.4 to 6.8 or 6.5, the zeta potential value of the micelles became positive due to increased protonation of the morpholino groups. Correspondingly, the cellular uptake of the micelles by HeLa cells was enhanced. (C) 2015 Elsevier Ltd. All rights reserved.

从研究生职业规划教育的发展现状和实际需求出发，结合实验科学类研究生的学习特点，南开大学化学学院不断探索研究生职业规划教育的创新模式，形成了以研究生自身、导师、辅导员、校友和职场人士五个方面协同创新，在研究生完成学业过程中的三个关键阶段全程推进的“5+3”职业规划教育模式，在实践中取得了良好效果。

求职择业期的准备工作 ☆☆ 心理准备 就业在即,许多大学生很早已开始“备战”,但不少大学生还是忽略了求职前最重要的一项准备:心理准备.当前大学生就业的心理问题主要表现在期望值过高、自我认识不充分、受挫准备不足、择业观存有偏颇等.大学生面对求职,应该如何准确的调整自我心理呢?

The supervisors and the advisors constitute the major force in postgraduate students'ideo-logical and political education.The College of Chemistry of Nankai University has initiated a new ap-proach for the supervisor and advisor to pool efforts to educate postgraduate students by selecting a student representative for each research team who serves as the liaison between the supervisor and the advisor and the bridge of interaction between classroom teaching and extracurricular activities.Joined efforts have enhanced the effectiveness of postgraduate ideological and political education.

<正>2012年,欧债危机持续发酵、全球经济复苏缓慢,我国经济增速创下近十几年来的最低值,这些经济大环境的不利因素直接影响到了大学生就业市场,增加了毕业生求职难度。在此背景下,相比于男生,女大学生在就业中受到的影响更大,求职困难也更为突出。在今年的就业指导工作中,我们着重关注了女研究生就业问题,实施了一系列帮扶措施,与去年同期相比,女应届生求职状况有了明显改善。

The development of graduate employment problem has been influenced by the national economic development,enrollment expansion,the prevailing concept on graduate employment and so on.With the rapid development of domestic economy and the enrollment expansion,graduates have been made to shift their position from demand exceeding supply to employment difficulty in the job market in recent twenty years.The supply-and-demand dynamics of graduates in job market,the adjustment of national employment policies and personal attitudes toward employment have influenced the graduate employment problem to different degree.To crack this severe problem,we need to make more efforts in expanding the employment demand,reforming the higher education training system,improving individual comprehensive ability,etc.

Stearic acid-grafted and lipoic acid-grafted chitosan were prepared by dehydration condensation reaction between the amino groups of chitosan and the carboxyl groups of stearic acid and lipoic acid. The modified chitosan possessed amphiphilicity due to the incorporation of the hydrophobic groups. The pKa value of the residual amino groups of the modified chitosan increased from 6.6 to 6.8~7.1 after methylation. Nanoparticles of the modified chitosan were prepared in aqueous medium through ultrasonic dispersion. The Zeta potentials of the nanoparticles were positive in values, which indicated that the residual amino groups and their methylation derivatives were located on the surface of nanoparticles. The chitosan-based nanoparticles were reduced by dithiothreitol and oxidized with oxygen in air, the disulfide cross-linked structures were formed in the core of the final nanoparticles.

Single-hole hollow polymer nanospheres were fabricated by raspberry-like template method using “graft-from” strategy through atom transfer radical polymerization (ATRP). Nanometer-sized silica spheres were covalently attached onto the surfaces of micrometer-sized silica spheres. Crosslinked polymer shells on the nano-sized spheres outside the attached area were formed by “graft-from” strategy through ATRP. After removal of the silica cores, single-hole hollow crosslinked polymer nanospheres were obtained. In this strategy, most of ATRP monomers may be used and thus many functional groups can be easily incorporated into the single-hole hollow crosslinked polymer nanospheres.

<正>日前,南开大学第二届研究生模拟招聘大赛总决赛在东艺演播厅举行。在一个多月的时间内,经过网络申请、辅导培训、半结构化面试、无领导小组讨论等环节的层层筛选,来自南开大学化学学院、周恩来政府管理学院、经济学院的10名同学从数家高校的300多名参赛学生中脱颖而出,进入总决赛。

天津，农历免年的第一场雪迟迟未来，可是，忙碌在求职旅途中的一些毕业生拿到的offer却比往年早了一些，多了一些。近日，在南开大学化学学院公布的第二期研究生签约进度中，有数家知名企事业单位的offer引起了广泛关注。其中宝洁公司（3人）、京东商城管培生（2人）、强生医疗（中国）投资有限公司、伊利集团、Discover金融服务公司、浙江朝晖过滤技术股份有限公司、中轻资源、中化石油、广汽菲亚特、扬子江药业、东莞新能源、正略钧策管理咨询有限公司、建设银行省级分行、国家知识产权局专利审查协作中心等，

Ibuprofen was loaded into polystyrene-based macroporous weakly basic anion exchange resins,D301R and D301T.The loading was driven by electrostatic and hydrophobic interactions.The optimized loading condition was: a suspension of the resin in 5~10% ethanol aqueous solution with dispersed ibuprofen was stirred for 12h at 60℃.The loading capacity could be up to 0.49g/g resin.The release of the loaded ibuprofen in buffer mimicking gastrointestinal pH environments(2h,4h and 18h at pH 2,7.4 and 6.7,respectively) was studied.The loaded ibuprofen was released almost linearly against time in the first 12h with release percentage of 58~60%.The release percentage in the followed 12h was quite low,being 13~17%.In simulated administrations taken at 12h interval,the loaded ibuprofen in D301R was released almost linearly against time during a 24h period after the second administration.In contrast,an initial burst release of the loaded ibuprofen in a polymethacrylate-based weakly basic anion exchange resin [n-butyl methacrylate/(N,N-dimethylamino)ethyl methacrylate/ethylene glycol dimethacrylate copolymer] at neutral pH was observed.These results showed that π-π stacking interaction between ibuprofen and the carrier played a key role in the sustained release of ibuprofen from the polystyrene-based weakly basic anion exchange resins.

Amphiphilic diblock copolymers with poly(ethylene glycol) as the hydrophilic block and a random copolymer of n-butyl methacrylate or styrene and (N,N-diethylamino)ethyl methacrylate as the hydrophobic block were prepared by atom transfer radical polymerization (ATRP). Ibuprofen, a model drug that contains a carboxylic group and hydrophobic moiety, was loaded into micelles formed from the amphiphilic diblock copolymers by a combination of ionic interaction and hydrophobic effect. The loading capacity of ibuprofen in the micelles reached 60%. Loaded ibuprofen was released in a sustained fashion into media simulating gastric fluid (pH 1.6, 2h), small intestinal fluid (pH 7.4, 4h), and colon fluid (pH 6.7, 18h). Simulating the case of oral administration at 2doses per day, loaded ibuprofen was released almost linearly against time after the second dose in media simulating human gastrointestinal tract fluids.

党中央十六号文件中提出了关于高校大学生思政教育的目标要求,结合当前研究生的思想特征、成长规律与学习兴趣,探讨了在研究生思政教育中实现党中央十六号文件目标要求的三大平台,以期切实提高研究生思想政治教育的实效性。

为满足国家对建设人才的多元化需求,研究生分类培养的呼声越来越高。相较于广受关注的研究生第一课堂的分类培养,在第二课堂中针对研究生在学期间的不同发展模式进行分类指导的研究与实践尚且不多。作为研究生分类培养的配套措施探索,将对研究生在学期间的发展模式进行分类总结,并提出了在第二课堂中进行分类指导的建议,以促进研究生分类培养目标的全面实现。

A 9-residue peptide, CP-1 (GLRILLLKV-NH(2)), is synthesized by solid-phase synthesis method. CP-1 is a C-terminal amidated derivative of a hydrophobic transmembrane segment (CP) of the T-cell antigen receptor (TCR) alpha-chain. CP-1 shows broad-spectrum antimicrobial activities against Gram-positive and Gram-negative bacteria with the minimal inhibitory concentration (MIC) values between 3 and 77microM. Circular dichroism (CD) spectral data shows that CP-1 adopts a well-defined beta-sheet structure in membrane-mimicking environments. CP-1 kills E. coli without lysing the cell membrane or forming transmembrane pores. However, CP-1 can penetrate the bacterial cell membranes and accumulate in the cytoplasm in both Gram-positive S. aureus and Gram-negative E. coli. Moreover CP-1 shows binding affinity for plasmid DNA. These results indicate that the killing mechanism of CP-1 likely involves the penetration into the cytoplasm and binding to intracellular components such as DNA.