Many cancers exhibit resistance to chemotherapy, resulting in a poor prognosis. The transcription factor NRF2, activated in response to cellular antioxidants, plays a crucial role in cell survival, proliferation, and resistance to chemotherapy. This factor may serve as a promising target for therapeutic interventions in esophageal carcinoma. Recent research suggests that NRF2 activity is modulated by ubiquitination mediated by the KEAP1-CUL3 E3 ligase complex, highlighting the importance of deubiquitination. However, the specific deubiquitinase responsible for regulating NRF2 in esophageal cancer remains unknown. In this study, a novel regulator of the NRF2 protein, Ubiquitin-Specific Protease 35 (USP35), has been identified. Mechanistically, USP35 modulates NRF2 stability through enzymatic deubiquitination. USP35 interacts with NRF2 and facilitates its deubiquitination. Knockdown of USP35 leads to a notable increase in NRF2 levels and enhances the sensitivity of cells to chemotherapy. These findings suggest that the USP35-NRF2 axis is a key player in the regulation of therapeutic strategies for esophageal cancer.

目的 胸椎旁神经阻滞对肺癌患者根治术后谵妄及认知功能的影响.方法 本研究对象为我院2019年1月～2021年1月招募的88例肺癌患者,均采用肺癌根治手术,数字表法将患者随机分为两组,对照组采用常规全麻,观察组在对照组基础上给予胸椎旁神经阻滞.比较两组患者术后12h、1d、3d疼痛视觉模拟评分(VAS)和简易智能精神状态评分(MMSE),并记录术后谵妄及认知功能障碍发生情况.结果 相比于对照组,观察组术后12h、1d、3d VAS评分和谵妄、认知功能障碍发生率显著降低(P＜0.05),而MMSE评分均显著升高(P＜0.05);观察组显著低于对照组(P＜0.05).结论 常规全麻联合胸椎旁神经阻滞能够显著提升肺癌患者根治术后镇痛效果,降低术后认知功能障碍、谵妄等精神类并发症的发生率.

目的 探讨术前焦虑对胸腔镜肺癌根治手术早期康复效果的影响.方法 本研究对象为我院2018年9月～2021年9月104例肺癌患者,均采用胸腔镜肺癌根治手术治疗,手术前1天采用医院焦虑抑郁量表(HADS)进行焦虑筛查,并设为焦虑组与非焦虑组,分别为42例,62例.比较两组患者术后1天、2天、3天疼痛视觉模拟评分(VAS),比较住院时间、肛门首次排气时间等,比较呕吐、心律失常等并发症发生率.结果 焦虑组术后1天、2天VAS评分均显著高于非焦虑组,(P＜0.05),术后3天差异无统计学意义(P＞0.05);焦虑组住院时间、肛门首次排气时间、首次下床时间、术后镇痛药用量均显著高于非焦虑组(P＜0.05);焦虑组恶心呕吐、心律失常等并发症发生率显著高非焦虑组(P＜0.05).结论 术前合并焦虑会影响患者的胸腔镜肺癌根治手术早期康复效果,增加术后早期疼痛感,增加并发症发生率等.

Objective:To investigate the clinical effect of subxiphoid and subcostal arch thoracoscopic surgery on patients with myasthenia gravis and its influence on stress inflammatory response.Methods:A total of 68 patients with myasthenia gravis treated in Luoyang Central Hospital Affiliated to Zhengzhou University from September 2017 to January 2020 were selected and divided into observation group (34 cases) and control group (34 cases), according to the surgical methods. Patients in the observation group underwent subxiphoid and subcostal arch thoracoscopic surgery; and patients in the control group underwent conventional thoracotomy. The changes of surgical indicators, postoperative complications, preoperative and 3-day postoperative stress inflammatory response, assessed by cortisol (Cor), C-reactive protein (CRP) and interleukin-6 (IL-6) of the two groups were observed. The clinical efficacy during 1 year follow-up of the two groups were observed and compared.Results:Compared with the control group, the amount of blood loss and postoperative drainage of the observation group were less, the postoperative hospital stay was shorter, while the operation time was longer ( P<0.05). The incidence of postoperative complications of the observation group (5.88%, 2/34) were less than those of the control group (26.47%, 9/34), P<0.05. Three days after treatment, the serum levels of Cor, CRP and IL-6 in the two groups were higher than those before surgery ( P<0.05), and these indexes of the observation group were lower those of the control group ( P<0.05). The effective rate of the observation group (94.12%, 26/34) was higher than that of the control group (76.47%, 32/34), P<0.05. Conclusions:The subxiphoid and subcostal arch thoracoscopic surgery has a good clinical effect on myasthenia gravis, with few postoperative complications, and less impact on the stress inflammatory response.

Mediastinoscopy was originally applied for lymph node biopsy and mediastinal tumor resection. Improved video imaging with spreadable working channels enabled mediastinoscopy for inspection and tissue biopsy in the superior mediastinum but it is rarely used in minimally invasive esophageal cancer surgery. In this prospective trial, the practicability and security of spreadable video-assisted mediastinoscopic combined with laparoscopic transhiatal esophagectomy (VAME) with video-assisted thoracoscopic esophagectomy (VATE) were compared. A total of 200 eligible patients with esophageal squamous cell carcinoma were randomly divided into VAME or VATE groups. Early postoperative outcomes and lymph node dissection between the two groups were compared. The operation time was significantly shorter (164.3 ± 47.0 min vs. 265.4 ± 47.2 min, P < 0.001), the number of dissected lymph nodes was less (15.8 ± 4.5 vs. 20.3 ± 6.5, P < 0.001), and the intraoperative blood loss was also significantly reduced (94.7 ± 56.7 mL vs. 184.4 ± 65.2 mL, P < 0.001) in the VAME compared to the VATE group, respectively. The incidence of pneumonia was lower (7% vs. 29%; P < 0.001) and the length of hospital stay was shorter in the VAME group compared to the VATE group (18.0 ± 7.6 days vs. 23.2 ± 7.2, P < 0.001, respectively). The chyle leak incidence appeared to be lower in the VAME group but statistical significance was not reached (1% vs. 4%; P = 0.369). There were no differences in the incidence of anastomotic leakages and recurrent laryngeal nerve paralysis between the groups. No 30-day mortality occurred in any of the cases. VAME appears to be a practicable and secure method for esophagectomy but needs further proof of concept. Clinical registration number: Registered at Chinese Clinical Trial Registry, ChiCTR1900022797.

Objective:To analyze the correlation between silent information regulator 6(SIRT6)and epithelium-Ca 2+ dependent cell adhesion molecule(E-cadherin)in the esophageal squamous cell carcinoma and adjacent normal tissues of the same patient. Methods:A total of 61 patients with esophageal squamous cell carcinoma(ESCC)who received surgical treatment in the department of Thoracic Surgery of Luoyang Central Hospital Affiliated to Zhengzhou University from June 2018 to December 2019 were selected from the sample, including 42 males and 19 females, aged(63.62±9.59)years old, ranging from 34 to 82 years old, whose cancer tissues and paracancerous tissues more than 3 cm from the margin of tumor resection(no cancer cells observed under microscope). The protein expression and immunohistochemistry of SIRT-6 and E-cadherin in esophageal squamous cell carcinoma were detected by immunocytochemistry(IHC)and Western blot assay.The correlation of SIRT6 and E-cadherin with clinicopathological data was analyzed.Results:The relative expression level of SIRT6 protein in esophageal squamous cell carcinoma(0.383±0.092)was significantly lower than that in adjacent tissues(1.037±0.116), and the difference was statistically significant( t=9.877, P<0.01). The relative expression level of E-cadherin protein(0.423±0.089)was significantly lower than that in adjacent tissues(0.967±0.116), and the difference was statistically significant( t=6.976, P<0.01). The positive expression of SIRT6 in esophageal squamous cell carcinoma was correlated with the depth of invasion, and the difference was statistically significant( P<0.05). There was no significant difference in tumor size, degree of differentiation and lymph node metastasis( P>0.05). The positive expression of E-cadherin in esophageal squamous cell carcinoma was correlated with differentiation degree and invasion depth, and the difference was statistically significant( P<0.05). There was no significant difference in tumor size and lymph node metastasis( P>0.05). Spearman rank correlation analysis showed that there was a positive correlation between the two, and the difference was statistically significant( r=0.538, P<0.01). Conclusion:The expression of SIRT-6 and E-cadherin affects the aggressiveness of esophageal squamous cell carcinoma, which can provide theoretical basis and target for clinical treatment of esophageal squamous cell carcinoma.

目的:分析单操作孔电视胸腔镜肺叶切除术治疗早期肺癌患者的临床效果.方法:选取早期肺癌患者92例,其中接受单操作孔电视胸腔镜肺叶切除术治疗的46例患者作为单操作孔组,接受常规多孔胸腔镜肺叶切除术治疗的46例患者作为多孔组,比较两组围手术期指标(手术时间、手术失血量、淋巴结清扫数、引流管置管时间、住院时间)、并发症状况以及术后1 d、3 d、5 d视觉模拟量表(VAS)评分.结果:两组手术时间、住院时间、引流管置管时间、淋巴结清扫数比较,差异无统计学意义(P>0.05);单操作孔组手术失血量少于多孔组(P<0.05);术后1 d、3 d、5 d单操作孔组VAS评分低于多孔组(P<0.05);单孔组并发症发生率与多孔组比较,差异无统计学意义(P>0.05).结论:单操作孔电视胸腔镜肺叶切除术与常规多孔胸腔镜肺叶切除术治疗早期肺癌，均可确保手术效果与安全性，但单操作孔电视胸腔镜肺叶切除术可缓解术后疼痛度，减少出血量.

Background: Discordant results about the causal relationship between hormone replacement therapy use (HRT) and lung cancer risk in women had been reported. We therefore conducted a meta-analysis of cohort studies to evaluate this association. Methods: The PubMed and Embase databases were searched. Fixed- or random-effects model was used to pool the study-specific relative risks (RRs) with corresponding 95% confidence intervals (CIs). Sensitivity analysis, publication bias, and subgroup analysis were performed. Results: A total of 13 cohort studies met the inclusion criteria. Combined results indicated that compared with nonusers, women with HRT use were at a decreased risk (RR: 0.95, 95% CI: 0.91-0.99, I 2 = 30.8%, P for heterogeneity = .137). In subgroup analysis by geographic area, smoking statue, type of hormones, and histology type of lung cancer, no significant association between HRT use and lung cancer was observed in most subgroups except in those studies which reported risk estimates adjusted for age, body mass index, smoking, and other confounders (RR: 0.95, 95 CI: 0.91-0.99, I 2 = 33.0%, P for heterogeneity = .214). Both Begg funnel plot and Egger test ( P = .243) suggested no evidence for publication bias. Conclusion: Our meta-analysis suggests ever use of HRT is associated with a decreased risk of lung cancer in women.

Background: Discordant results about the causal relationship between hormone replacement therapy use (HRT) and lung cancer risk in women had been reported. We therefore conducted a meta-analysis of cohort studies to evaluate this association. Methods: The PubMed and Embase databases were searched. Fixed- or random-effects model was used to pool the study-specific relative risks (RRs) with corresponding 95% confidence intervals (CIs). Sensitivity analysis, publication bias, and subgroup analysis were performed. Results: A total of 13 cohort studies met the inclusion criteria. Combined results indicated that compared with nonusers, women with HRT use were at a decreased risk (RR: 0.95, 95% CI: 0.91-0.99, I-2=30.8%, P for heterogeneity=.137). In subgroup analysis by geographic area, smoking statue, type of hormones, and histology type of lung cancer, no significant association between HRT use and lung cancer was observed in most subgroups except in those studies which reported risk estimates adjusted for age, body mass index, smoking, and other confounders (RR: 0.95, 95 CI: 0.91-0.99, I-2=33.0%, P for heterogeneity=.214). Both Begg funnel plot and Egger test (P=.243) suggested no evidence for publication bias. Conclusion: Our meta-analysis suggests ever use of HRT is associated with a decreased risk of lung cancer in women.

Objective: To investigate the method of operation for esophageal cancer to reduce incidence of cervical anastomotic leakage after resection Design: Prospective study Setting: Department of Thoracic Surgery, Luoyang Central Hospital Affiliated to Zhengzhou University Subjects: All esophageal cancer resection patients from August 2009 to August 2014 were included and grouped according to the admission time. Intervention: Mechanical cervical esophagogastric anastomosis through the highest point of the tubular stomach in addition to embedment and suspension of the anastomosis (group A, from August 2009 to November 2011, n = 37), mechanical cervical esophagus-tubular stomach anastomosis at the plane of the terminal branches of the right gastroepiploic vessels plus embedment and suspension of the anastomosis with redundant tubular stomach removed (group B, from December 2011 to August 2012, n = 39) and without (group C, from September 2012 to August 2014, n = 62). Main outcome measures: The incidence of cervical anastomotic leakage Results: All approaches were performed successfully and the anastomoses were tension-free. The incidence of cervical anastomotic leakage was 24.3% (9/32) in group A, 25.6% (10/37) in group B, and 1.6% (1/62) in group C, respectively. There was no statistical difference between groups A and B, while the anastomotic leakage incidence was much lower in group C than the other two groups (P < 0.05). Conclusions: The mechanical cervical esophagus-tubular stomach anastomosis approach without embedment and suspension of the anastomosis may lead to lower cervical anastomotic leakage after esophageal cancer resection.

气管支气管软骨瘤是一种起源于间叶组织的罕见良性肿瘤,发生于气管、支气管及细支气管软骨.其生长缓慢,临床症状在早期表现不明显,肿瘤逐渐增大阻塞气道,可出现咳嗽、呼吸困难,严重者造成窒息死亡. 外科手术的首要目的 是有效疏通呼吸道,缓解症状.

Background Primary adenosquamous carcinoma (ASC) of the lung is a rare and aggressive disease. The accurate diagnosis of ASC based on small biopsies is challenging because of the mixed components within the tumor, and this may lead to suboptimal treatment. Furthermore, information about the efficacy of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in lung ASC is limited. Patients and methods Data on a cohort of patients with lung ASC who underwent surgery between October 2008 and December 2016 at a single institution were retrospectively reviewed. Results This study analyzed 148 patients. Differences between the pre- and post-resection diagnosis were observed. Based on the results of preoperative biopsy, patients were diagnosed as having squamous cell carcinoma (n=26), adenocarcinoma (n=20), poorly differentiated carcinoma (n=20), and large cell carcinoma (n=1), and finally diagnosed as having ASC based on histopathological examination of the surgical specimens. Thirty patients (20.3%) with EGFR-sensitizing mutations (TKI group) were treated with EGFR-TKIs after surgery, whereas the remaining patients (79.7%) with unknown EGFR-mutation status received chemotherapy or chemoradiotherapy alone (non-TKI group). TKI treatment was associated with better median overall survival (OS) (HR=0.619; p=0.034). Multivariate analysis identified the presence of EGFR-TKI treatment as an independent prognostic factor for OS (HR=0.471; p=0.003). Conclusion Discrepancies between the pre- and post-operative diagnosis reflect the inadequacy of non-resection approaches to the diagnosis of ASC. ASC patients harboring EGFR-sensitizing mutations who were treated with EGFR-TKIs showed a significantly better prognosis than those receiving chemotherapy or chemoradiotherapy alone.

Objective To investigate the prognostic value of HOX transcribed antisense RNA expression in patients with thoracoscopic esophagostomy. Methods Totally 92 patients undergoing thoracoscopic esophageal cancer resection were included in this study. Cancer tissue as well as para-cancer normal tissue was collected. RT-PCR was utilized to detect the expression of HOX transcribed antisense RNA. Correlation between HOX transcribed antisense RNA expression and postoperative recurrence as well as survival was analyzed. Results RT-PCR showed that the relative expression of HOTAIR in cancer tissue increased significantly when compared with that in normal tissue [(0.673 ± 0.076) vs (0.387 ± 0.058), P < 0.05]. The area under the curve of HOTAIR for postoperative recurrence was 0.727 (95％ CI: 0.684, 0.884), and that for postoperative survival was 0.769 (95％ CI:0.692, 0.901). At time point of the 3rd year post operation, recurrence rate in group with HOTAIR less than 0.5 was dramatically lower than that of group with HOTAIR > 0.5 group (P < 0.05). Cox model analysis indicated that the degree of differentiation, clinical stage, tumor diameter, lymph node metastasis and HOTAIR were risk factors while postoperative adjuvant radiotherapy and chemotherapy was beneficial for the prognosis of patients. Conclusion HOTAIR is the risk factor for the prognosis of patients experiencing thoracoscopic esophagostomy, which can serve as a prognostic biomarker of esophageal cancer.

Objective :The purpose of this study was to compare perioperative outcomes in patients who underwent vid‐eo‐assisted thoracoscopic surgery (VATS group) or transsternal thymectomy surgery (TS group) and assess the VATS treatment for the myasthenia gravis .Methods :A total of 83 patients were enrolled ,including 50 cases in VATS group and 33 cases in TS group;the two groups were compared in duration of surgery ,amount of blood loss ,thoracic drainage volume of first‐24‐hours ,duration of chest drainage ,duration of postoperative hospital stay ,postoperative complications ,postoperative crisis ,CSR and effect etc .Results:There were significantly difference in duration of surgery [VATS group(110 .8 ± 38 .06)min VS TS group(199 .0 ± 36 .05)min] ,the intraoperative blood loss [VATS group(68 .5 ± 16 .22)ml VS TS group(205 .8 ± 34 .55)ml] ,the thoracic drainage volume of first‐24‐hours[VATS group(110 .0 ± 35 .50)ml VS TS group(326 .3 ± 56 .22)ml] ,the duration of chest drainages[VATS group(3 .6 ± 1 .25)d VS TS group (5 .6 ± 1 .19)d] ,the postoperative hospital stay [VATS group(9 .8 ± 1 .85)d VS TS group(16 .1 ± 13 .3)d] ,The rate of pneumonia[VATS group 7 .5% VS TS group 25 .8% ] .However ,there was no significantly difference between the CSR [VATS group 51% VS TS group 52 .9% ] .Conclusion:VATS treatment for the myasthenia gravis is technically feasi‐ble and safe and is less invasive than TS thymectomy .

Esophageal cancer is a common tumor for which morbidity and mortality are high worldwide. We aimed to study alterations in miR-486 expression in esophageal cancers, and the effect miR-486 on esophageal cancer cell function and behavior. We collected esophageal cancer tissues/corresponding normal tissues from 20 patients and utilized three esophageal cancer cell lines and normal esophageal epithelial cells, and the expression of miR-486, CDK4 and BCAS2 was detected by qRT-PCR. Western blotting was used to detect the expression of CDK4 and BCAS2 protein. Then, we overexpressed miR-486 in esophageal cancer cell line EC9706. A series of cell functional analyses, including cell growth, cell cycle, apoptosis, migration and invasion were performed in esophageal cancer cells using colony formation assay, flow cytometry, Transwell and scratch assays, respectively. Dual-luciferase reporter gene assay was used to detect the target genes of miR-486. We found that the expression of miR-486 in esophageal cancer tissues and cell lines was significantly lower than that in the normal tissues and normal esophageal epithelial cell line. Overexpression of miR-486 significantly inhibited the colony formation ability, induced G0/G1 phase arrest and apoptosis and suppressed cell migration and invasion in the EC9706 cells. Using bioinformatics and luciferase reporter assay, we identified that CDK4 and BCAS2 may be target genes of miR-486 and levels of CDK4 and BCAS2 were both significantly higher in the esophageal cancer tissues and cell lines than levels in the normal tissues and cells. Furthermore, knockdown of CDK4/BCAS2 coincided with the suppressive effects of miR-486 in esophageal cancer cells. Expression of apoptotic signaling molecules p21 and caspase-3 was upregulated in the CDK4/BCAS2-knockdown groups. These results suggest that miR-486 may suppress tumor cell growth and metastasis in esophageal cancer by targeting CDK4/BCAS2. The newly identified miR-486/CDK4/BCAS2 pathway provides further insight into the development and progression of esophageal cancer, which is of great significance to the early diagnosis and detection of esophageal cancer.

目的 探讨单孔胸腔镜手术治疗早期肺癌的安全性和优越性.方法 回顾性分析2014-07—2016-04间收治的112例早期肺癌患者的临床资料.其中单孔胸腔镜手术52例,常规2~3孔胸腔镜手术60例.记录并分析2组患者肿瘤大小、术后病理结果、手术时间、术中出血量、淋巴结清扫组数、淋巴结清扫个数、胸腔引流时间,术后住院时间,切口长度、术后疼痛应用止痛药用量、并发症发生等情况.结果 2组手术时间、术中出血量、淋巴结清扫组数、淋巴结清扫个数、胸腔引流时间及术后住院天数差异无统计学意义(P>0.05).切口长度、术后非甾体止痛药用量单孔组明显小于常规组(P<0.01).随访3~18个月,平均8.9个月,2组均无复发.结论 单孔胸腔镜手术治疗早期肺癌可达到常规胸腔镜手术同等疗效,而且切口小、疼痛轻、安全性高.

BACKGROUND The combined small cell lung cancer (c-SCLC) was rare and its clinicopathological characteristics had not been thoroughly described. The aim of this study was to determine prognostic factors and survival in c-SCLC patients. METHODS Clinical records of patients with c-SCLC who underwent surgery between January 2009 and December 2013 in two institutions were retrospectively reviewed. RESULTS Ninety-seven patients were identified. The most common pathology was combined SCLC and large cell neuroendocrine carcinoma (LCNEC, N=46), followed by combined SCLC and squamous cell carcinoma (SCC) (N=32), combined SCLC and adenocarcinoma (AC) (N=12), and combined SCLC and adenosquamous carcinoma (ASC) (N=7). The overall survival (OS) rates of the entire cohort were 42.4% and 35.2% at 3 and 5 years, respectively. Multivariate analysis identified sex [female vs. male, hazards ratio (HR) =0.38; 95% confidence interval (CI): 0.19-0.79; P=0.010], age (<53 vs. >53 years, HR =0.28; 95% CI: 0.09-0.81; P=0.019), performance status (<2 vs. >2, HR =0.08; 95% CI: 0.02-0.32; P<0.001), combined non-small cell lung cancer (NSCLC) components (LCNEC vs. non-LCNEC, HR =3.00; 95% CI: 1.03-8.76; P=0.045), adjuvant therapy (yes vs. no, HR =0.33; 95% CI: 0.17-0.67; P=0.002) as significantly prognostic factors of OS in patients with complete resection and lymphadenectomy. CONCLUSIONS The mixed NSCLC components within c-SCLCs had a significant influence on the survival. Compared with surgery alone, adjuvant therapy was associated with significantly improved survival in patients with complete resection and lymphadenectomy.

Objective To compare and analyze the effect of thoracoscopic and open pulmonary lobectomy on traumatic stress reactions,T lymphocyte subsets and pulmonary function.Methods According to different surgical methods,119 patients with early lung cancer were divided into the observation group (thoracoscopic surgery) and control group (open pulmonary lobectomy).The surgical time and bleeding volume during surgery were recorded.The traumatic stress reactions associated indicators,inflammatory factors,T lymphocyte subsets and lung function indexes were compared between the two groups before and after surgery.Results The surgical time,bleeding volume during surgery and length of hospital stay in the observation group were significantly shorter and less than those in the control group (P ＜ 0.05).Compared with one day before surgery,COR,ACTH,growth hormone,serum IL-6,CRP,FVC,FEV1 and PEF in the two groups were significantly increased on the 3rd day after surgery while CD4+ and CD8+ were decreased significantly (P ＜ 0.05),and the above indexes in the observation group were significantly better than those in the control group (P ＜ 0.05).The incidence of postoperative complications in the observation group was significantly lower than that in the control group (4.62％ vs.16.67％,P ＜ O.05).Conclusion The stress reactions of thoracoscopic surgery are mild.Compared with open pulmonary lobectomy,it has the advantages of shorter surgical time,less trauma and fewer postoperative complications.The inflammation and immunosuppression after thoracoscopic surgery are milder than those after open surgery,and it can effectively improve the lung function of the patients.

目的：比较胸腔镜下行肋骨接骨板固定术（VATS组）与保守治疗（保守组）多发肋骨骨折合并血胸的安全性和优越性。方法：回顾性分析2008年9月－2016年4月我院收治的113例多发肋骨骨折合并血胸病人，根据治疗方法分为两组，其中VATS组58例，保守组55例。比较两组胸腔引流管放置时间、住院天数、住IC U时间、带呼吸机时间、气管切开、肺部感染、死亡率等情况，随访2个月后比较两组肺功能情况。结果：VATS组术后胸腔引流管放置时间、住院天数、住IC U时间、带呼吸机时间、气管切开、肺部感染、死亡率和随访2个月肺功能情况均优于保守组。结论：VATS下肋骨接骨板固定术具有早期明确诊断，提早发现严重创伤，降低死亡率的作用；同时具有创伤小、并发症少以及恢复快的优点。

Objective To discuss common complications and precautions of thoracoscope and abdominoscope combined with resection of esophageal carcinoma.Methods300 patients received resection of esophageal carcinoma in thoracoscope combined with abdominoscope from August 2009 to October 2015, all kinds of complications occurred during perioperative period were recorded and reasons were analyzed. ResultsIn 300 cases, there were 31 cases of postoperative recurrent nerve injury; 29 cases of cervical anastomotic fistula; 22 cases of pulmonary infection.ConclusionRecurrent nerve injury, cervical anastomotic ifstula and pulmonary infection are the common postoperative complications of thoracoscope and abdominoscope combined with resection of esophageal carcinoma. Clear exposure is an effective method to prevent recurrent nerve injury. End of esophagus and stomach pure mechanical anastomosis can effectively reduce postoperative cervical anastomotic ifstula. Postoperative appropriate use of hormone, bronchoscope sputum suction timely can prevent postoperative pulmonary infection.