Homeobox B2 (HOXB2) is known to be correlated with the development and prognosis of various cancers. However, its role in colon cancer remains unclear. In this study, we explored the prognostic value of HOXB2 in colon adenocarcinoma (COAD). A total of 264 colon adenocarcinoma cases were retrospectively enrolled to evaluate HOXB2 expression and clinical significance. Chi-square test was applied to identify relationship between clinical features and HOXB2 expression. The effect of HOXB2 expression and clinical features on the survival of COAD patients was evaluated using Kaplan–Meier and Cox regression analyses. Cellular assays and mice models were conducted to validate the tumor-related role of HOXB2 in COAD. Higher expression of HOXB2 in COAD tissues was significantly associated with tumor size, invasion depth, and lymph node metastasis (all P < 0.05). Univariate and multivariate analyses showed that high expression of HOXB2 was significantly correlated with a poor overall survival. In vitro cellular assays combined with knockdown strategies demonstrated that HOXB2 can promote tumor proliferation and invasion of COAD, which was further confirmed by in vivo xenograft experiments. HOXB2 may be a valuable biomarker and potential therapeutic target for the treatment of COAD.

The drug nanoparticles free of additional carriers hold great promise in drug delivery and are suitable for the therapy of cancers. Herein, we developed a one-pot method to prepare chlorin e6 (Ce6) nano-precipitations (Ce6 NPs) for effective photodynamic therapy of colorectal cancer. The drug loading of Ce6 NPs was around 81% and showed acceptable stability, high biocompatibility as well as effective reactive oxygen species (ROS) generation capability. As a result, the Ce6 NPs can produce significantly elevated ROS upon laser irradiations and achieved better anticancer benefits than free Ce6.

Objective To investigate the clinical effect of laparoscopic repair for gastric perforation.Methods 88 patients with gastric perforation were randomly divided into a control group and an observation group by random number table method.The control group underwent traditional open repair,while the observation group laparoscopic repair.Both groups received symptomatic treatment and rehabilitation nursing intervention after operation.The hospitalization time,exhaust time,recovery time of bowel sounds,VAS pain score,GAS level,and therapeutic effects were observed.Results The postoperative hospital stay hexhaust time,bowel sound recovery time,VAS pain score,GAS levels 1,24,48,and 72 h after the operation and total effective rate were better in the observation group than in the control group [(4.53±1.12) d vs.(6.94± 0.87) d,(62.27±15.48) h vs.(84.55±22.69) h,(14.08±5.46) h vs.(28.71±9.10) h,(1.91±0.71) vs.(2.84±0.79),(37.46±7.15) ng/L vs.(34.38±7.01) ng/L,(47.39±11.08) ng/L vs.(39.44±10.71) ng/L,(58.89±14.81) h vs.(45.26±11.29) ng/L,(60.11±15.18) ng/L vs.(53.23±14.14) ng/L,and 97.7％ vs.84.0％;all P ＜ 0.05].Conclusion Laparoscopic repair is superior to traditional open repair in the treatment of gastric perforation,with shorter recovery time,better recovery of gastrointestinal function,obvious improvement of pain and other symptoms.The long-term effect is considerable,so it is worthy of clinical application and in-depth study.

目的 分析熊去氧胆酸联合莫沙必利治疗胆汁反流性胃炎的疗效.方法 96例原发性胆汁反流性胃炎患者,随机分为对照组和观察组,每组48例.对照组给予莫沙必利治疗,观察组给予熊去氧胆酸联合莫沙必利治疗.治疗4周后,对两组患者进行胃镜和病理学检查,对比分析两组的治疗效果、治疗前后的症状评分.结果 观察组的总有效率明显优于对照组(P<0.05);两组患者治疗前后症状评分比较,差异均有统计学意义(P<0.05);治疗后观察组症状评分明显低于对照组,差异均有统计学意义(P<0.05).结论 应用熊去氧胆酸联合莫沙必利治疗胆汁反流性胃炎取得了很好的治疗效果,值得临床推广应用.

目的 探讨3种不同肠道准备剂对肠道准备的效果.方法 294例需行结肠镜检查患者,随机分为A、B、C三组,每组98例.A组为复方聚乙二醇电解质组;B组为50％硫酸镁组;C组为20％甘露醇组,对A、B、C三组准备剂的肠道清洁效果、排便次数、不良反应和操作时间进行比较分析.结果 A组和C组总有效率均高于B组,差异均具有统计学意义(P＜0.05),A组与C组总有效率比较,差异无统计学意义(P＞0.05).A组不良反应发生率低于B、C组,差异均具有统计学意义(P＜0.05).结论 用复方聚乙二醇电解质行肠道准备,具有有效率高、副作用少、患者痛苦小的优点,值得在临床推广.

目的 探讨乳腺癌改良根治术中清扫腋窝淋巴结时保留胸外侧静脉的临床意义.方法 前瞻性分析我院乳腺外科2010年1月至2011年12月行改良根治术的Ⅰ期和Ⅱ期的乳腺癌患者140例,其中在腋窝淋巴结清扫术中保留胸外侧静脉65例(保留组),切除胸外侧静脉75例(切除组);对比分析两组术后患者患侧上肢水肿情况.结果 保留组患者患侧上肢水肿发生率为4.6％ (3/65),而切除组患侧上肢水肿发生率为17.3％(13/75),两组差异有显著性(P ＜0.05).平均随访1.6年,140例患者均未见局部复发.结论 乳腺癌改良根治术中腋窝淋巴结清扫时保留胸外侧静脉可以减轻患侧上肢水肿发生率,不增加局部复发的风险,应成为乳腺癌改良根治手术的有益组成部分.

<正>肠道除消化吸收功能外,在防止感染方面具有非常重要作用。肠道是人体最大的细菌储存器官,能够容纳约1012个细菌,产生大量的内毒素。正常情况下肠腔内细菌不能透过肠壁进入全身脏器和组织,这是因为肠黏膜具有阻止细菌和内毒素的屏障功能。肠黏膜屏障由四部分组成:机械屏障、免疫

目的:探讨胃小弯侧异位胰腺的临床及病理特点和诊治方法。方法:分析2009年10月—2009年12月大连市中心医院普通外科收治的3例胃小弯侧异位胰腺的临床资料。结果:3例均为非特异性消化系统疾病症状入院,行胃镜、超声胃镜、上腹部CT等检查,均诊断为胃小弯侧黏膜下肿物,均行小弯侧胃壁部分切除术。1例为腹腔镜手术,1例腹腔镜中转开腹,1例为开腹手术。手术中切除肿物及其周围1.0~2.0 cm正常胃壁组织,术中冷冻病理和术后病理报告均为异位胰腺。术后2例出现消化不良、胃排空障碍。结论:胃小弯侧异位胰腺无特异性临床表现,胃镜、超声胃镜是其诊断的主要手段,小弯侧胃壁部分切除术是其治疗的首选术式,术中冷冻病理检查是必要的,局部切除术后应注意消化功能异常和胃排空障碍等并发症的发生。

腹腔镜技术是近二十几年来刚刚发展起来的普通外科领域的一项外科治疗新技术,随着技术、设备、器械等的不断改进和更新,其所倡导的微创理念正在迅速被人们所接收和认可,给外科手术带来了巨大变革.大连市中心医院自1994年施行了首例腹腔镜胆囊切除术以来,腹腔镜技术得到了极大的发展.

例1 患者女,47岁.以＂发现左下腹包块半年＂入院.查体：左下腹可扪及固定肿物,光滑界清、质韧无触痛.结肠镜、常规化验及肿瘤标志物检查均正常.CT示左下腹前腹壁外下髂腰肌旁软组织肿物约3 cm×5 cm,密度较均匀,边界清晰;内部不均匀强化,边缘强化明显（图1）.手术探查：肿物位于腹膜外,包膜完整,后方与髂外血管相邻.术后病理为符合Castleman病（Castleman disease,CD）,