目的 探讨甘草栀子豉膏膻中穴贴敷在心房颤动(房颤)射频消融术后食管损伤相关恶心呕吐中的应用效果.方法 采取便利抽样法,选取2021年1月至2022年2月浙江省浙江大学医学院附属第一医院心内科符合纳排标准的行房颤射频消融术的86例患者作为研究对象,采用计算机产生的随机数法分为干预组和对照组各43例.干预组采用甘草栀子豉膏膻中穴贴敷,对照组采用安慰剂膻中穴贴敷,两组除穴位贴敷外常规护理措施相同.比较两组干预前后的炎症指标,恶心、呕吐、干呕症状严重程度.结果 干预后,干预组、对照组术后CRP分别为(6.71±6.42)mg/L、(15.65±11.83)mg/L,白细胞计数分别为(7.46±1.82)×109/L、(9.96±3.15)×109/L,中性粒细胞百分比分别为(69.89±9.49)％、(79.99±10.10)％;术后上消化道症状总分分别为(9.95±1.34)分、(26.62±2.27)分,两组比较差异均具有统计学意义(均P<0.001).结论 甘草栀子豉膏膻中穴贴敷可减轻房颤射频消融术后炎性反应,对缓解恶心呕吐干呕症状效果显著.

Objective: Data are limited on the psychological disorders of patients with cardiovascular disease during the post-COVID-19 period, although mental health status is associated with morbidity and mortality. We aimed to investigate the prevalence of anxiety and depression and risk factors among patients with cardiovascular disease in the post-pandemic period. Method: A cross-sectional survey was conducted through opportunistic and snowball sampling in southeast China from 10 October to 24 November. Anxiety and depression were assessed on the hospital anxiety and depression scale (HADS). Results: A total of 435 patients with hypertension (48.05%), atrial fibrillation (17.24%), coronary artery disease (14.48%), heart failure (9.89%) and other heart diseases (10.34%) completed the survey. Interestingly, most patients reported monthly income comparable to (90.11%) or even greater than (8.51%) pre-pandemic income. The occurrence of anxiety and depression was 11.72 and 9.20%, respectively. Marital status and treatment interruption during the pandemic were independent risk factors for both anxiety and depression. Moreover, current monthly income and access to telemedicine during the pandemic were independent risk factors for anxiety. Conclusion: Patients with cardiovascular disease may experience anxiety and depression not only because of disease complications but also because of the effects of the pandemic. In facing the global challenge posed by the coronavirus, efforts should be made to improve patients' psychological well-being in the management of populations with cardiovascular disease.

Safflower was one of the most prominent red dyes used on silk during the Qing Dynasty. Studies of traditional natural dyes and dyeing have always been an integral part of ancient textile research. A combination of literature analysis, dye identification, and machine learning regression analysis was used to reconstruct safflower dyeing and colors in the Qing Dynasty. Based on the dyeing archives collected by the Weaving and Dyeing Bureau, this study establishes a color prediction GPR model for safflower dyeing. Three types of red color dyes on a Qianlong Kesi robe in the Beijing Art Museum were analyzed by HPLC-DAD-MS. A correction set cyclic training method was developed to reconstruct the color and dyeing recipe on textile relics with high predictive efficiency. Furthermore, the effect of each dyeing parameter on the color was analyzed. A color gamut and dyeing recipe database were constructed for Pure Red, Peach Red, Water Red, Red, and Fish Red recorded in the dyeing archives, providing a reference for research on traditional dyeing technology.

综述了早期运动训练对提高急性失代偿性心力衰竭患者运动耐量的病理生理机制,运动训练的介入时机、实施方法,早期运动训练的安全性,为患者早期运动训练方案的制定及实施提供依据.

黄色是中国传统色彩中的五正色之一,也是清代宫廷特有的、应用于正式场合的礼吉服用色.文章探讨了清宫礼吉服中明黄、杏黄、金黄三种色彩的功用范围、色相区域及染色工艺.通过文献资料的梳理分析得知:礼吉服色中等级次序为明黄>杏黄>金黄,且有详细的使用规范.依据织染局染作档案记载进行模拟实验结果表明,炒槐子染液放置发酵5 d以上后,a?、b?和K/S值均明显上升,明黄色更可能是炒槐子染液放置发酵5～15 d染色而成.槐子和黄栌套染时,增加黄栌比例、以K2 CO3溶液进行后处理,可以使染得颜色向橙红色变化,从而获得杏黄和金黄色.

本文就心脏病患者运动恐惧现象的研究现状进行综述,从运动恐惧的概念和心脏病患者运动恐惧的发生情况及影响因素、评估工具、不良影响及干预措施等方面进行归纳与总结,旨在引起国内临床医护人员对心脏病患者运动恐惧的重视,有助于早期发现患者运动恐惧现象并进行干预,从而改善心脏病患者预后及提高生活质量.

Mutations in LIM domain binding 3 (LDB3) gene cause idiopathic dilated cardiomyopathy (IDCM), a structural heart disease with a complicated genetic background. However, the association of polymorphisms in the LDB3 gene with susceptibility to IDCM in Chinese populations remains unexplored as dose the impact on clinical presentation. We sequenced all exons and the adjacent part of introns of the LDB3 gene in 159 Chinese Han IDCM patients and 247 healthy controls. Then we detected the distribution of polymorphisms in the LDB3 gene in all participants and assessed their associations with risk of IDCM. Additionally, we conducted a stratified genotypephenotype correlation analysis. The A allele of rs4468255 was significantly associated with IDCM (P<0.01). The rs4468255, rs11812601, rs56165849, and rs3740346 were also associated with diastolic blood pressure (DBP) and left ventricular ejection fraction (LVEF) (P<0.05). Notably, a higher frequency of rs4468255 polymorphism was observed in implantable cardioverter defibrillator (ICD) recipients under a recessive model (P<0.01), whereas the significant association disappeared after adjusting for potential confounders. However, in the dominant model, notable correlations could only be observed after adjusting for multi parameters. The rs4468255 was significantly correlated with IDCM of Chinese Han population. A allele of rs4468255 is higher in IDCM patients with ICD implantation, suggesting the influence of genetic background in the generation of this response. In addition, rs11812601, rs56165849, and rs3740346 in LDB3 show association with brain natriuretic peptide, DBP, and LVEF levels in patients with IDCM but did not show any association with IDCM susceptibility.

故宫博物院所藏衣服类文物大多来自于清代紫禁城衣库,由于实物和档案的分离,很多衣物的穿用者身份不明.经文献考证,故42151和故42484分别为乾隆皇帝舒妃的吉服袍和常服褂,结合其他文献和文物可以推测舒妃吉服袍可能制作于乾隆中期.舒妃吉服袍的色彩和搭配呈现了这一时期重要的流行特征,绣线的色彩和织染局档案记载恰可互相参证,且清代织染局只服务于宫廷,以织染局染作档案再结合其他历史文献,对照实物,笔者已成功完成了33种颜色染色工艺的复原.进一步研究发现,织染局利用9种染料,5种助剂,通过控制浴比、浸染时间、浸染次数和温度等工艺条件,获得不同的染色效果,构成丰富的染织色谱.

[目的]对心内科介入围术期病人实施集束化护理干预,改善病人睡眠情况,促进病人康复.[方法]将201 6年7月-2017年8月住院行心血管介入术的156例病人按随机数字表法分为对照组与观察组,每组78例,对照组给予介入术常规护理,观察组给予集束化护理干预,比较两组病人睡眠状况(进入睡眠时间、睡眠质量、实际睡眠时间、睡眠效率)及焦虑程度.[结果]观察组病人术前1d、术后当天进入睡眠所需时间显著少于对照组、睡眠质量显著优于对照组、实际睡眠时间长于对照组、焦虑程度轻于对照组,经比较差异均有统计学意义(P＜0.05或P＜0.01);在术后当天观察组病人睡眠效率显著优于对照组(P＜0.01).[结论]实施集束化护理干预可有效改善心内科介入围术期病人的睡眠状况及焦虑情况,对病人的康复有积极意义.

目的:探讨三黄软膏在防治胺碘酮所致外周血管静脉炎的应用效果.方法:选取2016年1月~2017年1月经外周静脉途径使用的住院患者,按楼层随机分为观察组28例,对照组26例,观察组自用药开始应用三黄软膏外敷,对照组按照留置针常规护理.比较两组间静脉炎的发生率及严重程度.结果: 观察组的静脉炎发生率较对照组低(P<0.05),且静脉炎的严重程度轻于对照组.结论: 早期应用三黄软膏外敷法有效降低了胺碘酮所致外周静脉炎的发生率及严重程度.

目的 观察环型固定器加压包扎技术应用于起搏器安装术后的效果.方法 采用随机数字表将155例接受心脏起搏器植入的患者分成两组,对照组74例、观察组81例.对照组患者术后予常规沙袋加压包扎方式,观察组患者予新型加压包扎方式.观察两组患者术后出血量、疼痛评分及术后并发症发生情况.结果 对照组术后12 h出血量为(4.02±1.22)g,术后24 h出血量为(0.88±0.23)g,观察组分别为(1.41±1.26)g、(0.28±0.22)g,两组各时点出血量比较差异有统计学意义(P<0.05).观察组术后即刻疼痛评分高于对照组(P<0.05),但是术后4 h的疼痛评分观察组却低于对照组(P<0.05),术后12 h及24 h的疼痛评分两组比较差异无统计学意义(P>0.05).术后对照组发生1例囊袋水肿,观察组未发生.结论 使用环型固定器加压包扎技术可明显降低起搏器安装术后出血量.

目的：观察康惠尔透明贴在起搏器术后伤口护理中的疗效；方法：73例患者随机病房楼层分为实验组（康惠尔透明贴）和对照组（无菌纱布），术后第2天，第5天，第7天观察伤口，检测体温以确认是否存在伤口感染；结果：实验组平均换药次数1.2次，无一例发生感染，对照组为3.2次，有1例发生感染，但组间比较无统计学意义。（P>0.05）；结论：在起搏器术后伤口护理中，康惠尔透明贴可以作为传统纱布袋一种替代方式，在预防伤口感染不亚于传统方法，且换药方便，提高效率。

We previously found that endoplasmic reticulum stress (ERS) might be exhibited in the conventional protocol of the primary culture of neonate rat myocardial cells (NRMCs) and that the high glucose concentration (25 mmol/L) in the culture medium might be the cause. Here, we investigated if the high concentration of glucose might influence ERS in myocardial cells during culture. GRP78 expression (ERS marker) was similar in groups with tunicamycin (TM) and without TM in high glucose cultured cells (p > 0.01). Different glucose concentrations elicited different GRP78 expressions according to analyses of protein and RNA levels, which showed ERS in H/H groups. Finally, we found that GRP78 expression was higher in TM groups compared with M/M groups (p < 0.01). The conventional high-glucose culture media during primary culture of NRMCs induced ERS. We propose that medium-glucose culture media should be used and describe an improved protocol for the primary culture of NRMCs.

PURPOSEThe purpose of this study was to determine whether cyclophosphamide (CP) can decrease myocardial and systemic TNF-α expression and thus protects myocardial I/R injury.METHODSOpen chest rats were subjected to 30 min of ischemia followed by 3h, 12h or 24h of reperfusion. Rats were divided into sham group, I/R group and CP group, and each group included 3 timepoint subgroups (3h, 12h and 24h). Plasma TNF-α was measured by cytometric bead array (CBA) and immunohistochemistry was used to detect TNF-α in myocardium.RESULTSCompared with I/R group, rats treated with CP showed a significant difference with decreased plasma TNF-α (13.31 ± 2.62 vs 14.13 ± 5.95 pg/mL at 3 h reperfusion, 10.1 ± 2.73 vs 12.54 ± 5.00 pg/mL at 12 h reperfusion, 10.38 ± 5.59 vs 13.00 ± 3.59 pg/mL at 24 h reperfusion, p <0.05 respectively). Immunostaining was less intense with CP injection at each reperfusion time. The score of the intensity of myocardial TNF-α staining was down regulated.CONCLUSIONSTNF-α is expressed in the myocardium and plasma after myocardial I/R injury. CP might be a feasible strategy for anti-TNF-α to protect myocardial I/R injury.

Background: Impaired cardiac function leads to impaired renal function. We assessed renal function in pregnant patients with heart failure.Methods: This was a retrospective study. From 1999 to 2010, 42 pregnant patients with heart failure were classified into the single-pregnancy group and the twin or multifetation group. Clinical manifestations were assessed. Serum concentrations of creatinine and cystatin C were assessed. Estimated glomerular filtration rate (eGFR) based on serum concentrations of creatinine or cystatin C was completed.Results: There were 29 single pregnancies, 12 twin pregnancies, and one multifetation. Ten patients in the twin pregnancy or multifetation group had in-vitro fertilization. The concentration of creatinine was 84.6 +/- 33.8 mu mol/L and the creatinine-based eGFR was 87.2 +/- 34.9 mL/min per 1.73 m(2). The percentage of patients with a creatinine based eGFR<60 mL/min per 1.73 m(2) was 23.8%. The concentration of cystatin C was 1.5 +/- 0.7 mg/L and the cystatin C-based eGFR was 65.2 +/- 45.8 mL/min per 1.73 m(2). The percentage of patients with a cystatin C-based eGFR<60 mL/min per 1.73 m(2) was 52.4%.Conclusions: Serum concentrations of cystatin C and cystatin C-based eGFR are important indicators of renal impairment in pregnant patients with heart failure.

OBJECTIVE:To examine the hemodynamic and electrophysiological influence of left ventricular aneurysm (LVA) formation in patients with idiopathic dilated cardiomyopathy (IDCM).METHODS:All hospital records were retrospectively reviewed from IDCM patients admitted to our hospital between 2003 and 2008. Patients with coronary angiography evidenced ischemic cardiomyopathy were excluded. IDCM patients with LVA (I + L) diagnosed by left ventriculography were enrolled. Twelve age-, gender- and left-ventricular-diameter- matched patients with IDCM without LVA served as control group (I - L).RESULTS:Six out of 998 patients with IDCM were confirmed to have LVA (0.60%). The LV peak-systolic pressure was higher in the I + L group than in I - L group [ (130 +/- 10) mm Hg (1 mm Hg = 0.133 kPa) vs. (117 +/-9) mm Hg, P < 0.05]. The LV end-diastolic volume was significantly larger in the I + L group than in I-L group[ (272 +/- 57) ml vs. (207 +/- 60) ml, P < 0.05]. The LV ejection fraction was slightly lower in the I + L group than in I - L group [ (27 +/- 9)% vs. (35 +/- 6)%, P = 0. 09]. Ventricular arrhythmia occurred more frequently in I + L group than in I - L group.CONCLUSION:LVA formation in IDCM was a rare phenomenon. IDCM patients with LVA seem to have higher LV peak-systolic pressure, larger end-diastolic volume, worse LV systolic function and more frequent ventricular arrhythmia than those without LVA.

目的探讨前臂可塑性固定带对经桡动脉途径冠状动脉介入诊疗术后并发症发生率的影响。方法将323例患者,按术后是否使用前臂可塑性固定带分组,使用组(A组)167例,未使用组(B组)156例;比较两组局部出血及小血肿、大血肿、肢体肿胀、睡眠障碍等发生率。结果A组局部出血及小血肿、睡眠障碍发生率低于B组,两组比较有统计学意义。结论经桡动脉途径冠状动脉介入诊疗术后使用前臂可塑性固定带,可减少术后局部并发症,增加患者舒适度。

总结98例心房颤动患者应用Carto三维标测系统指导环肺静脉线性电学隔离术治疗的护理体会。治疗前加强心理护理,完善各项准备;治疗中做好生命体征观察及护理配合;治疗后加强穿刺局部的观察与护理,重视病情及并发症的观察与护理,认真做好出院指导。经治疗及护理,89例肺静脉电位完全隔离,9例部分肺静脉电位未完全隔离。

总结26例肥厚梗阻型心肌病患者行导管化学消融心肌术的并发症及护理。导管化学消融心肌术的主要并发症为胸痛、心肌梗死、心律失常、一过性低血压、血栓形成、局部血肿。护理重点是做好术前准备,术中严密观察,术后注意心电图和血压变化,26例经治疗护理,好转出院。

总结心脏三腔起搏器治疗扩张型心肌病伴心力衰竭的护理体会。认为重点是术前重视健康教育,完善各项检查;术后重视穿刺部位护理,防止感染,加强心电监护,严防起搏电极脱位,做好出院指导。3例起搏器功能良好,1例冠状窦电极微脱位,适当调整输出电压后纠正。