Objective:To explore the effects of lianpuyin combined with esmeprazole and mosapride on neurotransmitters, interleukin-17 (IL-17), serum calcitonin gene-related peptide (CGRP) and interleukin-1 in patients with reflux esophagitis β(IL-1 β)Influence of.Methods:96 patients with reflux esophagitis were treated prospectively from May 2020 to January 2022. They were randomly divided into two groups. 48 patients in the control group were treated with esomeprazole combined with Mosapride, and 48 patients in the observation group were treated with Lianpu Yin combined with esomeprazole and Mosapride. The therapeutic effects of the two groups were compared after 8 weeks of treatment.Results:the improvement of CGRP (1.85±0.51) pg/ml, ne (95.72±9.74) ng/ml and 5-HT (27.81±5.19) ng/ml in the observation group at 8 weeks after treatment was better than that in the control group (P<0.05). The endoscopic grading score at 4 weeks after treatment (1.68±0.33) and 8 weeks after treatment (0.51±0.18) were lower than those in the control group (P<0.05). At the same time, the remission rates of the observation group at 2, 4 and 8 weeks after treatment were 45.83%, 68.75% and 91.67% respectively, which were higher than those in the control group (P<0.05).Conclusion:the treatment of lianpuyin combined with esomeprazole and mosapride in patients with reflux esophagitis can reduce the current inflammatory reaction and improve clinical symptoms.

目的 研究当归芍药散联合Toll样受体4(Toll-likereceptor4,TLR4)抑制剂对大鼠肝纤维化的抑制作用及对核因子 κB(Nuclear factor kappa-B,NF-κB)/NOD 样受体蛋白 3(NOD-like receptor protein 3,NLRP3)通路的调节作用.方法 大鼠随机分为空白对照组及造模组,造模组采用腹腔注射四氯化碳(CCl4)法建立肝纤维化大鼠模型,造模完成后的大鼠随机分为肝纤维化模型组、当归芍药散组、TLR4抑制剂组及联合组,12只/组,当归芍药散组大鼠按照10g·kg-1(以生药含量计)灌胃给予大鼠当归芍药散,TLR4抑制剂组腹腔注射给予大鼠TAK-242(3mg·kg-1),联合组同时给予大鼠当归芍药散(10g·kg-1)及TAK-242(3mg·kg-1),1次/天,连续给药13周,测定大鼠体质量、肝脏重量及肝脏指数,使用全自动生化分析仪测定大鼠血清直接胆红素(Direct bilirubin,DBIL)、总胆汁酸(Total bile acid,TBA)及总胆红素(Total bilirubin,TBIL)水平,使用酶联免疫吸附法(ELISA)测定肝组织细胞间黏附分子-1(Intercellular cell adhesion molecule-1,ICAM-1)、超氧化物歧化酶(Superoxide dismutase,SOD)、丙二醛(Malondialdehyde,MDA)及还原型谷胱甘肽(Glutathione,GSH)水平,Masson染色法检查大鼠肝组织病理学变化,实时定量聚合酶链式反应(Real-time quantitative polymerase chain reaction,Rt-qPCR)测定肝组织 NLPR3 及 NF-κB mRNA 水平,免疫印迹法(Western blot)测定肝组织NLPR3及NF-κB蛋白水平,免疫荧光法测定肝组织α-SMA表达.结果 与空白对照组比较,肝纤维化模型组大鼠肝脏质量、肝脏指数,血清DBIL、TBA及TBIL水平、肝组织ICAM-1及MDA水平、肝组织NLPR3及NF-κB mRNA及蛋白水平、肝组织α-SMA免疫荧光强度显著升高(P＜0.05),体质量、肝组织SOD及GSH水平显著降低(P＜0.05),肝组织明显纤维化改变;与肝纤维化模型组比较,当归芍药散组、TLR4抑制剂组及联合组大鼠肝脏质量、肝脏指数,血清DBIL、TBA及TBIL水平、肝组织ICAM-1及MDA水平、肝组织NLPR3及NF-κB mRNA及蛋白水平、肝组织α-SMA免疫荧光强度显著降低(P＜0.05),体质量、肝组织SOD及GSH水平显著升高(P＜0.05),肝组织病理学明显恢复,且联合组各项指标变化显著优于当归芍药散及TLR4抑制剂单独给药组.结论 当归芍药散联合TLR4抑制剂能显著改善肝纤维化大鼠肝功能,抑制肝组织纤维化进展,降低氧化应激损伤,其机制可能与调节NF-KB/NLPR3通路有关.

目的 探讨五苓散联合艾灸对全膝关节置换术(total knee arthroplasty,TKA)后关节肿胀及功能康复的影响.方法 选择2020年1月至2021年1月于新疆维吾尔自治区人民医院骨伤科接受治疗的拟接受TKA患者105例.按随机数表法分为对照组(n=52)和试验组(n=53).对照组给予基础消肿止痛治疗,试验组给予五苓散联合艾灸.分别于术前及术后3d、7 d、15 d,采用疼痛视觉模拟评分法(visual analogue scale,VAS)、美国特种外科医院膝关节评分(hospital for special surgery knee score,HSS)进行评价,测量大腿围、小腿围及膝围,并检查红细胞沉降率(erythrocyte sedimentation rate,ESR)、C反应蛋白(C-reactive protein,CRP)及白介素(interleukin,IL)-6水平.结果 两组均顺利完成手术,其中4例(对照组3例,试验组1例)出现切口皮缘坏死,给予清创换药后愈合;深静脉血栓2例(对照组1例,试验组1例)为肌间静脉丛血栓,给予剔除研究.治疗后,试验组总有效率为94.34％,高于对照组的75.00％,差异有统计学意义(P＜0.05);术后7d、15d,两组患者大腿围、膝围、小腿围均显著大于术前,差异有统计学意义(P＜0.05).术后7d、15d,试验组大腿围、膝围显著小于对照组,差异有统计学意义(P＜0.05).术后3d、7d、15d,试验组VAS评分显著低于对照组,差异有统计学意义(P＜0.05).术后15d,试验组HSS评分显著优于对照组,差异有统计学意义(p＜0.05).试验组术后7 d的CRP、IL-6水平显著低于对照组,差异有统计学意义(p＜0.05).术后15d,试验组ESR、CRP、IL-6水平低于对照组,差异有统计学意义(P＜0.05).结论 五苓散联合艾灸可显著减轻TKA后关节肿胀,缓解疼痛,改善膝关节功能.

Objective:To observe the effects of the factors of dry cold food and dry cold environment on bio-logical characterization of the mice. Methods:Thirty healthy male ICR mice were randomized into the control group and the intervention group, 15 mice each group, body weight was weighed each day, food-intake, water consump-tion, stool volume and urine volume were detected, and the changes of biological characterization were observed.Results:The aspect of biological characterization, compared with the control group, biological characterization of the intervention group manifested dull-red tongue nature, less body fluid, sparse fur, less lustrous, crouching and moving less, lassitude, indifference, response lags, squint after flocking together, somnolence, semiformed stool, semiwet, clear urine in large amounts, manifested purple tongue, flabby fur, dim without luster, crouching and moving less, lassitude, indifference, response lags, squint after flocking together, deformed and sticky stool, clear urine in small amounts. The aspects of body weight, compared with the control group, body weight of the mice in the intervention group decreased at the seventh day, while the difference had no statistical meaning, body weight of the mice in-creased slowly at the 14th day, and the difference was obvious (P<0.05);body weight of the mice of the interven-tion group at the 21st day increased slowly compared with the control group, and there was a significant difference (P<0.01). Intake and output volume, compared with the control group, water consumption of the mice in the inter-vention group increased notably, and there was a significant difference (P<0.01);while there was no significant dif-ference(P>0.05) in the comparison of food intake volume, the volume of urine and stool. Conclusion:Dry cold food and dry cold environment could make the mice a series of changes of biological characterization, which contains body weight reduction, water consumption increase and others, as the time goes by and the intensity increases, dry cold food and dry cold environment could finally increase dry cold nature disorder pattern for uygur medicine.

目的:观察基础治疗上加用柴胡加龙骨牡蛎汤方治疗心律失常的临床效果.方法:随机将心律失常患者143例分为两组:对照组72例,予以内科规范治疗;治疗组71例,在对照组基础上加用柴胡加龙骨牡蛎汤方治疗.比较两组治疗前后中医证候积分、证候疗效及心电图疗效的变化,统计不良事件的发生情况.结果:两组中医证候积分均较治疗前下降,治疗组改善程度优于对照组,差异具有统计学意义(P＜0.05);中医证候疗效方面,治疗组为91.55％,高于对照组的70.83％,差异具有统计学意义(P＜0.05);心电图疗效方面,治疗组为90.15％,高于对照组的65.28％,差异具有统计学意义(P＜0.05);两组均未发生不良事件.结论:柴胡加龙骨牡蛎汤方治疗心律失常能显著改善患者症状,改善心电异常,且无不良反应发生.

Objective To observe the curative effect of Jianpi-qiangji decoction combined with rehabilitation training on the immunologic function and symptom improvement in patients with myasthenia gravis. Methods 81 subjects with myasthenia gravis were randomly divided into two groups. 39 subjects in control group were treated by pyridostigmine bromide combined with prednisone acetate tablets. 42 subjects in treatment group were treated by Jian-pi-qiangji decoction combined with rehabilitation training on the basis of control group treatment. The curative effect was evaluated three months after treatment in two groups. The levels of peripheral T-lymphocyte subgroup ( CD3+, CD4+, CD8+, CD4+/CD8+) and natural killer ( NK) cell before and after treatment were detected in two groups. The myodynamia was evaluated by four grade-five levels scoring method. Results The total effective rate in treat-ment group(85. 71%) was superior to that in control group (74. 36%,P<0. 05). The levels of CD3+, CD4+,CD4+/CD8+ and the myodynamia after treatment were decreased in two groups, and the CD8+and NK cells were increased, with statistical differences (P<0. 05), and there were statistical differences between two groups on the levels of CD4+, CD8+, CD4+/CD8+, NK cells and the myodynamia (P<0. 05). Conclusion Jianpi-qiangji decoction com-bined with rehabilitation training has exact effects on the treatment of myasthenia gravis, can obviously enhance myo-dynamia, and to correct imbalanced T-lymphocyte subgroup, with persistent and stable curative effect.

Objective It is to observe the effect of Tongxinluo ( TXL) on heme oxygenase -1 ( HO-1) mRNA gene ex-pression in myocardial tissue in the rats with pressure overload , and to investigate its protective effect on cardiac function . Methods 40 SD rats were selected , in which 8 ones were randomly selected as sham operation group , the other 32 rats were prepared abdominal aortic coarctation pressure overload models , the survival rats (n=24) after operation were randomly divid-ed into three groups:model group, TXL group and TXL+HO-1 inhibitor group, each group had 8 rats.TXL group was giv-en TXL superfine aqueous 1 g/(kg· d) orally, sham operation group, model group were given the same volume of normal sa-line, TXL+HO-1 inhibitor group was given Tongxinluo superfine aqueous 1 g/( kg· d) orally +ZnPP injection 1 mg/( kg · d) by intraperitoneal injection .Each set of daily 9:00 medication once daily for 4 consecutive weeks , interventricular sep-tum thickness (IVST), left ventricular wall thickness (LVPWT), left ventricular end diastolic diameter (LVEDD), left ven-tricular end systolic inner diameter ( LVESD) and left ventricular mass index ( LVMI) were detected by cardiac ultrasound .In 8 weeks the expression of HO -1mRNA in myocardial tissue was determined , and at the same time histopathological HE stai-ning was used to observe pathologic change in myocardial tissue .Results Compared with sham operation group , IVST, LVP-WT, LVEDD, LVESD and LVMI were significantly increased in model group ,TXL group and TXL+HO-1 inhibitor group(P<0.05),and these indexes in TXL group were significantly lower than that in model group and TXL +HO-1 inhibitor group (P<0.05).HO-1mRNA expression level in TXL group was significantly higher than that in the other three groups (P<0. 05).HE staining showed that compared with model group , myocardial tissue morphology were improved more or less in TXL group and TXL+HO-1 inhibitor group , and the improvements in TXL group were the most significant .Conclusion TXL can inhibit myocardial fibrosis , slow ventricular remodeling , protect myocardial tissue , these effects may be related with HO -1 overexpression induced by TXL .

气机升降是自然界的规律，气的运动是人体生命活动的基础，气机升降理论随着历史的演变，已成为中医学比较重要的理论之一。杨国华教授运用这一理论，结合现代医学对反流性食管炎的认识，自拟健脾升降汤运用于本病的临床，取得了理想的治疗效果。

气机升降是自然界的规律，气的运动是人体生命活动的基础，气机升降理论随着历史的演变，已成为中医学比较重要的理论之一。杨国华教授运用这一理论，结合现代医学对反流性食管炎的认识，自拟“健脾升降汤”运用于本病的临床，取得了理想的治疗效果。

<正>类风湿关节炎(rheumatoid arthritis,RA)是一种以关节病变为主,病情错综复杂,病因尚不明确的疾病[1]。主要表现是关节结缔组织的慢性炎症性病变,小关节起病较常见,呈对称性。主要特点是病变关节的滑膜炎症,当病情加重累及软骨和骨质时,可破坏关节结构,造成关节畸形和功能丧失,最终造成残疾。目前,RA的治疗手段主要

<正>马德孚系新疆自治区首届名老中医,历任新疆中医学院《金匮》教研室主任、教授、硕士生导师、主任医师。从事临床及教学40余年,擅长治疗各类疑难杂症,尤其在妇科领域积累了丰富的经验,笔者有幸跟师抄方多年,收益良多,兹将马德孚教授治疗痛经的经验总结如下。1马老对月经的认识经之产生始于肾气盛。《内经》云:"女子七岁肾气盛,齿更发

目的:通痹方治疗痛风疗效观察。方法:100例痛风患者随机分为对照组44例口服醋氯芬酸钠,治疗组56例口服通痹方。2周为1疗程,共2疗程,观察治疗前后疗效、疼痛评分、血尿酸比值的比较。结果:通痹方治疗痛风临床疗效比较,差异有统计学意义(P<0.05),治疗前后疼痛评分比较差异有统计学意义(P<0.01),治疗前后血尿酸值比较差异有统计学意义(P<0.01)。结论:通痹方改善临床疗效,减轻疼痛,降低血尿酸疗效较好。

<正>荨麻疹是常见的多器官变态反应性皮肤病,病因复杂,反复发作,往往迁延至慢性。2008-03—2011-11,笔者采用自拟养血疏风方治疗慢性荨麻疹59例,并与氯雷他定片口服治疗59例对照观察,结果如下。1资料与方法

<正>女性婚后夫妇同居2年以上,配偶生殖功能正常,未避孕而未受孕者,称为原发性不孕症;如曾孕育过,未避孕又2年以上未再受孕者,称为继发性不孕症。我们通过研究《内经》中的相关论述,就继发性不孕治疗经验总结如下。1《内经》对生育的认识1.1《内经》对孕的认识《内经》云:"地有四时不长草,人有无子。"此所谓无子,就是不孕,而且古人认识到不孕

目的 评价艾迪注射液治疗老年人晚期非小细胞肺癌的临床疗效.方法 152例老年晚期非小细胞肺癌患者采用静脉滴注艾迪注射液治疗,对肿瘤客观疗效、治疗进展时间(TTP)、生活质量、中医临床症状、不良反应等进行观察.结果 艾迪注射液治疗肿瘤的稳定率为68.42%;TFP为(2.81±0.47)个月;并能提高患者的生活质量(P＜0.05)、改善中医临床症状(P＜0.01),且无明显不良反应.结论 艾迪注射液对老年晚期非小细胞肺癌患者具有较好的临床疗效.

祖国医学认为情志因素与疾病发生具有十分紧密的关系.情志失调直接累及脏腑而致病;情志失调可致气机紊乱而致病;七情内伤,则气机逆乱,津液运化失常而生痰、瘀.情志疗法基本原理是脏腑情志论和五行相克论的结合,将人体归纳为五个体系并按五行配五脏五志,然后利用情志之间相互制约的关系来进行治疗的心理疗法,即运用一种情志纠正另一种失常情志.因此,它在心理治疗方法上独具特性。

目的评价消癌平注射液治疗老年晚期非小细胞肺癌的临床疗效。方法本文回顾分析了121例老年晚期非小细胞肺癌患者,采用静脉滴注消癌平注射液,对肿瘤客观疗效、治疗进展时间(TTP)、生活质量、中医临床症状、毒副反应方面进行观察。结果消癌平注射液治疗肿瘤的稳定率为70.25%;治疗进展时间为(2.65±0.53)个月;并能提高患者的生活质量(P<0.05)、改善中医临床症状(P<0.01),且无明显毒副反应。结论消癌平注射液对老年晚期非小细胞肺癌患者具有较好的临床疗效。

<正>消化性溃疡是一种常见、多发病,目前多采用西医疗法。但是,传统医学在消化性溃疡的治疗中也发挥着重要的、不可替代的作用。为此,我们观察了健胃愈疡片对消化性溃疡的治疗作用。报告如下。

酒精性脂肪肝是一种临床常见病,我科采用灯盏花素注射液治疗酒精性脂肪肝97例,取得较好的疗效,现报告如下: