Individuals with bipolar disorder (BD) undergo depressed episodes, frequently characterized by anhedonia. Neurotrophic factors and oxidative stress are linked to anhedonia. The precise association between these biomarkers and anhedonia in individuals with BD remains unclear. This study primarily examined the potential relationships among brain-derived neurotrophic factor (BDNF), superoxide dismutase (SOD), catalase (CAT), and anhedonia in individuals with BD. This study had 85 people diagnosed with bipolar disorder, of whom 61 exhibited depression symptoms. Additionally, there were 88 healthy control volunteers. The study thoroughly evaluated anticipatory and consummatory pleasure, childhood adversity, oxidative stress indicators, and BDNF levels in depressed BD patients and healthy controls. Partial correlation analysis and stepwise multiple linear regression analysis were employed to explore the relationships among oxidative stress indicators, BDNF and anhedonia. In comparison to the healthy control group, the depressed BD group demonstrated markedly diminished anticipatory and consummatory pleasure, elevated anxiety and depression ratings, and increased childhood adversity. There was a significant difference in CAT levels between the two groups. In depressed BD patients, BDNF and CAT were moderately and negatively correlated with consummatory pleasure. The regression analysis indicated BDNF as a significant predictor of consummatory pleasure. These data suggested that the anhedonia is affected by BDNF and oxidative stresses, so offering a critical insight for addressing anhedonia in BD. Not applicable.

Negative symptoms represent pervasive symptoms in schizophrenia (SZ) and major depressive disorder (MDD). Empirical findings suggest that disrupted striatal function contributes significantly to negative symptoms. However, the changes in striatal functional connectivity in relation to these negative symptoms, in the transdiagnostic context, remain unclear. The present study aimed to capture the shared neural mechanisms underlying negative symptoms in SZ and MDD. Resting-state functional magnetic resonance imaging data were obtained from 60 patients with SZ and MDD (33 with SZ and 27 with MDD) exhibiting predominant negative symptoms, and 52 healthy controls (HC). Negative symptoms and hedonic capacity were assessed using the Scale for Assessment of Negative Symptoms (SANS) and the Temporal Experience of Pleasure Scale (TEPS), respectively. Signal extraction for time series from 12 subregions of the striatum was carried out to examine the group differences in resting-state functional connectivity (rsFC) between striatal subregions and the whole brain. We observed significantly decreased rsFC between the right dorsal rostral putamen (DRP) and the right pallidum, the bilateral rostral putamen and the contralateral putamen, as well as between the dorsal caudal putamen and the right middle frontal gyrus in both patients with SZ and MDD. The right DRP-right pallidum rsFC was positively correlated with the level of negative symptoms in SZ. However, patients with SZ showed increased rsFC between the dorsal striatum and the left precentral gyrus, the right middle temporal gyrus, and the right lingual gyrus compared with those with MDD. Our findings expand on the understanding that reduced putaminal rsFC contributes to negative symptoms in both SZ and MDD. Abnormal functional connectivity of the putamen may represent a partially common neural substrate for negative symptoms in SZ and MDD, supporting that the comparable clinical manifestations between the two disorders are underpinned by partly shared mechanisms, as proposed by the transdiagnostic Research Domain Criteria.

This study aims to compare the differences in clinical features and inflammatory factors between unipolar depression and bipolar depression, and to investigate potential clinical characteristics and peripheral blood biomarkers that could be used to differentiate between these two conditions. Furthermore, the study seeks to establish a predictive model. Inpatients from the Shanghai Mental Health Center, admitted between June 2022 and June 2024, were selected as study participants. Based on diagnosis records, 274 patients were assigned to the unipolar depression group, and 128 patients to the bipolar depression group. A total of 128 patients were matched between the two groups using the propensity score matching method. Demographic data, clinical characteristics, and biological indicators were compared between the two groups. The biological markers assessed included neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte ratio (MLR), platelet/lymphocyte ratio (PLR), C-reactive protein (CRP), serum triiodothyronine (T3), thyroxine (T4), free thyroid hormones (fT3, fT4), thyroid-stimulating hormone (TSH), complement 3 (C3), complement 4 (C4), immunoglobulin A (IgA), immunoglobulin G (IgG), and immunoglobulin M (IgM). Binomial logistic regression analysis was employed to control for confounding factors and to explore the predictors of bipolar depression. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the predictive value of clinical features and biological markers for bipolar depression. Statistically significant differences were observed between the unipolar depression and bipolar depression groups with respect to life events (χ² = 15.397, P = 0.000), CRP (Z = 6.717, P = 0.000), TSH (Z = 1.988, P = 0.047), C3 (Z = 5.682, P = 0.000), C4 (Z = 4.216, P = 0.000), and IgM (Z = 2.304, P = 0.021). Logistic regression analysis indicated that life events (OR = 4.552, 95

Objective:To explore the molecular mechanisms underlying clozapine-induced metabolic syndrome (MetS) in schizophrenia patients, providing scientific evidence for clinicians to prevent and manage metabolic syndrome during the treatment of psychiatric disorders. Methods:Ten schizophrenia patients with MetS and ten matched controls were recruited from Shanghai Mental Health Center according to the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) criteria for schizophrenia and the 2016 Chinese Adult Dyslipidemia Prevention and Treatment Guidelines for MetS. Peripheral blood RNA sequencing was performed to identify differentially expressed genes (DEGs). Weighted gene co-expression network analysis (WGCNA) and protein-protein interaction (PPI) network were used to pinpoint hub genes. Mendelian randomization (MR) was conducted to validate causal relationship between serum brain-derived neurotrophic factor (BDNF) levels and MetS components. Results:A total of 1019 DEGs were identified, grouped into eight mRNA modules through WGCNA. Key hub genes included RP11-611O2.6, acid phosphatase-like 2 (ACPL2), T cell receptor alpha variable 12-2 (TRAV12-2), matrix metallopeptidase 8 (MMP8), piggyBac transposable element derived 4 pseudogene 1 (PGBD4P1), transmembrane protein 261 (TMEM261), and BDNF, with BDNF and MMP8 further validated by PPI network analysis. MR analysis confirmed a causal association between BDNF levels and MetS risk, reinforcing its role in metabolic dysregulation. Gene Ontology (GO) annotation and pathway enrichment analysis highlighted immune response, morphological changes, and metabolic processes as key biological processes, with pathways such as biological oxidation and defensins significantly enriched. Conclusion:Significant differences in gene expression are observed between schizophrenia patients with and without MetS. Individual variability in clozapine-induced MetS may be linked to DEGs.

The characteristic features of dissociative conversion disorder entail a partial or complete loss of normal integration in memory, identity awareness, immediate sensation, and motor control. This article documents a case of the disorder presenting with an onset of depressive mood, diminished interest, and facial tics, subsequently accompanied by intermittent fainting spells with limb convulsions. Despite multiple consultations in both general hospitals and psychiatric settings, and despite treatment with various antidepressants and antiepileptic medications, the patient's symptoms showed no significant improvement. The report of this case deepens the understanding of a complex and commonly misdiagnosed condition, offering valuable insights for the diagnosis and treatment of patients exhibiting similar symptoms.

Background Second-generation antipsychotic drugs are increasingly used to treat depressive disorders with psychotic symptoms. In addition to effectively managing psychotic symptoms, second-generation antipsychotics can also result in adverse drug reactions in patients., which should not be underestimated. Case presentation We report the case of 14 years old unmarried female patient with depression. At first, she started with moping and gradually developed into self-injury and whispering. After antidepressant treatment combined with the second-generation antipsychotic drug blonanserin, the patient's psychotic and depressive symptoms improved significantly, while the patient developed lactation, which stopped after the medication was changed. Conclusions Although Blonanserin's clinical trials have reported rare adverse reactions like elevated prolactin levels and even lactation, caution is still needed in clinical application of the drug. This case is expected to improve psychiatrists' choice of antidepressant therapy in combination with antipsychotic drugs.

Background: Major depressive disorder (MDD) is a serious and disabling condition characterized by abnormal mood changes. Clinical guidelines for depression treatment recommend antidepressant medications, with benzodiazepines acting as short-term synergists. However, little is currently known about the prevalence and associated clinical risk factors of benzodiazepine use among Chinese patients with MDD. This study aimed to explore the prevalence and clinical risk factors associated with benzodiazepine use in this population. Methods: A total of 2742 patients with MDD (males/females = 816/1926, aged 14-60 years) participated in this cross-sectional observational study. General information and psychosis assessments were collected online. Depressive symptoms were assessed using the Patient Health Questionnaire-9 (PHQ-9), anxiety symptoms using the Generalized Anxiety Disorder-7 (GAD-7), and sleep problems and suicidal tendencies using the third and ninth items of the PHQ-9. Multivariable logistic regression analysis models were employed to identify factors associated with benzodiazepine use. Results: The prevalence of benzodiazepine use among patients with MDD was 42.9 %. Among these patients, 99.6 % used a single benzodiazepine, with oxazepam being the most frequently prescribed. Age, severity of sleep problems, depressive symptoms, and anxiety symptoms were significantly correlated with benzodiazepine use (all P < 0.001). Limitations: The cross-sectional design of this study precludes establishing causal relationships. Conclusion: Our findings indicate a high prevalence of benzodiazepine use among Chinese patients with MDD. Factors such as severe depressive symptoms, anxiety symptoms, age, and sleep problems appear to be associated with benzodiazepine use. These results underscore the importance of vigilance regarding benzodiazepine use in patients with MDD.

Pinealoma often comorbid with obstructive hydrocephalus due to their specific location and type, therefore, patients with pinealoma need to be treated by a combined ventriculoperitoneal shunt (VPS) along with surgical resection. Shunt failure is the most common complication after surgery. In this paper, we report a case of obstructive hydrocephalus caused by shunt obstruction after pineal gland tumor resection combined with ventriculoperitoneal shunt. The patient first showed low mood, decreased interest and energy, and gradually developed into manifestations of less eating, less talking, less movement, repeated psychiatric visits, and showed no improvement after treatment with antidepressants. The purpose of the current study is to increase the knowledge of these diseases and reduce misdiagnosis.

Objective To explore the gender differences in the prevalence and influencing factors of nonalcoholic fatty liver disease（NAFLD） in hospitalized schizophrenia patients. Methods A total of 316 schizophrenic inpatients admitted to Shanghai Jiading District Mental Health Center from 1 July 2020 to 30 June 2021 were recruited. Multivariate Logistic regression analysis were applied to analyze schizophrenia inpatients and influencing factors of NAFLD in patients with different genders. Results The prevalence of NAFLD in hospitalized schizophrenics was 41.1%（130/316）, with a prevalence of 42.1%（82/195） in male patients and 39.7%（48/121） in female patients. Multivariate Logistic regression analysis showed that the influencing factors of NAFLD in hospitalized schizophrenia patients were female（OR=2.345, 95%CI=1.159-4.743）, high body mass index（BMI）（OR=1.445, 95%CI=1.296-1.610）, high triglyceride（TG）（OR=2.715, 95%CI=1.709-4.315）, high alanine aminotransferase（ALT）（OR=1.019, 95%CI=1.002-1.037）, long hospitalized time（OR=1.099, 95%CI=1.040-1.162）, diabetes（OR=2.879, 95%CI=1.225-6.768）（P＜0.05）. Multivariate Logistic regression analysis showed that high BMI（OR=1.524, 95%CI=1.324-1.753） and high TG（OR=2.841, 95%CI=1.652-4.887） were the risk factors of NAFLD in male hospitalized schizophrenia patients（P ＜ 0.05）; high BMI（OR=1.370, 95%CI=1.186-1.582） and high blood glucose（OR=1.982,95%CI=1.218-3.225） were the risk factors of NAFLD in female hospitalized schizophrenia patients（P ＜ 0.05）; elder age of onset（OR=0.939, 95%CI=0.889-0.991） was the protective factor of NAFLD in female hospitalized schizophrenia patients（P ＜0.05）. Conclusions The prevalence of NAFLD in hospitalized patients with schizophrenia is high, and significantly associated with gender, BMI, TG, ALT, length of hospitalization time and diabetes, and there are gender differences in influencing factors. Therefore, attention should be paid to the prevention and treatment of NAFLD in hospitalized schizophrenia patients in clinical practice.

Abstract Background: Many clinical studies have shown that patients with major depressive disorder (MDD) or obsessive-compulsive disorder (OCD) display evident cognitive deficits. However, little is known about the impact of these disorders on cognitive symptoms. Methods: This cross-sectional study was conducted with a convenience sampling method to distribute QR codes as an outpatient service. The Patient Health Questionnaire-9 (PHQ-9) assessed for depressive symptoms, and those with a total score ≥ 5 were selected for the analysis. A total of 218 outpatients with MDD were included. The Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) was used for OCS. MDD patients with a Y-BOCS score ≥ 6 were classified as MDD with comorbid OCS (MDDOC). The Perceived Deficits Questionnaire-Depression (PDQ-D-5) was used to evaluate subjective cognitive symptoms. A multivariate analysis of covariance and regression models was performed to estimate the effects of OCS on cognitive symptoms. Results: There was no significant difference in cognitive symptoms between MDD alone and MDDOC patients (p＞0.05). In the MDDOC subgroup, both the Y-BOCS score and the subdomain (obsession/compulsion) had significant correlations with the PDQ-5 score (r=0.510, 0.504, 0.428, all p＜0.01, respectively). Further hierarchical regression analyses showed that OCS or the OCS subdomain (compulsion/obsession) contributed to cognitive symptoms (all p﹤0.05), even when controlling for depression severity (p＜0.001; p=0.032; p=0.012, respectively). Moreover,mediation anallysis indicated the ralation between PHQ-9 and subjective cognitive sympton was mediated by OCS. Conclusions: Our findings suggest there is no significant difference in cognitive symptoms between the MDD alone and the MDDOC groups. However, OCS or OCS subdomain may contribute to subjective cognitive symptoms in MDDOC patients. Notably, when controlling for the severity of depression, comorbid OCS aggravated cognition impairment in the MDDOC group.

Background The etiopathogenesis of major depressive disorder(MDD)is strongly associated with neuroinflammation.MDD is a highly heterogeneous psychiatric disorder,and the disease subtyping is an essential step for the identification of biological markers.The presence of psychomotor retardation seriously affects the prognosis of MDD,whereas the underlying mechanism is not yet completely clear.A potential involvement of granulocyte colony-stimulating factor(G-CSF)and macrophage colony-stimulating factor(M-CSF)in the pathogenesis of MDD with psychomotor retardation has been suggested in previous studies,but little detailed research has been completed.Objective To analyze the correlation of plasma G-CSF and M-CSF levels with psychomotor retardation in patients with MDD,and to explore the potential biological underpinnings of psychomotor retardation in MDD.Methods A total of 50 MDD patients who met the diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders,fifth edition(DSM-5)and attended the outpatient clinics of Shanghai Mental Health Center from April 2018 to April 2019 were included.The severity of symptoms was assessed using the Hamilton Depression Scale-17 item(HAMD-17).According to the retardation factor in HAMD-17,patients with a score of≥8 were included in retardation group(n=22),and those with a score below 8 were included in non-retardation group(n=28).Another 22 age-and sex-matched healthy controls were concurrently recruited.Plasma G-CSF and M-CSF levels were measured in all subjects using Luminex liquid suspension chip technology.Spearman correlation analysis was adopted to verify the correlation of retardation factor score in HAMD-17 with plasma G-CSF and M-CSF levels in MDD patients.Results Plasma G-CSF levels were decreased in MDD patients compared with healthy controls[57.34(39.24,83.15)pg/mL vs.71.47(61.20,79.99)pg/mL,Z=-2.098,P＜0.05].A statistical difference was found in plasma G-CSF level[63.92(54.60,89.43)pg/mL vs.47.80(33.41,74.66)pg/mL vs.71.47(61.20,79.99)pg/mL,H=8.247,P= 0.016]and plasma M-CSF level[20.05(16.05,22.23)pg/mL vs.13.05(11.43,17.50)pg/mL vs.18.95(14.59,22.88)pg/mL,H=7.620,P=0.022]among retardation group,non-retardation group and healthy control group.The post hoc pairwise comparisons using Bonferroni correction indicated that plasma G-CSF level was lower in non-retardation group compared with healthy control group(adjusted P＜0.05),and plasma M-CSF level was higher in retardation group compared with non-retardation group(adjusted P＜0.05).The retardation factor score in HAMD-17 was positively correlated with plasma M-CSF level in MDD patients(r=0.348,P＜0.05).Conclusion The prevalence of psychomotor retardation in MDD patients may be related to abnormally elevated plasma M-CSF level.

Subthreshold depression (SD) is a global mental health problem given its high prevalence, comorbidity, functional impairment, and its association with increased service utilization. However, currently little is known about sex differences of SD in cognitive impairment with clinical correlates. This study aims to explore sex differences in subjective cognitive impairment and clinically associated risk factors in Chinese patients with subthreshold depression (SD). A total of 126 patients with SD, 40 males and 86 females, aged 18–45 years, were included in this cross-sectional observational study. Their general information, psychological assessments, and psychiatric symptom assessments were collected online. The Patient Health Questionnaire depression-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7), Perceived Deficits Questionnaire-Depression (PDQ-D), and Toronto Alexithymia Scale (TAS-20) with 3 subdomains were used. The obtained scores were analyzed with partial correlation and multiple linear regression analysis models. Our results showed that females had significantly higher PDQ-D-20 total score than males. However, the differences in TAS-20 and subdomain score according to sex were not significant. Notably, TAS-20 and DDF (difficulty describing feelings) subdomain contributed to cognitive impairment in males, whereas both PHQ-9 total score and TAS-20 or DDF subdomain contributed to cognitive impairment in females. These findings revealed significant sex differences in cognitive impairment and clinical correlates in SD, which should be further followed-up in the future. This study is the first to explore sex differences in subjective cognitive impairment and clinical associated risk factors in Chinese patients with subthreshold depression. Notably, TAS-20 and DDF (difficulty describing feelings) subdomain contributed to cognitive impairment in males, whereas both PHQ-9 total score and TAS-20 or DDF subdomain contributed to cognitive impairment in females.

多巴胺超敏性精神病(DSP)是指长期高剂量服用抗精神病药物后出现反弹性精神病、药物耐受性增加和迟发性运动障碍(TD).目前,DSP的发生机制不明确,缺乏有效的治疗方法.然而,DSP在精神分裂症患者中的流行率较高,尤其在治疗抵抗的精神分裂症患者中.近年来,有许多临床研究关注到DSP,掌握其发生机制并进行有效治疗可以缩短患者疾病病程,改善患者整体预后.因此,现对DSP的发生机制和治疗现状进行综述.

目的 探讨高频重复经颅磁刺激(rTMS)在抑郁症急性期治疗中的增效作用.方法 选择2020年1月至2021年9月上海市嘉定区精神卫生中心和上海交通大学医学院附属精神卫生中心收治的94例抑郁症急性期患者为研究对象,根据治疗方法将患者分为对照组(n=48)和观察组(n=46).观察组患者给予帕罗西汀联合rTMS治疗,对照组患者单用帕罗西汀治疗.分别于治疗前及治疗1、2、3周末,采用汉密尔顿抑郁量表(HAMD-24)评分评估2组患者抑郁症状.分别于治疗前和治疗3周末,采用临床总体印象量表-疾病严重度(CGI-S)量表评估2组患者病情严重程度.比较2组患者的临床疗效和治疗期间不良反应发生情况.结果 2组患者的HAMD-24评分随治疗时间延长显著降低(F=206.83、308.98,P＜0.001).治疗前,观察组与对照组患者的HAMD-24评分比较差异无统计学意义(P＞0.05);治疗1、2、3周末,观察组患者的HAMD-24评分均显著低于对照组(P＜0.05).2组患者治疗3周末CGI-S评分显著低于治疗前(P＜0.05);治疗前,对照组与观察组患者的CGI-S评分比较差异无统计学意义(P＞0.05);治疗3周末,观察组患者的CGI-S评分显著低于对照组(P＜0.01).治疗1周末,观察组患者治疗好转率高于对照组(x2=4.876,P＜0.05);治疗2、3周末,观察组患者治疗有效率均高于对照组(x2=7.153、5.041,P＜0.05);治疗3周末,观察组患者治疗临床痊愈率高于对照组(x2=4.055,P＜0.05).对照组与观察组患者的不良反应发生率分别为16.7％(8/48)、19.6％(9/46);对照组与观察组患者的不良反应发生率比较差异无统计学意义(x2=0.133,P＞0.05).结论 高频rTMS联合帕罗西汀治疗抑郁症急性期起效快,高频rTMS对抑郁症急性期治疗具有一定的增效作用,且安全性较高.

目的:探讨经皮迷走神经刺激(tVNS)联合阿戈美拉汀治疗难治性抑郁症(TRD)的临床疗效及机制.方法:选取100例TRD患者为研究对象,依据治疗方式不同分为对照组与观察组,每组各50例.对照组予以阿戈美拉汀治疗;观察组予以tVNS联合阿戈美拉汀治疗,疗程均为8周.比较两组患者治疗总有效率、汉密尔顿抑郁量表(HAMD)、比兹堡睡眠质量指数(PSQI)评分及血清5-羟色胺(5-HT)、去甲肾上腺素(NE)、脑源性神经营养因子(BDNF)水平和不良反应发生情况.结果:观察组患者治疗总有效率高于对照组(P<0.05).治疗2周、4周、8周后,观察组HAMD及PSQI评分均低于对照组(P<0.05).治疗8周后,观察组血清5-HT、NE、BDNF水平均高于对照组(P<0.05).两组患者不良反应发生率比较,差异无统计学意义(P>0.05).结论:tVNS联合阿戈美拉汀治疗TRD能够更好更迅速改善患者抑郁症状及睡眠状况,且安全性好,其机制可能与上调血清5-HT、NE、BDNF水平有关.

目的 探讨半封闭式管理加农场劳动对长期住院的慢性精神分裂症患者阴性症状和社会功能的影响.方法 前瞻性纳入2017年9月至2018年9月于上海市奉贤区精神卫生中心住院的80例慢性精神分裂症患者,按照随机数字表分为干预组(n=40)与对照组(n=40),干预组给予抗精神病药物结合半封闭式干预加农场劳动管理,对照组给予抗精神病药物结合封闭式管理,持续12个月.对所有受试者在干预前后进行阳性与阴性症状量表(PANSS)、住院精神病人社会功能评定量表(SSFPI)和自知力与治疗态度问卷(ITAQ)评估.结果 重复测量方差分析结果显示,PANSS的阳性症状因子分显示分组主效应差异有统计学意义(F=4.887,P=0.030);阴性症状因子分显示时间和分组交互效应差异有统计学意义(F=6.249,P=0.015),干预组在12个月末阴性症状分有下降;一般精神病理症状两组在时间主效应、分组主效应、时间和分组交互效应上差异均无统计学意义(均P>0.05);SSFPI的社会性活动技能显示,时间主效应差异有统计学意义(F=9.648,P=0.003),但分组主效应和时间与分组交互效应差异均无统计学意义(均P>0.05);SSFPI日常生活能力、动性和交往情况两组在时间主效应、分组主效应、时间和分组交互效应上差异均无统计学意义(P>0.05).ITAQ量表总分显示时间和分组交互效应差异有统计学意义(F=36.865,P<0.001).结论 半封闭式管理加农场劳动可以有效地改善长期住院慢性精神分裂症患者阴性症状、自知力与治疗的态度,对社会功能影响不明显.

目的 探讨女性精神分裂症患者心脏根据心率校正后的QT间期(corrected QT interval,QTc)与长期抗精神病药物单药或多药治疗的关系.方法 选取2016年1月至2018年12月在上海市精神卫生中心及上海市奉贤区精神卫生中心住院的女性精神分裂症患者60例,分为使用一种抗精神病药物组(单药组,n=20)和联合两种或以上抗精神病药物组(多药组,n=40),分别在基线期以及第3、6、12、18和24个月末检测心脏QTc,比较两组患者在不同时点的QTc差异,计算QTc延长的比例.结果 所有患者各时间点QTc延长所占的比例为26.7％～46.7％.两组QTc延长比例在各个时点差异均无统计学意义(P＞0.05).多药组的QTc在不同时间点差异有统计学意义(P＜0.05),且在第3、18及24个月QTc均超过440 ms,最大值在第18个月末.而单药组各个时间点QTc间期均未超过440 ms.从各时间点看,第18个月两组患者的QTc差异有统计学意义(P＜0.05),在第3、6、12及24个月多药组QTc长于单药组,但差异无统计学意义(P＞0.05).结论 女性精神分裂症患者,尤其是多药联用的女性患者在长期使用抗精神病药物期间应对其心脏QTc间期进行监测.

目的 了解青少年情感障碍患者主要照料者的心理健康状况.方法 选取66例青少年情感障碍患者的主要照料者为研究对象,分别采用广泛性焦虑量表(GAD-7)、健康问卷抑郁量表(PHQ-9)、抑郁症状快速评定量表(QIDS-SR16)及简明健康调查量表(SF-36)对其进行临床评估,了解其心理健康状况.结果 66例青少年情感障碍患者照料者年龄集中于35～59岁,多为女性.青少年情感障碍患者主要照料者QIDS-SR16得分显示有抑郁情绪的照料者占65.1％,PHQ-9得分显示有抑郁情绪的照料者占12.2％,GAD-7得分显示有焦虑情绪的照料者占33.3％.青少年情感障碍患者主要照料者SF-36生理机能、躯体疼痛、一般健康状况、社会功能评分均高于国内常模(P<0.05).Pearson相关性分析显示主要照料者SF-36各维度得分与QIDS-SR16、PHQ-9、GAD-7得分均呈负相关(P<0.05).结论 在青少年情感障碍患者照料者中,生活质量下降,焦虑抑郁占比高,应重视由此引发的健康问题.

Mitochondria are energy processing plants for cells. Mitochondrial metabolism is closely related to mitochondrial dynamics which plays the key role in nervous system development. Recent studies show that mitochondrial dynamics disorders has been thought to contribute to the pathophysiology of schizophrenia. This article discusses the influence of mitochondrial dynamics on nervous system development, and review recent work suggesting the relation between aberrant mitochondrial dynamics and schizophrenia.

恶性综合征是抗精神病药物引起的一种少见而严重的不良反应,临床上以发热、肌张力增高、自主神经功能紊乱和精神状态改变为特征,如不能及时发现与治疗,死亡率较高.