Objective To explore the clinical effect of sitagliptin combined with DMBG on treating patients with type 2 dia-betes mellitus accompanied with cardiovascular diseaseand its influenceonlevel of IMT、Hcy、haemodynamics. Methods 180 cases treated in our hospital from June, 2012 to July, 2015 were randomly divided into the observation group and control group with each group of 90 cases. The levels of FBG, HbA1c, FIN, HOMA-IR, IMT, Hcy, haemodynamics were compared in the two groups. Results After therapy, the level ofFBG、HbA1c、FIN、HOMA-IR in both groups were largely improved compared with those of before therapy, and the level of FBG、HbA1c、FIN in observation group were significantly improvedcompared with the control group; Similarly the level of IMT、Hcy in all the two groups were obviously decreased compared with those of before therapy, and those of the observation group were significantly lower than the control group; the blood flow velocityof CRA, PCA in two groups were obviously increased compared with those of before therapy, and those of the observation group were signifi-cantly increased than the control group. Conclusion Sitagliptin combined with DMBGwas effective methods in treating patients with type 2 diabetes mellitus accompanied with cardiovascular disease, could decrease levels of FBG, IMT、Hcy and increase microcirculation, which deserve clinical expansion.
目的 探讨中老年人群血清脂联素(APN)等脂类代谢指标在甲状腺功能紊乱疾病中的变化及其相关性.方法 采用电化学发光法检测159例甲状腺功能亢进症(简称甲亢)、120例甲状腺功能减退症(简称甲减)患者及140名体检正常者(正常对照组)甲状腺激素[三碘甲状腺原氨酸(T3)、甲状腺素(T4)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺素(TSH)]水平,采用酶联免疫吸附试验(ELISA)测定各组血清APN水平,对比各组血清APN、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A1 (apo A1)、载脂蛋白B(apo B)、载脂蛋白E(apo E)的差异,并分析其相关性.结果 甲亢组、甲减组、正常对照组之间血清APN、TC、TG、LDL-C、apo E水平差异有统计学意义(P＜0.05),血清HDL-C、apo A l、apo B差异无统计学意义(P＞0.05);相关分析显示甲亢组和甲减组FT4与TC的相关性最高(r值分别为-0.498、-0.461,P=0.000).结论 中老年甲状腺功能紊乱患者血清APN等脂类指 标有明显变化.TC与FT4的关系最为密切.
<正>1966年Brain等[1]首次报道1例桥本脑病(HE),临床表现为复发性,自行缓解的卒中样发作及昏迷,伴有桥本甲状腺炎。患者血清甲状腺抗体水平增高,对皮质类固醇激素治疗反应良好。本病亦称伴自身免疫性甲状腺炎的激素反应性脑病[1]。现报道1例HE。病例女,38岁。2009年4月入院。2008年2月无明显诱因出现心悸、怕热。半月后出现言语不清,右侧肢体无力,在外院住院作脑MRI、DSA等检查,诊断为脑梗死,治疗2周
<正>笔者所在科自2005年对激素停药后复发或每天需要泼尼松剂量15mg以上的难治性自身免疫性溶血性贫血(AIHA)患者,采用来氟米特(LFM)联合小剂量环孢菌素(CsA)方案治疗。现将治疗效果总结报告如下。
Objective To strengthen the screening and diagnosis of anaemic etiopathogenisis ,and preventing misdiagnosis and mistreatment.Methods Bone marrow,fecal occult blood,blood urea nitrogen were set up as a barometer for the etiological. Results of 268 cases of severe anemia patients,16 cases were confirmed as intestinal cancer. Conclusion Severe anemia is an early clinical manifestation of the small intestine cancer. Screening and diagnosis of anaemic etiopathogenisis is the key to patients with anaemic.
