以高度抛光的玻璃陶瓷、聚合瓷、氧化锆、纯钛为摩擦副,模拟口腔环境,使用微摩擦磨损实验机进行天然牙釉质和牙本质的摩擦磨损实验.用扫描电镜观察表面形貌、用粗糙度仪测粗糙度、用维氏硬度仪测表面硬度、用电子天平测磨损量,研究了天然牙釉质和牙本质与不同修复材料之间的摩擦磨损性能.结果表明,釉质和牙本质分别与四种材料对磨后的磨损量与对照组均有统计学差异(P＜0.05),对磨物的磨损量与四种材料及釉质、牙本质的硬度值呈显著正相关关系.其中牙本质与聚合瓷对磨后的磨损量与牙本质对照组最接近,釉质与玻璃陶瓷对磨后的磨损量与釉质对照组最接近.

目的 探讨自噬相关蛋白Beclin1和PI3KC3在乳腺癌组织中的表达及相关性.方法 随机抽取60例乳腺癌组织、55例癌旁组织,免疫组织化学染色检测Beclin1和PI3KC3表达,并结合临床病理因素进行统计分析.结果 免疫组化显示Beclin1和PI3KC3阳性表达定位于细胞质.PI3KC3和Beclin1蛋白在癌旁组织中的阳性表达率都高于乳腺癌组织,差异具有统计学意义(46.7％ vs 76.4％,43.3％ vs 70.9％,P＜0.05),伴随着TNM组织分化程度的降低、分期的升高,Beclin1和PI3KC3蛋白表达均会下调,随着肿瘤增大,Beclin1表达也下调,差异有显著意义(p＜0.05).结论 Beclin1、PI3KC3表达下调可能参与了乳腺癌的恶性转变过程.

目的 应用解剖学无纸化实验考试方法并进行调查分析.方法 将前期解剖学资源体系作为题库基础,建立和应用无纸化考试方法,并对180名学生进行无纸化测试和问卷调查.结果 绝大多数学生认为无纸化考试方法考点明确清晰、软件操作方便、考试更加客观公正而且考试环境更好,希望应用此种方式.结论 基于资源体系建设的解剖学无纸化实验考试改革具有诸多优势,有很强的现实意义和拓展价值.

病理学是重要的医学基础课程,实验教学是极其重要的教学环节,而在实验课上通过观察大量的切片、标本组织形态学结构变化是本学科的特色,传统实验课单一枯燥,缺乏趣味性,被动式填鸭式教学效果较差.现将微信公众号应用于病理学实验教学中,提高了学生学习的兴趣,方便学生主动性学习,辅助教学,提高了教学质量.

Objective:To compare the wear resistance between dentin and dental restoration material in vitro.Methods:The friction and wear behaviors of natural tooth dentin respectively against highly polished polymer ceramic,glass ceramic and zirconia were investigated in an artificial saliva test environment by UMT-2 friction and wear testing machine.Worn surface morphology was observed by scanning electron microscopy(SEM),roughness was measured by roughness instrument,the rigidity value was weighed by electronic balance.Results:The roughness of the 3 materials was similar to that of dentin(P ＞ 0.05),the rigidity of dentin was less than that of the 3 materials (P ＜ 0.05).After friction and wear test,the abrasion quantity of dentin respectively against the 3 materials was less than that of the materials (P ＜ 0.05).There was positive correlation between the wear loss and the hardness of the 3 materials and dentin(r =0.846).The mass loss of the dentin against Poly Ceramic after grinding abrasion was the closest among the 3 materials.Conclusion:Different materials have varying degrees abrasion against dentine.The Polymer Ceramic has closer abrasion performancez with dentin than the other 2 materials.

随着医学教育的发展,考试方法也在发生着变革.基于Authorware的形态学智能化题库实验考试软件,具有整合题库和随机抽题等优点,但是开发操作过程繁琐.本文通过设计智能化考试题库模板,在模版的基础上开发制作,大大提高了软件的开发效率,更好的促进了考试的公平公正.