Introduction: Apart from the fact that breast cancer patients experience self-blame and stigmatisation, their families may also face discrimination and societal rejection due to prevailing myths, misconceptions and causal beliefs related to breast cancer. Although a scale has been introduced to measure affiliate stigma in caregivers of cancer patients, it has not yet been psychometrically tested. This study aims to develop and validate a measurement tool that is sensitive to the affiliate stigma experienced by caregivers of women with breast cancer. Methods: The scale was developed in two phases: (a) item generation based on interviews amongst 18 caregivers of women with breast cancer; (b) psychometric properties of the scale, including content validity, structural validity, and internal consistency reliability. Data were collected from May to June 2023 in 426 caregivers of women with breast cancer from 5 tertiary A hospitals. Findings: An exploratory factor analysis produced a 24-item scale across four dimensions. The scale also showed good internal consistency and test–retest reliabilities. The total score of the scale was significantly and positively correlated with scores in caregiving burden and negatively correlated with scores in self-esteem and in social support. The item-level content validity index fell within the range of 0.8–1.0. Interpretation: The is a valid and reliable instrument to assess affiliate stigma status amongst caregivers of women with breast cancer and may serve as a unique instrument that can be used globally. The scale captured the spectrum of stigma relevant to caregivers of women with breast cancer.

Objective:Families of breast cancer patients may face discrimination and societal rejection due to prevailing myths, misconceptions and causal beliefs related to breast cancer. This study aims to develop and validate a measurement tool that is sensitive to the affiliate stigma experienced by caregivers of women with breast cancer. Methods:The scale was developed in two phases: (1) item generation based on interviews amongst 18 caregivers of women with breast cancer; (2) psychometric properties of the scale, including content validity, structural validity, and internal consistency reliability. Data were collected from May to June 2023 in 426 caregivers of women with breast cancer from 5 tertiary A hospitals. Results:An exploratory factor analysis produced a 24-item scale across four dimensions, including internal stigma, social isolation, perceived stigma, and reaction. The scale showed good internal consistency and test-retest reliability. The total score of the scale was significantly and positively correlated with scores in caregiving burden and negatively correlated with scores in self-esteem and in social support. The item-level content validity index fell within the range of 0.8-1.0. Conclusions:This is a valid and reliable instrument captured the spectrum of stigma relevant to caregivers of women with breast cancer and may serve as a unique instrument that can be used globally. This study is a step forward for stigma-related studies among caregivers of women with breast cancer and provides a reference for developing effective interventions for those with potentially stigmatized conditions.

BackgroundOlder patients are at high risk of falling, and regular assessments of their concerns about falling (CaF) are often recommended. The present study aimed to investigate the association between CaF and personality traits among older patients as well as to elucidate the mediating role of subjective age.MethodA cross-sectional study was conducted among 407 patients aged over 60 years in a tertiary hospital located in Chengdu, Sichuan Province, from March 2023 to May 2023. Predesigned electronic questionnaires were distributed to collect relevant data. Four different models (both crude and adjusted weighted linear regression models) were constructed based on the confounders. Confounders were gradually put into the models to control for bias and to examine the stability of the correlations. Bootstrap sampling was employed to examine the mediating role of subjective age.ResultAccording to the fully adjusted model, neuroticism (β = 0.17, 95% CI: 0.02 to 0.31, p for trend = 0.02), extraversion (β = −0.07, 95% CI: −0.15 to 0.001, p for trend = 0.05), and subjective age (β = 2.02, 95% CI: 1.28 to 2.78, p for trend <0.001) were consistently correlated with CaF. Mediating analysis revealed that extraversion was negatively related with CaF both directly and indirectly, via subjective age [23.2% partial effect, bootstrap 95%CI: −0.024(−0.080, −0.000)]. Higher neuroticism was consistently related to older subjective age (β = 0.002, 95% CI: 0.001 to 0.004, p for trend = 0.006), while higher levels of conscientiousness, openness, and extraversion were consistently correlated with younger subjective age(β = −0.002, p for trend = 0.04; β = −0.003, p for trend = 0.003; β = −0.002, p for trend = 0.0, respectively).ConclusionExtraversion and neuroticism were significantly correlated with CaF. Moreover, subjective age partially mediated the relationship between extraversion and CaF. Furthermore, subjective age was found to be associated with both CaF and personality traits. These findings highlighted the important roles of personality traits and subjective age in assessments of CaF and in the development of strategies for preventing falls among older patients.

BACKGROUND:Accurate estimation of prognosis can help provide early palliative care to patients. However, few studies have developed nomograms that are totally based on objective blood test parameters. The current study constructed a simple and objective prognostic nomogram and validated the model using advanced cancer patients. METHODS:A total of 245 patients were retrospectively analyzed (training sample, n=162; validation sample, n=54), from January 2020 to December 2021. Blood test and demographic data were collated. Cox proportional hazard regression was performed to identify the independent factors, which were built into a nomogram to visualize the probability of patient survival within 30 days. Calibration and discrimination of the model was assessed. The decision curve analysis (DCA) was developed to summarize the performance of the model in supporting decision making. RESULTS:The median survival was 17.0 [8, 37] days and 21.0 [10, 46] days for the training set and the validation set, respectively. Serum calcium (>2.65 mmol/L), neutrophil count (<2 mmol/L and >7 mmol/L), urea (>7.6 nmol/L), and glutamic oxalacetic transaminase (>40 U/L) were identified and an easily obtained nomogram predicting the 30-day probability of mortality was developed. The nomogram model had adequate discrimination and calibration. The Harrell's concordance index (C-index) of the training set and validation set was 0.69 and 0.71, respectively, while the values of the area under the curve (AUC) of the receiver operating characteristic (ROC) curve were 0.76 and 0.70, respectively. CONCLUSIONS:A simple and objective prognostic nomogram model for predicting the 30-day survival of patients with advanced cancer was developed and validated, with adequate calibration and discrimination. It is expected to guide practical prognosis evaluation in the clinical setting. Further validation is still required in a prospective, multicenter, and large sample study.

Abstract Background Growing breast cancer patients increases the demand for unmet needs. Few research has focused on any systematic research into unmet need among these groups. This aim is to clarify major elements of unmet needs and factors influencing in order to provide a basis for provision of appropriate medical services. Method A throughout search was conducted in Cochrane Library, PubMed, Embase, Web of Science, Medline from inception through December 2022. Studies investigated unmet supportive care needs of patients with breast cancer were included. Two independent researchers extracted the data, evaluated the quality of eligible studies, and performed double-checks. Methodological quality was independently appraised by two authors in accordance with JBI critical appraisal tools. Content analytic approach was applied to narrative synthesis. For quantitative studies, the meta-analysis was also performed to pool the proportions through Review Manager Software. Results Our present review identified 63 studies evidencing the unmet needs of patients with breast cancer. A total of 10534 records were retrieved and 63 studies were included finally. The overall risk of bias was low to moderate. Self-made questionnaire was the most used instrument, followed by The Short-form Supportive Care Needs Survey questionnaire (SCNS-SF34). Social support (74%), fear of cancer recurrence/ spreading (55%), daily activity (54%), sexual/intimacy (52%) and information support (50%) were the unmet needs with most proportion. Information need and psychological/emotional need were been found to appear most frequently. The most reported unmet needs among breast cancer patients were dignity (55.8%), physical/symptom (55%), and daily activity (52.7%). Meanwhile, in breast cancer survivors, peer communication (65.5%), daily activity (56.5%), medical counselling (52.2%), and fear of cancer recurrence/ spreading (52%) were frequently reported. It was found that unmet needs were significantly associated with many factors such as demographic data, treatment, disease status, quality of life, performance status and some psychological indicators. Conclusion Breast cancer patients are experiencing a large number of unmet needs in fear of cancer recurrence, daily activity, sexual/intimacy, psychology and information. Standard assessment tools that specifically to unmet needs among breast cancer patients were absent. Patients with different characteristics had various unmet support need, which emphasized the necessity to verified elaborate care plan for different patients. We identified some potential risk factors of unmet need. Data synthesis through meta-analysis to confirm the influencing factors are demanded.

BACKGROUND:Breast cancer is the most common type of cancer in women worldwide. Though improved treatments and prolonged overall survival, breast cancer survivors (BCSs) persistently suffer from various unmet supportive care needs (USCNs) throughout the disease. This scoping review aims to synthesize current literature regarding USCNs among BCSs. METHODS:This study followed a scoping review framework. Articles were retrieved from Cochrane Library, PubMed, Embase, Web of Science, and Medline from inception through June 2023, as well as reference lists of relevant literature. Peer-reviewed journal articles were included if USCNs among BCSs were reported. Inclusion/exclusion criteria were adopted to screen articles' titles and abstracts as well as to entirely assess any potentially pertinent records by two independent researchers. Methodological quality was independently appraised following Joanna Briggs Institute (JBI) critical appraisal tools. Content analytic approach and meta-analysis were performed for qualitative and quantitative studies respectively. Results were reported according to the PRISMA extension for scoping reviews. RESULTS:A total of 10,574 records were retrieved and 77 studies were included finally. The overall risk of bias was low to moderate. The self-made questionnaire was the most used instrument, followed by The Short-form Supportive Care Needs Survey questionnaire (SCNS-SF34). A total of 16 domains of USCNs were finally identified. Social support (74%), daily activity (54%), sexual/intimacy (52%), fear of cancer recurrence/ spreading (50%), and information support (45%) were the top unmet supportive care needs. Information needs and psychological/emotional needs appeared most frequently. The USCNs was found to be significantly associated with demographic factors, disease factors, and psychological factors. CONCLUSION:BCSs are experiencing a large number of USCNs in fearing of cancer recurrence, daily activity, sexual/intimacy, psychology and information, with proportions ranging from 45% to 74%. Substantial heterogeneity in study populations and assessment tools was observed. There is a need for further research to identify a standard evaluation tool targeted to USCNs on BCSs. Effective interventions based on guidelines should be formulated and conducted to decrease USCNs among BCSs in the future.

晚期艾滋病患者具有身体、心理等多方面的问题,安宁疗护需求高.本文从艾滋病患者安宁疗护的必要性、现状、影响因素进行综述,以期为国内安宁疗护在艾滋病患者中的推进提供依据和指导,为患者提供身体、心理、精神等多方面的照护,提高其生活质量.

Background Stroke has the highest disability-adjusted life-years lost in any disease, and approximately one-third of the patients get aphasia. Computers and tablets are innovative and aid in intensive treatments in speech rehabilitation for patients with aphasia. However, mechanical training limits the help to patients. Objective This study aims to provide a framework for an integrated virtual reality (VR) app to provide speech rehabilitation for patients with aphasia. Methods The content was generated through an in-depth literature review and discussion with experienced rehabilitation physicians and occupational therapists. We then conducted a 2-round Delphi study with 15 experts from hospitals and universities to rate the content using a 5-point Likert scale. The app was developed by an interdisciplinary team involving VR, medical science of rehabilitation, and therapeutic rehabilitation. Pilot usability testing of this novel app was conducted among 5 patients with aphasia, 5 healthy volunteers, 5 medical staff, and 2 VR experts. Results We designed 4 modules of speech rehabilitation: oral expression, auditory comprehension, cognition, and comprehensive application. Our VR-based interactive and intelligent app was developed to provide an alternative option for patients with aphasia. Pilot usability testing revealed user satisfaction with the app. Conclusions This study designed and tested a novel VR-based app for speech rehabilitation specifically adapted to patients with aphasia. This will guide other studies to develop a similar program or intelligent system in a clinical setting.

Objective:Hospitalized cancer patients are at high risk of venous thromboembolism (VTE). However, no predictive model has been specifically developed for this population. Machine learning (ML) is advantageous for model development. This study was aimed at developing predictive models using three different ML algorithms and logistic regression for VTE risk among hospitalized cancer patients and comparing their predictive performance.Methods:A retrospective case-control study was conducted on hospitalized cancer patients at Hunan Cancer Hospital, China, between October 1, 2021, and February 30, 2022. Patients diagnosed with vein thrombosis before or after admission were excluded. Patient, tumor, treatment, and laboratory indicator information was obtained from the hospital information system. The data were randomly split into distributions of 80% for training and 20% for testing. Logistic regression and three ML algorithms-the support vector machine, random forest, and extreme gradient boosting (XGBoost)-were used to develop the models. Model performance was compared using F1, G-mean, area under the receiver operating characteristic curve (AUROC), accuracy, precision, recall rate, and specificity. Feature rankings were achieved based on the permutation scores of the selected features in the optimal model.Results:A total of 1100 patients (mean [SD] age, 54.75 [11.08] years; 485 [44.09%] male) were included in this study. There were 340 patients (30.9%) in the VTE group. The XGBoost model achieved the best performance with the following evaluation metrics: F1 (0.750), G-mean (0.816), AUROC (0.818), accuracy (0.845), precision (0.750), recall rate (0.750), and specificity (0.888). D-dimer level, diabetes, hypertension, pleural metastasis, and hematological malignancies were identified as the five most significant features of the XGBoost model.Conclusions:Four predictive models were developed using ML algorithms. The XGBoost model was the optimal predictive model compared with the other three models. This study indicates that ML may play an important role in VTE risk estimation among hospitalized patients with cancer and provides a reference for thromboprophylaxis.

目的 调查分析育龄期乳腺癌患者生育忧虑现状及影响因素,为干预育龄期乳腺癌患者生育忧虑和全国性调查提供参考依据.方法 使用一般资料调查表、中文版癌症后生育忧虑量表、社会支持评定问卷、SF-12健康量表对2018年1月—2020年1月长沙市3所三级甲等医院收治的306例育龄期乳腺癌患者进行横断面调查.结果 育龄期乳腺癌患者生育忧虑总分为50.90±11.74分,多元线性逐步回归分析结果显示,婚姻状况、文化程度、术后时间、每月经济收入、化疗、放疗、与配偶的关系、职业、子女情况是育龄期乳腺癌患者生育忧虑的主要影响因素(P<0.05).结论 育龄期乳腺癌患者生育忧虑处于中等偏上水平,婚姻状况、文化程度、术后时间、每月经济收入、化疗、放疗、与配偶的关系、职业、子女情况是生育忧虑的影响因素,其中婚姻状况的影响最大.

This study aimed to conduct a retrospective cross-sectional study to investigate the prevalence of symptoms and symptom clusters on sociodemographic and disease characteristics, as well as factors associated with Do-Not-Resuscitate (DNR) consent. Advanced cancer patients were enrolled between 2018 and 2020 with available data. Demographic and clinical data were obtained for analysis from Hospital Information System (HIS) in China. Symptom clusters were extracted by hierarchical cluster analysis. Chi-square test and multiple logistic regression were conducted to investigate the prevalence characteristics of symptoms and influencing factors of DNR consent, respectively. 798 advanced cancer patients were enrolled. The most prevalent symptoms were pain (93%), anorexia (36.5%), and sleep disorders (34.2%). High heart rate was associated with poor performance status and more symptoms. Three clusters were extracted: fatigue-related, respiratory-circulatory system, and digestive system symptom clusters. The incidence of symptoms was statistically significant in age, gender, education level, residence, BMI, performance status, distress score, ADL, and primary pain level. The DNR signature rate was 15.5%. Female, distant metastasis, in-ward rescue, and appearance of dyspnea were independent influencing factors of DNR signature.Chinese hospitalized cancer patients had more symptoms burden that were influenced by various demographic characteristics, especially pain and fatigue-related symptoms. Concerning the trajectory of vital signs is important among advanced cancer patients. The DNR signature rate was lower and our finding indicating an urgency to accurately assess the prognosis and give more palliative care education to enhance DNR rates and early signing in Chinese context.

目的 组建安宁疗护病房团队会议团队,为多学科团队交流提供重要途径,提升多学科团队协作工作的效率与质量.方法 我院借鉴国内外多学科会议实践指南,立足专科特色,通过建章建制,对会议制度、流程、成员职责分工等进行规定,保证多学科团队会议的顺利进行.结果 2018—2020年,安宁疗护病房共计340例个案被纳入讨论.其中发生爆发痛的患者181例,经过多学科会诊后使用规范止痛处理,160例患者疼痛降至3分及以下,且爆发痛次数明显减少;患者拒绝心肺复苏签署率由2018年14.8％上升至2020年28.9％.结论 团队会议在医患沟通方面发挥了巨大作用,患者住院期间病情平稳、症状控制较好,实现了医患间零纠纷零争议.

Objective. This study aimed to conduct a retrospective observational study to understand the status of characteristics of pain and identify potential variables influencing the clinical presentation of breakthrough cancer pain (BTP) in advanced cancer patients. Methods. Advanced cancer patients over 18 years of age; diagnosed with cancer of any type and stage III or IV in the palliative care ward with available data were enrolled between 2018 and 2020. Demographic data and pain-related information were collected by using structured electronic extraction form from Hospital Information System (HIS). Patients who had well-controlled background pain with an intensity ≤4 on a 0–10 numerical scale for >12 hours/day, the presence of transient exacerbations of pain with moderate-severe intensity (≧5), and clearly distinguish from background pain were regarded to have suffered BTP. Spearman correlation was conducted to explore the relationship between pain score and demographics characteristics. Factors significant in univariate analysis were included in the multiple regression model to explore independent predictive factors associated with the BTP. Results. Of 798 advanced cancer patients, the mean age was 56.7 (SD = 11.84) years. Lung cancer (29.95%) was the most common cancer, and pain (93%) was the most common symptom. More than half (n = 428, 53.6%) of the patients experienced BTP. The median number of BTP episodes was 4 (IQR = 2, 7, range: 1–42). The median intensity of BTP was 6 (IQR = 6, 7, range 5–10). Patients with severe background pain or BTP had longer hospital stay and more symptoms. Besides, more severe background pain was related to higher activity of daily living. Intramuscular injection of hydromorphone hydrochloride was the main medication for BTP onset. Younger age, background pain, anorexia, and constipation were independently associated with the presentation of BTP. BTP pain intensity was independently associated with bloating. Symptom numbers were an independent factor and positively associated with BTP episodes. Conclusions. BTP resulted in poor prognosis, which has a variable presentation depending on interdependent relationships among different characteristics. Good controlling of background pain and assessment of pain-related symptoms are essential for BTP management. BTP should be managed individually, especially the invisible pain among aged patients. Furthermore, BTP-related education and training were still needed.

ObjectiveThis study systematically reviewed the effect of melatonin (MLT) on quality of life (QoL) and symptoms among patients with cancer.DesignSystematic review and meta-analysis.Data sourcesCochrane Library, PubMed, Embase, Web of Science, Medline, CINAHL, Scopus, ClinicalTrials.gov, China Biology Medicine (CBM), ProQuest and Open Grey were searched from inception to November 2021.Eligibility criteriaWe included randomised controlled trials (RCTs) assessing the effects of MLT on QoL, sleep quality, fatigue, depression, pain, stomatitis rate and stomatitis severity in adult patients with cancer, without language restrictions. Studies that reported the effects of MLT along with other interventions and had incomplete or absent outcome data were excluded.Data extraction and synthesisTwo independent reviewers extracted data, and another two reviewers assessed the risk of bias. The risk of bias for each eligible study was assessed using the Cochrane assessment tool. The mean difference or standard mean difference (SMD) with 95% CIs was used in the computation of continuous variables to synthesise data. The relative risk was used for dichotomous outcomes. Heterogeneity was assessed and quantified (I2 statistic).ResultsA total of 19 qualified studies that included 2101 patients with cancer (MLT: 1078, control: 1023) were included in the meta-analysis. The results indicated that MLT had no significant effect on QoL (SMD=−0.01, 95% CI (−0.14 to 0.11), p=0.83), sleep quality (SMD=−0.18, 95% CI (−0.62 to 0.26), p=0.42), fatigue (SMD=−0.34, 95% CI (−0.73 to 0.06), p=0.10), pain (SMD=−0.34, 95% CI (−0.7 to 0.02), p=0.06) or stomatitis severity (RR=0.78, 95% CI (0.47 to 1.30), p=0.35). MLT reduced stomatitis rate among patients with cancer (RR=0.47, 95% CI (0.26 to 0.88), p=0.02), except those with head and neck cancer (RR=1.09, 95% CI (0.92 to 1.29), p=0.35). MLT eased depression in patients who received administration for more than 14 days (SMD=−0.14, 95% CI (−0.27 to –0.01), p=0.03) and those who underwent surgery (SMD=−0.17, 95% CI (−0.32 to –0.03), p=0.02).ConclusionThe findings showed that MLT did not improve the QoL, sleep quality, fatigue, pain or stomatitis severity among patients with cancer. It had a limited effect on decreasing the stomatitis rate and easing depression. Different treatments, durations and cancer types were the main sources of heterogeneity. Further large-scale RCTs are urgently needed. In addition, the effects of different combinations of MLT dosage and duration, administration types and joint measures are worthy of further study.PROSPERO registration numberCRD42021292855.

目的:探讨五维教学体系在护理实习生临床培养的实施效果.方法:选取湖南省某三级甲等医院2019级、2020级护理实习生,分别作为对照组(420名)及试验组(380名).对照组于实习期间进行传统管理模式,试验组于实习期间开展理论带教、操作考核、护理查房、质量反馈和日常管理在内的五维教学体系;采用中文版批判性思维能力量表、护生临床实习满意度量表、护生考核成绩进行调查.结果:试验组护生评判性思维能力、护生满意度、考核成绩得分较对照组均有所提高(P<0.05).结论:五维教学体系一体化临床培养体系有助于提高护生评判性思维能力及临床实习满意度,能有效提高护生专业能力.

目的:建立安宁疗护专科护士培训基地,探索以库伯学习圈理论为基础的培训模式,培养高知识储备、高技能水平的专科护士,发挥专科辐射带动作用.方法:以学员需求为导向,以库伯学习圈理论为指导,以提升专科护士岗位胜任力为目标,通过多维度教学内容、多样化教学方式、多家机构实践、多手段考核形式、多方向培训平台、理论实践交互的"5多1交互"模式向学员提供全面专科培训.结果:自我院成为安宁疗护实践基地以来,成功举办了2期湖南省安宁疗护专科护士培训班,共培养87名安宁疗护专科护士;连续2届接收中华护理学会安宁疗护专科护士培训班的学员共48名到我院实践;基地教学质量持续改进,培训基地的建设促进了医院安宁疗护专科的发展.结论:安宁疗护专科护士实践培训基地的建立满足了国内护士的继续教育需求,需要继续加强培训基地建设,完善培养体系,培养更多高层次人才.

目的 调查了解年轻乳腺癌患者配偶二元应对现状,并分析其影响因素.方法 选取长沙市7所三级甲等医院乳腺科268名符合纳入标准的年轻乳腺癌患者配偶作为研究对象,采用自制的一般资料调查表、二元应对量表(The Dyadic Coping Inventory,DCI)、婚姻调适量表(Marriage Adjustment Test,MAT)及中文版痛苦自我表露指数量表(Distress Disclosure Index,DDI)进行调查,并采用多元线性回归分析乳腺癌患者配偶二元应对现状的影响因素.结果 年轻乳腺癌患者配偶DCI得分为(64.78±6.45)分,低于平均水平;多元线性回归分析显示文化程度、婚龄、亲密关系、痛苦自我表露水平是年轻乳腺癌患者配偶二元应对的影响因素(P＜0.05).结论 年轻乳腺癌患者配偶二元应对水平较低,医护人员应重视并根据影响因素采取有效干预措施,特别重视文化程度低、婚龄短、夫妻亲密程度低、痛苦自我表露水平低的年轻乳腺癌患者配偶.

目的:了解乳腺癌幸存者重返工作现状并分析其影响因素,为构建我国乳腺癌幸存者重返工作岗位干预方案提供指导.方法:采用便利抽样法,选取2020年1月—2021年5月于湖南省3所三级甲等医院门诊复查的415例乳腺癌幸存者为调查对象,采用一般资料调查表、重返工作准备度量表、生活质量评定量表、社会支持评定量表对其进行调查.结果:415例乳腺癌幸存者重返工作率为44.58％,子女数量是乳腺癌病人重返工作的阻碍因素;年龄、文化程度、经济收入、与配偶关系、社会支持是乳腺癌病人重返工作的促进因素,可解释变异的49.4％.结论:乳腺癌幸存者重返工作准备度水平仍处于较低水平,医护人员应综合评估其影响因素并给予针对性干预,帮助病人重返工作岗位.

Chemotherapy-induced nausea and vomiting (CINV) is a common side effect of cancer treatment. The factors influencing CINV in breast cancer patients remain unclear. In this study, we developed a nomogram for predicting the occurrence of CINV in this group using prospective clinical data. We pooled data from multiple studies which focused on the emetogenic chemotherapy. Then, we collected 334 breast cancer patients at Hunan Cancer Hospital (training set) to analyze the demographic and clinical variables. Using multivariate logistic regression, we identified the five significant factors that were associated with CINV: history of CINV, chemotherapy regimen, chemotherapy cycle, metastasis, and symptoms of distress. Then, we construct a prediction nomogram. The external validation set comprised an additional 66 patients. The reliability of the nomogram was assessed by bootstrap resampling. The C-index was 0.78 (95% confidence interval [CI], 0.73-0.85) for the training set and 0.74 (95% CI, 0.62-0.85) for the validation set. Calibration curves showed good concordance between predicted and actual occurrence of CINV. In conclusions, our nomogram model can reliably predict the occurrence of CINV in breast cancer patients based on five significant variables, which might be useful in clinical decision-making.

湖南省肿瘤医院立足专科特色,探索建立以患者为中心的具有肿瘤专科特色的安宁疗护病房.现将该院安宁疗护病房的管理模式、照护核心内容、多学科团队建设、照护质量标准建设、服务模式创新等经验进行分享.