Objective:To investigate the changes in cognitive and behavioral function in patients with cerebral small vessel disease and their correlation with serum homocysteine (Hcy) and cystatin C (CysC) levels.Methods:Ninety-four patients with cerebral small vascular disease who received treatment in Zhejiang Xin'an International Hospital from March 2019 to March 2021 were included in the observation group. An additional 80 healthy controls who concurrently received physical examination were included in the control group. The Mini-Mental State Scale (MMSE) and the Montreal Assessment Scale (MoCA) were used to evaluate cognitive function. The activity of daily living (ADL) was used to evaluate behavioral function. Enzyme-linked immunosorbent assay was used to measure serum Hcy and CysC levels. MMSE score, MoCA score, ADL score, serum Hcy and CysC levels were compared between the two groups. The receiver operating characteristic (ROC) curve was used to analyze the sensitivity and specificity of serum Hcy and CysC levels in the diagnosis of cerebral small vessel disease. Pearson correlation analysis was performed to analyze the correlation between serum Hcy and CysC levels and cognitive behavioral function.Results:MMSE score, MoCA score, and ADL score in the observation group were (21.21 ± 2.87) points, (20.18 ± 3.25) points, and (34.32 ± 5.45) points, which were significantly lower than (28.23 ± 1.02) points, (28.45 ± 0.89) points and (76.35 ± 8.29) points in the control group ( t = 20.78, 22.05, 40.03, all P < 0.05). Serum Hcy and CysC in the observation group were (16.28 ± 2.97) μmol/L and (1.21 ± 0.23) mg/L, which were significantly higher than (8.35 ± 1.76) μmol/L and (0.56 ± 0.12) mg/L in the control group ( t = 20.95, 22.77, both P < 0.05). ROC curve analysis showed that the sensitivity and specificity of serum Hcy in diagnosing cerebral small vessel disease were 85.29% and 53.85%, respectively; the sensitivity and specificity of serum CysC in diagnosing cerebral small vessel disease were 81.54% and 41.38%, respectively. Pearson correlation analysis revealed that serum Hcy level was linearly negatively correlated with MMSE score, MoCA score, and ADL score ( r = -0.79, -0.68, -0.71, all P < 0.05); serum CysC level was linearly negatively correlated with MMSE score, MoCA score, and ADL score ( r = -0.67, -0.75, -0.78, P < 0.05). Conclusion:The cognitive and behavioral function of patients with cerebral small vessel disease are decreased, and serum Hcy and CysC levels are increased. Serum Hcy and CysC levels are closely related to the cognitive and behavioral function of patients with cerebral small vessel disease.

经济高速发展下,各个行业都在蓬勃发展,经济发展使体检中心面向市场逐渐扩大,相应对体检中心的需求以及专业程度也更高,如何在发展中抓住机遇发展壮大,成为体检中心发展时必须面临的问题.文章通过SWOT管理分析法对体检中心的发展战略进行综合解析,通过改善管理增加体检中心竞争力.

目的 利用微信版糖尿病前期干预软件对糖尿病前期者进行早期、有效的干预和管理,以阻止或延缓病情进展,降低糖尿病发病率.方法 基于微信版糖尿病前期干预软件设置饮食、运动、健康宣教、健康预警、互动平台等干预技术,改变糖尿病前期者的生活方式,调控风险因素,使空腹血糖值和餐后血糖值逆转或延缓进展.结果 成功申请计算机软件著作权登记,对参与使用软件的150例糖尿病前期者发放调查问卷,103例参与者认为软件操作简单易学,120例参与者认为咨询方便快捷,143例参与者认为健康顾问专业性和干预方案的针对性非常强,7例参与者认为首页布局需要美化.结论 微信版糖尿病前期干预软件能发挥糖尿病前期者的主观能动性,有效地干预其生活方式,并具有不受时间、地域限制,方便快捷等特点.