目的:研究尿β2-微球蛋白(β2-MG)、肾损伤分子1(KIM-1)、血管紧张素1(Ang-1)检测对妊娠期高血压疾病(HDCP)早期肾损伤价值.方法:选取2016年3月-2019年3月本院收治的HDCP患者100例(妊娠期高血压组31例,子痫前期69例),肾损伤组64例(肾功能损伤)和非肾损伤组36例(肾功能正常),另选同期产前检查健康孕妇50例为对照组.比较各组尿β2-MG、KIM-1、Ang-1水平及与肾功能指标的相关性,以及对HDCP患者早期肾损伤的预测效能.结果:尿素氮、尿酸、尿蛋白、尿蛋白/肌酐值,子痫前期组最高,妊娠期高血压组居中、对照组最低,GFR水平对照组最高、妊娠期高血压组次之、子痫前期组最低;尿β2-MG、KIM-1及Ang-1水平,子痫前期组最高、妊娠期高血压组次之、对照组最低(P＜0.05).尿β2-MG、KIM-l、Ang-l水平,肾损伤组最高、非肾损伤组次之、对照组最低(P＜0.05).尿β2-MG、KIM-1、Ang-1分别与尿素氮、尿酸、24h尿蛋白、尿蛋白/肌酐呈正相关(P＜0.05),联合检测的ROC曲线下面积(0.881)最大.结论:β2-MG、KIM-1、Ang-1是HDCP早期肾损伤的敏感指标,联合检测诊断准确性最高.

Objective Study the blood gases of cord blood about FGR neonate and clinical value through the blood gases of cord blood about neonate between natural labour and caesarean birth.Methods A group are the FGR neonate who are natural labour;B group are the FGR neonate who are caesarean birth.C group are the nomal weight neonate who are caesarean birth.D group are the nomal weoght neonate who are caesarean birth.We compare the difference of pH,PO2 ,PCO2 ,BE,HCO3 between each group.Results pH,BE,HCO3 in group A are lower than that in group B. pH,BE,HCO3 in group A are lower than that in group C.BE in group B was lower,while PCO2 was higher in group D. BE in group C was lower,while PCO2 was higher in group D.Conclusions natural labour was more influence on the blood gases of cord blood than caesarean birth.The FGR neonates.are aerobic condition.Their abillity to tolerate the natural labour are lower than normal weight neonates.The roperly relaxation of caesarean birthindication can lower the incidence of anoxia neonatorum,and improve the prognosis of FGR neonate.

Objective Ti study the effect if different lying pisitiin during pregency in delivery mide. Method 300 pregnant wimen whi were befire active periid were selected. We researched their prenatal educatiin and lying pisitiin during pregency,and ibserved their preg-nancy iutcime. Results There were 218 pregnant wimen whi were lateral pisitiin,including 146 pregnant wimen whi were iccipitianterii pisitiin,51 pregnant wimen whi were iccipititransverse pisitiin,and 21 pregnant wimen whi were iccipitipisteriir pisitiin. While there were 82 pregnant wimen whi were free pisitiin,including 37 pregnant wimen whi were iccipitianterii pisitiin,31 pregnant wimen whi were iccipititransverse pisitiin,and 14 pregnant wimen whi were iccipitipisteriir pisitiin. Conclusion Lateral decubitus pisitiin in late pregnan-cy can reduce the head abnirmal fetal pisitiin,increase the rate if vaginal delivery.

目的:通过观察妊娠期高血压患者胎盘中IL-2和MMP-9的表达水平探讨妊娠期高血压疾病的发病机制.方法:选择妊娠期高血压孕妇114例,其中38例为轻度、35例为中度、41例为重度;另选择20例正常孕妇作为对照组,4组均于胎盘娩出后立即在胎盘脐带的对侧剪取胎盘组织,采用实时荧光定量PCR方法和酶联免疫法检测胎盘组织中IL-2和MMP-9的mRNA水平和蛋白含量.结果:轻度组孕妇与对照组孕妇胎盘组织中IL-2、MMP-9的mRNA水平及蛋白含量比较差异无统计学意义(P＞0.05);中、重度组孕妇MMP-9的mRNA水平及蛋白含量均低于对照组孕妇,IL-2的mRNA水平及蛋白含量均高于对照组孕妇,差异均有统计学意义(P＜0.01).结论:妊娠期高血压孕妇胎盘组织中IL-2、MMP-9的mRNA水平及蛋白含量随着分级增高而变化,为临床治疗妊娠期高血压疾病提供新的靶点.

Objective :To investigate the relationship between the state and the incidence of thrombosis in patients with early onset severe preeclampsia maternal blood .Methods :From 2010 January to 2013 January in our hospital during the early onset severe preeclampsia 70 cases as the research object ,at the same time from the same hospital delivery late on-set severe preeclampsia and normal pregnant women 70 cases as control group ,were recorded as early group ,late onset group and the normal group ,the three study group of four items of blood coagulation ,thrombosis dissolved two dimers (D-Dimer) ,antithrombin Ⅲ (AT-Ⅲ) and other coagulation hemostasis were detected and compared between the three groups ,the difference between the object of study .Results:The early onset group of antithrombin Ⅲ (AT-Ⅲ ) were significantly lower than the late group and the normal group ,and two bolt soluble polymer (D-Dimer) was significantly higher than that in control group and late onset group ,each group had significant difference in Statistics (P<0 .05) , and four items of blood coagulation shortened PT ,FIB was significantly higher than the normal group and late onset group ,APTT ,TT index had no significant difference between the three groups .Conclusion:The early onset of severe preeclampsia prethrombotic state is lower than that of the normal group is more serious ,in clinical monitoring ,to have risk factors of pregnant women through the changes of prethrombotic state detection to predict the onset of severe pre-eclampsia probability ,which can be used as an important reference index for early onset severe preeclampsia .